📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ 🧪 biomed.news/bims-imicid/... Incl. I) Hormonal rewiring of immunity during DR ensures host defense & systemic glucose conservation II) Asparagine sensing by TBK1 controls phase separation to drive antiviral innate immune resp.

Aude Bernheim @audeber.bsky.social and Eugene Koonin discuss one of most interesting questions in the field connecting bacterial and animal immunity! www.nature.com/articles/s41...

Lokiarchaeon CBASS ❤️

Good morning, all! Here is a beautiful selection of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "For everything you do, there will be a last time that you do it."-William B. Irvine

@biorxivpreprint.bsky.social RNP+Sm+ defines a high-risk, refractory, myeloid-driven lupus endotype characterised by activity linked hyperferritinemia that likely requires therapies directed at the underlying IFN and myeloid-centred pathways @ucl.ac.uk www.biorxiv.org/content/10.6...

Cooperative Architecture of Mitochondrial Proteome Homeostasis 🧪 www.medrxiv.org/content/10.6...

Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and pathogen escape 🧪 #immunometabolism www.researchsquare.com/article/rs-7...

Chrysanthi Moschandrea and I have developed a new conceptual framework for understanding the role of metabolism in cancer, which we term metabolic permissiveness. We are eager to hear your thoughts on this topic. genesdev.cshlp.org/content/earl...

🔊Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Interesting findings🧪: I) Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social

#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy! doi.org/10.1038/s415...

****2-NBDG does not measure glucose uptake**** Just your regular reminder of this fact 😁. See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper. This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄 pmc.ncbi.nlm.nih.gov/articles/PMC...

A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation www.nature.com/articles/s41... @natcomms.nature.com

YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice www.nature.com/articles/s41... @natcomms.nature.com

Immunometabolism researchers are meeting in Newcastle on 16-17 April! Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26 Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45

Looking forward to speaking at this #UKimmunomet26 conference in Newcastle. Make sure to check it out! @britsocimm.bsky.social www.immunology.org/events/fuell...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com

Why does mitochondrial disease still take ~8 years to diagnose? This study shows most delay happens before suspicion, despite early seizures, hypotonia & stroke being documented years earlier. Recognition — not testing — is the bottleneck. doi.org/10.1002/jmd2...

#WeekendRead! #LocationLocationLocation! Sng, Andoniou, @the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...

The transition from monocyte to tissue-resident macrophage requires DHPS 🧪 #immunometabolism www.nature.com/articles/s41... www.nature.com/articles/s41...

💡 #ListerFellow @tjryan.bsky.social et al. reveal how microglia immune cells help organise memory engrams during early development. A clue to the mechanisms regulating "infantile amnesia" and why we forget our baby days? @ryanlab.bsky.social 👉 PLOS Biology journals.plos.org/plosbiology/...

Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome #mitochondria rdcu.be/eZXXC

Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke www.researchsquare.com/article/rs-8...

#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 🦊 being protective in young & detrimental in aged mice!

⚠️ We are hiring a Postdoctoral Research Associate ⚠️ 🚨 Deadline 9th February 2026 🚨 👍 Please like and share with your network! 👍 #CambridgeUniversity #PostdoctoralResearch #JobOpportunity For enquiries please contact me at [email protected] or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...

Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social www.nature.com/articles/s42...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting paper: Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity @cellcellpress.bsky.social @thexavierlab.bsky.social @broadinstitute.org www.cell.com/cell/fulltex...

Obesity rewires nucleotide metabolism in immune cells, making inflammatory responses via NLRP3 inflammasome much easier to trigger www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social

Polyamine-dependent metabolic shielding regulates alternative splicing www.nature.com/articles/s41...

3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Albumin orchestrates a natural host defence mechanism against mucormycosis

Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading "Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...

How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. Great collaboration with the Schmoller Lab. journals.plos.org/plosgenetics... 🧬⚡

'Infection-triggered disease onset carried a significantly higher risk of liver involvement than spontaneous or other disease triggers.' Liver Involvement in POLG Disease—a Multicentre Cohort Study of 202 Patients onlinelibrary.wiley.com/doi/10.1002/...

The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function journals.sagepub.com/doi/10.1177/...

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

Congrats to Jan whose new paper on persulfide measurement is is out now in Nature Comms

Review @natrevdrugdiscov.nature.com Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications www.nature.com/articles/s41...

Widely Targeted Metabolomics and Machine Learning Identify Succinate as a Key Metabolite in Sepsis-Associated Encephalopathy: iScience www.cell.com/iscience/ful...

The selection has arrived - biomed.news/bims-imicid/... #immunometabolism

Lupus nephritis is a type of immune-mediated glomerulonephritis and a serious complication of systemic lupus erythematosus that can affect up to 60% of patients with this condition. #NephSky

📢Last weeks #immunometabolism report @biomednews.bsky.social hasn't come online so I'm highlighting this preprint from my selection: pmc.ncbi.nlm.nih.gov/articles/PMC... Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit

Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling @sciimmunology.bsky.social @kellybruton.bsky.social @mcmasteruniversity.bsky.social www.science.org/doi/10.1126/...

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...

☕Zhang et al. characterize the #mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner #mitochondria membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation. 👉https://rdcu.be/eXjMB bit.ly/3YZ0PNj

Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase: Cell Reports www.cell.com/cell-reports...

@biorxivpreprint.bsky.social Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade @mdanderson.bsky.social @jimallisonphd.bsky.social @pamsharmamdphd.bsky.social www.biorxiv.org/content/10.6...