As others have already said, this essay by James Marriott is well worth taking the time to read. Now, back to my book if I can just prise my iPhone out of my hand for a few minutes… open.substack.com/pub/jmarriot...

"Employees are using AI tools to create low-effort, passable looking work that ends up creating more work for their coworkers." I'm so shocked that I might swoon 😱 (Ironically, their attempt to be constructive at the end of the article comes across as AI generated.) hbr.org/2025/09/ai-g...

From descriptive to quantitative biocatalysis “The 1913 study ‘Die Kinetik der Invertinwirkung’, by Michaelis and Menten, marked a pivotal advancement in enzymology by illustrating the application of mechanistic models and quantitative kinetics to biocatalysis.” doi.org/10.1038/s419...

This is huge: “A drug that provides near-perfect protection against H.I.V. with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope… making lenacapavir a realistic choice in countries with constrained resources.”

And if you think you're not next in the chopping block, you're not paying attention

I am QT dunking but I think this is a case where it is warranted: Science is political and "not wanting to see politics" as a scientist is a political choice. You may decide it's what works for you, but you need to decide how that fits with the fact your (diverse) colleagues still exist 🧪

A really great and comprehensive resource on metapneumovirus from the labs of Becky Dutch and Bernadette van den Hoogen. journals.asm.org/doi/10.1128/...

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

The SerialEM Python interface has been a huge driver of innovation at the hardware-software boundary in cryo-EM: suddenly the scientist with some programming chops can readily implement their ideas 🥰 This looks like a fantastic meeting!

Fact for the day: paracetamol does not cause autism

Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection www.nature.com/articles/s41...

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them: www.sciencedirect.com/science/arti...

Dear American citizens, whatever you wish more German citizens would have done in 1933, do that now.

These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.

wait until they figure out that in addition to being a sociopathic white supremacist he's not an engineer either, and mostly just opportunistically gloms onto real innovators, taking singular credit for their work while usually having an often rudimentary understanding of the underlying technology!

Google AI overview...

I love the kind of papers that I sometimes get from the cryo-EM bot. Hedgehog coronavirus!🦔

This is amazing 🤩

A reminder that Elon Musk is still a Fellow of the Royal Society. Surely THIS is the point at which he is expelled @royalsociety.org

I miss the times when an operating system wasn't a surveillance instrument designed to harvest as much data from the user as possible...

Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...

Check out this Interview with @aripeskoe.bsky.social to hear about how ratepayers are covering the costs of the infrastructure needed to support the surge in AI and data centers.

Leishmaniasis is 95% fatal if untreated — yet it’s still overlooked, and media coverage is low. Our new report shows what gets decision-makers to pay attention ⤵️ wellcomeopenresearch.org/documents/10...

Happens to me every other day

That's just great! Let's get ChatGPT choose what project gets funded, I see absolutely zero problems with this scenario... fFS .... can we just get some smart people back in the room?! 🧪 AI enters the grant game, picking winners | Science | AAAS www.science.org/content/arti...

Possible causes of your problems. It’s a diagram that (sadly) still seems relevant in 2025, so reposting a year and a bit on.

On this topic... we have an open PhD position in a small group! And we'll open a postdoc position within a couple of months.

Words/phrases Democrats should never use: * bipartisan * my Republican friends * real, valid, legitimate, serious, important (to describe issue raised by Republicans) * yea (when voting on Republican bills) * distraction (to describe bad thing Republicans did) * woke (in derogatory sense)

I look forward to reading this! It feels like something that "someone should have done" twenty years ago.

As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers, according to research from last year. https://scim.ag/3JHinJs #ScienceMagArchives

More great cryo-ET benchmarking work from my colleagues Maarten Tuijtel, Tomáš Majtner, Beata Turoňová, & @becklab.bsky.social: Systematic study of how tilt increment choice affects downstream TM & STA. Preprint has the optimally balanced tilt increment. #TeamTomo www.biorxiv.org/content/10.1...

This COI is not even shameful. We're past beyond that. This requires a new term completely 🧪

Breath-taking from @chrischirp.bsky.social. "But “America the free” are just words and they are rapidly losing all meaning. Instead America is sleepwalking into a populist authoritarian regime - for the sake of its democracy it needs to wake up." Read: christinapagel.substack.com/p/grand-desi...

Good thing no one uses Microsoft Excel for anything related to legal, regulatory or compliance business functions www.theverge.com/news/761338/...

No they won’t.

Very pleased to have our new work out where we perform a structure/function study on the bornavirus polymerase complex with fantastic coauthors. Have a read www.nature.com/articles/s41... @warwicklifesci.bsky.social @loiccarrique.bsky.social @franziskaguenl.bsky.social

The structure of the mammalian bornavirus polymerase complex www.nature.com/articles/s41...

“A legitimate PhD-level expert in anything,” they said. “Show me a diagram of the US presidents since FDR, with their names and years in office under their photos,” I said.

Me: *sends 100% non-urgent email to an academic…receives an out-of-office message* Literally ten minutes later: “Sorry for the delayed reply, but I’m on holiday in the Swiss Alps…” 😭

I honestly can’t believe there are still any AI skeptics out there. This tech is obviously revolutionary

Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social‬. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...

Want more? 💡A Spotlight by Jen DuBois highlights lignin degradation and another by @maxrenner.bsky.social et al notes advances of Nipah virus polymerase 🛎️ A Forum on the expanding functions of AID/APOBEC by Lucyna Budzko et al 🔬 A #TechoftheMonth on NAPstar biosensors byBruce Morgan et al (3/n)

Also, 30,000 fake papers out of 1 million+ does not indict or threaten science as a whole. This entire "science is in crisis from within" narrative is a right-wing myth.

"A weather station in the Norwegian part of the Arctic Circle recorded temperatures above 30C (86F) on 13 days in July." www.theguardian.com/environment/...

An epic analysis of 5,000 years of civilisation argues that a global collapse is coming unless inequality is vanquished

A compost heap in Finland has yielded the country’s first giant virus. Bigger than some bacteria and packed with hundreds of mysterious genes, it might hold clues to early life and new biotech tools. Gabriel Almeida explains in the eLife Podcast.