Ana Elena Pérez-Cobas
@anaelenaperezcobas.bsky.social
📤 325
📥 680
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Microbiologist investigating the respiratory tract microbiome
pinned post!
New mini-review on the respiratory microbiome and its contribution to human health from biotechnology 🫁🦠
@tmcoque.bsky.social
@microbiotech.bsky.social
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
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The Respiratory Tract Microbiome and Human Health
The respiratory tract microbiome (RTM) trains the immune system and protects against infections. Changes in the RTM are linked to various respiratory diseases. High-throughput methodologies and compu...
https://enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.70147
10 months ago
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reposted by
Ana Elena Pérez-Cobas
Cristina Herencias
7 days ago
🧬New paper out! We report the first isolation of viable B. bacteriovorus predators from human gut microbiota.
www.frontiersin.org/journals/mic...
. Great work of Mario Romero
@migueldiezfdz.bsky.social
@josete600.bsky.social
and
@rosacampo.bsky.social
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Frontiers | Genome assembly and functional predation analysis of novel Bdellovibrio isolates from human gut microbiota
IntroductionPredatory bacteria of the Bdellovibrio and like organisms (BALOs) have long been postulated as living antimicrobials, yet their occurrence and ec...
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1752098/full
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reposted by
Ana Elena Pérez-Cobas
Jerónimo Rodríguez-Beltrán
12 days ago
New paper out in
@pnas.org
, and it made the cover! 👁️ We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve. ‼️Check Paula’s 🧵 and the paper👇 𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
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reposted by
Ana Elena Pérez-Cobas
Paula Ramiro-Martínez
13 days ago
New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story
www.pnas.org/doi/10.1073/...
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Plasmid mutation rates scale with copy number | PNAS
Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...
https://www.pnas.org/doi/10.1073/pnas.2526088123
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reposted by
Ana Elena Pérez-Cobas
Centro Nacional de Biotecnología (CNB)
3 months ago
Such an interesting session at the “Collaborating in Science: Pros and Cons” workshop, organised by the Postdoctoral Committee of
#CNB_CSIC
. Thanks to our amazing speakers: Ana Elena Pérez (H. U. Ramón y Cajal), Susana Guerra (
@uam.es
), Damián Lobato & Alberto Cobos (CNB).
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reposted by
Ana Elena Pérez-Cobas
Ken Timmis
3 months ago
The NoticiaSEM: an excellent monthly newsletter for Spanish-speaking microbiologists, now celebrating its 200th edition. It also publishes Portraits from the IMiLI. On the occasion of its 200th "birthday", it published an IMiLI "MicroChat" on......birthdays.
www.semicrobiologia.org/revista-noti...
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reposted by
Ana Elena Pérez-Cobas
Alfonso Santos Lopez
4 months ago
Do plasmids really move around that much? Well, maybe not always Thrilled to have contributed to this story with two of my favourite microbiologists:
@jrpenades.bsky.social
&
@sanmillan.bsky.social
This great work was led by Akshay Sabnis &
@wfigueroac3.bsky.social
www.cell.com/cell-reports...
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Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01227-6
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reposted by
Ana Elena Pérez-Cobas
Alicia Calvo-Villamañán
6 months ago
This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social
,
@sanmillan.bsky.social
and myself! 1/14
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Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens
Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...
https://rdcu.be/eBhe3
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reposted by
Ana Elena Pérez-Cobas
Jorge Sastre Domínguez
6 months ago
New paper out! 🔈🔈📣📣 Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation. Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
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Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation
Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...
https://www.biorxiv.org/content/10.1101/2025.08.12.669853v1
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reposted by
Ana Elena Pérez-Cobas
Jerónimo Rodríguez-Beltrán
7 months ago
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)
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The must-read of this Summer! 🤩 Congrats to all the authors for this beautiful work 🥳
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7 months ago
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reposted by
Ana Elena Pérez-Cobas
Jerónimo Rodríguez-Beltrán
7 months ago
Super proud of the lab for their outstanding presentations at
#FEMS2025
in Milano! Science is better when you work with such a stellar team!🚀✨
@femsmicro.org
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Proud of the talk of Iván Linares at the
#FEMS2025
on hospital-associated microbiomes and its role on pathogens persistance 🦠
@femsmicro.org
7 months ago
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Congratulations to
@cbuch.bsky.social
on the FEMS-Lwoff Award!!! Well-deserved ❤️#FEMS2025
7 months ago
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reposted by
Ana Elena Pérez-Cobas
Jerónimo Rodríguez-Beltrán
7 months ago
🚨🚨New paper out in
@natcomms.nature.com
!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉
www.nature.com/articles/s41...
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Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
https://www.nature.com/articles/s41467-025-61202-5
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reposted by
Ana Elena Pérez-Cobas
Jose A Escudero
9 months ago
🧪 Finally out after peer review, our work showing that "Mobile
#Integrons
carry Phage Defense Systems" is now published in Science 🎉 Short 🧵
www.science.org/doi/10.1126/...
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Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
https://www.science.org/doi/10.1126/science.ads0915
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New mini-review on the respiratory microbiome and its contribution to human health from biotechnology 🫁🦠
@tmcoque.bsky.social
@microbiotech.bsky.social
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
loading . . .
The Respiratory Tract Microbiome and Human Health
The respiratory tract microbiome (RTM) trains the immune system and protects against infections. Changes in the RTM are linked to various respiratory diseases. High-throughput methodologies and compu...
https://enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.70147
10 months ago
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5
reposted by
Ana Elena Pérez-Cobas
Alvaro San Millan
about 1 year ago
New preprint from the lab!! Check it out!
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Delighted to have contributed to this fascinating paper led by Prof. Timmis on how helpful microbes can be for humanity at different scales! "The future is not set. There is no fate but what we make for ourselves". -John Connor (Terminator)
@microbiotech.bsky.social
add a skeleton here at some point
about 1 year ago
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