-80 freezer at -20

The latest version of our collaboration with Katalin Torok and her lab is up. We report some new glutamate sensors. Great work from Sara Bertelli in Berlin and the whole team in London (Holly & Oanh particularly).

www.biorxiv.org/content/10.1...

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2026 SIBPA|IVSLA Intl School of biophysics, Venice 2-6 February 2026. venice.ibf.cnr.it This should be an interesting school for students to attend.

Also, an admirably succinct piece.

Sharing a recent, deep insight: The concept of a membrane-less organelle is an interesting one, like calling something a house without walls

Nothing new but Handbrake is still amazing. Defaults take a 100 Mb screen recording and spit out an indistinguishable 10 Mb .mp4 handbrake.fr #OpenSource

Meanwhile, in the UK, WHERE WE INVENTED RAILWAYS EXACTLY 200 YEARS AGO, 40% are electrified.

Nobel Prize in Physiology or Medicine 2025 awarded for discoveries that explain how the immune system attacks hostile infections, but not the body's own cells. The prize is shared by Japan's Shimon Sakaguchi & US researchers Mary Brunkow & Fred Ramsdell. 🧪 www.bbc.co.uk/news/article...

The Protein Society has regular free webinars and this Wednesday's will be really cool. I mean hot. Juan Du, @sobolevsky.bsky.social and David Julius. #Ionchannels #structuralBiology TRP channels at different temperatures www.proteinsociety.org/webinars

With instant SIM technology, the VT-iSIM delivers super-resolution images in real time, with no reconstruction or post-processing required. You get spatial resolution down to 100 nm, reduced photo-bleaching, and across a wide field of view. Faster. Clearer. Smarter imaging.

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager! I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...

🚂 Barely launched and already cancelled ? Let's save the night trains from Paris to Berlin and Vienna! My family and I took this environmentally-friendly train in the summer and it's an excellent service. How about a coherent pro-climate policy? Sign the petition! agir.greenvoice.fr/petitions/sa...

Yes, yes, Europe has its benefits. Walkable cities. Cultural heritage. Amazing food. Little gun violence. Healthcare. Governments that are not shut down. But the number of website pop-ups asking one to accept cookies renders the continent pretty much unlivable.

It’s getting cold in here. So put on all your clothes. I am getting so cold, I’m gonna put my clothes on.

Sam has now started her new group at the Helmholtz Center for Infection Research Diseases. Congratulations! I wish her the very best for her independent career. The time Sam spent with us was hugely successful in many respects and we will all be sad to see her go..

Group Leader in Biomedical Engineering at the @mdc-berlin.bsky.social in Berlin. It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend application.mdc-berlin.de/site/index.p...

Helge @ewerslab.bsky.social knows not only how to organize conferences (#BiomembraneDays25) but also how septins organize. Exceptional imaging #ExpansionMicroscopy of cytokinesis

We just finished watching the two series of Wolf Hall. One of the best things I've ever seen on TV. Mark Rylance's performance is out of this world. In France and in Germany, it's currently on ARTE www.arte.tv/en/videos/RC...

I’ve been listening to a lot of 80s music recently, stuff that was popular when I was in high school. There really were some absolutely banging tunes. Exhibit A, “I can’t wait” by Nu Shooz. The bonkers baseline! The synthetic cowbells! The chirpy fake brass! Perfection. youtu.be/UJ1tBVtYOBc?...

Our 6-hands review/perspective: "Hacking 3D printers as laboratory robots" is now on ChemRxiv. In there, we show how many robots you can make by simply modifying a 3D printer. #chemsky 1/n with @sandersays.bsky.social and @supersciencegrl.co.uk chemrxiv.org/engage/chemr...

I love this sort of thing! Use cheap, generic hardware to do complicated lab stuff!

Walking to the station in Dresden. Some architecture from across the eras.

Puzzling temperature-responsive membrane rods in cells now presented by Oliver Rocks with work by @pm-mueller.bsky.social at the #BiomembraneDays25

Are you sure?

The Eternal Bottom Line "You have to put good data in to get good information out." - Cori Bargmann seek.rockefeller.edu/biomedical-s...

Hotel carpet, yes carpet, is a trip.

Link for today's #GEF25 stream: www.youtube.com/watch?v=eG32...

Passionate about #SystemsBiology and ready to lead your own research group? Join us at the forefront of discovery — apply now to be a #GroupLeader at the NOVA Institute for Medical Systems Biology, in beautiful Lisbon, PT! Appl. by Oct 8: www.nature.com/naturecareer... #ScienceJobs #JobOffer

It’s your turn, Guru. www.youtube.com/watch?v=Y91X...

🎉 Finally: tomorrow Sept 29 we open BIOMEMBRANE DAYS 2025 in Berlin: 3 days packed with exciting science on membranes! Looking forward to an amazing program of invited & contributed talks, posters & lively discussions. 📍 events.mpikg.mpg.de/event/15/ @ewerslab.bsky.social @mpici.bsky.social

When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!

Lovely afternoon in Berlin to run a half-marathon - for the first time.

As others have already said, this essay by James Marriott is well worth taking the time to read. Now, back to my book if I can just prise my iPhone out of my hand for a few minutes… open.substack.com/pub/jmarriot...

Science is self correcting. Finally!

Go Lauren! Fantastic stuff.

#iglurs more intermediates and another bona fide open state. Congrats to all.

Awesome breakthrough! #neuroscience #neurodegeneration www.science.org/content/arti...

Really interesting to see some basic science research coming out of Apple Inc. SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.184... tldr: Apple used flow matching models to more efficiently predict protein folding structures. More of this, please... from ALL big tech.

New cures feel sudden, but the seeds were planted decades ago by basic scientists. Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵

This is a clever use of machine learning and I hate that it is always referred to as AI these days. 🧪 phys.org/news/2025-09...

Squeezed light field microscopy (SLIM) combines concepts from tomography and compressed sensing with light field microscopy for volumetric imaging at kilohertz rates. www.nature.com/articles/s41...

There's a Money Mark (Beastie Boys' sound engineer) song about this! youtu.be/wHn2tfOS5Pk?...

Another beautiful sunset in the Oregon coast But days are getting shorter Winter is coming 😞

Was this not… what critical AI researchers have been saying this entire time?

I wish all microscopy systems where ran on osx. I know, I know. But listen: every month, on a random weekend, there is a windows update push and our highthroughput confocal pc restarts. Which suuuuuuuucks.

'China’s new-build solar additions in the last six months are more than the US has installed in total: China Flow > US stock. Germany was once the global champion of solar. China’s new additions in six months are two times Germany’s installed capacity.' adamtooze.substack.com/p/chartbook-...

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EpIC News!  The first in-person EpIC meeting: "Emerging Research on Ion Channels in Health and Disease." 19-20 February 2026 UC Davis I can't attend myself, but this meeting organized by some of my favourite #ionchannels scientists will be 🔥🔥🔥 #SGP sgp-epic-seminars.com/epic2026

But it might be something to do with our transfection protocol - we’ve been hesitant to put too much time into optimizing there since there are many degrees of freedom and we knew just using AAV would solve things

Thanks! I’m fortunate to work with people who will basically run through walls to get data Re AAV vs lipofection - best guess is that it’s to do with higher and more variable copy number from lipofection; seems like it’s easy to make cells unhappy when lipofecting certain opsins in