Our January issue is out: journals.iucr.org/d/issues/202... The cover highlights a data survey of the PDB and CSD for macromolecular and ligand structures that have been determined at elevated temperatures. Read more at doi.org/10.1107/S205...

Check our new preprint smoothing rugged Cryo-EM landscapes: shorturl.at/gYs9U We tackle practical hurdles of Optimal Transport (OT) loss—differentiability, cost & noise sensitivity—make it a feasible inference workhorse. W/ G. Woollard, D. Herreros, @pilarcossio.bsky.social, K. Dao Duc 🧵👇 (1/9)

This is a classic of the genre!

RE: https://fediscience.org/@Guillawme/111534984107819771 Something really cool happened to me this year! @HRBridges re-processed a #CryoEM dataset from some previous work of mine and colleagues (publicly available as EMPIAR-10739; see quoted post below for a summary of this work). She […]

From Sameer Velankar & colleagues in @narjournal.bsky.social #NARDatabaseIssue | PDBe: enhanced structural data exploration to facilitate discovery | #Bioinformatics #Database #OpenScience #Proteomics #PDB 🧬 🖥️🧪🔓 ⬇️ academic.oup.com/nar/advance-...

BBC News - Top UK scientist says research visa restrictions endanger economy www.bbc.com/news/article...

Apply for #IUCr2026 travel grants Funds are available to support students, early-career researchers, and participants from under-resourced institutions and/or developing countries. Details at event.fourwaves.com/...

🚨 Apply now for the 2026 Erice School! From Structural Biology to Structural Cell Biology with the aid of Machine Learning 📅 May 31–June 9, 2026 ⏳ Deadline: Dec 7, 2025 🌐 Info: crystalerice.org/2026

It’s great to see people thinking about tracking errors in Fourier terms! EM_placement tries to infer effects of orientation bias from half maps, but it would be far better to do this directly in the reconstruction process. No surprise it’s people like ZO and Dominika doing this work!

Giles and Burnley: Ten years of the CCP-EM Spring Symposium ##Cryoem##ElectronCryoMicroscopy##CCPEM... ##IUCrhttps://journals.iucr.org/paper?S2059798325010496

I really like the new summary representation Airlie has come up with for the self rotation function!

Frontier structural biology chases low occupancies: weak binders in drug discovery & fleeting intermediates in time-resolved studies. When squeezing SNR, confirmation bias looms – you can see what you hope to see in the noise! Enter METEOR ☄️, our denoising+phasing framework! 1/8

Chris is a brilliant structural biologist and mentor. Would highly recommend applying!

🚨Attention prospective PhD students🚨 Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪 We have THREE fully-funded PhD projects available for October 2026 entry: www.findaphd.com/phds/?Keywor... Please share/repost, and get in touch if you're interested

Great collaborative environment with lots of exciting work!

Our November issue is available at journals.iucr.org/d/issues/202... On the cover: recent studies demonstrate that the range of samples suitable for cryo-EM single-particle analysis is expanding towards increasingly more native samples. Read the review at shorturl.at/mitjg

I’m biased, but it’s well worth an hour or so of your time! #cryoEM #crystallography 🧪

Don’t forget to apply for the 2026 Erice Course! Deadline is 30th November 2025. Apologies if earlier today I wrote Dec 15th.

OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇

There are some great new results!

ROCKET's webinar on cryo-EM+crystal data-guided protein structure prediction is now online 🚀: www.youtube.com/watch?v=_29C... Thank you to the many of you who attended and stayed overtime for more Q&A, and especially to @sbgrid.bsky.social for hosting us last week!

Major modes of behavior within low-pLDDT regions were identified through a survey of human proteome predictions provided by the AlphaFold Protein Structure Database #AlphaFold2 #StructurePrediction #ConditionalFolding doi.org/10.1107/S205...

This is reminiscent of the subset of bacterial toxins that hijack retrograde translocation and the ERAD machinery to get into the cytosol. Their active, translocated subunits are also lysine deserts!

Christopher did a great job on this cover!

I’ve frequently posted the version revised in response to referee comments to bioRxiv, on the assumption that anything up to and including the author accepted version is allowed, though not to Nature family. I wonder if @ritastrack.bsky.social could comment?

Well deserved! I’ve always been deeply impressed by David’s insights into a wide variety of areas!

This looks really impressive!

These are fantastic courses in an amazing location!

Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...

The September issue is here! tinyurl.com/bdeby9au The cover highlights XFBLD-Platform, a crystallographic fragment-screening platform at Shanghai Synchrotron Radiation Facility. Find out more at tinyurl.com/36rzxazr

This is well worth your time! Alisia and Minhuan are both rising stars!

"Bluesky now platform of choice for science community. It's not just you. Survey says: "Twitter sucks now and all the cool kids are moving to Bluesky" arstechnica.com/science/2025...

The August issue is out! journals.iucr.org/d/issues/202... On the cover: ~15% of the ligands in a high-resolution set of FABP structures had a different chemical composition to that expected from the starting materials or final synthesis product. Find out more at doi.org/10.1107/S205...

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics ‪@oncodeinstitute.bsky.social‬, ‪@nkinl.bsky.social‬

I have two fond memories of Rolf. In the late 1980s, when I was just becoming independent, he asked for a copy of my program, SIGMAA. I said sure, send me a mag tape, and he said no, I have a budget for this (Hoechst era) and offered several thousand dollars. Travel budget sorted for a couple years!

Pipe stems (Dutch)

Elspeth F. Garman: Perspective on a large-scale ligand structure characterization ... ##IUCrhttps://journals.iucr.org/paper?S2059798325006631

Blind structure prediction experiments like CASP and CAPRI are catalysts of new developments

A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/

The 27th Congress and General Assembly of the International Union of Crystallography will be held in magnificent Calgary in the heart of Alberta, Canada from Aug 11-18, 2026. Interested in cutting-edge structural science? Sign up for updates at www.iucr2026.org/

Wow, that brings back old memories from my PhD!

In case you tried the first link, here’s one that works!

It's day 4 of #ISMBECCB25 so do drop by the IUCr stand! Now featuring the IUCr Journals tablecloth and a rare appearance by our Managing Editor!

Fantastic news!

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...

If you’re attending #ACA2025 in Chicago, check out the talk by the amazing @alisiafadini.bsky.social. She’ll present new results on using experimental data (X-ray or #CryoEM) to guide AlphaFold even with very low resolution data! Session 2.1.3 at 11:10 on Sunday.

Read how Michael James, Louis Delbaere, Wilson Quail, and others inspired Canadian crystallographers in Sharing our excitement for structural science through mentorship Open Access pubs.aip.org/aca/sdy...

More arguments for choosing society journals, where any profits are ploughed back into science! For structural biology, please consider @actacrystd.iucr.org, @actacrystf.iucr.org and @iucrj.iucr.org!