Very excited about our new work highlighting the role of lipids in mediating multi-channel assemblies of Cx-46/50!

Dual-channel Cx46/50 gap junction assemblies in a shared lipid-nanodisc = lipid-mediated packing and a lipid site near the NT gating region that is absent from single channels. Plus a 1.8 Å open-state single-channel benchmark! #cryo-EM 🍩’s #NIH-funded-research www.biorxiv.org/content/10.6...

Long shot, but, with lots of labs turning from crystallography to cryo-EM I’m wondering if anyone knows of labs potentially looking to offload some of their old crystallography supplies to a PUI with potential screening hits and really eager students but nothing to harvest with, etc.?

Interested in microbiology, immunology, and host-pathogen interactions? Come work with us! Our department at OHSU is opening a search for a new tenure-track faculty position. See the job advertisement for details. Please share within your networks! www.nature.com/naturecareer...

This was fitting news to receive on May 1, international workers day. I will be returning to work on Monday after being kept on retaliatory administrative leave for 5 months and 3 weeks. I return along with the brave Katrina Declaration signers from FEMA, also reinstated this week. 🧵1/?

I love that portrait of you, Dr. Norton: weary but unyielding. You did not concede and your character speaks through your actions. We all know that you have acted at great cost. Thank you for your bravery and your dedication to our craft, and to the mission of the US National Institutes of Health.

The 2027 Biophysical Society #CryoEM Subgroup welcomes nominations for the June Almeida Award for Mid/Senior-Career Women in CryoEM. The nomination deadline is November 13, 2026, but feel free to submit nominations anytime. Eligibility & requirements found here: www.biophysics.org/Awards-Fundi...

My lab is recruiting for a highly independent and talented postdoctoral fellow to work on answering fundamental biological questions. Reach out if you have questions! careers.gene.com/us/en/job/20...

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

The next #CryoEM Current Practices Webinar speaker will be by Miao Zhang from University of Arizona speaking on "Structural basis for the pharmacological modulation of KCa2.2 channels" 4/30/2026 at 12 PM ET / 9AM PT Registration is at no-cost, but sign-up is required: us02web.zoom.us/webinar/regi...

Excited to see this work out as a preprint! Proud to be part of this incredible international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine. This journey started ~7 years ago, and it’s been amazing!

Great day at NYSBC, thanks for having me! 😊 If anyone wants to try out the tutorial, here it is: www.dropbox.com/scl/fi/054cm... There are linked videos for each step in the PDF, or I have also prepared the whole thing as a .PPT with embedded videos (2.7GB): www.dropbox.com/scl/fi/jnl9h...

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

🧪Help needed! I am currently gathering ideas for a new and updated Blender course tailored for chemists. Besides importing molecules into Blender, what topics or features would interest you the most? Any input is highly appreciated 😊

The next #CryoEM Current Practices Webinar speaker is Vladimir Kolyadko from Children’s Hospital of Philadelphia speaking on "Cryo-EM of Liposome-Assembled Macromolecular Complexes to Reveal Protein-Membrane Interactions in Hemostasis" 2/26/2026 at 12PM ET / 9AM PT us02web.zoom.us/webinar/regi...

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

Join us this summer for U-M's 2026 #CryoET Data Processing Workshop! This four-day workshop will introduce participants to standard image processing packages and all aspects of cryo-ET data processing. Apply by March 20: myumi.ch/lsi-cryo-workshop-2026 @jbquerido.bsky.social @shyamalm.bsky.social

Looking forward to #BPS2026 in San Francisco? Come by the NIH sponsored Transformative High-Resolution Cryo-Electron Microscopy National Centers for #CryoEM at booth 410. Our mission is to broaden access to high-resolution cryo-electron microscopy and tomography technologies - cryoemcenters.org

I've been working on Surface Morphometrics for a new version (coming soon), and made some significant (AI-assisted) performance improvements, especially in pycurv (20-50x!). If you've had technical issues or just felt like it was too slow, give it another try! #teamtomo github.com/GrotjahnLab/...

Are you a cell biologist who secretly thinks cellular cryo-electron tomography is just George Palade-era EM, but fancier? Join this webinar to see how modern #teamtomo has shifted from pretty pictures to quantitative, local membrane biology, and how that changes the questions we can ask.

this was published this week, in case you haven’t seen it: www.nature.com/articles/s41...

Kare 11 local news just read, in full, this statement from Michael and Susan Pretti, the parents of Alex Pretti. "Please get the truth out about our son."

in case you're curious about how angry Minnesota is about ICE, it was -20 today

Join us for a Presidential Lecture on 1/28 with Eva Nogales: "Visualizing Structure, Dynamics and Interactions Using Cryo-EM." Register: https://www.simonsfoundation.org/event/visualizing-structure-dynamics-and-interactions-using-cryo-em/ #science #biology

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others! Apply!

Curious about cryo-electron tomography but not sure how it fits into your research? This ASCB webinar with Danielle Grotjahn, Ph.D., breaks down what cryo-ET can do, where it shines, and how it works alongside other imaging methods.

Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!

Interested in learning or strengthening skills in #CryoEM single particle analysis? Apply for the CSHL cryo-EM course happening in March! This is a super intense 2 week course covering theory up through data deposition. Apps due Jan 9! Info here: meetings.cshl.edu/courses.aspx...

Yet again it pays to speak up & fight back! NIH has agreed to “evaluate each application individually and in good faith” for plaintiffs whose applications were unlawfully held in fiscal year 2025. In return, the plaintiffs dropped the lawsuit. www.aclu.org/press-releas...

JCB’s Cover of the Year voting is open! I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬 #teamtomo @attychang.bsky.social

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

As 2026 chair of the Biophysical Society Cryo-EM subgroup, I am thrilled to announce that Dr. Melanie Ohi has been selected as the recipient of the June Almeida Award: an honor recognizing women scientists whose leadership, scholarship, and mentorship have profoundly shaped the field of cryo-EM.

I'm giving a talk at One World Cryo EM (cryoem.world) tomorrow at 11:00am EST. Topic is 'Deconstructing Algorithms for “Discrete” Heterogeneity in Cryo-EM'. Sign up for their mailing list to tune in!

Out today, we can now multiplex receptor mapping at synapses thanks to a dimeric gold nanoparticle label optimized by Hoyoung that's distinguishable from monomers! Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...

🌟 WeINSPIREBio is hosting its first event! On Dec 4, we’re running a webinar: Structures of Success: Career Journeys of Women in Structural Biology If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼 lnkd.in/ewjD5WPt #cryoEM

So, if an institute or center decided not to fund any grant from University X or on Topic Y, then there would be no documentation in the official grant files about these applications. 2/2

Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁‍♀️💎✨VIP section💅🪩🥂 Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics. s/o to #teamtomo #cryoET co-authors @hamid13r.bsky.social @attychang.bsky.social @baradlab.com

Calcium and magnesium in the pore of NMDA receptors! Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O. Very stimulating work! Congrats @lab-furukawa.bsky.social #iglurs

Science, from Portland

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch

Nominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.

Events celebrating women in electron microscopy are rare, which made my recent experience at the Ernst Ruska-Centre (ER-C), Forschungszentrum Jülich, Germany, truly special. I had the privilege of not only attending but also serving as a young keynote speaker at this inspiring gathering. 🎉

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1...

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here: store.steampowered.com/app/4045010/... Give Muyuan feedback: steamcommunity.com/app/4045010 #ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

Frequent user of epitope tags? Try ours! IPI epitope tag antibodies & plasmids are now available through our partner @addgene.bsky.social! buff.ly/YEuZDIp

#Training 👨‍🏫 🧑‍🏫 #CryoEM ❄️ 🔬 #Science 🧬 🦠 #Education 📚 Huge shoutout to our SPoCs for making this a grand success! 👏 Marzia Miletto Marcelo Alexandre de Farias Omar Davulcu

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

Join us for the next CryoEM Current Practices Webinar on 9/25/2025 at 12 PM ET / 9 AM PT with Dr. Sarah Clark who will sharing her research on the "Architecture of a Bridge-like Lipid Transfer Protein." Register here: us02web.zoom.us/webinar/regi...

NEW: Hours before a new entry ban is supposed to go into effect, the federal government officially acknowledges for the first time that the restrictions do NOT apply to people who currently have H-1B visas. Link: www.uscis.gov/sites/defaul...