Excited to share our new Perspective in npj Antimicrobials & Resistance: "Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment.” www.nature.com/articles/s44... 1/3 #AMR #microsky

How do loci for bacterial capsules (Klebsiella) manage to get swapped around despite their outstanding phenotypes? They just plug and play, having little impact on the rest of the genome. Kudos to @julielebris.bsky.social , check her thread below

Continuing work on our exhibition #microbes 🎨 Honored by a talk from Prof. Itzik Hen, director of The Institute for Advanced Studies Jerusalem and a researcher, followed by a food tour at Mahane Yehuda Market, and a recital by Ido Grinshpan and Shelly Jonathan.🎻 Stay tuned for #exhibition details! 🦠

Sometimes you meet absolutely incredible bioinfo-magicians. It was a huge privilege when @shenwei356.bsky.social joined our group for a year on an @embl.org sabbatical. While here, he developed a new way of aligning to millions of bacteria, called LexicMap 1/n www.nature.com/articles/s41...

Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social #microsky #phagesky

Thrilled to share our two latest papers with the @tcostalab.bsky.social lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species. @imperialcollegeldn.bsky.social www.cell.com/cell/fulltex...

Our second paper with @tcostalab.bsky.social and GoogleDeepMind reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology. www.cell.com/cell/fulltex...

Antimicrobial Resistance (AMR) could cause 10 million deaths by 2050. At PLAS-FIGHTER, we are working to change this! 🔎 We study how plasmids spread resistance to open up new avenues for future containment and diagnostic strategies. Find out more 👇 plasmidlab.es/project/ #AntibioticResistance

For anyone who has used pling for comparing plasmids using rearrangement distances ("how many structural events apart are these plasmids"), here's how to tweak parameters, and integrate it with typing info, and the host phylogeny www.biorxiv.org/content/10.1... github.com/iqbal-lab-or...

Lots of heterogeneity in capsule production in Klebsiella and Acinetobacter. Given the pleiotropic impact of capsules, this provides opportunities for multiple types of phenotypical heterogeneity. Check @julielebris.bsky.social thread on our recent publication.

El grupo de Álvaro San Millán revela el coste de mantener la resistencia en enterobacterias El trabajo traza un mapa funcional del plásmido pOXA-48, con potencial para guiar nuevas terapias contra resistencias bit.ly/4p0fCmY @sanmillan.bsky.social @aliciapcv.bsky.social @jorgesastred.bsky.social

With over a million deaths annually linked to antibiotic resistance, tackling this crisis is urgent. At the PBE lab, we study how plasmids adapt and spread in real-world settings, such as the gut microbiota of hospitalized patients. Fighting #AntibioticResistance!

The session of Microbial adaptations to changing environments chaired and organized by @sanmillan.bsky.social @javierdelafuente.bsky.social @mtoll8.bsky.social just started by extremely inspaireing talk by @saramitri.bsky.social so much fun at the @eseb2025.bsky.social

Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨ 👉 www.nature.com/articles/s41... @cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social

First of all, we recommend reading a complementary study led by Yannick Baffert and @sbigot.bsky.social, in which they use Tn-seq to study the genetic determinants of pOXA-48 in plasmid maintenance and conjugation. Really cool piece of work that reaches similar conclusions to ours! 2/14

New paper out!

For those who love bacterial replicons, The ultimate review, from our lab, signed by the master of their evolution. ‪@val-meve.bsky.social‬ www.sciencedirect.com/science/arti...

See how phi3T phage shifts Bacillus subtilis cell shape in the absence of SPbeta prophage and alters its fitness - our new publication in @commsbio.nature.com from group of @annadragos.bsky.social together with @bramkamplab.bsky.social www.nature.com/articles/s42...

We are also hiring a 4-year postdoc to study the dynamics and evolution of mobile genetic elements in the C-fixing Icelandic host-spring microbiomes Join our exciting multidisciplinary team funded by @ukri.org BBSRC sLoLa www.jobs.manchester.ac.uk/Job/JobDetai...

As part of the ENW-XL UTIr project we have developed a novel fully defined synthetic artificial urine medium for urinary bacteria. www.biorxiv.org/content/10.1... #UTISky #AMR #MicroSky #MicrobiomeSky #InfectiousDiseases #ClinMicro

New paper in collaboration with the @asantoslopez.bsky.social lab! www.biorxiv.org/content/10.1...

Oxygen levels can affect how resistance genes work, impacting antibiotic efficacy. This can be relevant for the most used ones: for example, resistance to fosfomycin varies with oxygen. Learn more in our latest paper 👉 bit.ly/3T8sdpp a work led by @jaescudero.bsky.social #AntibioticResistance

A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon research.pasteur.fr/en/job/a-two...

New pre-print from my lab! Plasmids link antibiotic resistance and phage defense. E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!! #microsky#AMR#phage www.biorxiv.org/content/10.1....

Nice! Updating the classic “mobility of plasmids”. Probably the paper I’ve cited the most during the last 15 years. journals.asm.org/doi/10.1128/...

New paper alert! 🚨 Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate. We combine theory, simulations, experimental evolution, and bioinformatics to demonstrate that mutation rates scale with plasmid copy number. Let's dive in! 🧵👇

Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉 🧵 (1/14) www.doi.org/10.1038/s414...

Our latest paper explores the factors shaping plasmid-bacteria associations and highlights why studying plasmid-host interactions of clinical relevance is key for understanding the evolution and spread of AMR. Find out more 👉 plasmidlab.es/publications/ #AntibioticResistance

How may theoretical ecology & evolutionary theory push microbiology forward? At Environmental Microbiology, I am commissioning a series of Perspectives exploring that question. Excited to share them in the 🧵 below The series is open, so do get in touch if you'd like to propose a new contribution!

Plasmids are small, mobile DNA elements that enable bacteria to exchange genetic material, including genes for antibiotic resistance. We study these genetic vehicles with the aim to uncover how they facilitate the emergence and persistence of antibiotic-resistant pathogens. #AntibioticResistance

A few hours left for you to sneak in a cheeky last minute abstract! ECRs, you know what to do… #mevosky

It was an honor and a joy to receive the National Research Prize for Young (!) Researchers. The highlight? My grandma greeting the King of Spain. What a day! www.youtube.com/watch?v=oSQP...

Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨 doi.org/10.1038/s414... We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇

PLASFIGHTER’s results could lead to potential applications:  🔸 New compounds targeting bacteria carrying AMR plasmids  🔸 Methods to rapidly detect plasmid-driven resistance and limit its spread 🔸 Approaches reducing microbiome damage from antimicrobial treatments  #AntibioticResistance

Under the PLASFIGHTER project, we drive innovative solutions against AMR. 🔹 We use CRISPRi to dissect plasmid and multidrug-resistant enterobacteriaceae interactions 🔹 Through multi-omic data, we model real-world environments where AMR evolves  Learn more 👉 plasmidlab.es #AntibioticResistance

Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team. Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵 www.biorxiv.org/content/10.1...

For those that missed it this morning, our paper describing Noodlococcus (and what it has taught us about the evolution and taxonomy of Kocuria rhizophila) is now on BioRxiv www.biorxiv.org/content/10.1...

Through the new PLASFIGHTER project, we drive significant advances in unravelling and fighting AMR. We study plasmid-bacteria interactions to answer important questions about their role in generating and maintaining superbugs. Discover the project ➡️ plasmidlab.es/project/  #AntibioticResistance

Sexually transmissible shigellosis has gone from an obscure cause of sporadic outbreaks to a sustained endemic AMR priority in only two decades! 🧫💊 Check out our latest preprint to understand how this happened 1/11 www.medrxiv.org/content/10.1...

Exciting news!! Our latest paper is out in Nat. Microbiol. @natmicrobiol.nature.com We show that a sub-lineage of 7th pandemic V. cholerae has acquired mobile genetic elements packed with phage defense systems—rendering it multi-phage resistant 😳 ..... 1/3 www.nature.com/articles/s41...

Delighted to see this paper from danderson123.bsky.social 's PhD out. We have been building tools for AMR gene detection for over a decade now, but multicopy genes remain challenging. Dan shows that with a gene-space de Bruijn graph and long reads, you can do well www.biorxiv.org/content/10.1...

1/6 Excited to share our review 🚀 🧬 CRISPR–Cas therapies targeting bacteria! #MicroSky

New preprint led by @brunoluviano.bsky.social & Fernando Santos. We show that filamentation enhances bacterial survival under toxic stress — not as collateral damage, but as a regulated morphological response. TL;DR: Filamentation isn’t a symptom, it’s a strategy! www.biorxiv.org/content/10.1...

New opinion paper from the lab! www.cell.com/trends/micro...

Our updated lab website is live! We’ve kicked off a new project and a new look with it. Take a look and let us know what you think! 👉 plasmidlab.es

🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 www.science.org/doi/10.1126/...

Can resistance genes really hold their breath like pros? 🤔🤿 Outstanding work by Laura, Amalia, Nico and Ester from @jaescudero.bsky.social lab in collab with @sanmillan.bsky.social, Fernando Baquero and Rafael Cantón. Dive into our latest paper to find out! 👇🏼 www.sciencedirect.com/science/arti...

Phage satellites are now known to be very diverse, numerous and ancient. They pose many evolutionary, ecological and mechanistic questions. Lots of fun in perspective! Great pleasure to write this review to show it, with @jrpenades.bsky.social @dbikard.bsky.social Kim Seed & John Chen.

New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!

Our latest paper, in which @brinda.eu (along with @zaminiqbal.bsky.social and others) introduces phylogenetic compression for storage and search of enormous microbial genome libraries, was published today in @naturemethods.bsky.social: rdcu.be/eg4OA 1/