Lars-Anders Carlson
@lacarlson.bsky.social
📤 1896
📥 288
📝 301
Structural virology group leader at Umeå University, Sweden. www.carlsonlab.se
pinned post!
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology
#teamtomo
www.nature.com/articles/s41...
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Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
https://www.nature.com/articles/s41467-026-68483-4
20 days ago
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Dorian McILROY
about 11 hours ago
Some antibodies against Adenovirus pVII cross-react to platelet protein PF4, and the pathogenic autoantibodies all carry light chain K31E or K31D somatic hypermutation. So only individuals who expand one particular clonotype, and one specific SHM, during their response to AdV infection were at risk.
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SBGrid Consortium
1 day ago
If you missed Alice-Roza Eruera's January webinar on Building CryoET Training Workflows Using the SBGrid Ecosystem, you can now find it on our YouTube channel. Here:
buff.ly/CPcy0Nz
#SBGrid
#Webinars
#ScienceMatters
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SBGrid Ecosystem
SBGrid webinars are hosted with partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis of Belmont University.…
https://youtu.be/7nYke4ZoqEo
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The Wallenberg foundation published a very nice background article in relation to the grant we got last year. Thanks authors Elin and Maxwell, and photographer Johan for a great job!
kaw.wallenberg.org/en/research/...
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Examining the innermost machinery of viruses | Knut and Alice Wallenberg Foundation
Viruses are among the simplest biological structures in existence. Yet time and again they manage to take control of some of the most advanced systems we know of: living cells. How this actually happe...
https://kaw.wallenberg.org/en/research/examining-innermost-machinery-viruses
2 days ago
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Cool feature! It seems I am in the outskirts of the bluesky galaxy:
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3 days ago
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Ulrich Schwarz
13 days ago
📢Job alert📢
@uniheidelberg.bsky.social
has an opening for a full W3-position on “Modeling of Biological Processes” 😀👍 Here is the call
tinyurl.com/3w9e9dtf
and application deadline is March 15. The group would be located at the beautiful
#BioQuant
center right in the middle of Neuenheimer Feld.
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RCSB Protein Data Bank
4 days ago
He made beer that’s also a vaccine. Now controversy is brewing A scientist’s unconventional project illustrates many challenges in developing new vaccines
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He made beer that’s also a vaccine. Now controversy is brewing
An NIH scientist’s maverick approach reveals legal, ethical, moral, scientific and social challenges to developing potentially life-saving vaccines.
https://www.sciencenews.org/article/vaccine-beer-polyomavirus-chris-buck?mc_cid=29287d495d&mc_eid=f689923654
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bioRxiv Cell Biology
7 days ago
Robust quality assessment of cryo-EM maps, tomograms and micrographs by statistics-based local resolution estimation
https://www.biorxiv.org/content/10.64898/2026.02.03.703505v1
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Wikipedia
7 days ago
Looking for adventure? Start your rabbit hole with a truly random Wikipedia article ⬇️ No algorithm needed. One click sends you anywhere – from obscure villages to species of frogs. Experience serendipity without algorithms. Start your random adventure ➡️
w.wiki/_2n
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Thelonevirologist
8 days ago
Serious side effects dim hopes for the first chikungunya vaccine
www.science.org/content/arti...
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Serious side effects dim hopes for the first chikungunya vaccine
The shots fell short during a massive outbreak on a French island. A new vaccine may be safer
https://www.science.org/content/article/serious-side-effects-dim-hopes-first-chikungunya-vaccine
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Amen.
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9 days ago
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David Suter
10 days ago
I miss these pieces so much...sigh...
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Nature Microbiology
11 days ago
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Genomic features associated with sustained mammalian transmission of avian influenza A viruses
Nature Microbiology, Published online: 27 January 2026; doi:10.1038/s41564-025-02257-4Reduced GC-related content in the influenza A virus genome may be a necessary condition for sustained mammalian transmission and should be included in risk assessment tools for pandemic influenza.
https://go.nature.com/4qF9TmV
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Lars-Anders Carlson
Daniel Blanco-Melo
13 days ago
Excited to share our work on
#AncientRNA
from alcohol-preserved lungs, recovering the oldest human RNA virus genome (an 18th-century rhinovirus). Our study shows that viral RNA remnants persist in centuries-old tissue, opening new ways to study virus evolution and historical disease
#Paleovirology🫁🦠
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https://www.biorxiv.org/content/10.64898/2026.01.29.702071v1
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Danielle Grotjahn
11 days ago
Are you a cell biologist who secretly thinks cellular cryo-electron tomography is just George Palade-era EM, but fancier? Join this webinar to see how modern
#teamtomo
has shifted from pretty pictures to quantitative, local membrane biology, and how that changes the questions we can ask.
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Ricardo D. Righetto
13 days ago
Am I the only one increasingly annoyed by cryo-EM papers not showing *any* experimental density in figures? Sometimes not even in the supplementary material??
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RCSB Protein Data Bank
13 days ago
Build a paper model of dengue virus for WHO's World Neglected Tropical Diseases Day on January 30 #WorldNTDDay
pdb101.rcsb.org/lear...
More on dengue at Molecule of the Month:
pdb101.rcsb.org/motm...
#WorldNTDDay
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PDB101: Learn: Paper Models: Dengue Virus
Atomic structures of dengue virus are giving new hope for creation of a vaccine
https://pdb101.rcsb.org/learn/paper-models/dengue-virus
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Oded Rechavi
15 days ago
“ok so this is embarrassing but just for the record and just so we have it, your C.V says "Nature Scientific Reports"? sorry to have to even ask”
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Marvin Tanenbaum
15 days ago
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
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Pre-assembly of biomolecular condensate seeds drives RSV replication
Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.
https://rdcu.be/e1bBW
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Sartre said something for scientists to think about:
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15 days ago
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RCSB Protein Data Bank
15 days ago
January is Cervical Cancer Awareness Month Visit PDB-101 to learn how the capsid protein of papillomavirus is used in vaccines that prevent cervical cancer
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PDB101: Molecule of the Month: Human Papillomavirus and Vaccines
The capsid protein of papillomavirus is used in vaccines that prevent cervical cancer.
https://pdb101.rcsb.org/motm/221
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Structura Biotechnology
16 days ago
🚀 CryoSPARC v5.0 BETA is here! We’re excited to deploy another major
#CryoSPARC
release to help enable and accelerate
#cryoEM
data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread! Full changelog:
cryosparc.com/updates/v5.0.0
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Utz Ermel
16 days ago
New on the CryoET Data Portal: ~27,000 tomograms of affinity-captured lysosomes from HEK293T cells across 4 physiological states. Includes raw data, AreTomo3 reconstructions & Membrain-Seg annotations. Openly available for reuse!
cryoetdataportal.czscience.com/depositions/...
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Jason McLellan
16 days ago
Our third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint:
doi.org/10.64898/202...
. A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.
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My definition of HUGE cryo-ET data set just shifted by an order of magnitude: 13,694 tilt series!
cryoetdataportal.czscience.com/depositions/...
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https://cryoetdataportal.czscience.com/depositions/10318
16 days ago
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RCSB Protein Data Bank
16 days ago
Given the hollow cage-like structures of ROOL and GOLLD complexes, researchers suggest that they may act as structural scaffolds within the cell, helping to sequester or compartmentalize cellular components. More at Molecule of the Month:
pdb101.rcsb.org/motm...
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Harry M. Williams
16 days ago
And now out in Nature Comms (congrats Wyatt et al.):
www.nature.com/articles/s41...
.
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Admirable Women
17 days ago
Biochemist/molecular biologist Joan Steitz was born
#OTD
in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need.
#WomenInSTEM
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Reminder with <2 weeks to deadline:
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17 days ago
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Jeremy Berg
18 days ago
Jane changed how I both think about and teach biochemistry.
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Prof. Feynman
18 days ago
Imagine how much harder physics would be if electrons had feelings.
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Ervin Fodor
19 days ago
Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with
@loiccarrique.bsky.social
and Jon Grimes.
www.science.org/doi/10.1126/...
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I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology
#teamtomo
www.nature.com/articles/s41...
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Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
https://www.nature.com/articles/s41467-026-68483-4
20 days ago
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NO.NO.NO
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20 days ago
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Helen Branswell 🇨🇦
21 days ago
The US withdrawal from
#WHO
became official today, leaving the world less prepared for dangerous disease outbreaks. “When that will bite us in the ass, it’s impossible to predict. But there is a 100% certainty that it will bite us in the ass,” one expert told me.
www.statnews.com/2026/01/22/u...
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U.S. makes exit from the WHO complete
The U.S. withdrawal from the WHO became official Thursday, formalizing a fissure between the Trump administration and the Geneva-based global health agency.
https://www.statnews.com/2026/01/22/usa-divorce-world-health-organization-puts-america-at-risk/
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Shyamal
23 days ago
We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from
@baradlab.com
@williamnwan.bsky.social
and others! Apply!
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Dreadnought Holiday
21 days ago
Amazing sob story: "ChatGPT deleted all the work I hadn't done"
www.nature.com/articles/d41...
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When two years of academic work vanished with a single click
After turning off ChatGPT’s ‘data consent’ option, Marcel Bucher lost the work behind grant applications, teaching materials and publication drafts. Here’s what happened next.
https://www.nature.com/articles/d41586-025-04064-7
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Our World in Data
22 days ago
Globally, seasonal influenza kills an average of 700,000 people each year from respiratory disease or cardiovascular disease. During large flu pandemics, when influenza strains evolved substantially, the death toll was even higher.
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Beautiful infographic on a sad topic.
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22 days ago
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John R. Platt
23 days ago
The Species Declared Extinct in 2025 My annual look back is, of course, heartbreaking -- but it's also a reminder and encouragement that we can do more to prevent future extinctions:
therevelator.org/extinct-2025/
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Rocket Frog, Damselfish, and Bandicoots: The Species Declared Extinct in 2025 • The Revelator
This year’s list includes a notable extinction caused by climate change — and several caused by introduced predators.
https://therevelator.org/extinct-2025/
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Dawid Zyla
22 days ago
I never imagined I'd be writing this, but I am happy to share that, starting this June, I will be joining
@cuanschutz.bsky.social
@cu-bmg.bsky.social
as an Assistant Professor.
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Tom Peacock
23 days ago
Interested in high containment work on viruses? We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
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CL3- Research Assistant
The Pirbright Institute The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic a...
https://isw.changeworknow.co.uk/pirbright/vms/e/careers/positions/d2mAroLfDiBkMOio_VE7T-
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We wanted to build the ASU of an adenovirus using ModelAngelo, but accidentally used the full capsid map. It is ~95 nm in diameter and ~80 MDa. ModelAngelo built it! Biggest PDF file ever? :) Cool software, thanks
@kjamali.bsky.social
and
@sjorsscheres.bsky.social
!
23 days ago
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Lars-Anders Carlson
Wilfling Lab
23 days ago
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗
doi.org/10.64898/202...
#CryoET
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Joost Snijder
24 days ago
Just got this in the mail from
@addgene.bsky.social
, recognizing that 100+ labs have now ordered our anti-FLAG-M2 plasmids via their service.
@mfpronker.bsky.social
www.addgene.org/Joost_Snijder/
pubs.acs.org/doi/full/10....
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Stern-Ginossar Lab
28 days ago
Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper :
rdcu.be/eY5gx
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N1-Methylpseudouridine directly modulates translation dynamics
Nature - N1-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.
https://rdcu.be/eY5gx
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Alan Stedman
26 days ago
This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition, The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance Iconic imo
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Thelonevirologist
26 days ago
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles
link.springer.com/article/10.1...
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Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles - The EMBO Journal
Following cell entry, HIV-1 capsids enter the nucleus by passage through nuclear pores and reach nuclear speckles with subsequent uncoating of the reverse-transcribed genome and its integration into s...
https://link.springer.com/article/10.1038/s44318-025-00652-5?utm_source=springer_etoc&utm_medium=email&utm_campaign=CONR_44318_AWA1_GL_DTEC_054CI_TOC-170126&utm_content=etoc_springer_20260117
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Sven Klumpe
about 1 month ago
We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here:
doi.org/10.1016/j.ul...
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Rémi Fronzes
25 days ago
I love that !
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J. Emory Parker 🏳️🌈
28 days ago
Longer version with more detail:
www.npr.org/sections/kru...
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Dissolve My Nobel Prize! Fast! (A True Story)
It's 1940. The Nazis have taken Copenhagen, and physicist Niels Bohr has just hours, maybe minutes, to make two Nobel Prize medals disappear.
https://www.npr.org/sections/krulwich/2011/10/03/140815154/dissolve-my-nobel-prize-fast-a-true-story
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