I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩

#AlphaFold is five years old — these charts show how it revolutionized science 40k citations Alphafold database has been used by more than 3.3 million people worldwide www.nature.com/articles/d41...

Happy to contribute to this work!

Looking back on an inspiring and stimulating two days at the Ultra-Highfield NMR and 4D Structural Biology Symposium. Huge thanks to all speakers, participants, and organizers for making this such an insightful and engaging event! 🧲🧬

Fantastic opportunity! Great project with a great PI. A no-miss opportunity

Misfolded proteins can cause #Alzheimers, #Parkinsons and #Cancer. Johannes Buchner, part of the CHAPEROME team, receives an #ERC Synergy Grant to study how chaperone #proteins keep cells healthy: go.tum.de/904052 👏 #ERCSyG #biotechnology @erc.europa.eu 📷A. Heddergott

We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se). Register to attend: tinyurl.com/PMCseminar2 Recordings of previous seminars: www.youtube.com/@PMCModularity

I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat

Get important feedback from your community and move your work forward. Share your research at #bps2026! Submit an abstract today buff.ly/oOjstk6

#HelmholtzMunich’s BNMRZ has joined Germany’s Instruct-ERIC Centre 🔬 Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities. 👉 Read more: t1p.de/pjtyv

Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲

Do you want to learn about all relevant aspects of biomolecular solid-state NMR, from theory to application? Join the 10th European Solid-State NMR Summer School❗️ 🗓️ October 20-24, 2025 | Garching, Germany 📌 Application Deadline: 01.09.2025 www.bio.nat.tum.de/ocb/upcoming... #NMRchat #BioNMR

BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲

And it's out! I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025). This paper describes a new mechanism for the initiation of autophagosome biogenesis. We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

Featuring: The 2026 Biophysical Society Lecture, Lewis E. Kay, University of Toronto, The Essentiality of Solution NMR Spectroscopy in the Post-AlphaFold Era, Monday, February 23, 8:00 PM, Moscone Center www.biophysics.org/2026meeting/... #NMRchat 🧲

We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR For more detailed information, please follow the link: www.bio.nat.tum.de/ocb/upcoming...

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

🚨 We're hiring! Join our excellent Electron Microscopy Facility at @istaresearch.bsky.social as an a Cryo-EM Specialist, providing support for groundbreaking research in a fantastic environment: ist.ac.at/en/job/?titl... #CryoEM #MicroscopyJobs #ScienceCareers

Two postdoctoral positions in the group of Dr. Malene R. Jensen at the Institute for Structural Biology in Grenoble, France, protein kinase (MAPK) cell signaling pathways (incl NMR, X-ray crystallography and cryo-electron microscopy) www.jensen-nmr.fr #NMRjobs #NMRchat #NMR 🧲

Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.

Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1093/nar/...

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery www.nature.com/articles/s41...

Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....

An open #PhD position is available in my lab in Munich 🇩🇪 If you are interested in structural biology, #AlphaFold, or disordered proteins, see below for more details. jobs.helmholtz-muenchen.de/jobposting/b... #science #PhD #research

We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch! 3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...

🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.

Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...

NMR will be a cornerstone of our experimental toolkit at Bind. We're developing advanced NMR methods enhanced by AI-based tools to rapidly illuminate disordered protein interactions in powerful new ways. Find out more: bindresearch.org #NMRChat #AI 🧲

Delighted to announce @tlhr.bsky.social, @g-heller.bsky.social and I are building the UK’s first FRO @bindresearch.org with the goal of making disordered proteins druggable. Interested in doing breakthrough open science in an innovative organisation in Central London? We’d love to hear from you!

We’re thrilled to announce the launch of Bind Research, the UK’s first not-for-profit Focused Research Organisation, with long-term support from the Department for Science, Innovation and Technology’s Research Ventures Catalyst Programme, industry, and charities.

Accurate Stoichiometry Prediction of Protein Complexes by Integrating AlphaFold3 and Template Information https://www.biorxiv.org/content/10.1101/2025.01.12.632663v1

Professor Lewis E. Kay @lek-lab.bsky.social @uoft.bsky.social to receive the 2025 Eastern Analytical Symposium Award for Outstanding Achievements in Magnetic Resonance eas.org/eas-award-fo... #NMRnews #NMRchat #NMR 🧲

After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service. @jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases Details: cdn.rcsb.org/rcsb-pd...

📢 New preprint! 📄 Deciphering the molecular forces behind the exceptional binding affinity of the streptavidin-biotin complex via NMR and QM. 🔍 Check it out: www.biorxiv.org/content/10.1... #StructuralBiology #NMR #ComputationalChemistry #DrugDiscovery

Tailored NMR experiments combined with a new DNN provide high-resolution spectra of aromatic side chains and accurate uncertainty estimates - enabling quantifications of dynamics and kinetics doi.org/10.1126/scia... #ScienceAdvances @crick.ac.uk @uclofficial.bsky.social @ukri.org #NMRchat

The latest preprint from the lab. @lucassiemons.bsky.social improved the HMBC-HMQC method he had developed during his PhD with Flemming Hansen. The overall sensitivity gain in a 42 kDa kinase from BEST is 16% and 30% compared to the original scheme.

Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41... A timely release of this story... as it is a great setup to the next one, coming soon!!

A hidden figure of science unearthed for me. Many notable physicists and Nobel laureates state that the foundation of modern physics would not exist without Professor Emmy Noether’s theorem. If she were a man, she would likely be celebrated today in the ways that her contemporaries are.

“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.” www.researchamerica.org/2023-oped-us...

This is a great opportunity to join our group as PhD student to investigate the role(s) of intrinsically disordered proteins in biomedicine !

A few images of the steric interactions that lead to different rotamer frequencies (in a backbone-independent sense & backbone-conformation-dependent sense). On Ramachandran maps for each chi1 rotamer, you can see what interactions occur where in real data. I know these off the top of my head😀

Very pleased to see our latest study published at CDDpress. We show that #Seratrodast, an approved drug, is a suppressor of #ferroptosis by inihibiting lipid peroxidation. Thanks to Jule, Wulf, and the rest of the team! www.nature.com/articles/s41...

How to write a grant? 1. The application is for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. www.pnas.org/doi/epub/10....