Community Announcement: Position postings-Postdoctoral Fellow at Antonina Roll-Mecak Laboratory Please send your CV, a one-page research experience summary & contact information of three references to [email protected], and specify “Tubulin code structural cell biology” in the subject header.

Technical Notes: May's software push includes updates to AlphaFold3, autoPROC, BoltzGen, Buster, CCP4, ChemEx, COOT, cryoCAT , DIALS, Maxit, MotionCor3, OpenFreeEnergy, OpenMM, PowerFit, pytom-match-pick, TOMOMAN, Topaz, Volume_Seg_Tool, and Warp. More here: buff.ly/xcoDMki #SBGrid #Software

New Member Alert: @stephanieaw.bsky.social in her new lab at @asterainstitute.bsky.social joined SBGrid in May. Welcome!!

Uncovering a Lung-to-Brain Pathway for Nicotine-Induced Neural Stress: A highlight featuring a paper that appeared in Science Advances from SBGrid member Huanhuan Joyce Chen and colleagues at The University of Chicago. Read more here: buff.ly/ieYMfAd #SBGrid #Pulmonology

Not Too Cold, Just Right!: Highlight features a @natcomms.nature.com paper from the lab of Crina Nimigean at @weillcornell.bsky.social by Fisk University student Cariuna Ellison. Read more here: buff.ly/x4JTRLo #SBGrid #Thermosensitivity

In case you missed Jarrett Johnson's presentation on visualization and CryoEM in PyMOL in May, you can watch the recording on the SBGrid YouTube Channel. More here: buff.ly/OALcuXW #SBGrid #Webinars #ScienceMatters

New Title Alert: CryoBoltz- is a method for fitting atomic structures into cryo-EM density maps of dynamic proteins. It is built on top of Boltz-1, a state-of-the-art structure prediction model for biomolecular complexes. Learn more here: buff.ly/WqasX0M #SBGrid #Software #CryoEM

SBGrid's eLife paper received a citation in April from Dirk Slotboom from @rug.nl in @natcomms.nature.com : Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA & ABC transporters. Read more here: buff.ly/ErsJeXB #SBGrid #ScienceMatters

SBGrid's eLife paper received a citation in April from Antonina Roll-Mecak from the The National Institutes of Health in @jcb.org: Insights into retinal disease and non-tubulin glutamylation from a RPGR–TTLL5 complex structure. Read more here: buff.ly/FX9pvRT #SBGrid #ScienceMatters

New Member Alert: In April, Eric Sundberg from @emorybiochemistry.bsky.social joined SBGrid. Welcome!!

New Member Alert: Oluwatoyin Asojo from the @dartmouthartsci.bsky.social Geisel School of Medicine joined SBGrid in April. Welcome!!

SBGrid's eLife paper received a citation in April from Antonina Roll-Mecak from the The National Institutes of Health in @natsmb.nature.com: Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state. Read more here: buff.ly/NqQps9H #SBGrid #Stayconnected

New Member Alert: Harvard Center for Biological Imaging led by Doug Richardson at @harvard.edu joined SBGrid in April. Welcome!!

New Title Alert: AlphaJudge- is a Python pipeline for evaluating AlphaFold2 and AlphaFold3 protein complex predictions by combining model confidence metrics. Learn more here: buff.ly/PzX5b20 #SBGrid #Software #Proteins

Technical Notes: April's software push includes updates to twelve titles -AlphaPulldown, Avogadro, BioEmu, ChemEx, ColabFold, CryoAtom, Foldtree, OpenFold3, PyMOL, Relion, Scipion, and TomoNet. More here: buff.ly/ZwMJXDL #SBGrid #Software #StructuralBiology

Member News: Congratulations to Stephen Blacklow, Chair and Gustavus Adolphus Pfeiffer Professor of BCMP, and Johannes Walter, Edward S. Wood Professor of BCMP at Harvard Medical School on their election to the National Academy of Sciences! More here: buff.ly/zjQ3BY1 #SienceMatters

New Member Alert: In April, Kaavya Krishna Kumar from @weillcornell.bsky.social joined SBGrid. Welcome!

Community News: Upcoming event from our partners at [email protected] Instruct-ERIC Webinar Series: Structure Meets Function 47 Tuesday, May 19, 2026 Register here: buff.ly/Ek1eGqz #SBGrid #StructuralBiology

New Title Alert: af_analysis- is a Python package for analysis of AlphaFold protein structure predictions from AlphaFold 2/3, ColabFold, AlphaFold-Multimer, AlphaPulldown, Boltz1, Chai-1, and MassiveFold. Learn more here: buff.ly/BeBrAei #SBGrid #Software #Analysis

Join our software webinar on May 12th to hear from Jarrett Johnson, Senior Developer from Schrödinger, on Upcoming improvements to visualization and CryoEM support in PyMOL. Tuesday, May 12, 2026 - 12:00pm ET Register here: buff.ly/shCJxog #SBGrid #Webinars #StructuralBiology

Community News: Calorimetric & Spectroscopic Characterization of Biomolecules September 7-11, 2026 | CEITEC Brno, Czech Republic Organized in collaboration w/ the Biomolecular Interactions & Crystallography Core Facility at The Central European Institute of Technology Register here:

How proteins work together to support our vision: A paper in the @jcb.org from SBGrid member Antonina Roll-Mecak and colleagues highlighted by Meharry Medical College student Mudiare Ikoba. Read more here: buff.ly/BNi0oKH #SBGrid #Cytoskeleton #Retina

New Title Alert: AF3Complex- is a model equipped with the same improvements as AF2Complex, along with a novel method for excluding ligands, built on AlphaFold 3. Learn more here: buff.ly/GPEgFSF #SBGrid #Software #Predictions

Molecular Proofreading: Mechanisms of Enzyme Binding: An @elife.bsky.social paper from Jochen Zimmer's group at University of Virginia School of Medicine highlighted by Fisk University student Cariuna Ellison's. Read more here: buff.ly/J6kM0T6 #SBGrid #CryoEM #Binding

If you missed our March webinar with José Luis Vilas Prieto on Image processing made simple with ScipionTomo, you can catch up with the recorded version on YouTube. More here: buff.ly/6gp3mhJ #SBGrid #Webinars #ScienceMatters

New Title Alert: PXDesignBench- is a protein design evaluation suite for monomer & binder tasks that standardizes sequence generation, structure consistency assessment, & downstream metrics across tools including ProteinMPNN, ESMFold, AlphaFold2, & Protenix. Learn more here: buff.ly/CYTeClg #SBGrid

New Title Alert: MassiveFold- a tool designed to expand structure prediction sampling by optimizing the parallelization of AlphaFold-based predictions across GPU clusters. Learn more here: buff.ly/oqqmX0g #SBGridSoftware #SBGrid

New Title Alert: Protein-quest- is a Python package to search/retrieve/filter proteins and protein structures. Learn more here: buff.ly/VhUKHAM #SBGridSoftware #SBGrid

New Member Alert: Ryan Nett and @nbellono.bsky.social from Harvard University @harvardmcb.bsky.social joined SBGrid in March. Welcome!!

New Member Alert: Isaac Fianu from California Institute of Technology joined SBGrid in March. Welcome!!

New Title Alert: MolDiff- is a diffusion framework designed for generating 3D drug-like molecules, achieving a sampling success rate of over 99%. Learn more here: buff.ly/6Lr5iAH #SBGridSoftware #SBGrid

SBGrid member Stuart Orkin, the @harvardmed.bsky.social David G. Nathan Distinguished Professor of Pediatrics at @danafarber.bsky.social and @bostonchildrens.bsky.social, has been awarded the 2026 Breakthrough Prize in Life Sciences. Read more here: buff.ly/WaioMyc) #SBGrid #StayConnected

New Member Alert: Rebeccah Warmack from @yale.edu joined SBGrid in March. Welcome!!

New Title Alert: MolSnapper- is a tool for conditioning diffusion models to generate 3D drug-like molecules, built on the MolDiff codebase. Learn more here: buff.ly/AeO29wf #SBGridSoftware #SBGrid

New Member Alert: Eddy Arnold from @rutgersu.bsky.social joined SBGrid in March. Welcome!!

New Title Alert: MiCSPARC- is a CryoSPARC-based cryo-EM pipeline for microtubule image processing that combines automated filament tracing, particle picking, fast 3D refinement, protofilament-number assignment, alignment, register correction, & seam search. Learn more here: buff.ly/f1Jmkqe #SBGrid

SBGrid's eLife paper received a citation in March from Dhirendra Simanshu and Anna Maciag from the Frederick National Laboratory for Cancer Research in Cancer Discovery. Read more here: buff.ly/KCMi9Gc #SBGrid #ScienceMatters #StayConnected

New Title Alert: Napari-SegSelect- is a plugin for Napari to select a connected component from a Membrain-seg segmentation. Learn more here: buff.ly/q1RPNud #SBGrid #SBGridSoftware

New Member Alert: In March Mamuka Kvaratskhelia from @cuanschutz.bsky.social joined SBGrid. Welcome!!

Join our software webinar on April 14th to hear from José Luis Vilas Prieto on Image processing made simple with scipionTomo. Tues, April 14, 2026-12:00pm ET Jose Luis Vilas, Ph.D. Investigator, National Biotechnology Center, CSIC Register here: buff.ly/WBjGXUF #SBGrid #Webinars #StructuralBio

New Title Alert: MemBrain-v2- is a tool that includes MemBrain-seg, MemBrain-pick, MemBrain-stats, and several Napari tools. Learn more here: buff.ly/U3s12Ic #SBGrid #SBGridSoftware

SBGrid updated the wiki to include guidance for new & existing users. Our revised installation instructions provide clearer instructions for setting up SBGrid buff.ly/5QhSXOR Expanded Using SBGrid documentation provides more detailed guidance on working w/in the SBGrid environment: buff.ly/rs7dV0l

New Title Alert: AFmassive- is a modified AlphaFold implementation for massive conformational sampling, derived from AlphaFold v2.3.2 and designed to integrate with MassiveFold for parallelized prediction workflows. Learn more here: buff.ly/jPxTEV0 #SBGrid #SBGridSoftware

SBGrid's eLife paper received a citation in March from K. Christopher Garcia from @stanford.edu School of Medicine in @science.org: Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering. Read more here: buff.ly/WnBw3wr #SBGrid #StayConnected #ScienceMatters

Technical Notes: March's software push includes updates to AlphaPulldown, AreTomo, Coot, CCP4, CryoLithe, DIALS, Doppio, Java, MPicker, OpenFreeEenergy, Open Force Field, qfit, SAMtools, Schrodinger, Scipion, and Xmipp. More here: buff.ly/WXLwT6q #SBGrid #Software #StructuralBiology

New Title Alert: PXDesign- is a de novo protein-binder design suite combining a diffusion generator (PXDesign-d) with Protenix and AF2-IG confidence models for candidate selection and ranking. Learn more here: buff.ly/s455Ck8 #SBGrid #SBGridSoftware

Our member tale for March features @palencialab.bsky.social from @inserm.fr in Grenoble, France where his group is harnessing the matchmaking qualities of the LeuRS enzyme in efforts to advance a new class of drugs to tackle drug-resistant bacteria & parasites. Read more here:

SBGrid's eLife paper received a citation in February from @cryoet.bsky.social from @jhu.edu School of Medicine and Dylan Hale (now at University of Pittsburgh) in @natcomms.nature.com. Read more here: buff.ly/kx5Fiaw #SBGrid #Stayconnected

SBGrid's eLife paper received a citation in February from Philip Kranzusch from @danafarber.bsky.social in @Nature: Nucleotide signals coordinate activation and inhibition of bacterial immunity. Read more here: buff.ly/CFikpvv #SBGrid #StayConnected

SBGrid's eLife paper received a citation in February from Anthony Kossiakoff from The University of Chicago in @pnas.org : Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating. Read more here: buff.ly/3Oawrum #SBGrid #ScienceMatters