Julie Le Bris
@julielebris.bsky.social
📤 1238
📥 677
📝 28
PhD student interested in microbial evolution and ecology🧬 @Institut Pasteur
#Klebsiella
#MicroSky
pinned post!
Delighted to share our recently published work! Ever wondered how Klebsiella (and others) deals with capsule production’s costs ? The paper:
journals.asm.org/doi/10.1128/...
Thread👇
loading . . .
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
https://journals.asm.org/doi/10.1128/mbio.01807-25
7 months ago
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reposted by
Julie Le Bris
Eduardo Rocha
4 days ago
What happens when Klebsiella's capsule locus is swapped? Unexpectedly little in terms of cell growth. Yet, it does change the bacterium's environment and interactions with it: evolution by seamless plug-and-play capsule swap. Led by
@julielebris.bsky.social
@olayarendueles.bsky.social
add a skeleton here at some point
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reposted by
Julie Le Bris
Olaya Rendueles
4 days ago
Our latest manuscript explores capsule exchangeability & phenotypic portability We didn’t directly address its role in
#virulence
⏩️ that was already elegantly shown here—worth a look 👀👇🏻
doi.org/10.1371/jour...
🎯 Their results supports our plug-and-play model! Bonus: we kept 🐭 alive
#microsky
add a skeleton here at some point
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reposted by
Julie Le Bris
Olaya Rendueles
5 days ago
So happy to see this finally published in
@plosbiology.org
! This is the first chapter of
@julielebris.bsky.social
PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics w/
@epcrocha.bsky.social
#microsky
@klebclub.bsky.social
Link below- Check out her 🧵 for more details!
add a skeleton here at some point
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Julie Le Bris
PLOS Biology
5 days ago
How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis?
@julielebris.bsky.social
@olayarendueles.bsky.social
&co show the
#Klebsiella
capsule locus is a plug&play module that swaps with low fitness cost while preserving
#virulence
@plosbiology.org
🧪
plos.io/4s64Ko0
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reposted by
Julie Le Bris
FEMS Journals
21 days ago
🦠 How does
#Salmonella
find
#iron
in the gut?
@ferrytin.bsky.social
& colleagues show acidic pH pushes it to switch from using endogeneous to exogeneous
#siderophores—revealing
a flexible, pH-driven iron uptake strategy. 👉
buff.ly/90EZoqQ
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reposted by
Julie Le Bris
FEMS Journals
28 days ago
🦠 Beyond classic probiotics:
@schmitzstreitslab.bsky.social
lab reveals diverse
#Bacteroidota
gut strains that block
#biofilms
of major pathogens. Many also disrupt quorum sensing & show bile salt hydrolase activity—expanding the
#microbiome
toolbox against infection. 👉
buff.ly/sjPk8ZD
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reposted by
Julie Le Bris
Pedro Dorado-Morales
about 1 month ago
New preprint out on bioRxiv!
www.biorxiv.org/content/10.6...
Can conjugative plasmids be used to control plasmid and pathogen spread? Follow me down the rabbit hole that led to this story 🧵
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https://www.biorxiv.org/content/10.64898/2026.02.25.707879v1
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reposted by
Julie Le Bris
FEMS Journals
about 2 months ago
🧬 Dive into the small proteome of Methanosarcina mazei (across 5 conditions)! A key resource by
@schmitzstreitslab.bsky.social
@uni-kiel.de
for uncovering
#smallproteins
functions, motifs and proteoforms in
#archaea
. 👉
buff.ly/HJOi3E0
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reposted by
Julie Le Bris
FEMS Journals
2 months ago
🦠
@laurentterradot.bsky.social
lab reviews
#Brucella’s
#T4SS—a
key virulence factor—covering its structure, function, and growing effector arsenal. It also explores how effectors enter host cells, opening new paths to understand and target infection. 🔬 👉
buff.ly/KW4kVN4
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reposted by
Julie Le Bris
Olaya Rendueles
3 months ago
My team at
@cbitoulouse.bsky.social
is recruiting a postdoc
#bioinformatics
with solid experience in metagenomic analyses. Interest in evolution, ecology & MGEs is important. The offer stands until the perfect candidate is found, and it could be you 🫵 🔁 🙏
#microSky
#phagesky
#UTIsky
@cnrs.fr
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reposted by
Julie Le Bris
FEMS Journals
3 months ago
@archaellum.bsky.social
lab reveals how
#cdiAMP
and 4 RCK proteins shape osmotic stress responses in H. volcanii 🧬🦠. In highly halophilic
#archaea
, c-di-AMP coordinates ion balance and cell volume—mirroring bacterial strategies for environmental stress adaptation. 👉
buff.ly/ApWkCtg
0
13
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reposted by
Julie Le Bris
FEMS Journals
3 months ago
Review –by J. Yuan
@mpimicrobiomarburg.bsky.social
, HG. Koch & B. Berghoff— highlights bacterial small membrane proteins (SMPs) 🧫: from regulating membrane targets and insertion pathways to toxin roles. SMPs also offer potential as tools and templates for new antibiotics.💊 👉
buff.ly/9UzCwF2
1
4
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reposted by
Julie Le Bris
FEMS Journals
3 months ago
As 2026 begins, the EAM,
@Vdlorenzo.bsky.social
, Paul B. Rainey and many others remind us the urgency of renewing support to Society Journals and, taking action to reward quality research and curb predatory publishing. 👉
buff.ly/V36xgMO
👉
buff.ly/T8QE90G
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reposted by
Julie Le Bris
FEMS Journals
4 months ago
🦠Insight into the resilient world of prokaryotes! Koch lab –
@sfb1381.bsky.social
– reveals that E.coli use small membrane proteins (YohP & YncL) to condense their DNA & slow down metabolism, helping them survive to stresses. 🧬
buff.ly/dMzcQsP
0
10
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reposted by
Julie Le Bris
International Microbiology Literacy Initiative - IMiLI
4 months ago
Everything you need to explain AMR to family and friends-12:
@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social
@klebclub.bsky.social
@olayarendueles.bsky.social
the ESKAPE Rogues
www.imili-eah.com/prod-api/pro...
1
4
5
reposted by
Julie Le Bris
FEMS Journals
4 months ago
New insights into
#Hpylori’s
virulence machinery 🕵️🧪 Josenhans lab & coll. unravel new interactions between CagT4SS surface proteins and outer membrane proteins HopQ & HopZ—key for host interaction and
#proinflammatory
signaling. 🦠
@lmumuenchen.bsky.social
👉
buff.ly/toApn0c
0
4
2
reposted by
Julie Le Bris
FEMS Journals
5 months ago
🦠 Small changes, big defense! Jordan Vacheron & coll. show specific SNPs in
#Pseudomonas
protegens CHA0 (algC & ykcC) remodel LPS to block
#phage
ΦGP100—while growth, competitiveness & root colonization stay intact, in lab conditions. 🧬
@unil.bsky.social
👉
buff.ly/MFOH2er
1
4
3
reposted by
Julie Le Bris
FEMS Journals
5 months ago
What can an “orphan”
#Cas4
do? 🧫 In
#archaea
M. mazei, Solo-Cas4 cleaves dsDNA in a metal-dependent manner and is upregulated in stationary phase—hinting at roles in stress or DNA metabolism. Biochemical characterization by Schmitz lab
@uni-kiel.de
👉
buff.ly/kpz0yZ1
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3
3
reposted by
Julie Le Bris
FEMS Journals
5 months ago
#C.albicans
invades tissues as hyphae but spreads as yeast, How?
@jlspragu.bsky.social
& coll. show yeast can reach the bloodstream by hitchhiking with invasive hyphae or by switching forms. 🧫 More clues for understanding systemic infections ! 👉
buff.ly/0vklJeb
1
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reposted by
Julie Le Bris
FEMS Journals
5 months ago
🔍 From rods to stars, bacteria craft their shapes using bPBPs & GTases. Garcia-del Portillo lab’s global analysis reveals unexpected diversity & flexibility in these morphogenetic complexes. 🦠
@cnb-csic.bsky.social
👉 Read more :
buff.ly/D0pMhMr
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reposted by
Julie Le Bris
FEMS Journals
5 months ago
De-DUFing the DUFs 🧩
@franznarberhaus.bsky.social
lab uncovers how small DUF1127 proteins regulate
#phosphate
uptake by binding the sensor kinase PhoR. Their conserved role from Agrobacterium to E. coli highlights how even small DUFs can shape bacterial physiology 🦠
buff.ly/jJd9Eho
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reposted by
Julie Le Bris
FEMS Journals
6 months ago
New insights from
#CRISPR-Cas
systems! 🧬
@cyanolab.bsky.social
reveals that in the
#cyanobacteria
Synechocystis, RNase J works with RNase E to mature CRISPR3 RNAs—key for RNA-based immune defense. RNase J can also team up with PNPase in a degradosome-like complex.
buff.ly/CrxiQPy
0
3
1
reposted by
Julie Le Bris
FEMS Journals
6 months ago
New tools unlock
#Bdellovibrio
bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with
#CRISPRi-mediated
depletion for precise control of essential genes,
@lalouxlab.bsky.social
uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
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reposted by
Julie Le Bris
David Bikard
6 months ago
Entretien pour Brut sur la vie Miroir, l'ingénierie génétique et l'éthique de ces recherches:
www.brut.media/fr/videos/sc...
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Manipulations génétiques, virus créés par l’IA, bactéries miroirs : quelles limites à la recherche scientifique ?
Elles pourraient aider à lutter contre les cancers… mais aussi détruire toute trace de vie sur Terre ! Ce sont les bactéries miroirs. En avez-vous déjà entendu parler ? Et la vie miroir, ça vous dit q...
https://www.brut.media/fr/videos/sciences-technologies/sciences/manipulations-genetiques-virus-crees-par-l-ia-bacteries-miroirs-quelles-limites-a-la-recherche-scientifique
0
15
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reposted by
Julie Le Bris
FEMS Journals
6 months ago
A new subgroup of
#CRISPR-associated
transposons, V-K_V2, has been discovered in Nostocales
#cyanobacteria
by
@cyanolab.bsky.social
& colleagues 🧬. Its unique features suggest genetic mobility and V2 tracrRNAs are now included in the updated CRISPRtracrRNA tool.
buff.ly/gioIfEB
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5
2
reposted by
Julie Le Bris
FEMS Journals
6 months ago
Some
#Pseudomonas
aeruginosa strains naturally lack the major virulence system T3SS. 🦠
@inaattree.bsky.social
&
@cbuch.bsky.social
labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for
#biotech
use.
buff.ly/JST7ZR1
0
9
5
reposted by
Julie Le Bris
FEMS Journals
6 months ago
Phages are promising against antibiotic-resistant bacteria—but resistance can emerge. 🦠 New work from
@baerboletta.bsky.social
lab shows E. coli can resist phages in the lab, but in the gut that resistance comes at a cost: context is crucial for
#PhageTherapy
success.
buff.ly/NLOjnE2
1
8
3
reposted by
Julie Le Bris
Jeunes microbiologistes de la SFM
6 months ago
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
1
10
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reposted by
Julie Le Bris
Enninga Lab
6 months ago
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest
#preprint
🚨, led by our PhD student
@camimille.bsky.social
, where we show that
#Mycobacterium
tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!
add a skeleton here at some point
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reposted by
Julie Le Bris
FEMS Journals
6 months ago
New tool alert! 🚀 MCAAT uses de Bruijn graphs to detect
#CRISPR
arrays in
#metagenomes
, capturing data lost in assemblies. A step forward in uncovering the hidden diversity of CRISPR-Cas systems. By Talibli & Voß
buff.ly/QMX9yIe
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4
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reposted by
Julie Le Bris
FEMS Journals
7 months ago
Archaea thrive in harsh niches that challenge DNA integrity. 🧬 In H. volcanii, Sailer et al. revealed Cas1 & Hel308a as new Microhomology-Mediated End Joining (MMEJ) players, expanding the toolkit for archaeal genomes repair.
buff.ly/lnyY7JF
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reposted by
Julie Le Bris
Benoit Pons
7 months ago
How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter
@uniofexeteresi.bsky.social
with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky)
doi.org/10.1098/rstb...
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Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection | Philosophical Transactions of the Royal Society B: Biological Sciences
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance....
https://doi.org/10.1098/rstb.2024.0474
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How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes? That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus. The paper:
www.biorxiv.org/content/10.1...
Thread👇
loading . . .
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
https://www.biorxiv.org/content/10.1101/2025.08.29.672822v1
7 months ago
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reposted by
Julie Le Bris
Olaya Rendueles
7 months ago
Check out
@julielebris.bsky.social
’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter
@klebclub.bsky.social
This work started when I was still in
@pasteur.fr
& got finished in
@cbitoulouse.bsky.social
#microsky
#phagesky
add a skeleton here at some point
0
20
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Delighted to share our recently published work! Ever wondered how Klebsiella (and others) deals with capsule production’s costs ? The paper:
journals.asm.org/doi/10.1128/...
Thread👇
loading . . .
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
https://journals.asm.org/doi/10.1128/mbio.01807-25
7 months ago
2
42
32
reposted by
Julie Le Bris
FEMS Journals
7 months ago
#CRISPR
is more than Cas9 ✂️ 🧬 @BeiselLab reveals a short tracrRNA from S. pyogenes is toxic in L. paracasei, even without Cas9, underscoring challenges of using CRISPR-Cas9 in non-native hosts.
#microsky
buff.ly/qWjkxdK
0
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reposted by
Julie Le Bris
Anne Chevallereau
7 months ago
#phagesky
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ? Repost appreciated :)
1
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reposted by
Julie Le Bris
Olaya Rendueles
8 months ago
Looking forward to
#ESEB2025
Day 1! In this meeting, the team has two talks: I’ll present coevolutionary dynamics between bacteria & their prophages in S43 Tuesday PM &
@julielebris.bsky.social
will speak on Thursday AM, S34, on phenotypic heterogeneity of capsule expression.
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reposted by
Julie Le Bris
FEMS Journals
8 months ago
🔬 We’re past the midpoint of the year; perfect time to look back at what’s been discovered so far. From how Salmonella slows its escape from immune cells to the microbes thriving in oil reservoirs, these are the most-read
#microLife
papers of 2025 so far:
buff.ly/TfhOvEc
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reposted by
Julie Le Bris
Olaya Rendueles
8 months ago
Manuscript accepted just in time for
#ESEB2025
@eseb2025.bsky.social
@julielebris.bsky.social
will present phenotypic heterogeneity in some
#ESKAPE
pathogens 🧫 ! S34.01 - Mechanisms of adaptation to changing conditions in microorganisms Those not going to Barcelona, stay tuned for details!
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reposted by
Julie Le Bris
FEMS Journals
8 months ago
🌍 Health isn’t just about medicine.
#WHO’s
Health in All Policies (HiAP) shows every sector—transport, housing, economy—shapes our health. 🏙️ Since all human activity impacts the microbiosphere—life’s foundation—HiAP must go
#microbial
. 🧫 🔬 Read the editorial by K.Timmis & colleagues:
buff.ly/pcOjL6h
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reposted by
Julie Le Bris
FEMS Journals
8 months ago
#Actinomycetes
are rich in
#CRISPR-Cas
systems—many with unique features—yet their roles remain largely unknown.🧬 Mitousis et al. review highlights the need to explore these systems to unlock better genetic tools & new
#naturalproducts.🦠
⚙️
@unituebingen.bsky.social
buff.ly/84sehNp
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reposted by
Julie Le Bris
FEMS Journals
9 months ago
Why do
#phages
make short
#endolysin
isoforms? 🧬🦠 Dunne team in
@ethz.ch
, using Staph φ2638A, reveals both full-length and short variants form heterodimers to boost lysis & phage release—explaining conserved internalTSSs in phage genomes!
buff.ly/1I0H9ya
1
3
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reposted by
Julie Le Bris
FEMS Journals
9 months ago
Respiratory syncytial
#virus
(RSV) causes serious lung infections in infants & older adults. Brüssow @KU_Leuven reviewed decades of
#RSV
research, from failed vaccines to F protein–based breakthroughs. 🦠✨A comprehensive look at key
#milestones
in RSV prevention.
buff.ly/DQKw3Cw
0
2
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reposted by
Julie Le Bris
FEMS Journals
10 months ago
The methylcitrate cycle (MCC) – a lesser-known cousin of the TCA cycle – plays a key role in pathogenic fungi & bacteria. 🦠✨ Absent in humans, Korn and colleagues
@uni-jena.de
highlight its potential as a new
#DrugTarget
&
#biotech
tool.
#Microsky
buff.ly/TZNGfZS
1
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reposted by
Julie Le Bris
FEMS Journals
10 months ago
In the
#Archaea
H. volcanii, Marchfelder lab deleted all 4
#proviruses
(∆Halfvol1–4) and found: ⬆️ Swarming & chemotaxis ⬆️ H₂O₂ resistance ⬆️ Cell elongation ⬇️ CRISPR expression Turns out, these proviruses are active and likely cause chronic infection!🧬🦠
buff.ly/SSXPfdz
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reposted by
Julie Le Bris
FEMS Journals
10 months ago
🦠 Bacteria and archaea fine-tune CRISPR immunity by silencing ‘extraneous’ CRISPR RNAs (ecrRNAs) that could sabotage defense. Weinberg’s lab @UniLeipzig & @BeiselLab reveal 3 strategies in type II-C systems that mitigate ecrRNAs and maintain precision. ✂️🧬
buff.ly/xcSOMpG
1
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reposted by
Julie Le Bris
FEMS Journals
11 months ago
🦠 Dreaming of tracking real-time colony growth? SelinaRust, RandauLab built SMARTIS for you: a remote-controlled, smartphone-based time-lapse imaging system. 🔬📱 Early heterogeneity spotted within hours for cells with Type IV-A1 CRISPR-Cas activity!
@unimarburg.bsky.social
buff.ly/BBzh7cY
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reposted by
Julie Le Bris
Olaya Rendueles
11 months ago
Don't miss the 4rth and last session of
@klebclub.bsky.social
focusing on
#Klebsiella
as part of complex microbial communities ! Our keynote speaker will be Kevin Foster, followed by some
#phage
talks from Mark Mimee and Sara Forsstrom!
#microsky
#phagesky
Registration is free but necessary!
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reposted by
Julie Le Bris
FEMS Journals
12 months ago
🦠
#Paeruginosa
survival inside macrophages is a major challenge. Using mathematical modeling, Dimitriew & Schuster (@UniJena) unveiled how PA defends against the immune system and pinpointed potential new drug targets to combat
#infections
. 🔬♟️
buff.ly/G8l5Xgy
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