Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting paper: Activated T cells degrade extracellular proteins to enhance effector functions

Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35 pubmed.ncbi.nlm.nih.gov/41446167/

Deletion of Ptpn2 in B cells promotes autoimmunity via TLR and JAK/STAT signaling @insight.jci.org @cuanschutz.bsky.social insight.jci.org/articles/vie...

Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19 @insight.jci.org @hopkinsmedicine.bsky.social insight.jci.org/articles/vie...

🎄Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️ biomed.news/bims-imicid/... A great Christmas selection inside! I) Gut microbiota promotes immune tolerance at the maternal-fetal interface

link.springer.com/article/10.1... The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells

Natural daylight during office hours improves glucose control and whole-body substrate metabolism @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons @natneuro.nature.com @massgeneralbrigham.bsky.social www.nature.com/articles/s41...

New paper from @zhixingchen2.bsky.social's lab! It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime! www.nature.com/articles/s41...

Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy. doi.org/10.1038/s441...

We are very excited about the array of future applications for this technology, including diving deeper into the mechanisms of inflammation and accelerating the development of next-gen myeloid cell therapies. Check out the preprint here: www.biorxiv.org/content/10.6...

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

🔎 What are the consequences of hypermetabolism in human motor neurons? Our new study from the @htyynismaa.bsky.social lab is out! Using human iPSC-derived motor neurons, we show that increased energy demand drives key metabolic trade-offs. 🔗 www.nature.com/articles/s42...

www.nature.com/articles/s41... Congrats @soleimanpourlab.bsky.social !

Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase | Science Advances www.science.org/doi/full/10....

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ biomed.news/bims-imicid/... Interesting findings: I) Dynamic changes in mitochondria support phenotypic flexibility of microglia II) Mitochondria are absent from microglial processes performing surveillance

Our latest now published in @natcomms.nature.com, where we found a new role for mitochondrial programming of SC-β cell fate through PPARα. We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D! www.nature.com/articles/s41...

Double stranded RNA sensing is silenced during early embryonic development @natcomms.nature.com @edinburghup.bsky.social www.nature.com/articles/s41...

Fasting induces glucocorticoid receptor signaling that reduces AP-1 activity in ERα-positive breast cancers, acting as adjuvant to enhance endocrine therapy activity @nature.com @zwartlab.bsky.social www.nature.com/articles/s41...

I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer. Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile. Thank you very much!

A direct role for a mitochondrial targeting sequence in signalling stress

Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...

Have you heard about the Night Science Podcast, where we talk about the creative process of doing science? We explore this with discussions with brilliant scientists & philosophers and artists, to figure out the tricks of the creative scientific trade. podcasts.apple.com/us/podcast/n...

One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org www.embo.org/people/revie...

#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!

Spaceflight alters the immune regulatory functions of neutrophil granulocytes on T lymphocytes @cp-iscience.bsky.social www.cell.com/iscience/ful...

Finally out: FBXO11 loss establishes a stem cell program jci.org/articles/vie.... Many years and outstanding trainees and staff, including Hayle Kincross and Angela Wong, to get the manuscript over the finish line. @terryfoxresearch.bsky.social #CIHR @bccancerfdn.bsky.social #ubcpathology

Good Sunday, all. Don't miss this week's selection of papers in #cancermetabolism and #mitochondrialbiology as there are some true gems: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave

Excited to share the first December issue of bims-metlip featuring the latest advancements in small molecule analysis. biomed.news/bims-metlip/... A collaboration with @biomednews.bsky.social #SmallMoleculeAnalysis #Metabolomics #Lipidomics

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation

What causes bladder cancer initiating mutations? Our paper in Science Advances asks the question: can BK virus infections of normal urothelium lead to the APOBEC3 mutational signatures found in bladder cancers? We found that they can!

Preprint: Systematic discovery of TIR-based immune signaling systems in bacteria Conservation of TIR-derived signals accross the tree of life! We found bacterial TIR immune systems that signal via canonical cADPR (like in humans) and 2'cADPR (a plant immune signal). Documented 11 Thoeris types

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... A huge collection inside! Interesting finding: Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

#NoTimeToDie! Welcome mitoxyperiosis! ⁦‪Kanneganti, Wang‬⁩ &co show ⁦‪@cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!

SLC7A8 is essential for metabolic fitness and function of Th2 cells, say Santosh Panda, Marco Colonna and colleagues @washumedicine.bsky.social: rupress.org/jem/article/... #InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies

Super cool @nature.com paper from Kodi Ravichandran @washumedicine.bsky.social: Limited β-cell death reprograms islet macrophages into a tolerogenic state ("e-Mac"), expanding anergic-like CD4+ T cells and suppressing autoimmunity in NOD mice. Mechanism via IGF-1. www.nature.com/artic... 🧪

Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "Trying to define yourself is like trying to bite your own teeth."-Alan Watts

Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚 biomed.news/bims-mitdis/... biomed.news/bims-mitdis/... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social Demethoxy-CoQ and NUDT5 in nucleotide synthesis www.nature.com/articles/s42...

📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Exciting to have a paper in the collection! An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17

Termination of the integrated stress response | Science www.science.org/doi/10.1126/...

www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social