The last paper from our lab and our friends @mmarbout.bsky.social Ole Skovgaard @rkoszul.bsky.social. A milestone!

This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out! doi.org/10.1038/s414...

🚨 We're hiring! A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

Caution: Artificial intelligence tools contract science’s focus.... www.nature.com/articles/s41...

a quick reminder!

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...

Phenomenal! WOOOOOOOW .... speechless www.nature.com/articles/s41...

Let’s wrap things up: my commentary on the Asgard hypernucleosomes. Congratulations to all the authors of the paper 🍾! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity. academic.oup.com/nar/article/... 1/5

A fresh view on phage specificity, which challenges the traditional view of a narrow host spectrum of phages by unveiling that multihost associations are common across ecosystems kudos at @mmarbout.bsky.social & @rkoszul.bsky.social www.nature.com/articles/s41...

I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...

Striking and frightening 😒 "They found multiple instances of insecticide-resistance variants in this malaria vector, although most of these weren’t shared with museum specimens collected as recently as 1967, suggesting rapid emergence" www.science.org/doi/10.1126/...

Congratulations to PhD students Jasmin Ostermayer and Noa Guzzi (co–first authors 🎉), together with Jakub Czarnecki and Alfonso Soler-Bistué, for compressing the diverse, lineage-wide literature on large extrachromosomal replicons into <5000 words and 80 references 😅

For those who love bacterial replicons, The ultimate review, from our lab, signed by the master of their evolution. ‪@val-meve.bsky.social‬ www.sciencedirect.com/science/arti...

Message received…

A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon research.pasteur.fr/en/job/a-two...

A 2 yr postdoc position at the Bacterial Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇

A great step for archaea : connection between chromosome organization to genome segregation in Archaea www.nature.com/articles/s41... congrats to @danielabarilla.bsky.social

Thrilled to share my first PhD paper, out of the Mazel lab! @amazeld.bsky.social We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies doi.org/10.1101/2025...

Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...

very interesting! congrats Ankur! www.biorxiv.org/content/10.1...

Next Tuesday Clement Gilbert and myself will discuss impact and extent of HGT in both prokaryotes and eukaryotes! It will be broadcasted on France Culture (in French)

A spectacular discovery! Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus | Science www.science.org/doi/10.1126/...

La directrice de l'Institut Pasteur prévient que "les maladies infectieuses ont toujours représenté un risque, mais elles sont aussi l’une des principales menaces de santé publique à l’avenir." Longue interview, morceaux choisis ⤵️ @leparisien.fr 1/12 www.leparisien.fr/so...

7/ The actors (II) This was truly a memorable collaborative experience, involving multiple labs: Eric Le Cam (Gustave Roussy), Ole Skovgaard @oskov.bsky.social (Roskilde University), Abel Garcia-Pino (Université libre de Bruxelles), and the Mazel team @amazeld.bsky.social at Institut Pasteur !

8/ 🌍 Broader implications This study not only highlights the elegant coordination of replication between Chr1 and Chr2 in Vibrio but the mechanism described here may reflect a broader strategy used by bacteria to integrate and stabilize secondary replicons derived from ancestral plasmids.

1/ 🔬 Our work, "Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae", is now published in Nature Communications. Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵 Link : www.nature.com/articles/s41...

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...

PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or antibiotic resistance. Deadlines in January... www.findaphd.com/phds/?Keywor...

It is time to register:https://research.pasteur.fr/fr/course/resistance-to-antibacterial-agents-mooc/

Bacteria: the solution to everything 😍! www.nature.com/articles/s41...

A very interesting review! 👏 @mucosalimmunology.bsky.social, Mederic and others !https://www.embopress.org/doi/full/10.1038/s44321-024-00149-4#Fig3

Amazing story! kudos @GenevauxPierre and colleagues! the precise mechanism of MenT3 toxicity in M tb. www.nature.com/articles/s41...

Let’s start #Vibrio2024 !

Plasmids are essential drivers of bacterial evolution, but most of them lack conj° genes, yet they spread... @epcrocha.bsky.social and @M_AresArroyo developed a computational method for discovering new oriTs, identifying 21 new oriTs in nosocomial pathogens plasmids www.biorxiv.org/content/10.1...

I am particularly proud of this study from our laboratory, which explains how integrons have set up a kind of second-order selection. It reminds me of the time of the papiers on the selection of mutators to resist ABs. @FrancoisTaddei, Miro, Ivan, Jesus... www.science.org/doi/10.1126/...

nature.com/articles/s41... a collaborative success of CelineLoot (+ the rest of the PGB lab) with @epcrocha.bsky.social and the Biomics hub from the Pasteur

@amazeld What we report in this new article is 2 major discoveries for the price of one: - 10 % of bacterial genomes carry isolated cassettes!, even archaeal ones! - They integrate through sites that differs from the canonical attC end attI, unmasking what we have called attG.

Dear TE family, it is time! 🏃‍♀️🏃‍♂️ The early-bird registration ends January 15th already! Abstract for talks ends February 15th! Start procrastinating by doing something useful: register to #icte2024 ! See you soon! #transposon

Our Department at University of Lausanne is recruiting a tenure-track Assist. Prof. on microbial interactions linked to the nccr-microbiomes.ch Don't miss this opportunity to join a friendly, dynamic department in a city with hard-to-beat quality of life. Apply tinyurl.com/4k2mevax by Jan 31! 🧪

Just posted, Mazel et al. on how aminoglycosides, a critical class of antibiotics, function, interact with other antibiotics, and stress out Gram-negative bacteria #mmbr #ASMicro doi-org.colorado.idm.oclc.org/10.1128/mmbr... @amazeld.bsky.social

This week we had our annual meeting for the JPIAMR project MOB-TARGET. Two days of great scientific exchange and lots of fun at the Residencia de Estudiantes-CSIC in Madrid @craigmaclean.bsky.social @brockhurstlab.bsky.social @jaescudero.bsky.social @amazeld.bsky.social

Kudos to Justine Collier, Florian Fournés, and the others biorxiv.org/content/10.1... GREAT DISCOVERY : Agrobacterium controls its 2 chromosomes replication timing similarly to cholerae but with a COMPLETELY DIFFERENT SETUP.