Hekstra Lab
@hekstralab.bsky.social
π€ 111
π₯ 51
π 17
We're a big step closer to automated determination of protein structures. The key? Having AlphaFold listen to experimental data. Great work, led by
@alisiafadini.bsky.social
and
@minhuanli.bsky.social
in an inspiring collaboration with
@moalquraishi.bsky.social
and
@randyjread.bsky.social
.
add a skeleton here at some point
19 days ago
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reposted by
Hekstra Lab
Reciprocal Space Station
19 days ago
ROCKET-fueled refinement? That's on-brand, along with bad space-themed puns and other cool software projects at the frontier of structural biology. π ROCKET source code:
github.com/rs-station/r...
1/π§βπ More projects:
rs-station.github.io
add a skeleton here at some point
0
6
2
reposted by
Hekstra Lab
Harvard_MCB
19 days ago
ROCKET Launches Structural Biology Past AlphaFold π§ͺ π§¬
#AcademicSky
#higherEd
#RNA
#Protein
www.mcb.harvard.edu/department/n...
@hekstralab.bsky.social
@cam.ac.uk
@flatironinstitute.org
@umeauniversitet.bsky.social
@tcddublin.bsky.social
@stjuderesearch.bsky.social
@columbiauniversity.bsky.social
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ROCKET Launches Structural Biology Past AlphaFold - Harvard University - Department of Molecular & Cellular Biology
Five years ago, a team at Googleβs DeepMind won CASP14, the long-running protein structure prediction competition, with AlphaFold, a machine-learning system capable of predicting the three-dimensional...
https://www.mcb.harvard.edu/department/news/rocket-launches-structural-biology-past-alphafold/
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6
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Can AlphaFold refine structures for X-ray & Cryo-EM/ET data? Now it can! Great collab with
@moalquraishi.bsky.social
and
@randyjread.bsky.social
led by
@alisiafadini.bsky.social
and
@minhuanli.bsky.social
. π§΅below. Code to follow...
add a skeleton here at some point
about 1 year ago
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Crystal structures are *not* God-given truth. They approximate, w/ flaws & errors, X-ray diffraction data. AlphaFold etc. have been trained on structures, not data. SFCalculator now differentiably connects structures to diffraction data. What does this enable? π§΅ 1/4
www.biorxiv.org/content/10.1...
about 1 year ago
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Now in Cell: K+ ion channels enable electric currents consisting of potassium ions to generate action potentials in heart, brain, and muscle. For the first time, we can now see these currents atom-by-atom.
www.cell.com/cell/abstrac...
1/8
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https://www.cell.com/cell/abstract/S0092-8674(24)01419-3π§΅
about 1 year ago
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X-ray diffraction can access protein dynamics. Why so few datasets? One reason? Lack of powerful pulsed X-ray sources. XFELs are limited. Synchrotrons throw away >99% of photons. Working with Aaron Bewster (DIALS/LBNL) and BioCARS (
biocars.uchicago.edu/
) to change this! π§΅1/2
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laue-dials β laue-dials
http://rs-station.github.io/laue-dials/
about 1 year ago
1
1
0
Hello World! Catching up after not posting for a long time on Twitter/X/BlueSky (what happened to Mastodon?).
about 1 year ago
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