(1/5) As promised, here a short thread about this work. Why Pseudomonas protegens Pf-5? It is a key environmental host with unique interactions with soil’s biotic and abiotic compounds. Thus great for our Lab’s goal: ecosystems computing. We needed to know how this host interacts with circuits.

I just joined the Computational Synthetic Biology group at @i2sysbio.es. Looking forward to exciting science and new challenges. Thanks to the people of the Biocomputation Lab at @cnb-csic.bsky.social for the amazing last few years.

Great to see this one out. I agree it was challenging but watching it unfold was definitely exciting. The team worked brilliantly, truly thankful!

New paper out!📢 Exploring the computing power of microbes that shapes the environment. In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation. 🔗 doi.org/10.1016/j.mi...

Kudos to @crislaineksr.bsky.social and all the team on the publication of this review doi.org/10.1016/j.mi... regarding the complexity gap between current synthetic biology designs and the natural computing power of microbes.

Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife Our new strain KT-TTX is truly fascinating. Feedback welcome!

Preprint of our work tuning bacterial growth, something that changes context for genetic circuits and therefore, their behaviour. Very interesting observations from both experimental results and a model describing it in this piece of work with @mirobueno.bsky.social and @angelgm.bsky.social! :)

Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1

The CSIC @csic.es Doctoral Programme in #SyntheticBiology is currently offering 10 PhD positions on a number of projects. Good opportunities! syntheticcell.eu/synbio-csic-...

Our #ALIFE2025 paper is out! 🎉 We show that even when two circuits produce the same output, their evolutionary potential can differ greatly. #Evolution at the smallest scale. “Parameter Evolvability in Gene Expression Models Drives Phenotypic Adaptation” 🔗 direct.mit.edu/isal/proceed...

Next in the Lab's conference agenda: Synthetic Biology UK #SBUK. Always a target event for us! Look for Lewis @lewisgrozinger.bsky.social to hear about biocomputation and evolution: "Evolutionary algorithms to design biocomputing circuits beyond logic gates" - an upgrade of our #ALIFE 2023 story.

The 2025 Retreat of the Biocomputation Lab (in wonderful Chinchón, Madrid) comes to an end. Three days of fantastic discussions, with new (and revisited) goals ahead. What a brilliant team!

If you are attending the Designer Biology conference at Newcastle, do not miss the chance to speak to Crislaine Rocha and Paula Múgica at their posters re biosensors and quorum sensing toolkits for #Pseudomonas. www.efbiotechnology.org/designerbiol...

Next in Lab's conference agenda: Designer Biology! www.efbiotechnology.org/designerbiol... Paula Múgica has a poster on her recently published quorum sensing tools, and Crislaine Rocha will talk about environmental biosensors as input to logic gates.

El grupo de Angel Goñi lidera un proyecto "Proof of Concept" @erc.europa.eu para desarrollar gemelos digitales pioneros y analizar en profundidad el comportamiento de células vivas Más info: www.cnb.csic.es/proyecto-de-... @angelgm.bsky.social @csic.es @sommalliance.bsky.social

Thanks Ángel! Everything is already in place here at the #EESMicrobiology. Fun week ahead🧬

Looking forward to great science at #EESMicrobiology. If you are around Heidelberg this week, come visit me at poster 220 to discuss about host-controlled reconfigurability of genetic circuits. New approaches and concepts in microbiology www.embl.org/about/info/c...

Jungle Express promoter. Large dynamic range, low leak. Keeps expression tight, especially on low copy plasmids. Induced by cationic dyes—we use crystal violet. Has allowed us to clone some pretty toxic phage genes. www.nature.com/articles/s41...

New position at the @cnb-csic.bsky.social. I re-join @angelgm.bsky.social's lab. Exciting times ahead!