Atomic resolution structure of spinach rubisco reveals protons and dynamics @cblikstad.bsky.social www.biorxiv.org/content/10.6...

Really exciting new research from our friendly colleagues down the hall 🤩🤩🤩

An important question is, who is citing those papers? Should it be considered misconduct to not even check whether what you are citing *exists*?

🎄✨ Season’s Greetings from PDBe ✨🎄 The PDBe wishes you a very Merry Christmas and a Happy New Year. We are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, and we look forward to seeing you in the New Year.

Same with universities, in my humble opinion...

The whole idea of responsible AI use is just companies encouraging people to use tools irresponsibly while telling people to use them responsibly.

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

BBC News - Flu cases likely to 'spike' in coming weeks, warns health secretary - BBC News www.bbc.co.uk/news/article...

Only a few days left to apply for this PhD opportunity in my lab! More details and how to apply at: www.findaphd.com/phds/project...

Heute ist Welt-AIDS-Tag. HIV hat seinen Schrecken als tödliche Erkrankung verloren. Trotz des medizinischen Fortschritts steigen jedoch die Neuinfektionen, auch hier in Deutschland, und Infektionen werden spät diagnostiziert. (1/2) www.tagesschau.de/wissen/gesun...

🚨👇One week left to apply for this fully-funded PhD project to study RNA-protein complexes regulating enterovirus genome replication: www.findaphd.com/phds/project...

What do you think? Real SDS-PAGE gel or AI-generated ?

It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know. #virology #cryoEM go.bsky.app/Qxv95BL

Scientific journals: we don’t want you using generative AI because it makes shit up. Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote Same journal: AI cover art which makes no sense? Oooh!

Our latest T7SS study is now out in Science Advances! We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery. www.science.org/doi/10.1126/...

Imagine we would have a pan-herpesvirus vaccine. How would it improve human health? Based on the last few years of data, I am thinking it would change a lot.

🧪For anyone interested in EBV in autoimmunity, I strongly urge you to read this incredible study by @shady-myounis.bsky.social, Bill Robinson, and @tobiaslanz.bsky.social. It is not only a scientific tour de force, it has a deeply provocative discussion that everyone in the field should consider 1/

Tired of knowing what you are looking for in your tomograms? Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos) Code is on GitHub if you want to try it out

This is misinformation by default, so if you're a journal and you use AI slop for your cover or your announcements, you're not scientific in any way and should be shamed mercilessly 🧪

Truer words have not been spoken

We’re live! The Department of Medical Biochemistry & Biophysics at @umeauniversitet.bsky.social explores life at the molecular level: infection and structural biology, gene expression, mitochondria, neurodegeneration & biophysics for climate change. Follow for updates & collaboration! #Biochemistry

Withdrawing life-saving aid from developing countries and then demanding economically favourable conditions for restoring it would be bad enough, but the conditions and the approach also directly undermine international co-operation against future pandemics in favour of short-term national gain

I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...

Some still praise James Watson despite his racism. Same with colleagues who won’t condemn Elon Musk’s politics, hiding behind “scientists shouldn’t mix science and politics.”

November 7th, 2000.

Very happy to share our work on the Langya henipavirus nucleoprotein with everyone! 🥳 Check out the preprint to find more about how a serendipitous finding led us to this amazing story!

Proud co-supervisor of Rupesh @rupeshjayachandran.bsky.social, who has done an amazing job with this story in less than two years in Max's lab!

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/3X5lbUg

This is it. Word slurry formed into answer-shaped chunks. This is what Sam Altman says is now smarter than we are.

One day, when this national nightmare is over and speaking up has no consequences, everyone will claim they were against this.

warwick.ac.uk/fac/cross_fa... I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays. If you're interested reach out and I'd be happy to have a chat.

Thanks Petr for presenting this amazing work at cryoNET in Umeå! Congrats Moritz and all other authors!

Visualizing influenza A virus assembly by in situ cryo-electron tomography www.nature.com/articles/s41...

🚨 Postdoc position open! Join us at Umeå University to study proteins that maintain mitochondrial DNA stability. 2-year fellowship | International research environment | Apply now! 🔗 umustipendie.varbi.com/en/what:job/... #Postdoc #Mitochondria #Biochemistry #AcademicJobs

Very cool structure! And thanks again Jeremy for presenting it at cryoNET in Umeå recently.

The Louvre thieves should just say they're using the pieces to train their AI algorithm and it should all be good

This graph says it all: instead of starting to go down, the *annual increase* of atmospheric CO2 is setting new records. We're making climate change worse at a record rate. Turning this around should be our top priority, and it's not. From: www.carbonbrief.org/met-office-a...

I have a PhD position available in my lab at the University of Freiburg!! If you, or someone you know, might be looking for a position using modeling and simulations to uncover secrets in (glyco-)protein structure/function relationships please take a look at our website! www.kearnslab.org

FT Investigation: At least 30 individuals or companies that have collectively donated more than $116mn to Donald Trump’s causes have received benefits or advantages from White House moves. Read more here: on.ft.com/497fook

Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available go.nature.com/479Sni6

Dear European colleagues, I strongly advise you to forcefully repudiate this initiative before they end up in a position to influence policy. Let me know if I can help.

Yikes! In this paper the AlphaFold model of human plasminogen (PDB-8uq6) has been refined into noise (EMD-42462) using Phenix & ISOLDE. For some reason the authors even interpret side-chain interactions: #cryoEM

The recent trajectory, in broad strokes: - Regime starts militarizing the conflict in early summer - Regime declares all liberal/leftwing political activity as domestic terrorist or terrorism-adjacent in presidential memo - Regime ramps up the propaganda against “the Left” across all channels

An insightful read. I hadn’t appreciated the links between feudalism and privatization. The author’s evocation of how future historians may look back on our era in that respect felt important, and a fruitful way to think, to me. I’m hopeful the pendulum will swing back towards effective government.

One week from now I plan to be out marching against the idiotic criminals running our government. I'm not "getting paid" and I'm not part of any "Pro-Hamas" group. I'm just mad as hell. I will not be punching any police officers, nor setting fires, nor breaking any glass. Why will I turn out? (1/2)

possibly stupid question - does anyone in #teamtomo or #cryoem recognize these little stacks (from EMPIAR-12549, U2OS cell lamellae)? The green circle is 300Å, and the spacing between the layers is ~50Å. The fourth, bell-shaped thing is something else, also not sure of that one..

My HPLC was definitely overlooked www.nature.com/articles/d41...