#MicroSky: How does a methylotrophic yeast fine-tune methanol metabolism? Cai et al reveal high-res structures of two alcohol oxidase isozymes in Ogataea methanolica, showing distinct cofactor preferences & assembly into functional octamers: biotech protein production. doi.org/10.1111/1751...

#MicroSky: PET waste is tough to recycle, but Barriuso’s group upcycled it into biodegradable PHAs using a hybrid approach: fast glycolysis + engineered microbial consortium. By splitting tasks between microbes, they boost efficiency and valorize plastic waste. Read doi.org/10.1111/1751...

#MicroSky: Magnetospirillum MSR-1 produces magnetosomes, ie uniform, magnetic nanocrystals with huge biotech potential. Oxygen levels control their size: more O₂ → smaller crystals. Fine-tuning O₂ could boost scalable production of tailored magnetic nanoparticles. doi.org/10.1111/1751...

#MicroSky: Smarter bioreactors can better control how cells behave under real-world stress. Using real-time monitoring, Delvenne et al show how dynamic environments shape cell response and make biotech processes more reliable, scalable, and efficient. doi.org/10.1111/1751...

#MicroSky:Persister bacteria evade antibiotics by “hibernating” their ribosomes. Kim & Song show a shift from active (70S) to inactive (100S) states defines persistence & reversing this shift drives recovery.Targeting ribosome hibernation could help prevent infection relapse. doi.org/10.1111/1751...

#MicroSky: Bacterial vesicles could transform One Health—linking human, animal & environmental health with next-gen vaccines, diagnostics, and drug delivery. Tiny messengers, big impact. Read Arce-Rodriguez et al doi.org/10.1111/1751...

#MicroSky: ONE HEALTH: Turning pests into cures. Chen et al show that A cockroach-associated Streptomyces exhibits strong anti-Candida potential, revealing new antifungal compounds via multi-omics—opening ways to fight drug-resistant infections. Find more at doi.org/10.1111/1751...

#MicroSky: Decades of plant-focused breeding boosted yields, but reshaped (& often reduced) beneficial microbiomes. What if we bred plants and their microbiomes together? By combining rewilding & microbiome-aware genetics. An approach for climate-resilient crops. doi.org/10.1111/1751...

#MicroSky: Brüssow reviews COVID-19 antivirals. Remdesivir, molnupiravir & nirmatrelvir show variable benefits—greatest with early use in high-risk patients. Outcomes depend on timing, variants, and patient context. Right drug, right time = better impact. Highly recommended: doi.org/10.1111/1751...

#MicroSky: Boosting antibiotic production. BCAA metabolism regulates erythromycin biosynthesis via SACE_Lrp → ilvE. Tuning this axis + valine supplementation drives up to 71% higher yields. Regulatory + metabolic coupling ->better actinobacterial cell factories. doi.org/10.1111/1751...

#MicroSky: Metabolic engineering in action. Acetylation inhibits E. coli isocitrate lyase, but KR mutations restore activity, rebalance carbon flux, cut acetate overflow, and boost lycopene production +61%. Smarter enzyme control -> better cell factories. doi.org/10.1111/1751...

#MicroSky: Cell Factories meet Extracellular Vesicles (EV): Li et al establish S. cerevisiae as a model for EV biogenesis and cargo loading. By expressing ChiIFN-λ + cell wall perturbation, they boost EV yield 10× and reveal conserved sorting machinery (SNARE, ESCRT). doi.org/10.1111/1751...

Enrique Cerdá-Olmedo was a brilliant mind, a fearless thinker & a mentor who opened windows for generations. His legacy lives on in every curious question we dare to ask. A remarkable scientist, a devoted teacher & a person of immense generosity. Read his life & contributions doi.org/10.1111/1751...

#MicroSky: Hybrid vigour in yeast isn’t one-size-fits-all. They found that across 1,023 hybrids, heterosis depends on stress, ploidy, and parent genetics: strongest under ethanol & salt stress, but reduced at higher ploidy. Smarter breeding = better industrial strains! doi.org/10.1111/1751....

#MicroSky: One Health: Tumors hijack the constant crosstalk between ur gut, brain, and immune system. Decoding this neuroimmune: microbiome axis could supercharge immunotherapy and microbiota-based cancer treatments. Wang et al at doi.org/10.1111/1751...

Eco-Microbiology: A Frugal-Circular Framework for Biosafe, Low-Cost Practical Microbiology in Secondary Education. enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

#MicroSky: Mystery gut infections with no detectable pathogen are deadly- hard to treat. In severe cases, washed microbiota transplantation showed >60% response and 43% cure rates, hinting that restoring gut ecosystems may succeed where antibiotics fail. Zhang et al at doi.org/10.1111/1751...

Can We Breed Microbiomes to Sustain Plant Productivity? @microbiotech.bsky.social Opinion by Noémie De Zutter and Kris Audenaert enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....

#MicroSky: Synthetic biology boosts bio-production. A new “scaffoldomics” platform enables combinatorial enzyme colocalisation, increasing pathway efficiency up to 20 higher yield, demonstrated with naringenin synthesis in E. coli by Elias et al in Microb Biotech doi.org/10.1111/1751...

#MicroSky: Reduce nerve-related pain! Zhang et al report a breakthrough in Pregabalin synthesis. R-selective D-hydantoinases enable efficient production of key intermediate R-IBM. Engineered mutations boost enantiomeric purity >97%. A way for greener & cheaper manufacturing. doi.org/10.1111/1751...

#MicroSky: Fertility meets the microbiome. Healthy, Lactobacillus-rich environemnts may support implantation, while dysbiosis fuels inflammation& pregnancy loss. Next gen-therapies: from probiotics to microbiota transplants may redefine reproductive medicine. Read Li et al. doi.org/10.1111/1751...

#MicroSky: Fighting vaginitis. Probiotics vs. postbiotics—why not both? Dual Lactobacillus strains (and their postbiotics) restore vaginal immunity, suppress inflammation, and outperform single therapies in AV. A promising, resistance-proof path beyond antibiotics. doi.org/10.1111/1751...

#MicroSky: Therapeutic approach against fungal infection: Pseudolaric acid B directly eradicates C. albicans via Erg11 inhibition & uniquely, restores vaginal microecological homeostasis by promoting probiotic lactobacilli, addressing both the pathogen & dysbiotic environment doi.org/10.1111/1751...

#MicroSky: The HNH endonuclease HrdP is a highly conserved and essential determinant of infectivity among Skunavirus phages, required for successful completion of DNA packaging. HrdP is a promising and specific anti-phage target to protect dairy starter cultures from failure. doi.org/10.1111/1751...

#MicroSky: This study offers a novel strategy for optimizing the synergistic fermentation of L. plantarum and phenylethyl acetate, thereby enhancing alfalfa silage flavor quality & promoting sheep feed intake. Read Fu et al. doi.org/10.1111/1751...

#MicroSky: From Fecal Microbial Transplantation to Advance Microbiota Transplantation: precision microbiota therapy begins with the so-called “addition–subtraction” strategy that brings consistency to microbiome treatments. Smarter design & better outcome for microbiotherapy. doi.org/10.1111/1751...

#MicroSky: Turning fungi into insulin factories! Yan et al in Microb. Biotechnol. report that engineered Trichoderma unlocks efficient secretion of insulin glargine with high yields and bypassing stress. This paves the way for scalable production of complex therapeutics! doi.org/10.1111/1751...

#Microsky: New insights into fungal biocontrol and new targets for smarter plant disease management. The bZIP63.5 master regulator of Trichoderma boost antifungal power by blocking defense networks in Alternaria. Read Yang et al doi.org/10.1111/1751...

#MicroSky:Alcohol dehydrogenase in Candida isn’t just metabolic, it’s a morphogenesis regulator. Knocking it out drives hyperfilamentation, block hyphae & biofilms development by modulating SNF1 signaling.A new antifungal strategy emerges: hit virulence via metabolic enzymes! doi.org/10.1111/1751...

#MicroSky: Next Generation probiotics: S. clusii is a resilient G(+) spore-former with high potential for biotherapeutics & biotech. A new electropretion method + versatile shuttle vectors now unlock fast, scarless genome editing. Don’t miss Capella et al doi.org/10.1111/1751...

#MicroSky: Cleaner soils through Microbial evolution. Paenarthrobacter degrades the fungicide iprodione via IpaH/DhaH and DuaH. Comparative analysis revealed gene duplication, Horizontal Gene Transfer and pathway evolution by environmental exposure. doi.org/10.1111/1751...

#MicroSky: Probiotic benefits are clear, but survival in the gut is not! Advanced microencapsulation protect probiotics from acid, bile & stress enabling targeted intestinal release and paving the way for safer & more effective therapies. enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....

#MicroSky: Chronic Spontaneous Urticaria (CSU) is linked to gut dysbiosis and elevated serum uric acid/hypoxanthine. Lactobacillus paragasseri LG-1 alleviates urticaria by degrading these metabolites, inhibiting TLR4-NF-κB inflammation, and remodeling gut microbiota. doi.org/10.1111/1751...

#MicroSky: Fernández et al show that bacteria don’t just adapt by mutating genes, but they also tweak genes switches. In Salmonella structured changes in the opvAB promoter fine-tune surface traits, revealing a new layer of evolutionary adaptation beyond DNA coding changes. doi.org/10.1111/1751...

#MicroSky: Cao et al show in MBT how tiny genetic changes can flip bacteria life style. In Zymomonas mobilis, a single amino acid swap reshaped movement versus sticking together. They show how small DNA tweaks can rapidly rewire bacterial behaviour and evolution. Don’t miss doi.org/10.1111/1751...

#MicroSky: GREEN AGRICULTURE: Wood hemicelluloses from forestry waste can microencapsulate phages for storage & delivery. Against Ralstonia solanacearum, these capsules boost soil stability and enhance anti-bacterial wilt activity. READ Negroni et al doi.org/10.1111/1751...

#MicroSky: Acinetobacter ADP1 & its glyoxylate shunt mutant, grow on short-chain fatty acids and directly on acidogenic fermentate from arrested anaerobic digestion of biomass. Compositional control of the fermentate results in different growth and wax accumulation behaviour. doi.org/10.1111/1751...

#MicroSky: Bacterial & archaeal communities power plant-microbial fuel cells. Bueno-freire et al integrates current knowledge through comprehensive tables & knowledge graphs, emphasizes microbial diversity, functions & biotechnological potential for renewable energy use. doi.org/10.1111/1751...

#MicroSky: GREEN AGRICULTURE: Microbial VOCs can support sustainable crop protection, yet practical implementation remains limited. Belt et al propose practical and technological pathways to bridge the gap between laboratory discoveries and on-farm deployment. doi.org/10.1111/1751...

#MicroSky: Xie et al describe a novel cumate-inducible promoter, Pgc, that was engineered in K. pastoris by optimising the CuO operator and CymR repressor (A). This system achieved an approximately 11-fold increase in recombinant protein production upon induction (B). doi.org/10.1111/1751...

#MicroSky: Root-associated microbiota help shape crop architecture. Chen et al introduce “holobiont architecture,” where plant form is dynamically tuned through plant–microbiome synergy, offering new paths to breed resilient, architecture-smart crops. Don’t miss MBT at doi.org/10.1111/1751...

#MicroSky: Eco-friendly win for cabbage. Paraphaeosphaeria minitans (TNAU-CM1) suppressed 78.5% of Sclerotinia growth and matched chemical fungicides in field tests. A strong, sustainable biocontrol option for cabbage head rot. Find more in Ruppavalli et al doi.org/10.1111/1751...

#MicroSky: Novel organelles for synthetic biology. Engineered Salmonella form hybrid bacterial microcompartments via shell protein exchange, maintaining cargo segregation and revealing rules for modular BMC assembly. Exciting work in Microb. Biotechnology, doi.org/10.1111/1751...

#MicroSky: Since its discovery in 1983, HIV/AIDS treatment has evolved from daily pills to powerful prevention tools. Long-acting shots like cabotegravir (every 2 months) and lenacapavir (every 6 months) could game-changers, if access and cost barriers are overcome. doi.org/10.1111/1751...

#MicroSky: Antibiotic resistance crisis: Ansari & Nagar isolated jumbo lytic phage P19 targeting MDR Aeromonas. Its T4-type endolysin shows broad antibacterial activity across MDR Gram-negatives, highlighting phages as promising alternatives to antibiotics. doi.org/10.1111/1751...

#MicroSky: Khan et al report that E. cloacae thrives in chlorinated marine cooling systems, evolving cross-resistance and biofilms that promote barnacle settlement. A native bacteriophage disrupts these biofilms, reducing fouling, offering a sustainable control strategy. doi.org/10.1111/1751...

#MicroSky: AQUACULTURE: A new tool for sustainable aquaculture. Synechocystis extracellular vesicles function as stable, immune-stimulating nanocarriers with adjuvant activity. Marthina-Cardoso et al open a door to next-gen fish vaccines. In MBT doi.org/10.1111/1751...

#MicroSky: Green Biochemistry: Hybrid beats monoculture! Zini et al engineered a cyanobacterium into a natural photosynthetic microbiome, boosting resilience, scalability & PHB bioplastic production. A novel robust platform for industrial biotech. doi.org/10.1111/1751...

#Microsky: Repurposing the endogenous type II-A CRISPR–Cas system in Lacticaseibacillus rhamnosus GG enables efficient genome engineering making it a programmable chassis for functional strain development in food biotechnology, precision fermentation & live biotherapeutics. doi.org/10.1111/1751...

#MicroSky: Probiotic Lactobacillus salivarius Li01 alleviates acute pancreatitis in mice by reshaping the gut microbiota, boosting steroid hormone–related metabolites, and dampening inflammatory pathways (incl. TNF-α) along the gut–pancreas axis. Read Duan, Lou et al in MBT. doi.org/10.1111/1751...