#microsky #phagesky CRISPR-cas galore www.nature.com/articles/s41...

New paper with my (amazing) friend and mentor @jrpenades.bsky.social Really looking forward to see what plasmid aficionados think of this one!! With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others www.cell.com/cell-reports...

New pre-print www.biorxiv.org/content/10.1... Plasmid-dependent phage (PDPs) are ubiquitous, but the selective pressures that they impose on plasmids are not well understood. Project led by Daniel Cazares in collaboration with @brockhurstlab.bsky.social! #phagesky#microsky

New paper online at @nature.com from co-leads @erinedoherty.bsky.social + @benadler.bsky.social !

🔬PPU 2025 Call for Candidates - Discover the PhD projects Today's featured projects: 4 Cell Biology & Infection projects and 2 Parasites & Insect Vectors projects 🗓 Applications deadline: October 20, 2025 📍Program starts: October 2026 Discover all projects & apply now: bit.ly/4nlPz8x

Very happy to see this one out: doi.org/10.1093/molbev/msaf192 Here, we assessed the contribution of natural transformation to the acquisition of novel genes. See preprint thread. @molbioevol.bsky.social #microsky #evobio

El grupo de Álvaro San Millán revela el coste de mantener la resistencia en enterobacterias El trabajo traza un mapa funcional del plásmido pOXA-48, con potencial para guiar nuevas terapias contra resistencias bit.ly/4p0fCmY @sanmillan.bsky.social @aliciapcv.bsky.social @jorgesastred.bsky.social

Have you ever wondered what increasing environmental stress will do to microbial communities? In our new preprint, @martinadalbello.bsky.social, Jeff Gore and I studied the impact of salinity on microbial community composition and function. 🧵 (1/5) www.biorxiv.org/content/10.1...

#NatMicroPicks AI Designs Next-Gen Antibiotics! 💊🤖 Generative deep learning and genetic algorithms created structurally novel antibiotics that effectively target drug-resistant bacteria, offering a powerful new tool to combat drug resistance. #MicroSky #AMR www.cell.com/cell/abstrac...

Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨ 👉 www.nature.com/articles/s41... @cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social

🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...

For those who love bacterial replicons, The ultimate review, from our lab, signed by the master of their evolution. ‪@val-meve.bsky.social‬ www.sciencedirect.com/science/arti...

This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

#NewResearch Prion-like proteins in Escherichia coli trigger an abortive infection mechanism in response to phage infection—a process similar to amyloid-mediated immune signalling in fungi and animals. #MicroSky 🦠 www.nature.com/articles/s41...

Very happy to be a (small) part of this story! The role of plasmid-encoded ISs in the acceleration of AMR evolution, through inactivation of different bacterial genes.

White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...

Mapping of DNA-binding sites for 139 E. coli transcription factors and A neural network that predicts binding energy from DNA sequence and can be used to design new binding sites #NeuralNetworks #MachineLearning #Genomics

Hoy no te pierdas la charla de nuestra compañera, @aliciapcv.bsky.social, investigadora en el #CNB_CSIC en la X edición de @pintofscience.es 🕢19.45h 📍Mercado de San Leopoldo ( Distrito Tetuán, Madrid) ℹ️👇 pintofscience.es/event/viajan...

I *finally* get to share our work on plasmid competition– super proud to now have this on bioRxiv: CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred www.biorxiv.org/content/10.1... 1/6 👇

cool preprint from a few months back: www.biorxiv.org/content/10.1... Really intriguing IS strategy to become fixed in plasmids, where the IS cuts up any plasmid that doesn't contain the insertion sequence

Today, we Portuguese around the globe celebrate #25deAbril, also known as the Carnation Revolution. As fights for Democracy go, this one is a particularly beautiful one. 25 de Abril sempre, fascismo nunca mais 🌹

Preprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons @shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...

New online! Interactions and evolutionary relationships among bacterial mobile genetic elements

The Eligo team did it again! We just shared on biorxiv the work we did towards the development of a CRISPR-Cas therapy targeting Shiga Toxin producing E. coli (STEC). www.biorxiv.org/content/10.1...

I just posted "Some Experiments Work, and Some Don't." It features this new paper from Paul Rainey's group, along with a *failed* experiment that Paul Sniegowski and I ran in the 1990s trying to test the same idea. telliamedrevisited.wordpress.com/2025/02/21/s...

C. acnes is the most abundant bacterium on human skin. But what if we could make it the smarterst? 🦠✨ In our new @cellpress.bsky.social #CellSystems study, we programmed C. acnes to actively protect the skin for therapeutic applications! 🛡️ authors.elsevier.com/sd/article/S...

Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025... Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium @inrae-france.bsky.social[email protected][email protected]! Many thanks for this great journey!🙌

Happy International Day of Women and Girls in Science 👩‍🔬🧬 #womeninscience #girlsinscience

Hoy en el Ciclo #VisiblesCNB ampliamos nuestra mirada hacia las ciencias sociales con la ponencia de Mercedes Álvarez, profesora de Comunicación en @uc3m.es sobre la representación de género y su evolución en la animación. @csic.es @csicdivulga.bsky.social #DíaMujeryNiñaCiencia #TodasHacemosCiencia

Happy to share our latest piece of work on the PARIS bacterial immune system. We performed a detailed characterization of the AriB Toprim nuclease, the effector of PARIS immunity. www.biorxiv.org/content/10.1...

Exciting to see our paper now published 🙌 www.science.org/doi/10.1126/... In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇

¡Acompáñanos el 6 de febrero a las 10:00h en el CNB! Con motivo del #11F #díamujeryniñaenciencia, tendremos una interesante conferencia sobre personajes de animación, con Mercedes Álvarez San Román, profesora de Comunicación de la @uc3m.es #TodasHacemosCiencia @csic.es @csicdivulga.bsky.social

Could not recommend this fellowship and program enough.

The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky

Here's our new preprint led by @aleciarokes.bsky.social and @vscooper.micropopbio.org We investigated how two isolates obtained before and after clinical antibiotic use adapt to tigecycline. Hope you like it!

New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time. www.biorxiv.org/content/10.1...

New preprint from our Lesterlin Lab! Yannick Baffert and @nfrk92.bsky.social, in collaboration with @macerwan.bsky.social and @val-meve.bsky.social, shed light on the molecular mechanisms driving pOXA-48 plasmid maintenance and transfer. We reveal novel TA system, regulators, and T4SS components!

🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

✨Rethinking life's origins: Could stable molecular networks, or 'evosystems,' have kickstarted evolution before traditional reproduction?✨ An hypothesis paper by @vdlorenzo.bsky.social, @brionesci.bsky.social & colleagues https://academic.oup.com/microlife/article/doi/10.1093/femsml/uqae025/7931236

⚠️ Job(s) alert! ⚠️ We are launching a new postdoctoral program in Systems Biology at IBFG. Join us! 👉 Several positions available with competitive work conditions for up to 4 years 📄 More info: jdiazc9.github.io/files/jobs/2...

Proud Pasteurienne over here :)

Interested in the plasmidverse? Then, don't think twice and join the International Society for Plasmid Biology Virtual Seminars Series. 👇

What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret. www.biorxiv.org/content/10.1... Interactive UMAP to have fun mdmparis.github.io/antiphage-la...

🚨PhD studentship opportunity! Bacteria protect themselves with a huge arsenal of defences, but does this affect how they gain new traits on plasmids? 🧫🦠💫 Apply for a funded 4y position with me @livuni-ives.bsky.social, @brockhurstlab.bsky.social @jojofoth.bsky.social & @multidefence.bsky.social ⬇️

I'm new here, so I'll share our recent work here too 😁🧫 Using Tn-seq + live imaging in engineered airway organoids, we explored the fitness tradeoffs P. aeruginosa faces while growing and surviving antibiotic treatment on the mucosal surface. Check it out: www.nature.com/articles/s41... #MicroSky

Very happy to see this work published! We unveil a plasmid-chromosome crosstalk by showing that pOXA-48 encodes for a regulator that mediates the transcription of an enterobacterial chromosomal operon, resulting in a growth benefit for the plasmid-carrying bacteria! www.nature.com/articles/s41...

Now updated! www.biorxiv.org/content/10.1...

Excited to share that we have just released genomenotebook 1.0 together with @trichomedoctor.bsky.social ! If you like to analyze genomics data in Jupyter notebooks this is for you. You can get beautiful genome browsers directly in your notebooks: dbikard.github.io/genomenotebo...

PhD opportunity in St Andrews on plasmids, antibiotics and defence systems, in collaboration with Helen Alexander in Edinburgh. Funding via BBSRC EastBio, please share & pass on to anyone interested! #microsky🦠🧫🧬 www.findaphd.com/phds/project...