Kranzusch Lab
@kranzuschlab.bsky.social
📤 331
📥 119
📝 47
Harvard Medical School, Dana Farber Cancer Institute
https://kranzuschlab.med.harvard.edu
reposted by
Kranzusch Lab
Kevin Corbett
5 days ago
Congratulations to Doi Basu
@dwaipayanbasu.bsky.social
for publishing his first first-author paper from the lab! The cryoEM structure of a tubulin-like protein from bacteriophage Goslar forms "microtubules" with nine protofilaments!
authors.elsevier.com/a/1mM253SNvc...
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https://authors.elsevier.com/a/1mM253SNvcEQaa
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New structures of the HSV-1 helicase-primase complex from
@abrahamlabhms.bsky.social
www.cell.com/cell/fulltex...
5 days ago
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Kranzusch Lab
AI x Bio Discovery
6 days ago
Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens
[new] Mac1 co-folding eval: Pose prediction, conform. change, & hit ID post-training.
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Kranzusch Lab
Emmanuele Severi
14 days ago
#microsky
#phagesky
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in
#phages
www.biorxiv.org/content/10.6...
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High-throughput transposon mutagenesis defines the essential genome of diverse phages
Phages are important drivers of bacterial evolution with therapeutic potential as antimicrobials. However, gaps in our understanding of phages and our inability to rapidly engineer them with new genet...
https://www.biorxiv.org/content/10.64898/2025.12.19.695335v1
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Kranzusch Lab
Stephen Royle
19 days ago
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology
#WTFology
www.biorxiv.org/content/10.6...
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The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
https://www.biorxiv.org/content/10.64898/2025.12.12.693869v1
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Kranzusch Lab
Aude Bernheim
19 days ago
Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts.
www.biorxiv.org/content/10.6...
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Environment and physiology shape antiphage system expression
Bacteria and archaea encode on average ten antiphage systems. Quorum sensing, cellular, or transcription factors can regulate specific systems (CRISPR-Cas, CBASS). Yet, a systematic assessment of anti...
https://www.biorxiv.org/content/10.64898/2025.12.14.694197v1
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Kranzusch Lab
EMBO
24 days ago
The EMBO Gold Medal 2025 was awarded to Tanmay Bharat and David Bikard:
https://www.embo.org/press-releases/embo-gold-medal-2025-awarded-to-tanmay-bharat-and-david-bikard/
đź§Ş At
#CellBio2025
, the EMBO Gold Medal was handed over to David Bikard in recognition of his pioneering work on
#GeneEditing
.
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Exciting pre-print on new variants of anti-phage defense systems including CBASS, Pycsar, and Gabija!
www.biorxiv.org/content/10.6...
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Leveraging defense system modularity to discover anti-phage systems
Bacterial exposure to constant phage attack drives rapid diversification of anti-phage defense systems, often through the exchange of modular defensive domains. Here, we leverage this modularity signa...
https://www.biorxiv.org/content/10.64898/2025.12.08.692795v1
25 days ago
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Kranzusch Lab
Cluster of Excellence CMFI
26 days ago
🎥 New series: Paper in a Minute! CMFI researchers explain key findings from recent publications in under 60s. Ep. 1: Ana Rita Brochado
@brochadolab.bsky.social
on antifolate-triggered CBASS activation in V. cholerae. Watch:
youtu.be/q3EErS28oMs?...
#ERC
#AMR
@natmicrobiol.nature.com
#scicomm
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Paper in a Minute — Ana Brochado, Vibrio cholerae CBASS phage defence system. Nature Microbiology
YouTube video by CMFI - Cluster of Excellence
https://youtu.be/q3EErS28oMs?si=1o4y6W76JfXR1A2C
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Kranzusch Lab
Joe Bondy-Denomy
26 days ago
Phages are full of genes of unknown function that are likely adaptive in specific conditions. New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
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Kranzusch Lab
Jovana Kaljević ⬜️
about 1 month ago
Our preprint is now published in PNAS! This came together thanks to a great collaboration with Antoine Hocher and a strong team effort from the Le Lab. Thank you to the reviewers and to everyone who helped improve it. I hope ParB aficionados will enjoy it.
www.pnas.org/doi/10.1073/...
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Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states thro...
https://www.pnas.org/doi/10.1073/pnas.2527592122
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Kranzusch Lab
Erez Yirmiya
about 1 month ago
I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life.
www.biorxiv.org/content/10.6...
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Systematic discovery of TIR-based immune signaling systems in bacteria
Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...
https://www.biorxiv.org/content/10.64898/2025.12.03.692087v1
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Kranzusch Lab
Joe Bondy-Denomy
about 1 month ago
Check this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed)
sisb2026.rockefeller.edu
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SISB2026
https://sisb2026.rockefeller.edu/
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Kranzusch Lab
Marcin J. Suskiewicz
about 2 months ago
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
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Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
https://rdcu.be/eQjNK
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Kranzusch Lab
Sorek Lab
about 2 months ago
Congratulations to Sorek lab alumnus Nitzan Tal, who won the prestigious 2025 Science & SciLifeLab prize for the best PhD thesis in Systems Biology! đź’« Read her Prize Assay, published in the journal Science today
www.science.org/doi/10.1126/...
@nitzantal.bsky.social
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Kranzusch Lab
bioRxiv Microbiology
about 2 months ago
Cap1 forms a cyclic tetra-adenylate-induced membrane pore during the type III-A CRISPR-Cas immune response
https://www.biorxiv.org/content/10.1101/2025.11.13.688252v1
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Kranzusch Lab
Owen Tuck
about 2 months ago
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems:
www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole
@doudna-lab.bsky.social
and everyone at
@innovativegenomics.bsky.social
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
https://www.science.org/doi/10.1126/science.aea8769
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Gluing a bulky host protein onto an immune surveillance complex is a wild mechanism of viral immune evasion!
@natmicrobiol.nature.com
#phagesky
#phage
#microsky
www.nature.com/articles/s41...
about 2 months ago
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Kranzusch Lab
Veesler lab
about 2 months ago
Delighted to share the peer-reviewed version of our article describing a prefusion-stabilized MARV GP vaccine immunogen and a best-in-class MARV neutralizing and protective antibody! Led by
@aminaddetia.bsky.social
with
@virbiotechnology.bsky.social
@hhmi.org
www.nature.com/articles/s41...
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Potent neutralization of Marburg virus by a vaccine-elicited antibody - Nature
Nature - Potent neutralization of Marburg virus by a vaccine-elicited antibody
https://www.nature.com/articles/s41586-025-09868-1
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Kranzusch Lab
Antonio Camargo
about 2 months ago
🚨New preprint out! We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
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Kranzusch Lab
Osterman Ilya
about 2 months ago
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides. Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
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Kranzusch Lab
BejaLab
2 months ago
from 2021. A new family of globally distributed lytic roseophages with unusual deoxythymidine to deoxyuridine substitution
www.sciencedirect.com/science/arti...
@cyanoney.bsky.social
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A new family of globally distributed lytic roseophages with unusual deoxythymidine to deoxyuridine substitution
Marine bacterial viruses (bacteriophages) are abundant biological entities that are vital for shaping microbial diversity, impacting marine ecosystem …
https://www.sciencedirect.com/science/article/pii/S0960982221006734?via%3Dihub
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reposted by
Kranzusch Lab
bioRxiv Microbiology
2 months ago
A membrane-bound nuclease directly cleaves phage DNA during genome injection
https://www.biorxiv.org/content/10.1101/2025.11.03.685801v1
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Kranzusch Lab
Aude Bernheim
2 months ago
Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79). Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky
#Microsky
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Labs in bacterial immunity
https://docs.google.com/spreadsheets/d/1mKy0ALZSbGZsEmt3h20JNQ5MOpVsCQ276HybsMo-t4c/edit?gid=0#gid=0
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Kranzusch Lab
Dr. Cornelius Taabazuing
2 months ago
Check out our latest work led by two talented postdocs, Madhura
@mkulkarni.bsky.social
and Chris. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense!
www.biorxiv.org/content/10.1...
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Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.
Inflammasomes are multiprotein signaling platforms that activate inflammatory caspases to induce pyroptosis. In humans, canonical inflammasomes activate CASP1, which cleaves the pore-forming protein g...
https://www.biorxiv.org/content/10.1101/2025.10.31.685927v1
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Kranzusch Lab
Emmanuele Severi
2 months ago
#microsky
#phagesky
#phage
defence Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
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Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway - Nature Structural & Molecular Biology
Ye et al. define the structure and mechanisms of a bacterial pathway that performs ubiquitination-like protein conjugation, revealing new insights into the evolution and biological roles of ubiquitina...
https://www.nature.com/articles/s41594-025-01696-1
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Kranzusch Lab
Max Renner
2 months ago
Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇
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Kranzusch Lab
Sorek Lab
2 months ago
Last year it was discovered that a single bacterial NLR-like protein can recognize multiple, structurally unrelated phage proteins (Béchon et al, Kibby et al) Now, a new study shows the same for a plant NLR. Another example how principles of immunity remain conserved from bacteria to eukaryotes
add a skeleton here at some point
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Kranzusch Lab
Max Wilkinson
2 months ago
The Wilkinson Lab is open for science!
@mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
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Wilkinson Lab
We discover and study reverse transcriptases
https://wilkinsonlab.bio
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Kranzusch Lab
Landon Getz
2 months ago
Excited to share: DNA glycosylases are diverse antiviral effectors. They recognize phage base modifications and initiate genome destruction. A structure‑guided approach made the scope of this discovery possible! 🧪
#phagesky
doi.org/10.1101/2025...
#phage
#microbiology
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Antiviral Defence is a Conserved Function of Diverse DNA Glycosylases
Bacteria are frequently attacked by viruses, known as phages, and rely on diverse defence systems like restriction endonucleases and CRISPR-Cas to survive. While phages can evade these defences by cov...
https://doi.org/10.1101/2025.10.29.685425
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Kranzusch Lab
Michael Hothorn
2 months ago
By the
@cellsensing.bsky.social
and Zipfel labs: The plant receptor kinase HSL3 senses a cyclic, disulfide-bond stabilized peptide phytocytokine.
www.biorxiv.org/content/10.1...
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Kranzusch Lab
Yuki Haba
2 months ago
How does life evolve to adapt to modern cities? Out now in Science, my PhD work with
@lindymcbr.bsky.social
uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation. 🧵(1/n)
@science.org
www.science.org/doi/10.1126/science.ady4515
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Ancient origin of an urban underground mosquito
Understanding how life is adapting to urban environments represents an important challenge in evolutionary biology. In this work, we investigate a widely cited example of urban adaptation, Culex pipie...
https://www.science.org/doi/10.1126/science.ady4515
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Kranzusch Lab
Duerkop Lab
3 months ago
Excited to share some new work from the lab, led by
@shelbyeandersen.bsky.social
where we developed a method and computational pipeline to identify antiphage defenses across diverse bacterial phyla.
add a skeleton here at some point
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Kranzusch Lab
Shira Weingarten-Gabbay
3 months ago
🚨 Systems Virology Journal Club – 8th Series! 🚨
#BillSchneider
and I are delighted to announce another round of cutting-edge talks in
#SystemsVirology
! 🦠💡 Join us and an outstanding lineup of speakers, starting Oct 30. Free registration:
shiraweingartengabbay.com/systems-viro...
🔬✨
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Kranzusch Lab
Stephen Tang
3 months ago
Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
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Kranzusch Lab
Sternberg Lab
3 months ago
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
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Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
https://www.biorxiv.org/content/10.1101/2025.10.16.682844v1
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Perfect timing in the field for a beautiful review on NAD+ in bacterial immunity by
@hugovaysset.bsky.social
and
@audeber.bsky.social
@cp-molcell.bsky.social
#MicroSky
www.cell.com/molecular-ce...
3 months ago
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Kranzusch Lab
Harmit Singh Malik
3 months ago
Very excited for Jeannette Tenthorey!
@packardfdn.bsky.social
@ucsfhealth.bsky.social
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Jeannette Tenthorey • The David and Lucile Packard Foundation
A staggering 8% of the human genome derives from endogenous retroviruses, ancient evolutionary fossils that have been dismissed as vestiges. Yet recent work has revealed that some of these viral genes...
https://www.packard.org/fellow/jeannette-tenthorey/?cn-reloaded=1
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Kranzusch Lab
Nature Microbiology
3 months ago
The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition By Dustin Glasner, Matthew Daugherty & colleagues.
#microsky
www.nature.com/articles/s41...
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The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition - Nature Microbiology
Viruses generally have compact genomes, resulting in many viral mRNAs with short 5’ untranslated regions. An antiviral complex exploits this feature of viral mRNAs to selectively inhibit viral protein...
https://www.nature.com/articles/s41564-025-02138-w
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Kranzusch Lab
Eduardo Rocha
3 months ago
Two intensive sampling periods of oyster-associated vibrio and their phage, 4 years apart, and many surprises. Despite being washed by the Atlantic, wide tides, and vibrio (almost?) disappearing most of the year, we can find the exact same virulent phages 4 years later (down to 0 SNP)! preprint👇
add a skeleton here at some point
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Kranzusch Lab
Stephan Gruber
3 months ago
Happy that the final version of our Lamassu work
@yli18smc.bsky.social
is now out:
www.nature.com/articles/s41...
Thanks again to our awesome collaborators
@mblokesch.bsky.social
and David and co and Mark Szczelkun and
@steven-shaw.bsky.social
and the DCI Lausanne
@fbm-unil.bsky.social
add a skeleton here at some point
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Kranzusch Lab
Frédérique Le Roux
3 months ago
Phages evolve fast, or do they? In oysters, some stay identical for years. With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements. Proud of this collaborative work across our teams (Roscoff-UdeM and
@epcrocha.bsky.social
www.biorxiv.org/cgi/content/...
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Ecological constraints foster both extreme viral-host lineage stability and mobile element diversity in a marine community
Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...
https://www.biorxiv.org/cgi/content/short/2025.10.10.681744v1
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Differential activation of cGAS in naked mole rats! An exciting addition to our understanding of species-specific mutations tailoring the cGAS-STING pathway in individual organisms
www.science.org/doi/10.1126/...
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A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
https://www.science.org/doi/10.1126/science.adp5056
3 months ago
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Thank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at
@danafarber.bsky.social
@harvardmicro.bsky.social
@harvard.edu
bit.ly/4pZUDkF
blavatnikawards.org/news/items/t...
3 months ago
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Kranzusch Lab
Jason McLellan
3 months ago
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible.
#MacFellow
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Kranzusch Lab
Doudna Lab
3 months ago
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
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Kranzusch Lab
Malcolm White
3 months ago
My pleasure
@erinedoherty.bsky.social
and
@benmorehouse.bsky.social
- for me this was the stand-out discovery of the last year in the field
add a skeleton here at some point
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Kranzusch Lab
Max Fels
3 months ago
Are viruses capable of regulating protein synthesis in the nuanced way of cellular organisms? Kinda! I’m excited to share some of my postdoc work that leveraged giant DNA viruses to address this question.
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Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...
https://www.biorxiv.org/content/10.1101/2025.09.30.678621v1
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Kranzusch Lab
Ben Adler
3 months ago
Today in
@nature.com
, we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out
@erinedoherty.bsky.social
and my work from
@doudna-lab.bsky.social
lab here:
www.nature.com/articles/s41...
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A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
https://www.nature.com/articles/s41586-025-09569-9
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Kranzusch Lab
Ben Morehouse
3 months ago
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today!
www.nature.com/articles/s41...
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The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
https://www.nature.com/articles/s41586-025-09557-z
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