Kare 11 local news just read, in full, this statement from Michael and Susan Pretti, the parents of Alex Pretti. "Please get the truth out about our son."

in case you're curious about how angry Minnesota is about ICE, it was -20 today

Join us for a Presidential Lecture on 1/28 with Eva Nogales: "Visualizing Structure, Dynamics and Interactions Using Cryo-EM." Register: https://www.simonsfoundation.org/event/visualizing-structure-dynamics-and-interactions-using-cryo-em/ #science #biology

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others! Apply!

Curious about cryo-electron tomography but not sure how it fits into your research? This ASCB webinar with Danielle Grotjahn, Ph.D., breaks down what cryo-ET can do, where it shines, and how it works alongside other imaging methods.

Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!

Interested in learning or strengthening skills in #CryoEM single particle analysis? Apply for the CSHL cryo-EM course happening in March! This is a super intense 2 week course covering theory up through data deposition. Apps due Jan 9! Info here: meetings.cshl.edu/courses.aspx...

Yet again it pays to speak up & fight back! NIH has agreed to “evaluate each application individually and in good faith” for plaintiffs whose applications were unlawfully held in fiscal year 2025. In return, the plaintiffs dropped the lawsuit. www.aclu.org/press-releas...

JCB’s Cover of the Year voting is open! I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬 #teamtomo @attychang.bsky.social

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

As 2026 chair of the Biophysical Society Cryo-EM subgroup, I am thrilled to announce that Dr. Melanie Ohi has been selected as the recipient of the June Almeida Award: an honor recognizing women scientists whose leadership, scholarship, and mentorship have profoundly shaped the field of cryo-EM.

I'm giving a talk at One World Cryo EM (cryoem.world) tomorrow at 11:00am EST. Topic is 'Deconstructing Algorithms for “Discrete” Heterogeneity in Cryo-EM'. Sign up for their mailing list to tune in!

Out today, we can now multiplex receptor mapping at synapses thanks to a dimeric gold nanoparticle label optimized by Hoyoung that's distinguishable from monomers! Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...

🌟 WeINSPIREBio is hosting its first event! On Dec 4, we’re running a webinar: Structures of Success: Career Journeys of Women in Structural Biology If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼 lnkd.in/ewjD5WPt #cryoEM

So, if an institute or center decided not to fund any grant from University X or on Topic Y, then there would be no documentation in the official grant files about these applications. 2/2

Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁‍♀️💎✨VIP section💅🪩🥂 Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics. s/o to #teamtomo #cryoET co-authors @hamid13r.bsky.social @attychang.bsky.social @baradlab.com

Calcium and magnesium in the pore of NMDA receptors! Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O. Very stimulating work! Congrats @lab-furukawa.bsky.social #iglurs

Science, from Portland

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch

Nominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.

Events celebrating women in electron microscopy are rare, which made my recent experience at the Ernst Ruska-Centre (ER-C), Forschungszentrum Jülich, Germany, truly special. I had the privilege of not only attending but also serving as a young keynote speaker at this inspiring gathering. 🎉

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1...

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here: store.steampowered.com/app/4045010/... Give Muyuan feedback: steamcommunity.com/app/4045010 #ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

Frequent user of epitope tags? Try ours! IPI epitope tag antibodies & plasmids are now available through our partner @addgene.bsky.social! buff.ly/YEuZDIp

#Training 👨‍🏫 🧑‍🏫 #CryoEM ❄️ 🔬 #Science 🧬 🦠 #Education 📚 Huge shoutout to our SPoCs for making this a grand success! 👏 Marzia Miletto Marcelo Alexandre de Farias Omar Davulcu

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

Join us for the next CryoEM Current Practices Webinar on 9/25/2025 at 12 PM ET / 9 AM PT with Dr. Sarah Clark who will sharing her research on the "Architecture of a Bridge-like Lipid Transfer Protein." Register here: us02web.zoom.us/webinar/regi...

NEW: Hours before a new entry ban is supposed to go into effect, the federal government officially acknowledges for the first time that the restrictions do NOT apply to people who currently have H-1B visas. Link: www.uscis.gov/sites/defaul...

Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists: urldefense.com/v3/__https:/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social

Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket. www.pnas.org/doi/10.1073/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social

👏👏👏 👏👏

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW! facultycareers-ohsu.icims.com/jobs/35624/c...

PNCC Cryo-EM modeling and validation workshop on Sep 3-5, 2025. Register now! tinyurl.com/Cryo-EMModel...

🚨 #teamtomo!🚨 Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??

If you are at #MM2025 come by booth 1135 to learn more about the NIH sponsored transformative high resolution #cryoEM & #cryoET programs. We offer these technologies to the nation at no cost at the point of access. cryoemcenters.org cryoetportal.org

Wes Sundquist is one of the good guys. He is a scientists scientist and has carefully, passionately, and consistently carried his science out with this goal in mind. A cure for AIDS that is available to all. This is an amazing recognition for him and for the @utah.edu where he has done his work.

Less than 2 weeks to go! 🤯Mare sure you prepare your entries for our 2nd @arc_gov_au CCeMMP 'Bench to Art' Exhibition during National Science Week & win cash prizes 💰! Please like & share 👍 More info: ccemmp.org/events/arc-c... #CryoEM #CryoET #MembraneProtein #GPCR

The next #CryoEM Current Practices Webinar speaker will be Puja Majumder from MSKCC speaking on "From Micrographs to Maps: Structural Basis of a Filamentous CRISPR Effector Revealed by Cryo-EM" 7/31/2025 at 12 PM ET / 9AM PT Sign up today: us02web.zoom.us/webinar/regi...

Exciting news! The EPIC/SGP Symposium at UC Davis will be accompanied by a special issue in the Journal of General Physiology. Stay tuned for more details about this incredible event celebrating cutting-edge research on ion channels!

Big news indeed 👏 make sure you check out the post&link below 🤩 #cryoEM #cryoET #membraneproteins #GPCRs #scivis #scicomm

Apply here www.pairupscience.org/cryo-em-work...

I have lots of opinions—but for your sake, I’ve limited them to segmentation in cryo-ET for this article 😉 www.sciencedirect.com/science/arti... #teamtomo

Bipartisan letters from over 200 legislators urging "strong and sustained funding" for the NIH make me cautiously optimistic. www.aamc.org/advocacy-pol...

The next #CryoEM Current Practices Webinar speaker will be by Rebecca Page from University of Connecticut Health speaking on "Decoding mechanisms that control PPP specificity" 6/26/2025 at 12 PM ET / 9AM PT Registration is at no-cost, but sign-up is required: us02web.zoom.us/webinar/regi...

Looking for a deep dive into 2D classification in #cryoEM? These recent guide pages cover practical aspects & parameter choices when running these jobs in #CryoSPARC, along with the theory behind expectation maximization: guide.cryosparc.com/processing-d... and guide.cryosparc.com/expectation-...

Register Now for Tutorial: Introduction to Molecular Animation On June 24, learn how to use ChimeraX to create simple animations that can enrich your presentations, websites, and social media pdb101.rcsb.org/news...

What? Some good news on a Friday? Parent Fellowship Notices of Funding Opportunities are up! F30, F31, F32, F33 grants.nih.gov/grants/guide...

Now more than ever: DON'T TALK TO THE COPS. Listen to this outstanding lecture by a law prof at the extremely conservative Regent University. You need to understand WHY you should not talk to the cops. This will help.