While most AI models are trained on text and images, a multidisciplinary team of scientists has something different in mind: #AI trained on physics. https://www.simonsfoundation.org/these-new-ai-models-are-trained-on-physics-not-words-and-theyre-driving-discovery/ @polymathicai.bsky.social#AI#science

In 2025, our researchers pushed science into new territory through bold inquiry & transformative science. Look back at our biggest stories this year, highlighting the people and ideas reshaping our understanding of the universe — and of ourselves: simonsfoundation.org/from-ringing... #science #math

JWST found mysterious "Little Red Dots" in the early Universe, but what are they? Our new paper points to Quasi-Stars: supermassive black hole seeds hidden inside giant, *pulsating* envelopes! arxiv.org/abs/2512.17997

New paper! In work led by Matteo Cantiello @flatironinstitute.org we predict an instability strip for quasi-stars, which we argue is consistent with the observed variability properties of JWST’s Little Red Dots. arxiv.org/abs/2512.17997

Deadline in 2 weeks: Our Canonical Cortical Computations workshop, which aims to develop a project to understand canonical cortical computations at the circuit level: https://www.simonsfoundation.org/simons-foundation-now-accepting-applications-for-workshop-on-canonical-cortical-computations/

New AI models from @polymathicai.bsky.social use knowledge from scientific fields and apply it to others. Walrus (seen below) can tackle systems from exploding stars to Wi-Fi signals: https://www.simonsfoundation.org/these-new-ai-models-are-trained-on-physics-not-words-and-theyre-driving-discovery/

Just 3 days until Birth + Carnage comes alive! This collaboration between choreographer Marla Phelan and @flatironinstitute.org Blakesley Burkhart fuses dance with astrophysics to explore where cosmic forces meet human connection: https://www.lamama.org/birth-carnage #science #dance #astrophysics

Last month, our Accretion at the Disk-Halo Interface Workshop brought together simulators from #FlatironCCA and observers from around the country to figure out how gas accretes onto galaxies to fuel star formation. #science #astrophysics

A new study from #FlatironCCB researchers uses cutting-edge computational modeling of the fruit fly gut to lay the groundwork for understanding how organs and tissues take shape across many species: https://www.simonsfoundation.org/from-ring-to-keyhole-modeling-how-tissues-mold-the-fruit-flys-gut/

While popular AI models are trained on language or photographs, new models from @flatironinstitute.org and @polymathicai.bsky.social researchers are trained with scientific datasets: https://www.simonsfoundation.org/these-new-ai-models-are-trained-on-physics-not-words-and-theyre-driving-discovery/

Interested in joining the Flatiron Institute for an extended visit? Applications for our Idea Scholar program are due in just under a month! Learn more and apply: https://www.simonsfoundation.org/flatiron/idea_scholar_program/ #science #math #computationalscience

How do organs acquire their signature shapes? New research on the fruit fly gut is helping answer this question: https://www.simonsfoundation.org/2025/11/17/from-ring-to-keyhole-modeling-how-tissues-mold-the-fruit-flys-gut/ #science #biology

New AI ‘foundational models' from @polymathicai.bsky.social are leveraging knowledge from scientific fields to address seemingly completely different problems in others: https://www.simonsfoundation.org/these-new-ai-models-are-trained-on-physics-not-words-and-theyre-driving-discovery/ #AI #science

Applications are due in one month for our summer research internships! View full list of open positions: https://apply.interfolio.com/52828/positions #science

Humans have always looked to the moon, but there's so much left to discover. At our December Presents event, "Reflections on the Moon," @flatironinstitute.org's Adrian Bayer, sociologist Tracy Scott and NASA's Denise Hill explored what the moon still has left to teach us.

The Center for Computational Biology at the Flatiron Institute is accepting applications for summer intern positions. CCB is a great place to work, and the intern program is excellent. Please check out the Computer Vision and Developmental Dynamics groups in particular. apply.interfolio.com/177779

The Simons Foundation is #hiring! Browse our open positions, including software engineer intern, events coordinator, and grants administrator: https://www.simonsfoundation.org/careers/ #science #math #jobs

Members of the @polymathicai.bsky.social collaboration present two new #AI models trained using real scientific datasets to tackle problems in astronomy and fluidlike systems: https://www.simonsfoundation.org/these-new-ai-models-are-trained-on-physics-not-words-and-theyre-driving-discovery/

Apps for our Fellows-to-Faculty Award are due in 1 month! This program supports talented early career scientists in #neuroscience & #autismresearch by facilitating their transition into tenure-track positions. Deadline is 1/14/26: https://www.simonsfoundation.org/grant/fellows-to-faculty-award/

Interested in a summer internship in computational bio, math, catalysis, quantum physics, or neuroscience? Check out our summer research positions: https://apply.interfolio.com/52828/positions #science

New simulations created by @flatironinstitute.org and Institute for Advanced Study astrophysicists reveal how material flowing around and into black holes creates intense light shows: https://www.simonsfoundation.org/2025/12/03/groundbreaking-simulations-show-how-black-holes-glow-bright/ #science

#FlatironCCA scientists Ore Gottlieb, Brian Metzger, Maximiliano Isi, and colleagues solved the mystery of an 'impossible' merger between two massive black holes: https://www.simonsfoundation.org/2025/11/10/mysterious-impossible-merger-of-two-massive-black-holes-explained/ #science #astrophysics

Applications are due in one month for our Workshop on Canonical Cortical Computations: https://www.simonsfoundation.org/2025/11/13/simons-foundation-now-accepting-applications-for-workshop-on-canonical-cortical-computations/ #science #neuroscience

Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...

Super excited to be at my first ASCB in Philly! Here's a photo dump, including @mahsamofidi.bsky.social presenting her poster! #cellbio2025

#FlatironCCB biologists and collaborators examined the embryo of a well-studied organism — the fruit fly — to track how its hindgut (shown here in red) develops: https://www.simonsfoundation.org/2025/11/17/from-ring-to-keyhole-modeling-how-tissues-mold-the-fruit-flys-gut/ #science #biology

Check out my poster today (Thurs) at 11am--2pm session. Exhibit Hall C,D,E Poster Location: #602 "Fisher meets Feynman: score-based variational inference with a product of experts" (NeurIPS spotlight) with Robert Gower, David Blei, and Lawrence Saul @flatironinstitute.org #NeurIPS2025

Applications are now open for the 2026 Neuroscience Software Summer Internship at the Flatiron Institute! Join us to build tools for neural data analysis and computational neuroscience. Apply now! neurorse.flatironinstitute.org/events/2025/...

A team of computational astrophysicists has developed the most comprehensive simulations ever made of how black holes create dazzling light shows: https://www.simonsfoundation.org/2025/12/03/groundbreaking-simulations-show-how-black-holes-glow-bright/ #FlatironCCA #science #astrophysics

Birth + Carnage — a collaboration between choreographer Marla Phelan and @flatironinstitute.org scientist Blakesley Burkhart — fuses #dance and #science. Live performances will be held December 19–21 at the Ellen Stewart Theater: https://www.lamama.org/birth-carnage

Applications are now open for our summer research internships! Positions are available for undergrad + grad students interested in computational #science research. https://apply.interfolio.com/52828/positions

Happy #BlackHoleFriday! @flatironinstitute.org#BlackHoleFridayscientists recently detected a black hole merger, providing the clearest evidence yet of how black holes work and confirming Einstein & Hawking's predictions: https://www.simonsfoundation.org/ringing-black-hole-confirms-einstein-and-hawkings-predictions

Researchers from @flatironinstitute.org and @princeton.edu demonstrated how mechanical forces from surrounding tissues can shape the fruit fly gut: https://www.simonsfoundation.org/2025/11/17/from-ring-to-keyhole-modeling-how-tissues-mold-the-fruit-flys-gut/ #science #biology #FlatironCCB

A comprehensive set of simulations by @flatironinstitute.org astrophysicists, including this 3D rendering, solved a black hole merger mystery: https://www.simonsfoundation.org/2025/11/10/mysterious-impossible-merger-of-two-massive-black-holes-explained/ #science #astrophysics #FlatironCCA

We're recruiting summer interns at all levels (Bachelors, Masters, PhD) and across all groups at @flatironinstitute.org Center for Computational Biology. Come work with us in New York City! (Full-time paid, June 1-August 14 2026, applications close January 16 2026) apply.interfolio.com/177779

This #BlackHoleFriday, revisit a huge result from this summer: the largest merger of two black holes ever measured. Read more: https://www.simonsfoundation.org/2025/07/21/gravitational-waves-reveal-most-massive-black-hole-merger-ever-detected/ #science #astrophysics #FlatironCCA

A mysterious "impossible" merger of two massive black holes has now been explained: https://www.simonsfoundation.org/2025/11/10/mysterious-impossible-merger-of-two-massive-black-holes-explained/ #FlatironCCA #science #astrophysics

#FlatironCCB researchers and collaborators demonstrated how mechanical forces from surrounding tissues can shape the fruit fly gut: https://www.simonsfoundation.org/2025/11/17/from-ring-to-keyhole-modeling-how-tissues-mold-the-fruit-flys-gut/ #science #biology

Inviting apps for a workshop to develop a project focused on a mechanistic understanding of canonical cortical computations at the circuit level. Deadline is 1/5/2026: https://www.simonsfoundation.org/simons-foundation-now-accepting-applications-for-workshop-on-canonical-cortical-computations

It was a joy to co-organize this meeting. The work presented and discussed at the meeting was exceptional. The experimental methods for quantifying key aspects of germ cell development are getting better — and the time is ripe for proposing and testing mathematical modeling of these processes!

#FlatironCCB's recent ScoRe meeting highlighted quantitative experimental work and mathematical models for germ cell development and for early developmental stages post-fertilization. Thanks to all who joined us! #science #biology

The mysterious origins of two supermassive, fast-spinning black holes have finally been explained thanks to complex computer simulations from @flatironinstitute.org: https://www.simonsfoundation.org/mysterious-impossible-merger-of-two-massive-black-holes-explained/ #science #astrophysics

#FlatironCCN neuroscientist @sueyeonchung.bsky.social was selected by @thetransmitter.bsky.social#FlatironCCNas one of its 2025 Rising Stars in Neuroscience: https://www.simonsfoundation.org/2025/11/15/ccn-sueyeon-chung-named-a-rising-star-in-neuroscience/ Congrats, SueYeon! #science #neuroscience

Our everyday decisions are guided by “priors” — expectations built on past experiences that help us make predictions. New research on priors is providing insight into autism: https://www.simonsfoundation.org/mapping-mouse-brains-points-to-how-autism-can-affect-expectation-updating/ #science

We have five more talks tomorrow (11/19) at #SC25! Stop by booth #105 to hear from our researchers.

The Flatiron Institute will be hosting a number of talks at our #SC25 booth this week. Stop by booth #105 to learn more about what some of our researchers are working on! #science

Having a great time at the @flatironinstitute.org CCN software workshop in San Diego! Do check out their fantastic Python packages Pynapple @pynapple.bsky.social (for general neurophys analysis) and NeMoS (for GLM) github.com/flatironinstitute/nemos - they are an absolute pleasure to work with 🤩

Checkout our cryo-EM simulator in JAX: paving the way for cryo-EM probabilistic modelling & statistical structural biology #cryoEM with @m0bri3n.bsky.social @miroastore.bsky.social + Harvard, Flatiron & Cornell!

What does the moon reveal about us and the universe? Join us on 12/5 for a free Presents event “Reflections on the Moon” with cosmologist Adrian Bayer, sociologist Tracy Scott, and NASA's Denise Hill. Register here: https://www.simonsfoundation.org/event/reflections-on-the-moon/ #science

The Flatiron Institute is heading to #SC25 next week! Visit us at booth #105 to learn more about our job opportunities, summer internship program and scientific research. #science #math