How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!

We developed a MS and machine learning approach to globally identify protein regulators of metabolism. We found protein LRRC58 controls cellular cysteine catabolism by mediating degradation of CDO1, the rate-limiting enzyme of the catabolic cysteine shunt to taurine. www.nature.com/articles/s41...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Cryo-ET visualization of HTT bound to F-actin, highlighted in the yellow square on the left. On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.

The mechanism of STING NF-κB signaling has remained a mystery. An exciting new study from the Paludan lab now uses data throughout animal STING evolution to provide new answers – including isolating white blood cells from turtles and carp! www.nature.com/articles/s41...

Proud to present our new paper in @natmetabolism.nature.com The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases lnkd.in/eVzFrmUY Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).

Genetic Code Expansion Facilitates Programmable Ubiquitylation via UBE2W https://www.biorxiv.org/content/10.1101/2025.09.22.676137v1

New Online! Visions of the future of molecular cell biology

A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy: Neuron www.cell.com/neuron/fullt...

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

#ICYMI spearheaded by Sofia Lövestam, Michel Goedert & @sjorsscheres.bsky.social's groups have identified a combination of 12 residues in tau’s fuzzy coat which, when mutated, facilitates assembly of amyloid filaments. Read more in AlzForum: www.alzforum.org/news/researc... #LMBintheNews #PAD12

In situ structure determination of Respiratory Supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane. https://www.biorxiv.org/content/10.1101/2025.09.19.677273v1

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink

RFdiffusion3 is here: www.biorxiv.org/content/10.1...

De novo design of All-atom biomolecular interactions with RFdiffusion3 www.biorxiv.org/content/10.1...

Structure and substrate recognition by the Twin-arginine translocation (Tat) pathway core complex https://www.biorxiv.org/content/10.1101/2025.09.18.677151v1

Finally in @nature.com 🎉 We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism. www.nature.com/articles/s41...

First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins. www.nature.com/articles/s41...

Clathrin-coated vesicles are targeted for selective autophagy during osmotic stress. https://www.biorxiv.org/content/10.1101/2025.09.16.676479v1

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

Version of Record Structural basis for mTORC1 activation on the lysosomal membrane www.nature.com/articles/s41...

ICYMI: New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression

Covariation MS uncovers a protein that controls cysteine catabolism www.nature.com/articles/s41... Beautiful work from Ed Chouchani!

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis www.nature.com/articles/s41...

🚨🧠🔬 A major breakthrough in molecular neuroscience: I am excited to share a new story from our lab, published in accelerated format today by @nature.com: "Delta-type glutamate receptors are ligand-gated ion channels" Read more here (free article link): rdcu.be/eGIKz

New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression

Molecular structure of the ESCRT III-based archaeal CdvAB cell division machinery www.biorxiv.org/content/10.1101/2025.09.15.676241v1 #cryoem

Do melanoma cells rewire interorganelle iron flow? ⚡️We found that BDH2 controls lysosome-to-mitochondria Fe2+ transport, coupling lysosomal pH to ferroptosis vulnerability. Huge congrats to @francirizz.bsky.social, thanks to @juliebonnereau.bsky.social and collabs 🙏 www.nature.com/articles/s42...

Delighted to share our review on how those malaria parasites get into our blood cells and how we might stop them. rdcu.be/eGnUl

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Wow, this paper provides crucial understanding of local translation and processing of transmembrane proteins in axons, one of the big mysteries that have haunted the field for a long time!!!!!!!! Fantastic!!!!!!!! Nguyen et al., 2025, bioRxiv 2025.09.09.674816ff. -- doi.org/10.1101/2025...

Congratulations Cole! Such a beautiful paper!

Why are α-synuclein aggregates in Parkinson’s disease (PD) toxic at the cell biological level? Our new study shows that α-syn fibrils hijack the ESCRT membrane repair system, triggering a feedback loop that worsens aggregation. You can find it at: authors.elsevier.com/sd/article/S...

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons www.nature.com/articles/s41...

1973: Max Perutz explains the solution of hemoglobin. 53 years later, we’re still waiting for someone to solve the missing pointer

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

Beautiful data from @dvillarroelc.bsky.social showing a key role for TBK1 in #AxonalTransport of signalling endosomes: www.biorxiv.org/content/10.1... @uclqsion.bsky.social @mndassoc.bsky.social #ALS #MND

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...

'How bacterial immune components were first acquired & adapted within eukaryotic cells remains poorly understood. Here we identify a complete cGLR-STING signaling axis in choanoflagellates, the closest living relatives of animals, that exhibits a mosaic of features from bacterial & animal immunity'

The world's oldest bacterial DNA found in a million-year-old mammoth! New results from researchers at #CpgSthlm published in Cell! Paper: www.cell.com/cell/abstrac...

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation https://www.biorxiv.org/content/10.1101/2025.09.05.673478v1

New from the lab: Fatty Acid Metabolism Sets the Species-specific Tempo of Cortical Development through Protein Acetylation Dynamics. Led by amazing trio: @ryo2iwata.bsky.social , Isabel Gallego, @emirerkol.bsky.social, together with @steinaerts.bsky.social , @fendtlab.bsky.social

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin. 👇 Reserve your spot using the link below. 📅 September 8 ⏰ 11:00 AM EST RSVP: bit.ly/4mUJeAc

Their findings were now published in the journal Science - one day after the Clausen lab had a groundbreaking publication in the journal Cell! Full story: www.imp.ac.at/news/article...

Researchers around @clausenlab.bsky.social & @dangrabarczyk.bsky.social have unveiled the three-dimensional structure of UBR4, a giant protein complex that safeguards cells by targeting defective proteins for destruction—offering fresh insights into health & disease. www.science.org/doi/10.1126/...