The trumpocracy at work. Deaths ensue.

Once again, @dereklowe.bsky.social is not holding back and I am here for it. www.science.org/content/blog... 1/2

The DiffUSE Project wants examples where structural heterogeneity matters but cannot be encoded in PDBx/mmCIF. X-ray, cryo-EM, time-resolved, multi-map, or fragment screening data welcome. Submit yours: diffuse.science/submit/

President of MIT not mincing words today in @statnews.com www.statnews.com/2026/05/27/s...

Flirtation, by Eugene de Blaas, 1894

Spot on. The dangers of rejecting wisdom and expertise. Somewhat analogous, though milder: “A month in the laboratory can often save an hour in the library”.

This entire administration is an exercise in discovering why you need government and then scrambling to assemble an arm while cutting off another leg.

One more thing - this (the life sciences, and its associated products) is, in my opinion, the last place where America has/had the 'commanding heights' and Trump/Russell Vought is 100% trying to give that advantage away. Our children and grandchildren will be poorer and sicker for it.

Just spent 3+ hours researching candidates and voting in California’s primary. My first vote as a US citizen and it was a lot of work!!

This is THEFT. There is no other word for it. They are stealing almost $1.8 BILLION dollars to pay Trump‘s allies, despite knowing that these people are not legally entitled to any money and be laughed out of court if they filed a lawsuit for money damages.

The groundbreaking research into the KRAS protein that led to the development of daraxonrasib was funded in part by the NIH. Public funding is the bedrock of pharmaceutical research.

While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

This would constitute one of the most brazen, most appalling acts of corruption in U.S. history. I know we’re numb to all of this but this is a seven-alarm fire. www.nytimes.com/2026/05/12/b...

This is really great work - look forward to using these new improved scattering factors in Servalcat and eventually in other packages.

Measurement of atomic scattering factors by cryoelectron microscopy pubmed.ncbi.nlm.nih.gov/42101996/ #cryoem

Not my field but I am generally skeptical of “reproducibility crisis” cries of alarms. AFAICT it has always been very difficult to reproduce cutting-edge science.

📣 The difference between replicable and not replicable is not itself scientifically replicable. 📣 New work with Erkan Buzbas, showing that verdicts such as "X% of results replicated" are based on an inferential machinery that doesn't work. arxiv.org/abs/2604.26268

🚀 Soft-launching BenchOS today. An agentic OS for molecular & structural biology labs, combining ELN, biologics databases, equipment booking, cryo-EM tracking, cloning tools, and more. Powered by state-of-the-art LLMs to help you plan and run experiments faster. Learn more: BenchOS.ai

Laurence would be well able for that himself. But he’s right - getting it across is hard. www.theguardian.com/science/occa...

This was a very rewarding 1-year Genentech project thanks to everyone involved, @alisterburt.bsky.social, @dtegunov.bsky.social, Miguel Leung, and Joyce van Loenhout. Software development was done with Alister and Dimitry remotely while I was embedded at the Hubrecht Institute in Utrecht.

I’m incredibly impressed by @martenchaillet.bsky.social, @alisterburt.bsky.social and @dtegunov.bsky.social ‘s work to improve tilt series alignment. And proud to work at #Genentech, where we believe #OpenSoftwareAcceleratesScience and support the development of #cryoET for drug discovery.

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

Excited to share our paper on the NLRP3 inflammasome condensate at the Microtubule Organizing Center (MTOC) by "precise!" cryo-electron tomography (cryo-ET), in collaboration with Jue (phyllis) Wang in the labs of Grant Jensen (BYU) and Pete Dahlberg (Stanford)! www.science.org/doi/10.1126/...

Will @kevinmullin.house.gov support this?

I’m no expert, but I’ve yet to be convinced that adding more Justices to the Supreme Court would help in the long run. The proposed reforms below, however, seem sensible.

Most striking to me about these memos is the radically different assessment of the harm imposed by the president not being able to pursue his initiatives. Over the last 15 mos., that harm has in numerous cases been treated as almost per se serious and irreparable. Here, it gets no analysis at all.

Right. The Chief Justice worried a lot that energy companies would have to spend money, but did not consider in his analysis the cost (in lives and health and $$) of global warming. Other takeaway: Root cause of all this was Congress’ inability to legislate, in this case due to R climate denialism.

So there's a really important debate on civil liberties and national security going on on the House floor right now. It is shameful that it's taking place at this late hour of the night / morning. But I'm going to at least do something productive & try to explain here:

WELL NOW, would you look at that? A massive, 4-YEAR-LONG study of NEARLY 30 MILLION people in France found that individuals who received a COVID-19 mRNA vaccine had a 74% LOWER risk of death from severe COVID-19 compared to unvaccinated individuals and ZERO increased risk of all-cause mortality.

New online: Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state

Coot 1.2 released With side-by-side stereo and Agentic Coot pemsley.github.io/coot/blog/20... pemsley.github.io/coot/blog/20...

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...

Congratulations @alisiafadini.bsky.social , @randyjread.bsky.social and other co-authors!

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

cc @offspringmusic.bsky.social

I joined a few hundred people for my local #nokings protest today in San Mateo, California. It was my first time ever taking part in a protest. Also my first ever attempt at making a stencil! (Bonus points to those who get the musical reference)

I agree 100% with Steven Vickers that authors will be falsely accused of using AI in the coming years. In particular, authors like myself whose works were stolen to train AI systems are at risk. When we write in our own unique styles, AI trained on us will quite likely flag us as using AI.

The most effective and influential urban transformations of any city in the world during Hidalgo’s term. “What’s most remarkable is the sheer volume of aggressive new policies @annehidalgo.bsky.social has managed to push through. Sunday’s mayoral election may determine the direction of her legacy.”

𝗣𝗗𝗕𝗲 𝗺𝗺𝗖𝗜𝗙 𝗩𝗮𝗹𝗶𝗱𝗮𝘁𝗼𝗿: validate your mmCIF files against PDBx/mmCIF dictionary ✅ Real-time check ✅ Metadata completeness indicator pip install pdbe-mmcif-validator install VS code extension: marketplace.visualstudio.com/items?itemNa... GitHub - PDBeurope/mmcif-validator: github.com/PDBeurope/mm...

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

Donald Trump spent more than $11 BILLION in a week bombing Iran for reasons he cannot explain, but he can't find a nickel to help the 82M people who are struggling to pay for their health care. It's all about priorities.

It’s crystal clear now that Trump has lost control of this war. He badly misjudged Iran’s ability to retaliate. The region is on fire. 1/ I’m going to explain to you in this🧵what I’ve learned - in part from closed door briefings - about the four biggest current crises.

“But, as you see, it's a beautiful day, the Strait of Hormuz is open and people are having a wonderful time.”

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Another Q for the #cryoEM crowd. Has anyone read the cryoSENSE manuscript? I only scanned it quickly, but the key test of the method, in Fig4b, where they do FSCs of reconstructions using their compressed and reconstructed images doesn't seem convincing to me. arxiv.org/html/2511.12...

The New York Times published an extraordinary study of the role of billionaires in politics earlier this week, that naturally got lost in everything that is going on, including in Iran. Here is a gift link to the article, and a few select quotes: www.nytimes.com/2026/03/09/u...

Holy smoke. What ultimately happened???

Good on China. Now imagine if a superpower coupled this kind of science and tech investment with free speech and a non-planned economy. That would be a truly potent recipe for success. Oh wait…

I was in a 2 hour briefing today on the Iran War. All the briefings are closed, because Trump can't defend this war in public. I obviously can't disclose classified info, but you deserve to know how incoherent and incomplete these war plans are. 1/ Here's what I can share:

When a writer on politics and foreign affairs also turns out to be a Celtics fan, and to encourage optimism not cynicism, they really deserve your attention (or mine at least)!