Lars-Anders Carlson
@lacarlson.bsky.social
📤 1939
📥 302
📝 379
Structural virology group leader at Umeå University, Sweden. www.carlsonlab.se
pinned post!
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology
#teamtomo
www.nature.com/articles/s41...
loading . . .
Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
https://www.nature.com/articles/s41467-026-68483-4
5 months ago
1
108
33
reposted by
Lars-Anders Carlson
Andrew Wehrman
1 day ago
Today is the 250th anniversary of Boston’s mass inoculation against smallpox on July 3, 1776. The city was effectively closed to commerce from July through September 1776. The mass immunization effort was cheered as evidence of true independence. Here's how I described it in my book:
7
825
408
reposted by
Lars-Anders Carlson
1 day ago
Titans of Virology and Vaccinology presents: Dr. Louise Chow, whose electron microscopy work with
#adenovirus
was instrumental is the discovery of
#RNA_splicing
. Hear her talk about her career studying
#phage
,
#adenovirus
, and
#HPV
.
virologyunmasked.com/louise-chow/
loading . . .
Louise Chow
Dr. Louise Chow “Of course it is obvious it is splicing – it’s cut and paste – just like film editing” Dr. Chow on discovering RNA splicing, on Virology Unmasked, 2026 Dr. Chow in 1977 …
https://virologyunmasked.com/louise-chow/
0
7
4
reposted by
Lars-Anders Carlson
cryoEM papers
about 8 hours ago
Using spIsoNet to address the preferred-orientation problem in cryoEM reconstructions
www.biorxiv.org/content/10.64898/2026.06.29.735357v1
#cryoem
0
2
2
reposted by
Lars-Anders Carlson
Holthuis Lab
2 days ago
📯 Our paper “VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair” out now in Nature Communications
rdcu.be/frKmN
loading . . .
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Nature Communications - Not all components of the lysosome damage response pathway have been defined. Here, the authors discover that the bridge-like lipid transport protein VPS13C senses lysosomal...
https://rdcu.be/frKmN
1
30
16
reposted by
Lars-Anders Carlson
Paula Navarro
1 day ago
🚨 New in
@natmicrobiol.nature.com
! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs
@dmf-unil.bsky.social
, with
@avettiger.bsky.social
. Congratulations to all authors! 🦠❄️🔬
#teamtomo
bit.ly/3SCbOg1
👇
loading . . .
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
https://doi.org/10.1038/s41564-026-02403-6
2
67
27
reposted by
Lars-Anders Carlson
Ben Engel
1 day ago
Super excited to launch this search for a new endowed professor at the
@biozentrum.unibas.ch
! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩🔬👨🔬
add a skeleton here at some point
1
43
39
reposted by
Lars-Anders Carlson
BEACON
1 day ago
Ongoing African swine fever transmission in Catalonia's wild boar population sustains risk to the swine sector, Spain
https://beaconbio.org/en/report/?reportid=b6b8d083-fc22-47ed-9c4e-9260863c64d3&eventid=bfc25d17-d0b5-483e-aa54-fa9fc984c3ee&utm_source=bluesky&utm_medium=social
0
2
3
reposted by
Lars-Anders Carlson
Harry M. Williams
2 days ago
Dear
#cryoem
community, does anyone if its possible disable atlas categorization in EPU? And if so, how?
1
0
2
reposted by
Lars-Anders Carlson
Ján Bíňovský
2 days ago
🔥My first (co)first-author paper is out🔥 The surfaces of Gram+ and Gram- bacteria are markedly different from each other. How are phages equipped to breach the Gram+ envelope❓ 💡We report a baseplate structure uniquely adapted to infect Gram+ S. aureus. A 🧵⬇️ 1/8
#phagesky
#cryoEM
🧪
loading . . .
3
51
14
reposted by
Lars-Anders Carlson
RCSB Protein Data Bank
3 days ago
Thankfully quarantine for MV Hondius cruise passengers just ended without any new cases, but it is always a good time for Molecule of Month to explore how a family of rodent-borne viruses can cause severe illness in humans...
loading . . .
PDB101: Molecule of the Month: Hantavirus
Family of rodent-borne viruses that can cause severe illness in humans
https://pdb101.rcsb.org/motm/319
0
9
7
reposted by
Lars-Anders Carlson
Eliza_coli
3 days ago
Sneaky peek of a chapter of Seeing Cells (A comic history of
#microscopy
) 1/3 🧪🐡🧫🔬
2
11
4
Become our colleague! Reach out if you are curious about the environment here.
add a skeleton here at some point
3 days ago
0
2
1
reposted by
Lars-Anders Carlson
Prof. Shane Crotty
4 days ago
Excited to share our new Nature paper published today: Vaccination elicits HIV broadly neutralizing antibodies in primates
www.nature.com/articles/s41...
A project 14 years in the making with an outstanding team at
@lji.bsky.social
, @scrippsresearch.bsky.social and many collaborating institutions
loading . . .
Vaccination elicits HIV broadly neutralizing antibodies in primates - Nature
Nature - Vaccination elicits HIV broadly neutralizing antibodies in primates
https://www.nature.com/articles/s41586-026-10837-5
2
24
16
Congrats everyone, but especially my department colleague Sjoerd
@wanrooij20.bsky.social
!
add a skeleton here at some point
4 days ago
0
2
1
reposted by
Lars-Anders Carlson
Stella Hurtley
8 days ago
Take a look at this new paper in
@science.org
Reversible suppression of autophagy in a mouse model reveals neuronal resilience | Science
www.science.org/doi/10.1126/...
loading . . .
Reversible suppression of autophagy in a mouse model reveals neuronal resilience
Impairments in intracellular quality-control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aimed at slowing neuronal deterioration, it remains uncle...
https://www.science.org/doi/10.1126/science.ady3911
1
24
10
reposted by
Lars-Anders Carlson
Marten Chaillet
5 days ago
From v0.2.0 MissAlignment now has an inference mode where you can apply the trained models from one dataset to a new dataset to skip training time. I haven't tested it extensively, so double check if the results look decent 😉 The program calls changed slightly, see here:
github.com/warpem/miss-...
loading . . .
https://github.com/warpem/miss-alignment/blob/main/docs/usage.md
1
26
9
reposted by
Lars-Anders Carlson
Max Renner
7 days ago
add a skeleton here at some point
0
5
1
reposted by
Lars-Anders Carlson
Keith Smith
8 days ago
Why did Springer Nature retract two papers by Max Planck, ~70 years after they were published? Any why were they selling blank PDFs for $40? The answer seems to involve a misbehaving unsupervised algorithm. Because of course it does. 🧪⚛️🔭
www.science.org/content/arti...
loading . . .
Why have papers by one of history’s most famous physicists been retracted?
Springer Nature has removed two studies by Max Planck. A bot may be to blame
https://www.science.org/content/article/why-have-papers-one-history-s-most-famous-physicists-been-retracted
5
58
33
reposted by
Lars-Anders Carlson
Ben Barad
8 days ago
Just in time for the weekend, the 2nd beta for our Surface Morphometrics 2.0 release:
github.com/GrotjahnLab/...
. Beyond the major API change from the first beta (which used for the michigan class!), this one includes a major overhaul of the dual gaussian fitting for thickness and refinement.
loading . . .
Release 2.0.0b2 · GrotjahnLab/surface_morphometrics
A quality and robustness release on top of 2.0.0b1, focused on the density-profile bilayer fitting (mesh refinement and thickness measurement), a forgiving centralized config system, and packaging ...
https://github.com/GrotjahnLab/surface_morphometrics/releases/tag/2.0beta2
0
17
7
reposted by
Lars-Anders Carlson
openRxiv
8 days ago
📣 New feature 📣 Reviewer3 is now available on bioRxiv! Authors can now opt to get comprehensive AI-powered technical manuscript feedback directly from their Author Area. It's fully opt-in & designed to complement traditional peer review, not replace it. Learn more:
openrxiv.org/reviewer3-fe...
loading . . .
A new automated feedback option for authors - openRxiv
Authors who post preprints on openRxiv servers can get formal and informal feedback on their manuscripts in a number of ways. Our bioRxiv to journal (B2J) and medRxiv to journal (M2J) pipelines are li...
https://openrxiv.org/reviewer3-feedback-option/
0
2
3
reposted by
Lars-Anders Carlson
Katharina Geißler
8 days ago
What is the best way to distribute the electron dose across your tilt series in cryo ET? Thanks to Maarten Tuijtel, we finally know --> head over to eLife for the publication!
doi.org/10.7554/eLif...
add a skeleton here at some point
1
11
7
reposted by
Lars-Anders Carlson
Sjors Scheres
9 days ago
I'm worried authors will quickly adapt how they claim novelty in their papers to get good AI-generated scores. I have always loved a beautifully understated paper. Will we see even less of those? 🤔
2
8
1
reposted by
Lars-Anders Carlson
Richard Sever
9 days ago
This is an interesting idea. Since journals are keen to make authors declare when they have used AI, might authors want editors to do the same...?
add a skeleton here at some point
3
27
6
reposted by
Lars-Anders Carlson
Juan Carlos De la Concepcion
9 days ago
Welcome to the age of the AImpact factor...
0
8
5
reposted by
Lars-Anders Carlson
RCSB Protein Data Bank
9 days ago
World Cup players don't skip leg day. Conditioning builds muscles, like the muscle tissue shown in David Goodsell's painting at PDB-101
loading . . .
PDB101: Goodsell Gallery: Biosites: Muscle
Biosites: Muscle (2005) by David S. Goodsell
https://pdb101.rcsb.org/sci-art/goodsell-gallery/biosites-muscle
0
3
1
reposted by
Lars-Anders Carlson
Helen Branswell 🇨🇦
10 days ago
Have you ever seen this iconic image of the Ebola virus, from the first known outbreak in DRC in 1976? An electron microscopic image, it was captured by
#CDC
's Fred Murphy, a virological giant and a very kind interviewee. He died yesterday. He will be missed, but his scientific legacy lives on.
18
4279
922
reposted by
Lars-Anders Carlson
Knut and Alice Wallenberg Foundation
9 days ago
As of the turn of the year, the Wallenberg Foundations will be led by a new, broad-based academic leadership team comprising four of Sweden’s most highly qualified academics. The professors: Magnus Berggren, Siv Andersson, Anders Ynnerman, Astrid Söderbergh Widding
tinyurl.com/43f5dnc6
loading . . .
New Leadership for the Wallenberg Foundations | Knut and Alice Wallenberg Foundation
https://tinyurl.com/43f5dnc6
0
2
1
Does the proposed AI tool to "score" if papers have glam journal potential complete the circle of the AI parallel universe of scientific publishing?
9 days ago
0
1
0
reposted by
Lars-Anders Carlson
cryoEM papers
11 days ago
Cryoelectron tomography of HIV-1 cell-cell transmission conjugates reveals a secluded environment for viral assembly and transfer
pubmed.ncbi.nlm.nih.gov/42327053/
#cryoem
0
2
2
reposted by
Lars-Anders Carlson
Knut and Alice Wallenberg Foundation
10 days ago
A tiny parasite causes disease in around 280 million people every year, yet much of its biology still remains a mystery. Researcher Ellen Bushell is studying the
#malaria
parasite at the molecular level to identify the genes that play a crucial role in the infection process.
#research
#medicine
1
2
1
reposted by
Lars-Anders Carlson
Veijo Salo
11 days ago
How does a cell remodel the ER membrane into a lipid droplet? Excited to share our new bioRxiv preprint, where we find that regulated opening of the seipin ring defines a functional ER–lipid droplet interface — and identify SMLR1 as a regulator of this transition.
www.biorxiv.org/content/10.6...
3
72
31
reposted by
Lars-Anders Carlson
Pedro Beltrao
10 days ago
@qedscience.bsky.social
has come up with a really controversial idea - an AI score for scientific impact. This trained score correlates with the impact factor of published preprints and the binning of papers into discrete quality bins accessed by independent scientists. Backlash in 3, 2, 1... (more)
2
32
21
reposted by
Lars-Anders Carlson
Liz Szabo
11 days ago
The news about HPV vaccines just keeps getting better.
www.bbc.com/news/article...
loading . . .
HPV vaccine means young women now have 'close to zero' risk of cervical cancer death
A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.
https://www.bbc.com/news/articles/c621z28z138o
0
29
18
reposted by
Lars-Anders Carlson
Christophe 🔬 Leterrier
10 days ago
Getting lost in technical nitpicking was not enough to replicate what the worst human reviewers can do. Happy to announce a decisive further step: QED can now also spit nonsense on manuscript impact
add a skeleton here at some point
1
25
7
reposted by
Lars-Anders Carlson
Alexis Rohou
17 days ago
Great to see a formal treatment of the key problem of how to decide how many conformational states one should even attempt to reconstruct from cryoEM data.
add a skeleton here at some point
0
7
1
reposted by
Lars-Anders Carlson
17 days ago
*Preprint Alert*: How do we measure resolution when biomolecules won't sit still? 🔬 Estimating it for a static cryo-EM reconstruction is standard. But what about a conformational ensemble?
arxiv.org/abs/2606.14449
with the amazing
henryhmattingly.bsky.social
and
@lukeevanshandle.bsky.social
#cryoEM
loading . . .
0
18
10
reposted by
Lars-Anders Carlson
Biohub
18 days ago
Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️
www.biorxiv.org/content/10.6...
0
43
17
reposted by
Lars-Anders Carlson
Danielle Grotjahn
18 days ago
Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization? I explore how
#teamtomo
is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures.
tinyurl.com/localmembrane
loading . . .
Think globally, act locally: Redefining organellar membrane environments through cryo-electron tomography
Early enthusiasm for the “cellular revolution” in cryo-electron tomography (cryo-ET) was largely driven by the promise of resolving protein structures…
https://www.sciencedirect.com/science/article/pii/S0959440X26000850?via%3Dihub
2
57
24
reposted by
Lars-Anders Carlson
Crystal Fleming クリスタル
18 days ago
I'm attending a digital humanities event in Montreal. There was a keynote on AI and something about the talk made me wonder if it had been written by Claude. I said as much in the Q&A. As I posed the question, the speaker shifted, looking slightly uncomfortable. What he said next shocked the room +
80
4824
2284
reposted by
Lars-Anders Carlson
MadScientist
18 days ago
This is absolutely horrendous. People are destroying the human and scientific endeavor 🧪
add a skeleton here at some point
1
36
6
reposted by
Lars-Anders Carlson
Utz Ermel
22 days ago
You can take a look at a demo tomogram acquired with the xLPP of apo-ferritin on the cryoET data portal here:
cryoetdataportal.czscience.com/datasets/10496
Raw data is of course also available for download!
loading . . .
Dataset
https://cryoetdataportal.czscience.com/datasets/10496
0
21
7
reposted by
Lars-Anders Carlson
19 days ago
Reinisch's lab work with the Vanni's lab is online in Cell!! Combining cryoEM and MD simulations, we reveal how the bridge-like lipid-transfer protein VPS13A works with the scramblase XK to deliver lipids to plasma membrane and redistribute them across the bilayer.
www.cell.com/cell/fulltex...
loading . . .
Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK
The cryo-electron microscopy structure of the bridge-like lipid-transfer protein VPS13A in complex with the scramblase XK—coupled with molecular dynamics simulations—suggests that VPS13A-transported l...
https://www.cell.com/cell/fulltext/S0092-8674%2826%2900586-6
0
20
8
reposted by
Lars-Anders Carlson
Matthew Cobb
19 days ago
Goodness me what bollocks. Of both kinds. Neuro- and AI-bollocks. Tell me how the 30 neurons in the lobster‘s stomach do what they do, lads - dig out the “core algorithm” of that and we might be getting somewhere...
add a skeleton here at some point
4
94
30
I suggest someone write an article about service contract costs called "The Revolution Eats Its Children".
add a skeleton here at some point
24 days ago
0
7
1
reposted by
Lars-Anders Carlson
Alexey Amunts
25 days ago
Cryo-EM: the revolution continues
doi.org/10.1107/S205...
loading . . .
Cryo-EM: the revolution continues
The increasing democratization and implementation of electron cryo-microscopy appears poised to drive a new revolution in digital structural biology.
https://doi.org/10.1107/S2052252526003842
0
27
17
reposted by
Lars-Anders Carlson
Our World in Data
26 days ago
The world has become much more resilient to disaster events over the last century. In the chart here, you can see estimates of average death rates — measured as the number of deaths per 100,000 people — by decade since the early 20th century.
2
63
17
reposted by
Lars-Anders Carlson
Alejandro Montenegro
26 days ago
A paper was submitted with 4 authors. During revision, the *entire* group of 4 original authors was replaced with others during revision. No explanation. The authors *disagree* with the retraction 😅
5
14
6
Not to ignore how upsetting and unethical this is, but there is some dark humor in the western blot GIF, or? To me, it pairs well with a jingle like
www.youtube.com/watch?v=NNv2...
add a skeleton here at some point
29 days ago
1
2
1
reposted by
Lars-Anders Carlson
Reese Richardson
29 days ago
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
loading . . .
18
590
443
ATG16L2 creates a VAIL-dedicated heterodimer with ATG16L1
www.biorxiv.org/content/10.6...
loading . . .
https://www.biorxiv.org/content/10.64898/2026.06.01.729256v1
29 days ago
0
3
2
Load more
feeds!
log in