🦠💊 L’Institut @pasteur.fr vient de publier un communiqué de presse sur nos récents travaux, qui décrivent une nouvelle piste pour augmenter l’efficacité des antibiotiques. #Pasteurdon #Recherche #Science #AMR Merci à toutes celles et ceux qui ont contribué. 📘 English version coming soon!

Many thanks to all those involved, including Jeffrey Liang, who stayed in our lab for several months, our own Charles Bernard and, of course, @fredoleroux.bsky.social and the usual suspects @agencerecherche.bsky.social @erc.europa.eu @cnrsbiologie.bsky.social @pasteur.fr @umontreal.ca etc

Two intensive sampling periods of oyster-associated vibrio and their phage, 4 years apart, and many surprises. Despite being washed by the Atlantic, wide tides, and vibrio (almost?) disappearing most of the year, we can find the exact same virulent phages 4 years later (down to 0 SNP)! preprint👇

Phages evolve fast, or do they? In oysters, some stay identical for years. With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements. Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...

Thrilled to share our two latest papers with the @tcostalab.bsky.social lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species. @imperialcollegeldn.bsky.social www.cell.com/cell/fulltex...

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization: Cell www.cell.com/cell/fulltex...

The ecology and evolution of microbial immune systems: a look on the wild vibrio side Phil. Trans. R. Soc. B by @fredoleroux.bsky.social royalsocietypublishing.org/doi/10.1098/...

👉 Next stop: Montréal! 🇨🇦 Thrilled to join the Canada Society of Microbiology (CSM) conference, June 17-20. Science, community, and reconnecting with old friends — can’t wait!

The study involves our‪ microbiologist @fredoleroux.bsky.social, whom we profiled in late 2023 as a new hire and Canada Excellence in Research Chair: nouvelles.umontreal.ca/en/article/2...

Allo Montreal, 11 juin –18H au café La brassée: "Des sphères aux spirales, des extrémophiles aux probiotiques: plongez dans l’univers fascinant des bactéries ! " Appéro- Science, qui dit mieux? #cinqascience #5ascience

commemorating pride from the clinical microbiology lab

And I've written a few reviews on the subject over the years, but this one is pretty short, so why not start there ;) www.sciencedirect.com/science/arti...

Allo Montreal, 11 juin –18H au café La brassée: "Des sphères aux spirales, des extrémophiles aux probiotiques: plongez dans l’univers fascinant des bactéries ! " Appéro- Science, qui dit mieux? #cinqascience #5ascience

🧬 Bacteria fight both antibiotics and viruses with the same genetic tool: integrons! New study (Institut Pasteur, CNRS, Université Paris Cité & Montréal): ~10% of gene cassettes may defend against phages. 🛠️ One step closer to smarter therapies. 🔗 www.pasteur.fr/en/research-...

Exciting news!! Our latest paper is out in Nat. Microbiol. @natmicrobiol.nature.com We show that a sub-lineage of 7th pandemic V. cholerae has acquired mobile genetic elements packed with phage defense systems—rendering it multi-phage resistant 😳 ..... 1/3 www.nature.com/articles/s41...

Allo Montréal, prochain Cinq à Science, 14 mai, le microbiote intestinal par Corinne Maurice, mc Gills 🙂

Have also a look at our back-to-back study for mobile integrons by Nicolas Kieffer from @jaescudero.bsky.social group ! www.science.org/doi/10.1126/... + a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social www.nature.com/articles/s41...

An enormous thanks for the great co-first author @eloilittner.bsky.social and for our supervisors @celineloot.bsky.social @epcrocha.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social. Many thanks to all co-authors !!

On the bioinformatic side, eloilittner.bsky.social found a diverse arsenal of anti-phage defenses in SCIs. Strikingly, systems in integrons are always compact (< 3 genes), and smaller than their homologs outside integrons (likely due to cassette size constraints)

The integron of our favorite model Vibrio cholerae was mostly “dark matter” as most cassettes had no known role. We found this intriguing and cloned 88 cassettes, testing them for phage resistance. We found 16 defensive cassettes and named the systems after gallic mythology

White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...

Habemus paper! Our story on integron-encoded anti-phage defenses is now out in @science.org! 16 new systems, small versions of known ones, and a lot more in this highly-collaborative study. Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social bsky.app/profile/bapt...

Allo Montréal! Prochain Cinq à Science, le 14 mai, 6pm, Corinne Maurice, Mc Gill, Microbiote intestinal. #cinqascience

Pas de recul. / No retreat. Pas de silence. / No silence. Pas de haine chez nous. / No hate here. 🇨🇦 Liberté, justice, solidarité. / 🇨🇦 Freedom, justice, solidarity. Résistons ensemble! ✊ / Let’s resist together! ✊ #CanadaLibre #DefendDemocracy #LoveWins

🚨 Postdoc Alert! Join my lab @ Montréal’s Faculty of Medicine via the 2025 CIB Fellowship Competition 🧬 Project: “The Paradox of Parasitism” – bioinformatics + marine parasite evolution 💸 $63,819/yr + full benefits (2 yrs) Apply 👉 cibmontreal.ca/en/news/laun...

New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!

Allo Montréal, demain, venez écouter Karine Dufresne sur le monde mystérieux du microbiote vaginal! #cinqascience #5ascience

Great collaboration with @fredoleroux.bsky.social . Kudos for everyone, esp. Charles Bernard & Yannick Labreuche. Thanks to the funders and @pasteur.fr @cnrsbiologie.bsky.social @umontreal.ca @sbroscoff.bsky.social Here's the paper in OA: doi.org/10.1093/isme...

🌏🌿🦈 Mark your calendars and join #EESWildModels! Learn how exploring the wild frontiers of model systems is increasing our understanding of the biology, ecology, and evolution of organisms, ranging from microbes to plants and animals. Submit abstract by 14 Jan 👉🏻 http://s.embl.org/ees25-02

Allo Montréal, prochain Cinq à Science, venez découvrit le monde mystérieux du microbiote vaginal! #cinqascience #5ascience

Allo Montréal, prochain Cinq à Science, venez découvrit le monde mystérieux du microbiote vaginal! #cinqascience #5ascience

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See lnkd.in/dVVk4N3s. #microsky

C'est chouette d'aimer le post, et c'est encore mieux de le diffuser ;-)

allo Montréal c'est demain!

allo Montréal c'est demain!

Allo Montréal, prochain "Cinq à Science" se tiendra le 12 mars, à la brassée, Fred Sorgeloos nous parlera virus eucaryotes (il n'y a pas que les phages dans la vie ;-) #cinqascience

Allo Montréal, c'est demain! Un aspect des microbes rarement raconté au public (comme aux chercheurs!)

Allo Montréal, notre prochain Cinq à Science aura lieu le 12 février à la brassée. Sebastien Zappa nous parlera d'art microbien. Au plaisir de vous y voir! #cinqascience #5ascience

Bienvenue à la SCM2025 et à Montréal! event.fourwaves.com/fr/scm-csm20...

Allo Montréal, notre prochain Cinq à Science aura lieu le 12 février à la brassée. Sebastien Zappa nous parlera d'art microbien. Au plaisir de vous y voir! #cinqascience #5ascience

Perfect illustration for today

10 years...

New preprint. Large genomes vibriophages have it all: multiple functions, autonomy (full set of tRNA genes!), anti-defenses, broad host range. Yet, they remain rare, pinpointing the limits of generalists. Great collaboration with @fredoleroux.bsky.social led by Charles Bernard in our lab.

Excited to share our latest preprint on the genetic and evolutionary mechanisms behind the generalism of the Schizotequatrovirus (T4 giant vibriophage). Another great collaboration with @epcrocha.bsky.social and a relay effort from my lab in Roscoff to Montreal University biorxiv.org/cgi/content/...

Excited to host our first EDI seminar as part of my CERC! Thanks to Yannick Fouda, CEO of MyLumen (mylumen.ca), 'International Students: Understanding the Challenges to Better Support Them.' We ended with a warm raclette—convivial moments make all the difference! 🧀🌍 #EDI #CERC #Inclusion

Bravo, Manon Lang, on an amazing conference! Your talent for breaking down complex science so that anyone can understand it is truly remarkable. 👏🎉 @cinqascience.bsky.social

Exciting times! Our latest preprint is now live 🤩! After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n www.biorxiv.org/content/10.1...

Hey peeps! Manon, postdoc in @fredoleroux.bsky.social lab, will talk about antibiotic resistance on 11/27 for the next Cinq à Science (in French)! Do come support and get immersed in a joyful discussion! 🦠💊 #cinqascience #5ascience #montreal #antibioticresistance tinyurl.com/ycyz3cbc