📣 Latest paper out! I'll write a thread about it next week: growth control, cellular context, genetic circuits... A fascinating story by @angeles-hg.bsky.social & @mirobueno.bsky.social #synbio #biocomputation link.springer.com/article/10.1...

Este miércoles, a las 19h, estaré en el Moe’s Club (Madrid) en el @pintofscience.es de Madrid 😄. Representando al @cnb-csic.bsky.social, hablaré de si los ordenadores pueden estar vivos y cómo podemos crearlos en el laboratorio. ¡Nos vemos allí!

Gene expression noise is not always noise. If expression comes from stable rates and events (blue lines) it is noiseless information (yet stochastic & probabilistic!). If there are sudden perturbations on the channel (green), then there is noise. I find that word particularly misleading 🤔

This paper is most interesting for us. It'll take us some time to digest; the amount of information in it is near infinite! doi.org/10.1021/acs....

Interested in synthetic biology & microbiomes? 🧬🧫 We are recruiting a PhD student to develop biosensors to study microbe–microbe & microbe–host interactions. In beautiful Lausanne, Switzerland🏔️⛵ @dmf-unil.bsky.social @fbm-unil.bsky.social Apply by 24.05.2026 👇 shorturl.at/6X7M4 Boosts appreciated!

It's all about the Moon now, but here is the Sun from my office window this morning.

Our special issue "Biology computes: Information processing across biological scales" Editorial - authors.elsevier.com/a/1moUK3si8Q... Contributions from @drmichaellevin.bsky.social, Chris Barnes, Matthias Függer, Thomas Nowak, @angelgm.eurosky.social - www.sciencedirect.com/special-issu...

🦠Un equipo del #CSIC ‘domestica’ mediante ‘computación viva’ una bacteria clave para el control de patógenos vegetales  🌱Este conocimiento es clave para la utilización de esta especie bacteriana como herramienta biotecnológica en suelos ➡️ https://tinyurl.com/yf7nus3r

El equipo de @angelgm.eurosky.social en el CNB-CSIC domestica P protegens, una bacteria clave para controlar patógenos vegetales con gran valor medioambiental  Más información: https://f.mtr.cool/ugejpdzuir Artículo en Cell Systems: https://f.mtr.cool/dwxrylxwkm

Just migrated to @eurosky.social. I guess all my data is in EU servers now. Everything else looks the same: network, apps, etc.

Can we engineer the resilience of fragile ecosystems? In this paper with @vmaull.bsky.social @lizashpilkina.bsky.social & @vdlorenzo.bsky.social, we discuss "Emergent Bioengineering" bringing together complexity, #synbio and ecology across scales www.preprints.org/manuscript/2...

(1/5) As promised, here a short thread about this work. Why Pseudomonas protegens Pf-5? It is a key environmental host with unique interactions with soil’s biotic and abiotic compounds. Thus great for our Lab’s goal: ecosystems computing. We needed to know how this host interacts with circuits.

Latest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...

Back at the lab after a week in Copenhagen for @aliceworkshop.org! A brilliant week—full of ideas and enthusiastic colleagues. So many things to discuss with the lab now. Kudos to the organizers, and thanks for bringing this energy to #ALIFE topics.

On my way to Copenhagen for the ALICE workhsop @aliceworkshop.org! Discussions around #ALIFE topics for a full week — looking forward. I'll be talking about cellular computing (what else? :-)

New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/

Next in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.

Just published our workflow for genotyping transposon libraries. All methods, files, scripts... are open source and publicly available. 🔗 link.springer.com/article/10.1...

The biological messiness, as the quantum weirdness, as a source of (unconventional) computing.

New paper out!📢 Exploring the computing power of microbes that shapes the environment. In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation. 🔗 doi.org/10.1016/j.mi...

Bacteria do compute and can be reprogrammed for new capacities—but not exactly by following Turing’s rules. Evolution, context dependence, and the soft-matter nature of living hardware redefine what computation means in biology. From @angelgm.bsky.social Lab 👉🏻 www.sciencedirect.com/science/arti...

Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife Our new strain KT-TTX is truly fascinating. Feedback welcome!

Preprint of our work tuning bacterial growth, something that changes context for genetic circuits and therefore, their behaviour. Very interesting observations from both experimental results and a model describing it in this piece of work with @mirobueno.bsky.social and @angelgm.bsky.social! :)

Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1

🔔 Exciting News from the ALIFE Community 🔔 We are pleased to share that the proceedings of ALIFE 2025, the 2025 edition of the premier conference on artificial life, held in Kyoto are now published and accessible - direct.mit.edu/isal/proceed...

This book is brilliant. Impossible to read without current scenarios in mind...

Huge news for #biocomputation! In a major call (€30M total) for AI proposals, Spain just funded an initiative for implementing AI with living matter using #synbio as the programming tool. The 'AI in vivo project' is a massive, official recognition of biocomputation as a leading field in computing.

2⃣ equipos #CNB participan en nuevos proyectos de investigación en #InteligenciaArtificial 'GRAINS', coordinado desde la @uc3m.es, y 'AI en vivo', coordinado por @upm.es ➡️Iniciativas subvencionadas en la convocatoria de la #AEI ( @cienciagob.bsky.social) www.cnb.csic.es/nuevos-proye... @csic.es

The CSIC @csic.es Doctoral Programme in #SyntheticBiology is currently offering 10 PhD positions on a number of projects. Good opportunities! syntheticcell.eu/synbio-csic-...

El disco de Ana Crismán es alucinante! Como aficionado al flamenco me ha encantado. Muy valiente, muy bonito. Como guitarrista me he quedado un poco descolocado 😅 arpaflamenca.es

Our #ALIFE2025 paper is out! 🎉 We show that even when two circuits produce the same output, their evolutionary potential can differ greatly. #Evolution at the smallest scale. “Parameter Evolvability in Gene Expression Models Drives Phenotypic Adaptation” 🔗 direct.mit.edu/isal/proceed...

In Wikipedia, the German entry for DNA computer mentions the cellular supremacy de.wikipedia.org/wiki/DNA-Com...

Next in the Lab's conference agenda: Synthetic Biology UK #SBUK. Always a target event for us! Look for Lewis @lewisgrozinger.bsky.social to hear about biocomputation and evolution: "Evolutionary algorithms to design biocomputing circuits beyond logic gates" - an upgrade of our #ALIFE 2023 story.

If you are at the Emerging Applications of Microbes conference in Leuven, go to poster #24: Engineering growth control to modulate circuit host dependencies, by @angeles-hg.bsky.social. This is a brilliant story about growth rates vs. genetic circuit function. And, of course, noise! #synbio

The 2025 Retreat of the Biocomputation Lab (in wonderful Chinchón, Madrid) comes to an end. Three days of fantastic discussions, with new (and revisited) goals ahead. What a brilliant team!

Vuelvo de dar un seminario sobre biocomputación en la escuela de teatro de Jorge Eines. Cosas de aquí, de Madrid.

ALICE Workshop 2026 | Artificial Life, Intelligence, Complexity & Evolution Submission deadline: October 31 #Workshop #ALife #Intelligence #Complexity #Evolution ./19 amahury.github.io/posts/ALICE-...

I'm at a meeting on Unconventional Computing in... Bristol docks! Notes: 1) discussions around Turing Machines are endless, as infinite as the tape, and 2) reservoir computing with all physical substrates (not sure about this trend being the best but here we are).

This year's ALICE guest speakers 🧑‍🔬 - Angel Goñi-Moreno - @angelgm.bsky.social - Alyssa Adams - @alyssa-m-adams.bsky.social - Alexander Mordvintsev - Eric Medvet - @ericmedvetts.bsky.social - Kyrre Glette - @kyrre2000.bsky.social - Stefano Nichele - @stenichele.bsky.social - Susan Stepney

Off to Madrid from an amazing #ALIFE2025 conference in beautiful Kyoto. Kudos to the organisers.

Last day in #ALIFE2025 talking about evolutionary robotics. Sounds like here "evolution" and "learning" are clearly separated. I'm still unsure what is the interplay between #evolution, #learning and #adaptability. Surely, #information, #knowledge and #memory are keywords in this discussion.

I am a bit skeptical here I guess... At least when it sort of matches the lego brick metaphor in #synbio.

#ALIFE2025 Day 3 keynote Chris Kempes discusses the possibility of universal laws of life

1st evolution session of the day at #ALIFE2025. Our story on evolvability by Pablo Japón. In evolution, it is not only the visible that matters!

My first day at #ALIFE2025 was about 1) noise and 2) information. Noise as a perturbation that pushes a system outside viability, or as a resource for computation. Two views that are not the same but complementary. Information leads to (is?) correlation and knowledge (memory?). Most inspiring talks!

Making the most of Kyoto after a great #ALIFE2025 first day. Here training with the Kyoto University #Judo Club!

I hear new definitions of evolution and open endedness every now and then. I wonder if the definition itself is evolving.

Off to #ALIFE conference @alife2025.bsky.social in Kyoto! Although I've been involved in many, this is the first ALIFE I attend since Odense 2012 😅. Pablo Japon will be presenting our work on evolvability in #synbio - Wed at 9 in the Auditorium.

Pleased to announce that our book on the evolution of biological agency is now available, thanks to @templetonfdn.bsky.social It condenses +2 years of discussions between a philosopher and a biochemist, including our conversations in the Jardí Botànic @uv.es @ehu.eus @i2sysbio.es @dicv.csic.es