Connor Garrels
@garrels.bsky.social
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đź“Ą 60
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PhD Candidate - Reichow Lab at OHSU He/Him
pinned post!
Very excited about our new work highlighting the role of lipids in mediating multi-channel assemblies of Cx-46/50!
add a skeleton here at some point
3 days ago
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Very excited about our new work highlighting the role of lipids in mediating multi-channel assemblies of Cx-46/50!
add a skeleton here at some point
3 days ago
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13
5
reposted by
Connor Garrels
Reichow Lab
over 1 year ago
#NIHFundedDiscovery
How do cells avoid the "kiss of death"? Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.
#CryoEM
reveals the molecular switches behind this process!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
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reposted by
Connor Garrels
Reichow Lab
over 1 year ago
Super excited for this one! High-res
#cryo-EM
ensemble of sHSP/client complexes, uncovering 'Mechanism of small heat shock protein client sequestration and induced polydispersity'
www.biorxiv.org/content/10.1...
A teaser...👇
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reposted by
Connor Garrels
Reichow Lab
over 1 year ago
Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's:
www.nature.com/articles/s41...
A timely release of this story... as it is a great setup to the next one, coming soon!!
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Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM - Nature Communications
Here the authors show that mutating αB-crystallin’s NT-IXI motif transforms polydispersed oligomers into ordered fibrils, enabling cryo-EM to provide insights into the principles of high-order assembl...
https://www.nature.com/articles/s41467-024-54647-7?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20241128&utm_content=10.1038/s41467-024-54647-7
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Inaugural post sharing a newly updated version of our little protocol for high quality fiducial removal in
#CryoET
processing
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Tomogram Reconstruction and Gold Fiducial Removal with WarpTools, Etomo, and Fidder
While gold nanoparticle fiducials greatly improve tilt-series alignment in cryo-electron tomography data, they can cause artifacts during later image processing steps. We presen...
https://www.protocols.io/view/tomogram-reconstruction-and-gold-fiducial-removal-6qpvr8qbblmk/v3
over 1 year ago
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