🇬🇧🇫🇷 "By working together we can overcome challenges faster" Pasteur Foundation UK launched the formal @institutpasteur x @ox.ac.uk partnership in London. From climate to AMR, cross-border collaboration is science's engine. ↘️ www.pasteurfoundation.uk/pasteur-oxfo...

De-DUFing the DUFs 🧩 @franznarberhaus.bsky.social lab uncovers how small DUF1127 proteins regulate #phosphate uptake by binding the sensor kinase PhoR. Their conserved role from Agrobacterium to E. coli highlights how even small DUFs can shape bacterial physiology 🦠 buff.ly/jJd9Eho

Thus, single-cell metabolic dynamics can forecast infection outcomes. In the spirit of @stephenwolfram.bsky.social's ideas, bacterial infection exhibits pockets of computational reducibility at the single-cell scale. Might this point to new ways to predict infection progression?

So we trained an explainable Machine Learning model using Δψm + mROS dynamics, and the AI model predicted which infected cell will support replication with 83% accuracy before bacterial replication begins

What make these permissive macrophages different? Before bacteria replicate, macrophages that will permit bacterial growth already show sustained mitochondrial membrane potential (Δψm) and higher mitochondrial ROS (mROS). These are early mitochondrial signals of permissive cells!

We tracked thousands of living primary human macrophages during infection with Legionella pneumophila, using high-throughput live imaging + our BATLI backtracking software. Legionella only replicates in ~20% infected primary macrophages! www.nature.com/articles/s41...

New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵

Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use. buff.ly/JST7ZR1

Save the date! The @pasteur.fr Pasteur course on image analysis is announced: It will happen from the 1st of June to the 5th 2026. This year there will be only one track: the Early Career Investigator track (beginners). 👇

I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...

New publication | Science Advances www.science.org/doi/10.1126/...

🔎 Find us at the 77th #DGHM Meeting in #Jena! Gabriele Pradel, Anja Lührmann, Sandra Reuter, Bärbel Stecher and others are happy to tell you more about our German network for women in infection research! 💜 👩‍🔬@gabrielepradel.bsky.social @sandrareuter.bsky.social @baerboletta.bsky.social

Phages are promising against antibiotic-resistant bacteria—but resistance can emerge. 🦠 New work from @baerboletta.bsky.social lab shows E. coli can resist phages in the lab, but in the gut that resistance comes at a cost: context is crucial for #PhageTherapy success. buff.ly/NLOjnE2

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!

🇪🇺 Smooth publishing experience with #microLife, the new @femsjournals.bsky.social journal of the European Academy for Microbiology. 🙏 @erc.europa.eu, F.R.S-FNRS & WEL-RI for support 4/4

🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr

🔬 We’re past the midpoint of the year; perfect time to look back at what’s been discovered so far. From how Salmonella slows its escape from immune cells to the microbes thriving in oil reservoirs, these are the most-read #microLife papers of 2025 so far: buff.ly/TfhOvEc

I was very honored to receive on of the Poster prizes at FEMS MICRO 2025 in Milan a few weeks back. It was such a great conference, heard so many interesting and stimulating talks & poster discussions.

Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites @femsjournals.bsky.social #microLife from @inaattree.bsky.social with @cbuch.bsky.social academic.oup.com/microlife/ad...

This 👇

Congratulations to 2025 GRC Microbial Adhesion and Signal Transduction Poster Award Winners!! 🎆🥂🙌 Thank you @cp-cell.bsky.social and @femsmicro.org for sponsoring! From, Your secret judges 🤫

Congratulations @cbuch.bsky.social ! 👏

FEMS MICRO Milan 2025 is off to a great start with Prof. Carmen Buchrieser presenting her keynote on Legionella pneumophila and the fascinating ways this pathogen mimics eukaryotic cells.

What an inspiring first day at FEMS MICRO Milan! We heard from FEMS Pres. Antonio Ventosa at the Opening while former Pres. Hilary Lappin-Scott helped connect new attendees. Thanks to keynotes Profs. Carmen Buchrieser and Gian Rossolini for sharing their expertise. #FEMS2025

One of the most controversial sessions of the @femsmicro.org Congress—run by Malick Gibani—deals with the so-called *Human challenge studies* of pathogens ie deliberate inoculation of human subjects with virulent agents. The benefits are clear but … is informed consent enough 🤔?

Four leading researchers on bacterial computing in the @femsmicro.org Workshop on the the topic during the Congress—quite amazing talks by @angelgm.bsky.social, Yolanda Schaerli, Manish Kushwaha & Samgram Bagh. Do bacteria compute? Can we make them to compute wth our logic or do they have their own?

At my 1st @femsmicro.org congress (in Milan!) - it's a fantastic meeting. I co-chaired a superb session on Microbial Dark Matter with @jlewillett.bsky.social, who also kicked off the session with a talk on her lab's work. 🤩 We also heard from my FEMS Microbes co-EIC Kathleen Scott! 💪🏽 #FEMS2025

Delighted to have contributed to this fascinating paper led by Prof. Timmis on how helpful microbes can be for humanity at different scales! "The future is not set. There is no fate but what we make for ourselves". -John Connor (Terminator) @microbiotech.bsky.social

New preprint from the lab!! Check it out!

New mini-review on the respiratory microbiome and its contribution to human health from biotechnology 🫁🦠 @tmcoque.bsky.social @microbiotech.bsky.social enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

Congratulations to @cbuch.bsky.social on the FEMS-Lwoff Award!!! Well-deserved ❤️#FEMS2025

ᑎEᗯ IᑎᑎᗩTE IᗰᗰᑌᑎE EᖴᖴEᑕTOᖇ! Anaya-Sanchez et al Infected macrophages switch to aerobic glycolysis, generating toxic METHYLGLYOXOL Bacteria lacking detox enzyme 𝘨𝘭𝘰𝘈 become highly mutagenic, lose virulence Boosting methylglyoxal helps control 𝘓𝘪𝘴𝘵𝘦𝘳𝘪𝘢 or TB infection www.cell.com/cell-host-mi...

🎶 Straight from the Lab to the Mic: when a Pasteur scientist turns her thesis into a rap 🎶 #FeteDeLaMusique

www.biorxiv.org/content/10.1.... New pre-print of the lab in which we dive deep into Klebsiella-macrophage interface. High structural resolution of the lipid A produced by Klebsiella within the Klebsiella containing vacuole governed bt TLR4 signaling. Superb job led PhD student Toby Bartholomew

Isabel from the BacDive Team will be at the @leibniz-dsmz.bsky.social booth at #FEMS2025 🦠 to answer your questions on #DSMZDigitalDiversity 🖥️🧬 databases.

Thrilled that our latest paper showing that DCs undergo either pyroptosis or apoptosis upon bacterial blockade of host translation to restrict Legionella is now online at the @asm.org journal mBio! Congrats to 1st author @vvazquez.bsky.social & co-authors! 🎉 journals.asm.org/doi/10.1128/...

🧬 Don’t miss the inspiring keynote by Manu Prakash about #frugalscience and #innovation, renowned biophysicist and innovator during our Adapting to Change conference 👇 @pasteur.fr @prakashlab.bsky.social @ibeidlabex.bsky.social www.labexibeid.fr/en/keynote-m...

🌍Explore the frontlines of global health with Peter Hotez! A must-watch conference on vaccines and infectious disease challenges. Dive into the science shaping our world 👇 @pasteur.fr @ibeidlabex.bsky.social www.labexibeid.fr/en/ibeid-pet...

Let’s start our 14th edition of the Labex Day with a keynote lecture by @drrachellowe.bsky.social on how to improve surveillance, preparedness and response to climate-sensitive disease outbreaks & emergences. @ibeidlabex.bsky.social @pasteur.fr @bastinlab.bsky.social @salehlabparis.bsky.social

@cristancholina.bsky.social, laureate of our last call for proposals, is now presenting her work on modeling the spread of Chikungunya in Réunion island. @scauchemez.bsky.social @institutpasteur.bsky.social

Mathilde Gendrin, IBEID junior group, has joined us from Institut Pasteur de la Guyane to present her work on the role of the microbiota in mosquito physiology. @institutpasteur.bsky.social

Very interesting results by Nathan Ribot on the identification of a novel type of Plasmodium oocystes division. @institutpasteur.bsky.social

We conclude our morning sessions with Isabelle Louradour, S2I IBEID fellow, guiding us through her results on how Leishmania and Sauroleishmania hybridization can inform on parasite genomic compatibility and transcriptomic adaptation. @pasteur.fr

We are now moving to Mycobacterial phenotypic variation with Giulia Manina, formerly supported as an IBEID junior group. @institutpasteur.bsky.social

Let’s move to TBEV pathogenesis and neurological outcomes using innovative mouse models with our Seed Grant laureate Caroline Manet. @institutpasteur.bsky.social

Elena Capuzzo, PhD student selected for an End of thesis extension, is now presenting her results on controlling Staphylococcus aureus infection by cold atmospheric plasma in skin burn wound models. @institutpasteur.bsky.social @00capu.bsky.social

Adeline Mallet, head of the Ultrastructural Bioimaging facility, is presenting cutting-edge technologies to visualize intraflagellar transport in Trypanosomas. @pasteur.fr @bastinlab.bsky.social