Withdrawing life-saving aid from developing countries and then demanding economically favourable conditions for restoring it would be bad enough, but the conditions and the approach also directly undermine international co-operation against future pandemics in favour of short-term national gain

I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...

Some still praise James Watson despite his racism. Same with colleagues who won’t condemn Elon Musk’s politics, hiding behind “scientists shouldn’t mix science and politics.”

November 7th, 2000.

Very happy to share our work on the Langya henipavirus nucleoprotein with everyone! 🥳 Check out the preprint to find more about how a serendipitous finding led us to this amazing story!

Proud co-supervisor of Rupesh @rupeshjayachandran.bsky.social, who has done an amazing job with this story in less than two years in Max's lab!

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/3X5lbUg

This is it. Word slurry formed into answer-shaped chunks. This is what Sam Altman says is now smarter than we are.

One day, when this national nightmare is over and speaking up has no consequences, everyone will claim they were against this.

warwick.ac.uk/fac/cross_fa... I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays. If you're interested reach out and I'd be happy to have a chat.

Thanks Petr for presenting this amazing work at cryoNET in Umeå! Congrats Moritz and all other authors!

Visualizing influenza A virus assembly by in situ cryo-electron tomography www.nature.com/articles/s41...

🚨 Postdoc position open! Join us at Umeå University to study proteins that maintain mitochondrial DNA stability. 2-year fellowship | International research environment | Apply now! 🔗 umustipendie.varbi.com/en/what:job/... #Postdoc #Mitochondria #Biochemistry #AcademicJobs

Very cool structure! And thanks again Jeremy for presenting it at cryoNET in Umeå recently.

The Louvre thieves should just say they're using the pieces to train their AI algorithm and it should all be good

This graph says it all: instead of starting to go down, the *annual increase* of atmospheric CO2 is setting new records. We're making climate change worse at a record rate. Turning this around should be our top priority, and it's not. From: www.carbonbrief.org/met-office-a...

I have a PhD position available in my lab at the University of Freiburg!! If you, or someone you know, might be looking for a position using modeling and simulations to uncover secrets in (glyco-)protein structure/function relationships please take a look at our website! www.kearnslab.org

FT Investigation: At least 30 individuals or companies that have collectively donated more than $116mn to Donald Trump’s causes have received benefits or advantages from White House moves. Read more here: on.ft.com/497fook

Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available go.nature.com/479Sni6

Dear European colleagues, I strongly advise you to forcefully repudiate this initiative before they end up in a position to influence policy. Let me know if I can help.

Yikes! In this paper the AlphaFold model of human plasminogen (PDB-8uq6) has been refined into noise (EMD-42462) using Phenix & ISOLDE. For some reason the authors even interpret side-chain interactions: #cryoEM

The recent trajectory, in broad strokes: - Regime starts militarizing the conflict in early summer - Regime declares all liberal/leftwing political activity as domestic terrorist or terrorism-adjacent in presidential memo - Regime ramps up the propaganda against “the Left” across all channels

An insightful read. I hadn’t appreciated the links between feudalism and privatization. The author’s evocation of how future historians may look back on our era in that respect felt important, and a fruitful way to think, to me. I’m hopeful the pendulum will swing back towards effective government.

One week from now I plan to be out marching against the idiotic criminals running our government. I'm not "getting paid" and I'm not part of any "Pro-Hamas" group. I'm just mad as hell. I will not be punching any police officers, nor setting fires, nor breaking any glass. Why will I turn out? (1/2)

possibly stupid question - does anyone in #teamtomo or #cryoem recognize these little stacks (from EMPIAR-12549, U2OS cell lamellae)? The green circle is 300Å, and the spacing between the layers is ~50Å. The fourth, bell-shaped thing is something else, also not sure of that one..

My HPLC was definitely overlooked www.nature.com/articles/d41...

This was an interesting read. cmarmitage.substack.com/p/i-research...

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1...

OpenAI’s planned data centers will use more power than New York City & San Diego use at their peak consumption, combined. More power than the entire nations of Switzerland & Portugal combined. And San Altman’s buddies in this administration have been cutting all of our energy infrastructure upgrades

I'm excited to report that a species has been named after my son Ze Frank, "in recognition of his outstanding contributions to science communication, which have inspired curiosity, wonder, and deeper public engagement with the natural world"

Thanks to all speakers, participants and organisers of cryoNET 2025 in Umeå! It was a great meeting! See you all in Copenhagen from cryoNET 2026. www.umu.se/en/chemical-...

In memory of a wonderful, kind, lremarkable and infinitely inspirational human. Che la terra le sia lieve 🖤 #RIPJaneGoodall

As others have already said, this essay by James Marriott is well worth taking the time to read. Now, back to my book if I can just prise my iPhone out of my hand for a few minutes… open.substack.com/pub/jmarriot...

"Employees are using AI tools to create low-effort, passable looking work that ends up creating more work for their coworkers." I'm so shocked that I might swoon 😱 (Ironically, their attempt to be constructive at the end of the article comes across as AI generated.) hbr.org/2025/09/ai-g...

From descriptive to quantitative biocatalysis “The 1913 study ‘Die Kinetik der Invertinwirkung’, by Michaelis and Menten, marked a pivotal advancement in enzymology by illustrating the application of mechanistic models and quantitative kinetics to biocatalysis.” doi.org/10.1038/s419...

This is huge: “A drug that provides near-perfect protection against H.I.V. with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope… making lenacapavir a realistic choice in countries with constrained resources.”

And if you think you're not next in the chopping block, you're not paying attention

I am QT dunking but I think this is a case where it is warranted: Science is political and "not wanting to see politics" as a scientist is a political choice. You may decide it's what works for you, but you need to decide how that fits with the fact your (diverse) colleagues still exist 🧪

A really great and comprehensive resource on metapneumovirus from the labs of Becky Dutch and Bernadette van den Hoogen. journals.asm.org/doi/10.1128/...

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

The SerialEM Python interface has been a huge driver of innovation at the hardware-software boundary in cryo-EM: suddenly the scientist with some programming chops can readily implement their ideas 🥰 This looks like a fantastic meeting!

Fact for the day: paracetamol does not cause autism

Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection www.nature.com/articles/s41...

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them: www.sciencedirect.com/science/arti...

Dear American citizens, whatever you wish more German citizens would have done in 1933, do that now.

These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.

wait until they figure out that in addition to being a sociopathic white supremacist he's not an engineer either, and mostly just opportunistically gloms onto real innovators, taking singular credit for their work while usually having an often rudimentary understanding of the underlying technology!