www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social

I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏 full text access here rdcu.be/ePcEK

A new collection of papers on #mitochondrialdisease from #week45! 📚 💚 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia www.nature.com/articles/s42...

Hexokinase 2, the latest glycolytic enzyme that also controls mRNA translation! Nonmetabolic function of HK2 acting as an RBP and translation regulator. dx.plos.org/10.1371/jour...

Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria www.cell.com/molecular-ce...

Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social www.nature.com/articles/s41...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

Wonderful work from @mito-oncogene.bsky.social and @edreznik.bsky.social on the role of mito ribosomal RNA in cancer.

Cell membrane stress upon viral infection induces expression and stabilization of host SMPDL3B, which, in turn, degrades cGAMP to suppress cGAS-STING signaling and promote viral replication @cp-immunity.bsky.social www.cell.com/immunity/ful...

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy

Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity www.nature.com/articles/s41...

An atlas of mitochondrial ATP synthase activity across the lifespan #mitochondria www.sciencedirect.com/science/arti...

Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans @jem.org @au.dk rupress.org/jem/article-...

Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice www.science.org/doi/10.1126/... @roystrowdmd.bsky.social @wakeforestmed.bsky.social @weillcornell.bsky.social Great to see @labwaggoner.bsky.social alum Taylor Brooks contributing

SARM1 senses dsDNA to promote NAD+ degradation and cell death @cellcellpress.bsky.social www.cell.com/cell/fulltex...

📢 last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms

Mitochondrial and lysosomal signaling orchestrates Treg cell metabolic states and functional fitness @sciimmunology.bsky.social @stjuderesearch.bsky.social www.science.org/doi/10.1126/...

Fundamental role of spatial positioning of Mycobacterium tuberculosis in mycobacterial survival in macrophages @natcomms.nature.com @ashwanikumar.bsky.social www.nature.com/articles/s41...

Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!

Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Not turbo cancer but turbo cancer-immunotherapy! Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com www.nature.com/articles/d41... www.nature.com/articles/d41...

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Lots of excellent work inside incl. Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.

@cellcellpress.bsky.social spotlight Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy www.cell.com/molecular-ce... on @nature.com www.nature.com/articles/s41...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Wow, @pascual-reguant.bsky.social, very impressive talk at #EMBLSpatialBiology! Presented preprint with @hoheyn.bsky.social: www.biorxiv.org/content/10.1... You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells www.nature.com/articles/s41... @natimmunol.nature.com @idoyagalab.bsky.social

Quantitative cellular characterization of extracellular mitochondria uptake and delivery #mitochondria #transfer www.nature.com/articles/s41...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Many highlights inside! incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

Metabolic profiling reveals channeled de novo pyrimidine and purine biosynthesis fueled by mitochondrially generated aspartic acid in cancer cells www.nature.com/articles/s41...

Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading "To see takes time, like to have a friend takes time." -Georgia O'Keeffe

Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

A brilliant new paper by @Marilia Meira Dias and @Thomas MacVicar and others is out! It has discovered that a mitochondrial carrier SLC25A45 is involved in the uptake of methylated lysine and arginine, a key step in carnitine biosynthesis! www.sciencedirect.com/science/arti...

Whoo hoo! The final version of our first paper is online! So proud of the team. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

PREACH! www.nature.com/articles/s41...

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

Delighted to see this out in @NeuroCellPress!!! Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS www.cell.com/neuron/fullt...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this. www.science.org/doi/... 1/9

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science www.science.org/doi/10.1126/...

Gene therapy and mRNA drugs approach for mitochondrial OXPHOS deficiencies: Molecular Therapy www.cell.com/molecular-th...

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...