Jan Siemens
@jansiemens.bsky.social
đ€ 139
đ„ 84
đ 53
Heat, cold, brain - viva sensory science and the hypothalamus
https://siemenslab.de/
đŁ Postdoc position in Heidelberg (Neurobiology Ă Engineering): neuromodulation of thermoregulatory brain circuits to improve health. Deadline: March 31, 2026.
6 days ago
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Outside temperature affects our eating habits: when itâs warm, many of us eat less. How does the brain link thermal state to appetite â and prevent overheating? âïžđ§
8 days ago
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I just did an interview in the Sueddeutsche Zeitung about how we detect cold temperatures â the journalist, Felix HĂŒtten, did a nice job to make it accessible also for non-scientists.
www.sueddeutsche.de/gesundheit/m...
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Warum manche Menschen schneller frieren als andere - selbst die Wissenschaft tut sich schwer
Temperaturwahrnehmung ist einer der ursprĂŒnglichsten Sinne des Menschen. Warum ist das so? Fragen an den Pharmakologen Jan-Erik Siemens.
https://www.sueddeutsche.de/gesundheit/menschen-frieren-waermeempfinden-temperatur-antworten-wissenschaft-li.3344634
3 months ago
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Jan Siemens
Felix Viana
5 months ago
It was really one of the best conferences I have ever attended: great science in a friendly atmosphere and a gorgeous setting.
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It was great having you all there! Excellent discussions and fun! I hope all of you made it home safely.
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5 months ago
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What a great Titisee Conference! âWarm, cold, and lifeâ brought together brilliant minds exploring how temperature shapes the brain, physiology, and behaviour â from mice, wild animals to humans. Thanks to Boehringer Ingelheim Fonds for the support!
5 months ago
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How does temperature interact with the brain? This coming Wednesday Eve Marder, Laura Duvall and I will talk about thermally-induced neural activity, plasticity and the like.
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10 months ago
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How do mice decide which ambient temperature they prefer? Our new eLife paper by Muad (
@hummuscience.bsky.social
) explores how TRPV1 and TRPM2 channels shape temperature preference. A quick breakdown đ đ
pubmed.ncbi.nlm.nih.gov/40215103/
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Diverging roles of TRPV1 and TRPM2 in warm-temperature detection - PubMed
The perception of innocuous temperatures is crucial for thermoregulation. The TRP ion channels TRPV1 and TRPM2 have been implicated in warmth detection, yet their precise roles remain unclear. A key c...
https://pubmed.ncbi.nlm.nih.gov/40215103/
11 months ago
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reposted by
Jan Siemens
Meg Tirrell
11 months ago
Amid the Trump admin's dismantling of the US scientific ecosystem, Nobel Prize-winner
@ardemp.bskyverified.social
writes on
@cnn.com
: "Iâve already been approached with an offer to relocate my lab to China, complete with a promise of 20 years of stable research funding."
www.cnn.com/2025/04/09/h...
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Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches âwith deep sadness as the United Statesâ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
https://www.cnn.com/2025/04/09/health/nobel-laureate-research-funding-patapoutian/index.html
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This was a great meeting to mix and mingle with scientists of diverse fields broadly interested in how long-term environmental changes modulate neurobiology - thank you
@kavlifoundation.bsky.social
⏠and
@alleninstitute.bsky.social
!
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11 months ago
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Very interesting study by Lin Yuan & Co in the Julius lab, explaining how sensory neurons can adapt to exitotoxicity and calcium challenges e.g. by Trpv1 activation. Spoiler alert: the electron transport chain is involved - we enjoyed discussing it in Journal club.
www.biorxiv.org/content/10.1...
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Metabolic tuning facilitates nociceptor resilience to excitotoxicity
The capsaicin receptor, TRPV1, mediates the detection of harmful chemical and thermal stimuli. Overactivation of TRPV1 can lead to cellular damage or death through excitotoxicity, a phenomenon associa...
https://www.biorxiv.org/content/10.1101/2024.12.23.630176v1.full
12 months ago
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Jan Siemens
Stefan Niggemeier
about 1 year ago
Bodo Ramelow ĂŒbt sehr nachvollziehbare Kritik auch an der Rolle der Medien beim Wahlerfolg der AfD, weil alle ĂŒber kein anderes Thema als âkriminelle AuslĂ€nderâ mehr gesprochen haben.
www.deutschlandfunk.de/interview-mi...
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Interview mit Bodo Ramelow, Linke, Ex-MinisterprĂ€sident ThĂŒringen, zur Wahl
https://www.deutschlandfunk.de/interview-mit-bodo-ramelow-linke-ex-ministerpraesident-thueringen-zur-wahl-100.html
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reposted by
Jan Siemens
Kristin Knouse
about 1 year ago
Can we perform genome-wide screens in any cell type in the body?! Excited to share our roadmap for leveraging advances in sgRNA delivery, library design, and phenotypic selection to enable unprecedented genetic dissection of organismal physiology and disease.
www.cell.com/cell-genomic...
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A roadmap toward genome-wide CRISPR screening throughout the organism
Genome-wide CRISPR screening in the organism has tremendous potential to answer long-standing questions of physiology and disease; however, technical limitations have prevented its broad application. ...
https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00033-3
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On February 12, shortly before âHigh noonâ, scientists at German research campuses, including here in Heidelberg, will stand up for Democracy: âfacts, not fake news are needed for democracyâ. See
aufstehenfuerdemokratie.de/englisch/
â there is also find a Petition related to the cause. Get involved.
about 1 year ago
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Jan Siemens
Katharine Gammon
about 1 year ago
This is true. LA County has a population greater than that of 40 individual U.S. states.
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Just finished the book "Transformer" by Nick Lane, great inspiration to evolutionary biologists, bochemists and, yes, also neuroscientists - its all about transformation of organic molecules and energy flow and not (only) about genes. Highly recommended
nick-lane.net/books/transf...
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Transformer: The Deep Chemistry of Life and Death â Nick Lane
What brings the Earth to life, and our own lives to an end? Nick Lane turns the standard view upside down, focusing on Krebs cycle
https://nick-lane.net/books/transformer-the-deep-chemistry-of-life-and-death/
about 1 year ago
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A short, personal account how our recent heat acclimation study came to life -- paywall-free version can be found here
rdcu.be/d38Xr
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Heat acclimation induces hypothalamic temperature sensitivity that promotes heat tolerance
Nature Neuroscience - After long-term heat exposure, a discrete group of hypothalamic neurons in the anterior ventromedial preoptic area become hyperactive and acquire temperature sensitivity. This...
https://rdcu.be/d38Xr
about 1 year ago
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Interesting thoughts on the type of biological problems AI research can help with, the complexity of biology that requires human intellect (and cannot be replaced by AI -- at least not currently, but I think it never will...), and human language that connects it all.
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about 1 year ago
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Jan Siemens
Richard Sever
about 1 year ago
Many academics point to bioRxiv as âthe one thing improving science publishingâ. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
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Pain research: Exciting insight into "silent" (or "sleeping") pain-sensing neurons from the Lampert Lab!
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about 1 year ago
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Jan Siemens
The Transmitter
about 1 year ago
A strong, long-lasting sensory stimulusâbe it visual, auditory, olfactory or tactileâtriggers plasticity in the neurons that respond to it. But
@jansiemens.bsky.social
wondered: Does the same principle apply to prolonged heat? By
@callimcflurry.bsky.social
www.thetransmitter.org/thermoregula...
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To beat the heat, hypothalamus neurons in mice ramp up their firing
The uptick may help the rodents acclimate to temperature hikes and keep their cool.
https://www.thetransmitter.org/thermoregulation/to-beat-the-heat-hypothalamus-neurons-in-mice-ramp-up-their-firing/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20241211-hypothalamus-neurons-mice-ramp-up
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My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (
www.nature.com/articles/s41...
) Here is the gist đ§” (1/n):
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Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature Neuroscience
Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...
https://www.nature.com/articles/s41593-024-01830-0
about 1 year ago
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Jan Siemens
Andrew Plested
over 1 year ago
I applaud this initiative to try to break the fascination with journal name prestige. As long as I remember to do it, I put only the PMID for my papers in the slides for my talks. If
@ardemp.bsky.social
can do it, so can you!
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