Structure of the mouse cytoplasmic lattice pubmed.ncbi.nlm.nih.gov/41917274/ #cryoem

Out Now! Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice #MicroSky

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How do peroxisomal import receptors return to the cytosol while maintaining the membrane's permeability barrier? We solved cryoEM structures that demonstrate: 1) how receptors find and engage the recycling complex 2) engage with a transiently gated pore t.co/KhqWKJh758

Vinith Kishore et al.: ICECREAM: high-fidelity equivariant cryo-electron tomography ##CryogenicElectronTomography##SelfSupervisedLearning##MachineLearning@insadelyon...##IUCrhttps://journals.iucr.org/paper?S2059798326001622

Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin1 www.biorxiv.org/content/10.6... Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen. Thanks to @danielhurdiss.bsky.social @utrechtvirology.bsky.social #covid #pais

Resurfacing this post in the light of #RELION-5.1. Would be interesting to hear people's experiences now that Relion added "real subvolume" extraction.

Extended this (map_salami) a bit - added a movie option which will generate a labeled movie (1080p or 4k) transitioning between all scenes, with a short rocking motion at each scene for depth perception:

Excited to share my postdoc work on the cryo‑EM structure of the budding yeast telomerase holoenzyme! 🧫🧬 It’s been a real privilege to be part of the awesome Kelly Lab @kellythd-nguyen.bsky.social. Grateful as well to the incredible facilities @mrclmb.ac.uk.

FACT OF THE DAY. 26 March 1953. In a huge medical breakthrough, US medical researcher Dr Jonas Salk announced that he had created the first polio vaccine. Polio cases fell from 58,000 per year in 1952 to 6,000 by 1958. Salk’s vaccine was replaced by a new one developed by Albert Sabin in 1962.

“There are more things in Heaven and Earth, Horatio, than are dreamt of in your philosophy.”

Knut and Alice Wallenberg Foundation is extending its support for Alpha Cell with an additional SEK 320 million. Alpha Cell is a #research program that develops predictive models to understand how human cells function, adapt, and change in the presence of disease @scilifelab.se tinyurl.com/mr2wkun9

Sweden continues major investments in research and life science, with more KAW foundation funding for trainee positions in the Data-Driven Life Science Program, with total investment of 330 MEUR / 380 MUSD!

Lenacapavir prevents production of infectious HIV-1 by abrogating immature virus assembly pubmed.ncbi.nlm.nih.gov/41867786/ #cryoem

Just fueled up with a high-performance breakfast! 🚀 It’s amazing how prioritizing the right inputs can drive such impactful results for the day ahead. Grateful for the small wins that set the tone for success. #Productivity #MorningRoutine #FuelForSuccess

Amazing structures!

Congratulations to Dr. Julia Mahamid on receiving the 2026 Gottfried Wilhelm Leibniz Prize! 🎉 Her pioneering work in cryo-ET is reshaping our understanding of how molecular architecture drives cellular processes and disease. #teamtomo #LeibnizPrize #StructuralBiology #LifeSciences #Innovation

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...

AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk

"My name may be forgotten when it comes, but the time will arrive when great outbreaks of cholera will be things of the past. And it is the knowledge of the way in which the disease is propagated which will cause them to disappear" Happy birthday to John Snow! His name & his work is not forgotten.

We just covered this paper in our joint journal club with @maxrenner.bsky.social group. Very impressive! Congrats all authors. www.nature.com/articles/s41...

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

This is Nathan Cavanaugh, another DOGE staffer explaining how he flagged grants at NEH for "DEI" which would be reviewed for termination. 404 Media has reviewed hours of this footage and we'll have more soon. Part of a lawsuit by @acls1919.bsky.social, @modernlanguage.bsky.social + @historians.org

I'll be at GfV (Society for Virology) in Heidelberg next week. Haven't had time to check in with "everyone" who is going, so feel free to reach out if you'll be there and want to meet up. :)

De novo generation of the furin cleavage site (FCS) in influenza viruses In SARS-CoV2, the existence of an FCS was a key argument of lab leakers that it must have been constructed in the lab. Fantastic work

Automatic screening of cryo-EM grids using EPU is fast and efficient, but reviewing the generated data & picking the best areas for data collection can be slow and cumbersome. We made a little tool that makes this process more streamlined and enjoyable: github.com/mvorlander/E... 1/4

The countdown begins! Less than one week until the 35th Annual Meeting of the Society for Virology is taking place in Heidelberg. Check the website for all current updates (incl. detailed program): virology-meeting.de #GfV #GfV2024 #virology #virologymeeting #VirusResearch

I used this page for fun a few times in the past, it is indeed nice. Thanks for creating it!

Remembering Philip E. Bourne Phil was a key figure in launching the RCSB PDB and served as Associate Director from 1998-2013

The juvenile sea squirt swims the ocean currents, actively searching for the perfect place to live. Once it finds a nice, solid rock, it sticks itself down and gets to work reabsorbing bits it no longer needs - including its own brain. This post is about human civilisation.

The number of cancer deaths worldwide has more than doubled since the 1980s. Does that mean we're losing the fight against cancer? Not necessarily, because it depends on how you measure it. On this chart, you can see three ways to look at the same data. 🧵

Hot off the press! I'm thrilled to share that our paper "Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM" has been published! Link to the paper: www.pnas.org/doi/10.1073/... Nature is full of remarkable protein nanomachines, and now we can watch one more in action.

Culex homini lupus!

Visited @pirbrightinst.bsky.social some days ago. What an incredible density of smart and creative virologists! Thanks especially to Helena Maier who arranged my visit, and to everyone I had a chance to talk. Their no-photo-policy makes this post a bit dry, but the place is really outstanding!

Build a paper model of the HIV capsid using this template from PDB-101 #ASBMB2026 #ASBMB26 pdb101.rcsb.org/lear...#ASBMB2026

Researchers found that treatment of intact HIV capsids with lenacapavir causes capsids to rupture, with ruptures occurring first in areas of the capsid with the highest level of curvature. #ASBMB2026 #ASBMB26 Watch in 3D at PDB-101: pdb101.rcsb.org/motm...

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

I wonder... 🤔🤔🧪 #chemsky a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT b) how such high school science level of disgrace pass peer review in @nature.com? Note this was Fig.4.a NOT in SI www.nature.com/articles/s41...

Train booking in Germany!

A scientist is never certain.

Check out this beautiful study, spearheaded by Kenny @denkenny.bsky.social, on mitochondrial remodeling. Some of the prettiest organelle segmentations I have seen 😍😍😍 www.science.org/doi/10.1126/...

CDC issued a Global Polio Level 2 Travel Health Notice advising enhanced precautions Tragic. We had polio almost eradicated, but disruption to vaccination campaigns due to COVID, global instability, defunding & vaccine hesitancy have led us here #VaccinesWork 🧪 wwwnc.cdc.gov/travel/notic...

A research team from the Max Planck Institute for Multidisciplinary Sciences, the Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate. Check out the MPI press release: www.mpinat.mpg.de/5179649/pr_2...

Students (and scientists) seem to hate saying “I don’t know.” It’s viewed so negatively. But I have long believed that thinking of “I don’t know” as a negative is wrong. It’s an *opportunity*.

Françoise Barré-Sinoussi, Prix Nobel de médecine 2008 pour la découverte du VIH, reçoit un doctorat honoris causa de l'Université de Montréal. Cette scientifique d'exception continue d'inspirer la lutte mondiale contre le #VIH. @umontreal.ca Crédit image : André Caty

March 4 is International HPV Awareness Day Build a paper model of the capsid protein used in vaccines that prevent cervical cancer.

A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere www.biorxiv.org/content/10.1...

The HPV vaccine is durably AMAZING.A massive Swedish registry study w 18 years of follow-up found no waning protection against invasive cervical cancer. If vaccinated before age 17, cancer risk is cut by ~80%. Even those vaccinated later still had substantial protection. www.bmj.com/content/392/...