Lars-Anders Carlson
@lacarlson.bsky.social
📤 1913
📥 297
📝 340
Structural virology group leader at Umeå University, Sweden. www.carlsonlab.se
pinned post!
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology
#teamtomo
www.nature.com/articles/s41...
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Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
https://www.nature.com/articles/s41467-026-68483-4
2 months ago
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cryoEM papers
about 1 hour ago
Structure of the mouse cytoplasmic lattice
pubmed.ncbi.nlm.nih.gov/41917274/
#cryoem
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Nature Microbiology
27 minutes ago
Out Now! Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice
#MicroSky
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Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice
Nature Microbiology, Published online: 01 April 2026; doi:10.1038/s41564-026-02303-9Ongoing chikungunya virus replication leads to the accumulation of inflammatory macrophages and CD4+ T cells in joint-associated tissues. Inhibition of chikungunya virus replication during chronic disease reduced viral RNA and joint inflammation in mice.
https://go.nature.com/3PzXiUB
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Basil Greber
about 21 hours ago
👀
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Nate
8 days ago
How do peroxisomal import receptors return to the cytosol while maintaining the membrane's permeability barrier? We solved cryoEM structures that demonstrate: 1) how receptors find and engage the recycling complex 2) engage with a transiently gated pore
t.co/KhqWKJh758
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Structural Biology
4 days ago
Vinith Kishore et al.: ICECREAM: high-fidelity equivariant cryo-electron tomography
##CryogenicElectronTomography
##SelfSupervisedLearning
##MachineLearning
@insadelyon...
##IUCr
https://journals.iucr.org/paper?S2059798326001622
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ICECREAM: high-fidelity equivariant cryo-electron tomography
We present ICECREAM, a self-supervised approach that achieves substantially better denoising and more reliable missing-wedge recovery in cryo-ET, while reducing training and inference time relative to comparable baselines.
https://journals.iucr.org/paper?S2059798326001622
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Joost Snijder
2 days ago
Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin1
www.biorxiv.org/content/10.6...
Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen. Thanks to
@danielhurdiss.bsky.social
@utrechtvirology.bsky.social
#covid
#pais
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Resurfacing this post in the light of
#RELION-5.1
. Would be interesting to hear people's experiences now that Relion added "real subvolume" extraction.
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2 days ago
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Oli Clarke
5 days ago
Extended this (map_salami) a bit - added a movie option which will generate a labeled movie (1080p or 4k) transitioning between all scenes, with a short rocking motion at each scene for depth perception:
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Hongmiao Hu
5 days ago
Excited to share my postdoc work on the cryo‑EM structure of the budding yeast telomerase holoenzyme! 🧫🧬 It’s been a real privilege to be part of the awesome Kelly Lab
@kellythd-nguyen.bsky.social
. Grateful as well to the incredible facilities
@mrclmb.ac.uk
.
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Prof Frank McDonough
6 days ago
FACT OF THE DAY. 26 March 1953. In a huge medical breakthrough, US medical researcher Dr Jonas Salk announced that he had created the first polio vaccine. Polio cases fell from 58,000 per year in 1952 to 6,000 by 1958. Salk’s vaccine was replaced by a new one developed by Albert Sabin in 1962.
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“There are more things in Heaven and Earth, Horatio, than are dreamt of in your philosophy.”
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6 days ago
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Knut and Alice Wallenberg Foundation
6 days ago
Knut and Alice Wallenberg Foundation is extending its support for Alpha Cell with an additional SEK 320 million. Alpha Cell is a
#research
program that develops predictive models to understand how human cells function, adapt, and change in the presence of disease
@scilifelab.se
tinyurl.com/mr2wkun9
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SEK 590 million for Alpha Cell – initiative extended through 2033 | Knut and Alice Wallenberg Foundation
https://tinyurl.com/mr2wkun9
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Tuuli Lappalainen
7 days ago
Sweden continues major investments in research and life science, with more KAW foundation funding for trainee positions in the Data-Driven Life Science Program, with total investment of 330 MEUR / 380 MUSD!
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cryoEM papers
7 days ago
Lenacapavir prevents production of infectious HIV-1 by abrogating immature virus assembly
pubmed.ncbi.nlm.nih.gov/41867786/
#cryoem
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Just fueled up with a high-performance breakfast! 🚀 It’s amazing how prioritizing the right inputs can drive such impactful results for the day ahead. Grateful for the small wins that set the tone for success.
#Productivity
#MorningRoutine
#FuelForSuccess
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7 days ago
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Andrew Bissette
8 days ago
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Amazing structures!
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8 days ago
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Leah Lavery
9 days ago
Congratulations to Dr. Julia Mahamid on receiving the 2026 Gottfried Wilhelm Leibniz Prize! 🎉 Her pioneering work in cryo-ET is reshaping our understanding of how molecular architecture drives cellular processes and disease.
#teamtomo
#LeibnizPrize
#StructuralBiology
#LifeSciences
#Innovation
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Julia Mahamid, Ph.D. – Gottfried Wilhelm Leibniz Prizewinner 2026
https://www.dfg.de/en/funded-projects/prizewinners/leibniz-prize/2026/mahamid
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André Nadler
9 days ago
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in
@natcellbio.nature.com
brought to you by
@mathilda95.bsky.social
changes that:
www.nature.com/articles/s41...
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Martin Steinegger 🇺🇦
15 days ago
AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄
research.nvidia.com/labs/dbr/ass...
🌐
alphafold.ebi.ac.uk
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Peter Tennant
17 days ago
"My name may be forgotten when it comes, but the time will arrive when great outbreaks of cholera will be things of the past. And it is the knowledge of the way in which the disease is propagated which will cause them to disappear" Happy birthday to John Snow! His name & his work is not forgotten.
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We just covered this paper in our joint journal club with
@maxrenner.bsky.social
group. Very impressive! Congrats all authors.
www.nature.com/articles/s41...
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Mechanism of co-transcriptional cap snatching by influenza polymerase - Nature
Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II reveal the molecular mechanisms of RNA cap snatchin...
https://www.nature.com/articles/s41586-026-10189-0
19 days ago
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Mohammed AlQuraishi
19 days ago
New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9
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404 Media
20 days ago
This is Nathan Cavanaugh, another DOGE staffer explaining how he flagged grants at NEH for "DEI" which would be reviewed for termination. 404 Media has reviewed hours of this footage and we'll have more soon. Part of a lawsuit by
@acls1919.bsky.social
,
@modernlanguage.bsky.social
+
@historians.org
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I'll be at GfV (Society for Virology) in Heidelberg next week. Haven't had time to check in with "everyone" who is going, so feel free to reach out if you'll be there and want to meet up. :)
19 days ago
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Friedemann Weber
19 days ago
De novo generation of the furin cleavage site (FCS) in influenza viruses In SARS-CoV2, the existence of an FCS was a key argument of lab leakers that it must have been constructed in the lab. Fantastic work
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Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis
Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the...
https://www.science.org/doi/10.1126/science.adr6632
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Plaschka lab
20 days ago
Automatic screening of cryo-EM grids using EPU is fast and efficient, but reviewing the generated data & picking the best areas for data collection can be slow and cumbersome. We made a little tool that makes this process more streamlined and enjoyable:
github.com/mvorlander/E...
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GfV - Gesellschaft für Virologie
20 days ago
The countdown begins! Less than one week until the 35th Annual Meeting of the Society for Virology is taking place in Heidelberg. Check the website for all current updates (incl. detailed program):
virology-meeting.de
#GfV
#GfV2024
#virology
#virologymeeting
#VirusResearch
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I used this page for fun a few times in the past, it is indeed nice. Thanks for creating it!
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20 days ago
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RCSB Protein Data Bank
21 days ago
Remembering Philip E. Bourne Phil was a key figure in launching the RCSB PDB and served as Associate Director from 1998-2013
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Remembering Philip E. Bourne
Phil was a key figure in launching the RCSB PDB and served as Associate Director from 1998-2013
https://www.rcsb.org/news/feature/69b1615f8557ae0f261bc714
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Tristan Croll
22 days ago
The juvenile sea squirt swims the ocean currents, actively searching for the perfect place to live. Once it finds a nice, solid rock, it sticks itself down and gets to work reabsorbing bits it no longer needs - including its own brain. This post is about human civilisation.
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Our World in Data
21 days ago
The number of cancer deaths worldwide has more than doubled since the 1980s. Does that mean we're losing the fight against cancer? Not necessarily, because it depends on how you measure it. On this chart, you can see three ways to look at the same data. 🧵
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Roger Castells
22 days ago
Hot off the press! I'm thrilled to share that our paper "Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM" has been published! Link to the paper:
www.pnas.org/doi/10.1073/...
Nature is full of remarkable protein nanomachines, and now we can watch one more in action.
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Culex homini lupus!
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23 days ago
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Visited
@pirbrightinst.bsky.social
some days ago. What an incredible density of smart and creative virologists! Thanks especially to Helena Maier who arranged my visit, and to everyone I had a chance to talk. Their no-photo-policy makes this post a bit dry, but the place is really outstanding!
24 days ago
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RCSB Protein Data Bank
24 days ago
Build a paper model of the HIV capsid using this template from PDB-101 #ASBMB2026 #ASBMB26
pdb101.rcsb.org/lear...
#ASBMB2026
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RCSB Protein Data Bank
24 days ago
Researchers found that treatment of intact HIV capsids with lenacapavir causes capsids to rupture, with ruptures occurring first in areas of the capsid with the highest level of curvature. #ASBMB2026 #ASBMB26 Watch in 3D at PDB-101:
pdb101.rcsb.org/motm...
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Joshua Weitz
25 days ago
The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.
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John Rubinstein
26 days ago
I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
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Elisa Fadda
26 days ago
I wonder... 🤔🤔🧪
#chemsky
a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT b) how such high school science level of disgrace pass peer review in
@nature.com
? Note this was Fig.4.a NOT in SI
www.nature.com/articles/s41...
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Train booking in Germany!
26 days ago
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Prof. Feynman
26 days ago
A scientist is never certain.
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Max Renner
26 days ago
Check out this beautiful study, spearheaded by Kenny
@denkenny.bsky.social
, on mitochondrial remodeling. Some of the prettiest organelle segmentations I have seen 😍😍😍
www.science.org/doi/10.1126/...
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Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Cryo–electron tomography reveals how mitochondria reorganize their translation and folding systems under proteostatic stress.
https://www.science.org/doi/10.1126/sciadv.aed3579
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Nonia Pariente
26 days ago
CDC issued a Global Polio Level 2 Travel Health Notice advising enhanced precautions Tragic. We had polio almost eradicated, but disruption to vaccination campaigns due to COVID, global instability, defunding & vaccine hesitancy have led us here
#VaccinesWork
🧪
wwwnc.cdc.gov/travel/notic...
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EMBL
27 days ago
A research team from the Max Planck Institute for Multidisciplinary Sciences, the Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate. Check out the MPI press release:
www.mpinat.mpg.de/5179649/pr_2...
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Mark O. Martin
27 days ago
Students (and scientists) seem to hate saying “I don’t know.” It’s viewed so negatively. But I have long believed that thinking of “I don’t know” as a negative is wrong. It’s an *opportunity*.
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Institut Pasteur | 130 years of biomedical research
28 days ago
Françoise Barré-Sinoussi, Prix Nobel de médecine 2008 pour la découverte du VIH, reçoit un doctorat honoris causa de l'Université de Montréal. Cette scientifique d'exception continue d'inspirer la lutte mondiale contre le
#VIH
.
@umontreal.ca
Crédit image : André Caty
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RCSB Protein Data Bank
28 days ago
March 4 is International HPV Awareness Day Build a paper model of the capsid protein used in vaccines that prevent cervical cancer.
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PDB101: Learn: Paper Models: Human Papillomavirus (HPV)
The capsid protein of papillomavirus is used in vaccines that prevent cervical cancer.
https://pdb101.rcsb.org/learn/paper-models/human-papillomavirus-hpv
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BejaLab
28 days ago
A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere
www.biorxiv.org/content/10.1...
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BK. Titanji
30 days ago
The HPV vaccine is durably AMAZING.A massive Swedish registry study w 18 years of follow-up found no waning protection against invasive cervical cancer. If vaccinated before age 17, cancer risk is cut by ~80%. Even those vaccinated later still had substantial protection.
www.bmj.com/content/392/...
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Extended follow-up of invasive cervical cancer risk after quadrivalent HPV vaccination: nationwide, register based study
Objectives To evaluate the long term risk of invasive cervical cancer after receiving the quadrivalent human papillomavirus (HPV) vaccine, how risk varies by time since vaccination, and to assess the ...
https://www.bmj.com/content/392/bmj-2025-087326
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