Stephen Tang
@stephentang23.bsky.social
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MD-PhD student at Columbia University | Sternberg Lab | Genome editing and RNA biology
Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
21 days ago
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Our new paper on DRT9 is now online
@nature.com
! This remarkable reverse transcriptase synthesizes homopolymeric DNA to protect bacteria against viral infection. Congrats to all authors!
www.nature.com/articles/s41...
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Protein-primed homopolymer synthesis by an antiviral reverse transcriptase - Nature
Nature - Protein-primed homopolymer synthesis by an antiviral reverse transcriptase
https://www.nature.com/articles/s41586-025-09179-5
5 months ago
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Thought polyA tails were only for mRNA? Here's a protein with a poly-dA tail, that it synthesized itself!
add a skeleton here at some point
8 months ago
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you reached the end!!
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