📢 Last 2 weeks of #immunometabolism discoveries brought to you from EUROMIT 2026 in sunny Angers Saint-Laud ☀️ @biomednews.bsky.social ⬇️ ⬇️ ⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Interesting finding: Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

Does mitochondrial respiration in DCs just “fuel” activation? In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s www.science.org/doi/10.1126/... At: CNIC_CARDIO @inmunosky

New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite www.nature.com/articles/s41... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social

Identification of an STING inhibitor targeting the allosteric transmembrane domains

🚨 We’re hiring! 🚨 1/n I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️ Please share widely and see below for app details ⬇️

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... New tool Universal conditional knockout approach to multiple species.. pubmed.ncbi.nlm.nih.gov/42132111/ @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social

#Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation www.nature.com/articles/s41...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke

“In my lifetime I have witnessed a terrible decline. In yours, you could and should witness a wonderful recovery.” What an immense privilege it has been to be alive at the same time as this incredible human being—David Attenborough. #Happy100thBirthday🥳 www.theguardian.com/tv-and-radio...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress.

I’m delighted to share this news and grateful to the @wellcometrust.bsky.social for supporting our work. We will soon be recruiting for both a Research Associate and Research Assistant position. More details will follow shortly, but please feel free to get in touch! www.tcd.ie/news_events/...

Cytochrome P450 1B1 directs pathogenic Th17 cell generation and autoimmune disease by fine-tuning redox homeostasis and mitochondrial integrity @pnas.org www.pnas.org/doi/10.1073/...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding - an 'immune-independent' function of B cells! B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

Is there life on Mars? Organic molecules from clay-bearing sandstones found by the Sample Analysis at Mars instrument suite onboard the Curiosity rover 🧪 @natcomms.nature.com www.nature.com/articles/s41...

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️ biomed.news/bims-imicid/... Lot's of exciting findings! 1) Purine salvage pathway protects CD8+ T cells from metabolic stress 2) Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies portlandpress.com/biochemj/art...

🤔Do you think that OXPHOS in DCs = tolerance? In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance. Life (& #immunometabolism) is not simple ⚡️ OPEN: www.cell.com/cell-metabol... #immunoSky

#WeekendRead! #SharingIsCaring! #CatchMeIfYouCan! Roska, Ayupov, Moreno-Juan &co show @nature.com that healthy #mitochondria can be efficiently delivered to distinct cell types via a selective #MitoCatch system that allows their intracellular transfer & protection of cells!

In its 2025 PhD survey, Nature asked more than 3,700 doctoral candidates around the world a simple question: what is the best thing your supervisor has done for you during your studies? Nature highlights several moments when good supervision made the difference. #Academicsky 🧪

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award. Prof. Yates: www.gairdner.org/winner/john-... Prof. Aebersold: www.gairdner.org/winner/ruedi... Prof. Mann: www.gairdner.org/winner/matth... #2026GairdnerAwards

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting new 'immunometabolism' method: Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease www.medrxiv.org/content/10.1...

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

Good Sunday, all! Don't miss this weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology, it contains wonderful discoveries. Check it here: biomed.news/bims-camemi/... Biomed News #keepreading "You're only as free as your attention is."-Sam Harris

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging.

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting papers 🧪: I) The immunometabolic topography of cellular organization in TB II) The human antibacterial factor APOL3 couples lysosomal damage to mtDNA efflux and type I IFN induction.

Increasing evidence that STING has functions beyond DNA viruses. A new study reports that STING restricts influenza infection, independently of IFN. This work complements prior studies that STING prevents infection with diverse RNA viruses. www.science.org/doi/10.1126/...

Pioneer factor IRF1 unlocks latent enhancers to rewire chromatin and #immunometabolism in inflammatory macrophages 🧪 www.biorxiv.org/content/10.6...

Glutathione is critical for NK cell-mediated immunity #immunometabolism www.cell.com/cell-reports...

📢Last weeks #immunometabolism discoveries 🧪@Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling #mitochondria #metabolites

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ 🧪 biomed.news/bims-imicid/... Incl. I) Hormonal rewiring of immunity during DR ensures host defense & systemic glucose conservation II) Asparagine sensing by TBK1 controls phase separation to drive antiviral innate immune resp.

Aude Bernheim @audeber.bsky.social and Eugene Koonin discuss one of most interesting questions in the field connecting bacterial and animal immunity! www.nature.com/articles/s41...

Lokiarchaeon CBASS ❤️

Good morning, all! Here is a beautiful selection of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "For everything you do, there will be a last time that you do it."-William B. Irvine

@biorxivpreprint.bsky.social RNP+Sm+ defines a high-risk, refractory, myeloid-driven lupus endotype characterised by activity linked hyperferritinemia that likely requires therapies directed at the underlying IFN and myeloid-centred pathways @ucl.ac.uk www.biorxiv.org/content/10.6...

Cooperative Architecture of Mitochondrial Proteome Homeostasis 🧪 www.medrxiv.org/content/10.6...

Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and pathogen escape 🧪 #immunometabolism www.researchsquare.com/article/rs-7...

Chrysanthi Moschandrea and I have developed a new conceptual framework for understanding the role of metabolism in cancer, which we term metabolic permissiveness. We are eager to hear your thoughts on this topic. genesdev.cshlp.org/content/earl...

🔊Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Interesting findings🧪: I) Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social

#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy! doi.org/10.1038/s415...

****2-NBDG does not measure glucose uptake**** Just your regular reminder of this fact 😁. See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper. This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄 pmc.ncbi.nlm.nih.gov/articles/PMC...

A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation www.nature.com/articles/s41... @natcomms.nature.com

YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice www.nature.com/articles/s41... @natcomms.nature.com

Immunometabolism researchers are meeting in Newcastle on 16-17 April! Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26 Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45