The MRC LMB just continues to amaze as a catalyst of great discoveries and major advances.

I share this sentiment. If the science, medicine and ethics are in place and the only reason medical progress is not made is because public officials, even after being presented with the evidence, act deliberately against the interests of the population, they deserve to be treated as criminals.

Waaaay to accurate...

Late to this, but this is wrong. Trump lies right and left about how the BLS is against him and - as you know - fired the commissioner. But the data - so far - have not been tampered with.

The idea of a bill rendering people deportable for following religious law should make every Jew ill

More evidence also that the federal administration is NOT pursuing actual criminal activity- they have forced out the very prosecutors who were working on the social services fraud cases that had been the proclaimed casus belli for sending federal forces to MN.

More evidence of the US’ slide toward authoritarianism

I'm sorry the guy changing the rules on the fly is named what

As much as the NYT’s editors drive me up the wall at times with overly cautious headlines, other parts of the coverage is really excellent IMO. This autocracy index tracker is crisp and unflinching. Surely not perfect but a great overview of where we stand on the autocratic spectrum.

“Your mountainish inhumanity” We’re doing this to ourselves

For those in California, please consider signing the petition to support a $23 billion initiative for the California Foundation for Science and Health Research www.fundcascience.org

Again, this is FALSE. Administrative warrants are NOT signed by an immigration judge (or any judge at all). They are generated and signed by ICE officers themselves with no external oversight whatsoever. Here is a blank sample warrant. Note who signs off on it; an "immigration officer."

Beautiful writing!

So many lucid points below. Incl on how to think abt free speech issues brought up by backlash on campuses when illiberal right-wingers are invited to speak. Also, and this has agitated me since Jan 2025: those who railed against cancel culture seem at ease with state-enforced speech restrictions.

I was a White House staffer. When having a lunch with anyone who worked at law firm, corp, embassy, *newspaper* I had to document that I'd paid exactly my share of the bill. ("No free lunch" policy.) At some formal event dinners, had to calculate fair-market cost of my serving, and reimburse it

Some jawdropping CBP crime statistics here...

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During WWII, the U.S. government forcibly took over 100,000 people of Japanese ancestry from their homes and held them in internment camps. Fred Korematsu was arrested and convicted for defying the government’s order and refusing to go to the camps.

A rule I follow when reviewing cryo-EM manuscripts: if a claim relies on the orientation or interactions of a side chain, the evidence supporting the claim (ie the map density) must be shown. In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.

this was published this week, in case you haven’t seen it: www.nature.com/articles/s41...

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free

Lots of guys with backwards ball caps and truck nutz never gonna listen to Philip Glass again

Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...

RIP Sly Dunbar. He now joins Robbie Shakespeare again. Hard to choose from hundreds of recordings but the session with Gainsbourg was recorded and mixed so well… it is a beautiful exemplar of perhaps the most famous rhythm section of reggae. Here is a later version featuring Big Youth.

I’m no historian, nor political scientist, and the term is definitely overused, but…

"Today, lawless and masked thugs masquerading as law enforcement officers brutally killed another American citizen on the streets of Minneapolis without justification”

Don't forget: the reason ICE is in Minnesota is because Trump wanted to score some points with his xenophobic base by going after Somalis who committed financial fraud. And the GOP was fine with that.

A hideous, unbelievable insult to our allies, who suffered a full third of the war dead in Afghanistan. And this from a soulless swine who knows everything about using his bone spurs to stay all the way back, entirely off the front lines. Every day, he shames the United States as a nation.

It seems that a crux of this matter is that there is no statute that specifies that victims of 4th amendment violations by fed agents can sue for damages. Recent Supreme Court rulings apparently makes this necessary- otherwise there’s no remedy available, even if the DHS policy is unconstitutional

The rule of law; separation of powers; the constitution and its amendments. According to the citizenship test I took just weeks ago, those are foundational principles of life in the USA. Available evidence shows that the current administration deliberately ignores and/or sabotages them. For shame!

She was absolutely right. And she would have been an amazing President.

My quote of the day North Atlantic Treaty Signed April 4, 1949

DOJ investigating whether Denmark lied on its Greenland mortgage.

“Epidemic trespassing”. Seems like a useful phrase! First time reading it.

Dark times

Stop scrolling and post two characters who bring you happiness

I've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;

GERMAN PRESIDENT STEINMEIER: “.. the United States has broken with the values that it helped to establish .. “.. we have now moved beyond the stage where we can lament the lack of respect for international law or the erosion of the international order; we are far beyond that, I believe.”

Corvid aficionados 🐦‍⬛, one the crows at work (SF Bay Area) was making a very unusual call today. I’ve never heard a crow make that kind of sound. Not captured in video but it made usual caws after flying off so I’m pretty sure it’s a crow… anyone heard that kind of call before? @carlbergstrom.com?

Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!

Y’all might not appreciate it, but it took him 87 moves and 14 hours to get here

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

RIP HopetonJames, what a sweet voice. youtu.be/bU2vFSRmz8E?...

My quote of the day For every complex problem there is an answer that is clear, simple, and wrong. H. L. Mencken

Oh wow, this is 🤯 amazing: ~3-fold acceleration of running #relion on A100 GPUs for realistic single-particle refinement by the group of Guangwen Yang at @tsinghuauniversity.bsky.social . What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍 dl.acm.org/doi/full/10....

This bring me back to one of my favorite anecdotes. In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS. It received a fairly poor score (~60th percentile). 7/13

Lest we forget

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...