How does treatment induced antibiotic resistance happen in real-world infections? We analysed 25k Pseudomonas isolates from 180 patients in a clinical trial to find out! TLDR: The ecological and evolutionary paths are surprisingly diverse & complex even in patients receiving identical treatment…

🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover. 🔗 www.biorxiv.org/content/10.6...

New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...

New preprint: www.biorxiv.org/content/10.6...

New preprint!👇 Pyruvate secreted by P. aeruginosa acts as a signaling molecule during infection, reducing oxidative stress, dampening immune activation and promoting persistence Bacterial metabolism isn’t just a background process but an active player in infection🦠🧫 www.biorxiv.org/content/10.6...

The @imili-micro.bsky.social project is such a beautiful and necessary initiative! I am really glad we could contribute. Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text - @cbitoulouse.bsky.social

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-10: @pablolaborda.bsky.social @crisherencias.bsky.social @pharmageddon.bsky.social @ecdc.europa.eu @eberllab.bsky.social the ESKAPE Rogues grupos.eez.csic.es/imili/wp-con...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-11: @pablolaborda.bsky.social @crisherencias.bsky.social @pharmageddon.bsky.social @ecdc.europa.eu @eberllab.bsky.social the ESKAPE Rogues grupos.eez.csic.es/imili/wp-con...

The NoticiaSEM: an excellent monthly newsletter for Spanish-speaking microbiologists, now celebrating its 200th edition. It also publishes Portraits from the IMiLI. On the occasion of its 200th "birthday", it published an IMiLI "MicroChat" on......birthdays. www.semicrobiologia.org/revista-noti...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-5 @pablolaborda.bsky.social How we can fight AMR imili.org/new_gallerie... @sbigot.bsky.social

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-6 @pablolaborda.bsky.social, @crisherencias.bsky.social How we can fight AMR imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7 @pablolaborda.bsky.social @crisherencias.bsky.social How we can fight AMR imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-8 @pablolaborda.bsky.social @crisherencias.bsky.social How it works imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-9 @pablolaborda.bsky.social @crisherencias.bsky.social How it works imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-4 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-3 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-2 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-1 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

New preprint out! 📣🚨 We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠 #Microsky

We just opened the Bluesky account of the International Microbiology Literacy Initiative (IMiLI) headed by Ken Timmis. Follow us to know more about the initiative or even better become one of our volunteers to bring Microbiology to kids all ages around the world 🦠 🏫

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

New paper out! 🔈🔈📣📣 Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation. Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻 www.biorxiv.org/content/10.1...

Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)

Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉 🧵 (1/14) www.doi.org/10.1038/s414...

🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...

Una nueva investigación identifica un mecanismo molecular que interviene en la pérdida de la resistencia bacteriana al antibiótico ciprofloxacino. 📰Lee aquí más información: bit.ly/4mMl2AN DOI: bit.ly/43uUtbT

Aquí os cuentan mis compañeras Susana de Lucas y Jennifer Palencia, de Comunicación y Cultura Científica del @cnb-csic.bsky.social, nuestro último trabajo. Describimos una estrategia de base evolutiva para eliminar la resistencia a ciprofloxacino en aislados clínicos de P. aeruginosa. Felices! 🤩

Check out this cool collaboration with @hernando-amado.bsky.social, just out in @natcomms.nature.com! We show that ciprofloxacin resistance rapidly declines in clinical P. aeruginosa strains under drug-free conditions, suggesting that ciprofloxacin restriction periods could help in clinics 🦠🧫

Ceftazidime-avibactam (a last resort drug) use selects multidrug-resistance and prevents designing collateral sensitivity based therapies against P. aeruginosa (no robust patterns emerge). Happy to see it published! 🥳 @cnb-csic.bsky.social @idisba.bsky.social www.nature.com/articles/s41...

Are you a #Pseudomonas researcher? Please take our survey and help shape the direction and priority of future pseudomonas.com database development: forms.gle/gTPT6ruf3mqb... #microsky #idsky

Last month, I had the chance to share my research in my hometown – more than 7 years since I did my bachelor’s degree over there! Today, the local newspaper @heraldo.es features some insights from the event participants about their research (and life) abroad www.heraldo.es/noticias/ara...

Our group is looking for a PostDoc with a strong background in molecular microbiology, strain design and genetic engineering. Join us at DTU to work on bacterial infections and antimicrobial resistance! www.rigshospitalet.dk/job-og-uddan...

⚠️ Job(s) alert! ⚠️ We are launching a new postdoctoral program in Systems Biology at IBFG. Join us! 👉 Several positions available with competitive work conditions for up to 4 years 📄 More info: jdiazc9.github.io/files/jobs/2...

📣 Postdoc Position open in our lab m in Madrid. If you are motivated with AMR transmission using Genomics and Metagenomics for the next 3 years send your cv and a motivation letter to [email protected] #OneHealth @ucm.es @escmid.bsky.social

Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms -in NPJ Biofilms and Microbiomes from Andrea M. Smania (Argentina) www.nature.com/articles/s41...

www.nature.com/articles/s41... New paper out!!

Sharing three fully funded PhD opportunities to join my lab at Queen’s to work on topics spanning bacterial pathogens, antibiotic resistance, microbial interactions, & mobile genetic elements 🦠. Closing dates in January and February, and open to international candidates 🌍 Projects detailed below ⬇️

How can the use of adjuvants improve the effectiveness of antibiotics and reduce the burden of antimicrobial resistance? Check our latest review! Gil-Gil T, @pablolaborda.bsky.social & JL Martínez. www.tandfonline.com/eprint/ZC5JQ...

Join our #MicroClock @microclockerc.bsky.social #ERCSyG team as #Postdoc to discover the components of a bacterial circadian clock Apply by 17 Jan 2025, if you have experience -with liquid handling robots/screening of bacterial strains -in molecular biology of model bacteria tinyurl.com/2d2c8fe5

Podemos solicitar juntos este contrato predoctoral si quieres hacer la tesis en Ecología y Evolución de la Resistencia a los Antibióticos. www.cnb.csic.es/index.php/es... Más info en 🐥👇

Yesterday was a very special day where we celebrated the career and legacy of José Luis Martínez. We were able to learn some life lessons from him once again - he will be truly missed as an active researcher! It was a also pleasure to reconnect with so many friends at @cnb-csic.bsky.social 😁

The Pseudomonas Genome Database is now on Bluesky with the Pseudomonas.com web address! We encourage using the #pseudomonas hashtag to note interesting research #pseudomonas #bacteria #microsky #idsky #PsWatch

Just did my first Starter Pack, I think it can be useful. Let me know if you miss any journal and I will add it. Enjoy!! go.bsky.app/QPFZpj9

JL Martínez has been included on the @Clarivate Highly Cited Researcher list (Microbiology field) 2024. On November 28 we will pay homage to him for his great contributions to the Ecology and Evolution of Antibiotic Resistance field at @CNB_CSIC. clarivate.com/highly-cited...

Hello #MicroSky community, we would love to reconnect with you here. FOLLOW US for studies related with Microbiology and its applications 🧫 🦠

Jose Luis Martinez—not active in social media ☹️—a legend of Spanish Microbiology will retire soon. His friends & colleagues have organized this Nov 28 a warm homage in celebration of his lifelong dedication to Microbiology & his many contributions to Ecology and Evolution of antibiotic resistance 👏

Este premio PRAN a la mejor publicación científica es también de Pablo Laborda y JL Martínez. Gracias a la Agencia de Medicamentos y Productos Sanitarios, a la financiación y al director del CNB, Mario Mellado, por su apoyo a los jóvenes científicos que empezamos nuestra carrera independiente.

👋 Hi, #MicroSky community! I’m a postdoctoral researcher at the Technical University of Denmark, where we study the ecology and evolution of antibiotic resistance and the infection microbiology of Pseudomonas aeruginosa. Excited to join this space and share insights from my work!