Calcium and magnesium in the pore of NMDA receptors! Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O. Very stimulating work! Congrats @lab-furukawa.bsky.social #iglurs

Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756

My OpEd piece in US News & World Report, about not wanting my life to be book-ended by two fascist regimes and about the state of higher education in this country, www.usnews.com/opinion/arti... has now been republished in German translation by JOSHA: josha-journal.org/en/categorie...

Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!

Great Job - Great Colleagues - Great Science👍 Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows Relocation to DC is required, perfect for academic PIs looking for their next chapter hhmi.wd1.myworkdayjobs.com/External/job...

#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪

Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

🚨🧠🔬 A major breakthrough in molecular neuroscience: I am excited to share a new story from our lab, published in accelerated format today by @nature.com: "Delta-type glutamate receptors are ligand-gated ion channels" Read more here (free article link): rdcu.be/eGIKz

Post an image from your summer that confers peace. (from the Telluride ion channels workshop)

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

This is not who we are. We must join together to call this out, to make more people understand what is happening and work to stop it.

Happy to share the my lab's latest preprint, where we investigated sensorimotor circuit formation in the developing spinal cord. We show that proprioceptive axons target motor neurons in neighboring spinal segments to give rise to intersegmental reflex responses. www.biorxiv.org/content/10.1...

Kainate receptor modulation by Neto including an open state. Surprising, to me: I would never have imagined that Neto works like a membrane-tethered lectin (ConA). Auxiliary proteins influence dimer-dimer interactions, as we and others also showed in AMPARs. #iGluRs www.nature.com/articles/s41...

New Story in The Atlantic about NIH www.theatlantic.com/health/archi... 1/3

Congratulations 2025 Gilliam Fellows and Advisors! 🎉 The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments. Through this program, HHMI supports both graduate students and their faculty thesis advisors.

No matter where you went to school, the Trump admin has targeted YOUR college/university for cuts and obedience. If you've got your alumni association's contact info, let them know where you want your alma mater to stand. www.americanprogress.org/article/mapp...

Checkout this preprint - they find that fever induces long-term synaptic enhancement through AMPARs. www.biorxiv.org/content/10.1... Quite interesting to consider along with our finding that temperature enhances AMPAR activation: www.nature.com/articles/s41...

Link here! guide.cryosparc.com/processing-d...

Your participation in the election of the Society's leaders is vital to our future. Exercise your right as a Society member to vote by casting your ballot by August 1 for president-elect and council

Come work at Nature Methods! A dream job. I know from experience 😄

The DEI research cuts we are facing in the US are far-reaching. Proud of a PhD student in my lab, Lucas Dillard, for sharing his story with @nytimes.com (gift link): www.nytimes.com/2025/07/10/u...

Here is our foray into the biophysics of cation permeation in AMPA receptors, now available as a preprint on @biorxivpreprint.bsky.social: www.biorxiv.org/content/10.1... Led by former student Dr. Alejandra Montaño Romero, in collaboration with Albert Lau!

Wow, just wow! www.nature.com/articles/s41... I was working on that at the MRC-LMB from 2017-2019...

Wow, Raimund does it again. What a super paper. Tweety grabbing the APOE frisbee! #membranes #biophysics

Attending the NYC #CryoEM meeting today - looking forward to a fantastic day of science! Thanks @fravallese.bsky.social & Bill Rice for organizing a great meeting, and looking forward to a keynote from Ed Twomey @cryoet.bsky.social this arvo! 🗽❄️🔬

Check out our latest preprint with the Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: www.biorxiv.org/content/10.1...

NYT story about Judge Young’s ruling

Interesting results. Perampanel (AMPA blocker approved for epilepsy) has a big effect on T-cell mobilisation. Perhaps an off-target effect? Maybe I missed a KO control using the floxed GluA123 mouse. But useful either way, given that Pmp is quite mild. #iGluRs www.science.org/doi/epdf/10....

Here's our new preprint led by @wdhale.bsky.social with @rhuganir.bsky.social: "Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor" www.biorxiv.org/content/10.1... #iGluRs #cryoEM Some key points below that Dylan discovered:

As the United States cuts budgets and restricts immigration, China and Europe are offering researchers money and stability. Article Link: www.nytimes.com/2025/06/03/u...

The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology. Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at [email protected]. Fee waivers and bursaries available. ! Please share widely !

Political appointees controlling what constitutes truth or fact in science? Not a great idea. Why not, you ask? Give the HBO show Chernobyl from a few years ago a watch: www.imdb.com/title/tt7366...

Kilmar Abrego Garcia was illegally abducted and is being held in a notorious prison in El Salvador — barred from contacting his family or lawyers. I’m speaking to the press now after we were denied access to the prison to check on his condition. Tune in:

Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.

There we go. Support this man.

Where is Abrego Garcia? @alsobrooks.senate.gov @vanhollen.senate.gov need to rally Congress together ASAP for justice and rule of law. And in this video is clear evidence of intent to expand this disgusting practice.

I hope other universities follow suit...

So proud of friend & colleague @britshmit.bsky.social for standing up for science. Thank you for all you’re doing to safeguard America’s biomedical research!

Hopkins researchers use cryoEM microscopy to advance understanding of glutamate AMPA receptor action. Article link: www.oneneurojhu.org/2025/04/02/b...

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature #ionchannels www.nature.com/articles/s41...

People/organizations with means and a vision for the future of biomedical science - we need an “Arc Institute” equivalent in the DMV area to sponge up all the incredible talent, opportunity of a lifetime for a visionary entrepreneur, I will help! @mcuban.bsky.social

As someone who grew up in NJ, and an American, I am so proud of @corybooker.com for making a stand. I would love to see my current representation in the Senate @vanhollen.senate.gov @alsobrooks.senate.gov do the same.

Structural Insights into Kainate Receptor Desensitization https://www.biorxiv.org/content/10.1101/2025.03.27.645769v1

Multiple tenure track positions at @uofguelph.bsky.social! A fantastic 🇨🇦 University with a long history of excellence in biological research. + in Guelph, Ontario (a progressive town of 150k people only 1 hour from Toronto). I have very fond memories of doing my undergrad there just a few years ago

Writing an op-ed is not illegal activity. They are revoking visas for thought crimes and for constitutionally protected expression.