Paula Ramiro-Martínez
@paularamiro.bsky.social
📤 143
📥 124
📝 21
Predoctoral researcher at evodynamics lab in Madrid. Bacterial and plasmid evolution 🫧🧬💻
pinned post!
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
loading . . .
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
https://doi.org/10.1038/s41467-025-61202-5
6 months ago
4
120
59
reposted by
Paula Ramiro-Martínez
Nature Microbiology
6 days ago
#NewResearch
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
#MicroSky
🦠
@peterdoug.bsky.social
@emggroupucph.bsky.social
www.nature.com/articles/s41...
loading . . .
Persistent virulent phages exist across bacterial isolates - Nature Microbiology
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
https://www.nature.com/articles/s41564-025-02207-0?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
1
15
5
reposted by
Paula Ramiro-Martínez
Nature Microbiology
6 days ago
#NewResearch
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
#MicroSky
🦠
www.nature.com/articles/s41...
loading . . .
Large-scale analysis of bacterial genomes reveals thousands of lytic phages - Nature Microbiology
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
https://www.nature.com/articles/s41564-025-02203-4?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
0
14
5
reposted by
Paula Ramiro-Martínez
Jerónimo Rodríguez-Beltrán
19 days ago
🎁 Getting a paper acceptance right before Christmas break is one of the best feelings. 100% recommend. Happy holidays, everyone! 🎄✨
1
13
2
reposted by
Paula Ramiro-Martínez
Teresa M. Coque
about 2 months ago
A pleasure and an honour to have received this prestigious grant with my admired colleagues and friends
@sanmillan.bsky.social
and
@asanchezlab.bsky.social
. More about AMR under plasmid lens!. My sincere gratitude to
@caixaresearch.bsky.social
@microryc.bsky.social
@esgem-sg.bsky.social
add a skeleton here at some point
2
16
7
reposted by
Paula Ramiro-Martínez
AnniZLab: [🦠, 🧬 , ✨]
4 months ago
A plasmid golden ratio? 🧬 Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC...
@jerorb.bsky.social
🧪
#microbesky
add a skeleton here at some point
0
43
23
reposted by
Paula Ramiro-Martínez
Microbetv
5 months ago
In episode 337 TWiM explains a study that examines pathogen presence in ancient humans and concludes that zoonoses emerged 6500 years ago with the domestication of livestock, and determination of universal rules that govern plasmid copy number. This week's special guest:
@markowenmartin.bsky.social
loading . . .
TWiM 337: Lifestyles of the plasmids
YouTube video by MicrobeTV
https://youtu.be/GrWwvWb9yJ0?feature=shared
1
10
3
reposted by
Paula Ramiro-Martínez
Alicia Calvo-Villamañán
5 months ago
This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social
,
@sanmillan.bsky.social
and myself! 1/14
loading . . .
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens
Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...
https://rdcu.be/eBhe3
6
82
46
reposted by
Paula Ramiro-Martínez
Alfonso Santos Lopez
5 months ago
Our new manuscript is out! A bit of everything cool: Plasmids ✅ Insertion Sequences ✅ AMR Evolution ✅ Microbial Communities ✅ Databases analyses ✅ Mathematical modeling ✅ See the scientific thread below of Jorge Sastre, who has brilliantly led this work with
@palomarodera.bsky.social
add a skeleton here at some point
1
23
5
reposted by
Paula Ramiro-Martínez
Jorge Sastre Domínguez
5 months ago
New paper out! 🔈🔈📣📣 Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation. Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
loading . . .
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation
Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...
https://www.biorxiv.org/content/10.1101/2025.08.12.669853v1
2
51
34
reposted by
Paula Ramiro-Martínez
Jerónimo Rodríguez-Beltrán
6 months ago
🚨🚨 New paper in
@narjournal.bsky.social
! 🍾 Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons). We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín. 👇
loading . . .
ExcludonFinder: mapping transcriptional overlaps between neighboring genes
Abstract. Bacteria regulate neighboring genes via overlapping transcription in untranslated regions (UTRs), forming excludons. This overlap leads to transc
https://academic.oup.com/nar/article/53/14/gkaf686/8211924
0
35
22
reposted by
Paula Ramiro-Martínez
Laura Álvaro-Llorente
6 months ago
Had an amazing time at
#FEMS2025
last week, where I presented our latest findings on collateral sensitivity mediated by beta-lactamases ☯️ Big thanks to everyone who came by! So proud of my colleagues for their brilliant talks and posters ✨
0
4
1
reposted by
Paula Ramiro-Martínez
Jerónimo Rodríguez-Beltrán
6 months ago
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)
add a skeleton here at some point
2
71
41
reposted by
Paula Ramiro-Martínez
Ana Elena Pérez-Cobas
6 months ago
The must-read of this Summer! 🤩 Congrats to all the authors for this beautiful work 🥳
add a skeleton here at some point
0
8
1
New paper alert! 🚨 Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate. We combine theory, simulations, experimental evolution, and bioinformatics to demonstrate that mutation rates scale with plasmid copy number. Let's dive in! 🧵👇
loading . . .
Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate
Plasmids are autonomously replicating DNA molecules that stably coexist with chromosomes in bacterial cells. These genetic elements drive horizontal gene transfer and play a fundamental role in bacter...
https://www.biorxiv.org/content/10.1101/2025.07.21.665944v1.article-metrics
6 months ago
2
73
39
reposted by
Paula Ramiro-Martínez
bioRxiv Microbiology
6 months ago
Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate
https://www.biorxiv.org/content/10.1101/2025.07.21.665944v1
0
11
2
reposted by
Paula Ramiro-Martínez
Dave Baltrus 🦦
6 months ago
This is a legitimately incredible result that hints at something fundamental about plasmids that we don’t yet understand
add a skeleton here at some point
1
46
17
reposted by
Paula Ramiro-Martínez
Jerónimo Rodríguez-Beltrán
6 months ago
Super proud of the lab for their outstanding presentations at
#FEMS2025
in Milano! Science is better when you work with such a stellar team!🚀✨
@femsmicro.org
0
23
5
reposted by
Paula Ramiro-Martínez
Jerónimo Rodríguez-Beltrán
6 months ago
It was an honor and a joy to receive the National Research Prize for Young (!) Researchers. The highlight? My grandma greeting the King of Spain. What a day!
www.youtube.com/watch?v=oSQP...
5
34
6
reposted by
Paula Ramiro-Martínez
naturepoker
6 months ago
Oh this is fantastic 🦠🧫
add a skeleton here at some point
0
5
1
reposted by
Paula Ramiro-Martínez
Javier DelaFuente
6 months ago
If you're into plasmid biology, you can't miss this back-to-back by two inspiring teams!
add a skeleton here at some point
0
6
2
reposted by
Paula Ramiro-Martínez
Jerónimo Rodríguez-Beltrán
6 months ago
🚨🚨New paper out in
@natcomms.nature.com
!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉
www.nature.com/articles/s41...
loading . . .
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
https://www.nature.com/articles/s41467-025-61202-5
4
185
90
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
loading . . .
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
https://doi.org/10.1038/s41467-025-61202-5
6 months ago
4
120
59
reposted by
Paula Ramiro-Martínez
Ana Elena Pérez-Cobas
8 months ago
New mini-review on the respiratory microbiome and its contribution to human health from biotechnology 🫁🦠
@tmcoque.bsky.social
@microbiotech.bsky.social
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
loading . . .
The Respiratory Tract Microbiome and Human Health
The respiratory tract microbiome (RTM) trains the immune system and protects against infections. Changes in the RTM are linked to various respiratory diseases. High-throughput methodologies and compu...
https://enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.70147
0
8
5
reposted by
Paula Ramiro-Martínez
Alicia Calvo-Villamañán
11 months ago
Happy International Day of Women and Girls in Science 👩🔬🧬
#womeninscience
#girlsinscience
2
15
7
reposted by
Paula Ramiro-Martínez
Ignacio (Nacho) de Quinto
12 months ago
Just migrated here from twitter! Hello everyone. Also, I've just put up a super simple (and free) to use APP to streamline experiment design and result analysis of 96 (or 384) wells plate experiments for my lab pals. You can try it here:
rosettier.streamlit.app
Feedback is very welcome 😁!
loading . . .
Rosettier
A free, user-friendly web application for planning 96 or 384-well plate experiments. Rosettier si...
https://rosettier.streamlit.app
0
6
4
reposted by
Paula Ramiro-Martínez
Jerónimo Rodríguez-Beltrán
12 months ago
Really beautiful day receiving the “Margarita Salas” Award from the Madrid Region! Really proud to share it with my colleagues, friends and family!!
11
25
4
you reached the end!!
feeds!
log in