CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!

Exciting !

I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)

mStayRose is published in JBC 🥳🎉 Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable: www.jbc.org/article/S002...

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Lots of excellent work inside incl. Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

Mitochondrial transfer www.nature.com/articles/s42...

Feeling mitochondrially challenged lately? Here are two classic reviews on #mitochondria that should help. www.cell.com/current-biol... www.cell.com/current-biol...

📣📣📣📣

Kailash Venkatraman, Nicolas-Frédéric Lipp & @ibudin.bsky.social examine the similarities between prokaryotic intracytoplasmic membranes & mitochondrial IMs, & discuss whether cristae evolution has driven specialisation of the #mito lipidome. journals.biologists.com/jcs/article/... #JCSMitoSI

I had some absolutely incredible papers come online this week, and I need to take a minute to post about each of them. First, let me tell you about the CarboTag probes for imaging plant cell walls! From the Sprakel lab (a short thread) www.nature.com/articles/s41...

So excited for this work to be out!! Thanks to @attychang.bsky.social, @hamid13r.bsky.social, blue sky less Daniel Fuentes, @nanigrotjahn.bsky.social and @tomo.science!!!

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

#invertefest needs some more marine representation, so here are 2 Liriope sp. hydrozoan and a teeny ctenophore amongst numerous copepods. Data recorded (5 fps) via a benchtop shadowgraph camera from a non-filtering end plankton net tow.

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩 @zidlab.bsky.social @tomo.science @hamid13r.bsky.social

Happy to share Asha Joseph and Inchara Adhikashreni's latest work from the lab, describing replisome speed variation in Caulobacter! www.cell.com/current-biol...

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

At @standupforscience.bsky.social and the signs are statistically significantly excellent

Happy to share that the final version of record for our ( @nanigrotjahn.bsky.social) #teamtomo mitochondrial cotranslation story is online at @jcb.org! We combined STA with surface morphometrics to learn how ribosomes bind to and alter mitochondrial membranes in yeast. rupress.org/jcb/article/...

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

Had the incredible opportunity to present my work at #EMBOinsitu workshop in Heidelberg. It was filled with fantastic science and new friends! #teamtomo

When does a DNA polymerase degrade DNA? Read Akshaya’s work from the lab to find out more!

Hey #teamtomo, if you often find yourself using the excellent membrain-seg from @lorenzlamm.bsky.social et al., you might find my napari plugin "napari-segselect" useful. Let's say your tomogram contains the edges of two bacterial cells, each with a membrane and cell wall:

I know, I know... HHS freezes are occupying our attention. Please free up a little bandwidth for this: nature.com/articles/d4158… NASA FOUND AN ASTEROID WITH ALL 5 NUCLEOBASES & 14 L-AMINO ACIDS!! WAIT, THERE'S MORE: THE ASTEROID CONTAINS NEARLY EQUAL AMOUNTS OF D-AMINO ACIDS!

NSF Career Award supported invention of Foldscope - now reached 3 million kids globally with ~1 million kids in US - bringing joy of science to grassroots & communities with very little support. It’s brought communities working together on global problems. www.goldengooseaward.org/01awardees/f...

Ooh almost forgot the shameless plug for the paper @sarraceniamason.bsky.social and I published a year ago. A curated collection of good printable tools. Enjoy! bsapubs.onlinelibrary.wiley.com/doi/10.1002/...

Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social

mtDNA sitting pretty in the pearls 💅

Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @jcellbiol.bsky.social! A wonderful early present to see this now online! rupress.org/jcb/article/...

Beautiful work led by @gavsturm.bsky.social and @jclandoni.bsky.social in the two preprints. And beautiful mitos 😍

How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography www.biorxiv.org/content/10.1...

Labs that clay together, stay together 🩶🌪️🥣 @hamid13r.bsky.social @mmedina300kv.bsky.social @callmemich.bsky.social @nitishdua.bsky.social

Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...

Hello @bsky.app family!

Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1

This is mind blowing! Sequencing DNA INSIDE single nuclei to map the 3D position of genes. I love the combination of technologies--imaging powered by expansion microscopy and state-of-the art sequencing, all underlain by good old Fred Sanger 🧪

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added! #Mito #Mitochondriac go.bsky.app/J6Bu5fL

I was today years old when I found out "Aspartic acid was abbreviated to D, because the amino acid's name sounds like aspar-D-ic acid. Similarly, glutamine became Q, sounds like Qlutamine" www.sciencedirect.com/science/arti...