🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...

New paper alert! 🚨 Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate. We combine theory, simulations, experimental evolution, and bioinformatics to demonstrate that mutation rates scale with plasmid copy number. Let's dive in! 🧵👇

Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)

Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨ 👉 www.nature.com/articles/s41... @cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social

This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Un placer estar en Logroño en tan buena compañia hablando de resistencia a los antibióticos. #fundacionibercaja

www.nature.com/articles/s41... In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements. #phage #plasmid #evolution #bacteria #plasmidbiology #MGE

In our new paper we discuss how modern coexistence theory can help microbial ecologists tackle fundamental & applied questions, and how microbial systems can help to push coexistence theory forward! With Andrew Letten and Dave Armitage (@darmitage.bsky.social). doi.org/10.1111/1462...

Just migrated here from twitter! Hello everyone. Also, I've just put up a super simple (and free) to use APP to streamline experiment design and result analysis of 96 (or 384) wells plate experiments for my lab pals. You can try it here: rosettier.streamlit.app Feedback is very welcome 😁!

Really beautiful day receiving the “Margarita Salas” Award from the Madrid Region! Really proud to share it with my colleagues, friends and family!!

El Prof. José Luis García, investigador del CIB, ha recibido el Premio de Investigación Margarita Salas 2024 otorgado por la CAM, en reconocimiento a su trayectoria investigadora y de transferencia, que ha posicionado la Biotecnología Española como referente internacional. ➡️ s.mtrbio.com/gukzeylqqs

⚠️ Job(s) alert! ⚠️ We are launching a new postdoctoral program in Systems Biology at IBFG. Join us! 👉 Several positions available with competitive work conditions for up to 4 years 📄 More info: jdiazc9.github.io/files/jobs/2...

www.nature.com/articles/s41... New paper out!!

Very excited to have this paper officially out. This one is pretty special... Unfortunately, @kevinwoodum.bsky.social passed away when this paper was in its final stages. He was my biggest supporter, and I miss him deeply as a mentor and friend.

Nora finished her paper with a sentence I like a lot "Our results show that even under extremely restrictive, competitive conditions, the simplest biological entities on Earth can still find paths to coexistence." There is a curious dichotomy in her experiments... 1/3 www.science.org/doi/10.1126/...

New preprint in collaboration with @asantoslopez.bsky.social lab and led by Jorge Sastre. Combining experimental evolution and analyses of longitudinal samples from hospitalised patients, we unveiled a new mechanism of plasmid-mediated evolution beyond HGT 1/8 www.biorxiv.org/content/10.1...

Excited to share the first preprint from my lab, collaborating with the fantastic @sanmillan.bsky.social 's lab, led by the amazing Jorge Sastre. We've demonstrated how insertion sequences encoded in plasmids promote bacterial adaptation. This project has been incredibly fun!