A very nice write up about our recent work taking a peek at Cx46/50 channel-channel interactions! Thanks, @structurabio.bsky.social!

My personal summer of code continues with another ChimeraX plugin - this time, MorphometricsX! Load quantified meshes from morphometrics (or pycurv) in ChimeraX with color-by-quantification and display alongside tomos and particles. Coming to the toolshed soon! #teamtomo github.com/baradlab/mor...

Just in time for the weekend, the 2nd beta for our Surface Morphometrics 2.0 release: github.com/GrotjahnLab/.... Beyond the major API change from the first beta (which used for the michigan class!), this one includes a major overhaul of the dual gaussian fitting for thickness and refinement.

Very excited about our new work highlighting the role of lipids in mediating multi-channel assemblies of Cx-46/50!

#NIHFundedDiscovery How do cells avoid the "kiss of death"? Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage. #CryoEM reveals the molecular switches behind this process! www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Super excited for this one! High-res #cryo-EM ensemble of sHSP/client complexes, uncovering 'Mechanism of small heat shock protein client sequestration and induced polydispersity' www.biorxiv.org/content/10.1... A teaser...👇

Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41... A timely release of this story... as it is a great setup to the next one, coming soon!!

Inaugural post sharing a newly updated version of our little protocol for high quality fiducial removal in #CryoET processing