We present NOAH-ARK: combining de novo marker design ARK1 with in silico linker optimization program NOAH enables semi-automated, high-resolution GPCR structures—clear enough to resolve ligands, waters, and ions. (2/2)

We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join and pursue unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-spr...

Where does anti-NMDAR autoimmune encephalitis come from? Our new work suggests that ectopic NMDAR expression in tumors can trigger anti-cancer immunity, and the resulting antibodies may drive encephalitis-like symptoms. A dynamic Janowitz-Furukawa lab collaboration. www.nature.com/articles/s41...

At the #cshlcourses cryo-EM course, Rich Waldo from @structurabio.bsky.social gave us a tutorial on cryoSPARC and did a fabulous job! I was honored to be used for an Einstein from noise demo.

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

Good opportunity for a grad student looking to get some industry experience before they graduate: www.linkedin.com/jobs/view/43... Get involved with protein expression, purification, biochemical and biophysical assays, and get familiar with the process of drug discovery!

The HF Lab postdocs, Hyunook Kang and Ruben Steigerwald, are presenting their posters today at #BPS 1:45 pm~2:45 pm. LB35 (Hyunook) and LB37 (Ruben) Please drop by!!

Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026. 1/3

MYRF-1/LIN-42 timing complex controls temporal patterning! www.biorxiv.org/content/10.6...

Our paper on conductance control and neurosteroid binding in NMDAR has been officially published. I have attached a movie that describes a sub-open and a full-open channel. Also, neurosteroid binding patterns are surprisingly quite diverse www.nature.com/articles/s41...

Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...

www.nature.com/articles/s41... The first paper from the lab led by the HF lab alumna Johanna Syrjanen. www.syrjanenlab.com A big congratulations!

Calcium and magnesium in the pore of NMDA receptors! Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O. Very stimulating work! Congrats @lab-furukawa.bsky.social #iglurs

Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6

A new study from the Furukawa lab (@lab-furukawa.bsky.social) identifies the neurological ‘doorstops’ that keep the brain’s NMDA receptors fully or partially open. The findings could have implications for treating neurodegenerative conditions like #Alzheimers disease. www.cshl.edu/a-doorstop-f...

How are NMDA receptor channel conductance states regulated? We uncover a mechanism for tuning ion flow and reveal striking diversity in neurosteroid binding. Our structures captured two distinct open-channel states. A fantastic collaboration with the Traynelis lab. www.nature.com/articles/s41...

The Rutgers Brain Health Institute @rutgersbhi.bsky.social is looking for an accomplished scientist to serve as the Director of the new Rutgers Center on Research in Pain and Pain Therapeutics. Feel free re-post and/or reach out to me if you have any questions jobs.rutgers.edu/postings/225...

We have postdoctoral positions available for patch-clampers and structural biologists #cryo-EM #electrophysiology #cancer-neuroimmunology #neuropharmacology jobrxiv.org/job/cold-spr...

academic.oup.com/brain/advanc... with Hongjie Yuan and Steve Traynelis. We went back to x-ray crystallography to capture radiprodil, a classic psychiatric compound.

Our paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching! Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv! www.biorxiv.org/content/10.1...

After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN: www.biorxiv.org/content/10.1...

🚨🧠🔬 A major breakthrough in molecular neuroscience: I am excited to share a new story from our lab, published in accelerated format today by @nature.com: "Delta-type glutamate receptors are ligand-gated ion channels" Read more here (free article link): rdcu.be/eGIKz

We have two postdoctoral fellow positions—one for a structural biologist and another for an electrophysiologist. We have new, exciting projects related to neurobiology, neuro-cancer-immunology, and neuropharmacology. #electrophysiology #cryo-EM #neuro-xyz

Kainate receptor modulation by Neto including an open state. Surprising, to me: I would never have imagined that Neto works like a membrane-tethered lectin (ConA). Auxiliary proteins influence dimer-dimer interactions, as we and others also showed in AMPARs. #iGluRs www.nature.com/articles/s41...

jobrxiv.org/job/cold-spr... We have a postdoctoral fellow position available. Please visit our lab website (furukawalab.labsites.cshl.edu), learn about us, and apply if you're interested in our science!

Have a read of our new article now out in Neuron! www.sciencedirect.com/science/arti... We used Cryo EM, electrophysiology and MD simulations to determine the structure of S-(+)-Ketamine at its most pharmacologically important NMDA receptor subtype, and show the basis for DQP subtype selectivity!

www.sciencedirect.com/science/arti... We are delighted to share our latest publication, where we present the first open-channel structure of tri-heteromeric NMDA receptors and uncover a new allosteric inhibition mechanism. This study focuses on a tri-heteromeric NMDAR composed of GluN1, 2B, and 2D

www.science.org/doi/10.1126/... A nice summary of our work by prominent figures in the field.

www.nature.com/articles/s41... A fantastic "News and Views" piece by Laurent Groc et al., highlighting recent papers from our lab and the Zhu lab

www.nature.com/articles/s41... Our study on the structural and functional characterization of anti-NMDAR autoimmune encephalitis is officially published. Key findings include: (1) Autoantibodies from three distinct patients exhibited unique binding patterns, with two binding sites per tetramer. 1/n)

jobrxiv.org/job/cold-spr.... The HF_Lab has a postdoc position to study the structural and functional aspects of signaling complexes involved in neuroplasticity, cancer immunology, and autoimmunity. Candidates with experience in cryo-EM and/or electrophysiology are highly encouraged to apply.