You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range. @rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social www.nature.com/articles/s41...

Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes. @nfrk92.bsky.social @narjournal.bsky.social academic.oup.com/nar/article/...

YprA family helicases provide the missing link between diverse prokaryotic immune systems https://www.biorxiv.org/content/10.1101/2025.09.15.676423v1

We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded. Link to the job emploi.pasteur.fr/offre-de-emp... Thx for sharing!

For anyone who has used pling for comparing plasmids using rearrangement distances ("how many structural events apart are these plasmids"), here's how to tweak parameters, and integrate it with typing info, and the host phylogeny www.biorxiv.org/content/10.1... github.com/iqbal-lab-or...

At last ! A tool specifically for phage-plasmid hunters. Check tyPPing by @karinailchenko.bsky.social and @eugenpfeifer.bsky.social

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Delighted to share our recently published work! Ever wondered how Klebsiella (and others) deals with capsule production’s costs ? The paper: journals.asm.org/doi/10.1128/... Thread👇

Happy to see our paper out! Functional assessment of anti-phage defence systems in their native clinical E. coli host royalsocietypublishing.org/doi/10.1098/... Thread in previous post 👇

How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky) doi.org/10.1098/rstb...

🎉🧪 The MEEP lab @mmsb.cnrs.fr celebrates its first anniversary! A year of experiments, caffeine-fueled late nights, and nerdy excitement. 🚀🔬 I'm very grateful to the team of amazing #WomenInScience who joined this incredible journey @josie-e.bsky.social Clarisse Plantady and Elodie Kenck.

Can CRISPR-Cas systems target any phage? Yes, no, it depends? What does it depend on? The second paper from my PhD came out today in a special issue of Phil Trans B on the ecology and evolution of bacterial immune systems doi.org/10.1098/rstb...

#ResultatScientifique🔎| Des scientifiques ont révélé comment le plasmide pOXA-48 rend les bactéries ultra-résistantes aux antibiotiques 🦠 🤝 @cnrs.fr @mmsb-lyon.bsky.social @cnrs-rhoneauvergne.bsky.social ✍️ @sbigot.bsky.social 📕 @natcomms.nature.com | buff.ly/u3Cy4Db

Plasmids can be lost from a bacterial community even under positive environmental selection: doi.org/10.1101/2025...

Cool preprint by Mathieu Berge @polardlab.bsky.social showing that the Spr1630 toxin (RipA) toxin targets the replication sliding-clamp (DnaN) and that this induces competence in Streptococcus pneumoniae. www.biorxiv.org/content/10.1...

#CNRSnews 📰 As antibiotic resistant bacteria are proliferating, causing millions of deaths worldwide, scientists are turning to a century-old, neglected solution: that of using bacteriophage viruses, which only attack bacteria

Check out the first preprint from our lab describing a direct molecular cross-talk between (p)ppGpp and c-di-GMP nucleotide messengers! Great work from first-author Corentin Jaboulay who was a postdoc in our lab, and great collaborations! @mmsb-lyon.bsky.social @cnrsbiologie.bsky.social

Cross-regulation of (p)ppGpp and c-di-GMP pathways controls a cell-cycle transition https://www.biorxiv.org/content/10.1101/2025.08.22.671821v1

www.nature.com/articles/s41... #phagesky #phage

Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨ 👉 www.nature.com/articles/s41... @cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social

This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

#phagesky I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ? Repost appreciated :)

Ever wondered why some bacteria have multiple CRISPR-Cas systems? Our new study led by Leah Smith shows how type I CRISPR systems can promote the acquisition and retention of new spacers into a co-occuring type III system. www.sciencedirect.com/science/arti...

As part of the ENW-XL UTIr project we have developed a novel fully defined synthetic artificial urine medium for urinary bacteria. www.biorxiv.org/content/10.1... #UTISky #AMR #MicroSky #MicrobiomeSky #InfectiousDiseases #ClinMicro

🧬💊Our new paper in @ismepublications.bsky.social🧬💊 "Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance" In collaboration with @umweltbundesamt.bsky.social Read the thread below: academic.oup.com/ismej/advanc... #AMR 1/9

New preprint out! 🧬🦠🌱 What shapes #phage–bacteria #networks in #plant environments? - Ecological origins of bacteria and phages? - Phage taxonomy? - Bacterial phylogeny? - #Prophages? #Defence-systems? 📖 here: www.biorxiv.org/content/10.1... Discover which of these actually shape the network 👇

#phage #phagesky #microsky

#phage #phagesky #microsky www.nature.com/articles/s41...

Fluid flow generates bacterial conjugation hot spots by increasing the rate of shear-driven cell–cell encounters #PNAS by Matti Zbinden et al www.pnas.org/doi/abs/10.1...

Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you www.jobbnorge.no/en/available...

📝New preprint! We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments. A short thread 🧶

Expression level of anti-phage defence systems controls a trade-off between protection range and autoimmunity By Nitzan Aframian and Avigdor Eldar. www.nature.com/articles/s41...

After many years in the making, here is our host range #phage paper with #ecology, #evolution and #biocontrol perspectives published in Molecular Ecology! @phimresearch.bsky.social‬ @inrae-pv.bsky.social‬ #PVBMT #JulianGarneau onlinelibrary.wiley.com/doi/10.1111/... These are our key findings:

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

Please share! 🦠 Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra. Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/... #MicroSky

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins Structural predictions to improve #phage genome annotation! @hannelorelongin.bsky.social @gbouras13.bsky.social y.social @susiegriggo.bsky.social @veravannoort.bsky.social www.biorxiv.org/content/10.1...

New paper alert! 🚨 Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate. We combine theory, simulations, experimental evolution, and bioinformatics to demonstrate that mutation rates scale with plasmid copy number. Let's dive in! 🧵👇

New online! Viromics approaches for the study of viral diversity and ecology in microbiomes

Experimental evolution in an era of molecular manipulation www.nature.com/articles/s41... #jcampubs

Phage counter-defense repertoires: New work IDs broad & specific anti-defense genes in variable regions of Pseudomonas phage genomes. Inhibitors neutralize diverse bacterial immune systems, highlighting how phages evolve broad & specific strategies www.cell.com/cell-host-mi...

New paper with @rwheatley8.bsky.social and Cedric Lood Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy. Sensationalist title: Plasmids carry useless genes academic.oup.com/ismej/articl...

📢Preprint out! Excited to share my final work from the @soreklab.bsky.social! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!

🌿Congrats to the Equipe Projet VERT: Marine Blanc, Sandrine Magnard, Lauriane Lecoq (MMSB UMR 5086), Sandrine Vadon-Le Goff (LBTI UMR 5305), Nicolas Grimault (IBCP UAR 3760) and Virginie Gueguen-Chaignon (SFR Biosciences UAR 3444) for their Cristal Collectif Medal! ✨Towards more sustainable science!

🚨NEW PAPER ALERT!!!🚨 The BBH lab is proud to present the latest www.nature.com/articles/s41... from our collaboration with @joshuasweitz.bsky.social (now at UMaryland), evaluating the importance of alveolar macrophages (AM) for the efficacy of phage therapy against P. aeruginosa Let's dig in (1/6)

New paper joint with @phagepasteur.bsky.social (including joint experimental/modeling first authors Sophia Zborowsky and Jeremy Seurat) on in vivo phage therapy efficacy given immunomodulated animal hosts. Nat Comms: rdcu.be/euikl Accessible summary: cmns.umd.edu/news-events/...

Nous recrutons un IE en bioinformatique pour faire de l'analyse évolutive de séquences biologiques (CDD de 22 mois) dans le cadre d'un projet ANR. L'offre est disponible ici : emploi.cnrs.fr/Gestion/Offr... N'hésitez pas à partager ! Merci ! 🙏 Me contacter pour toute info supplémentaire.

It's out! We used the T4P-dependent phage Luz19 to select against the type IV pilus virulence factor in P. aeruginosa, despite the presence of competing S. aureus.

🎉 Congratulations to Alexia from the Drug Resistance & Membrane Proteins Group at MMSB and her coworkers for being awarded the 'Article of the Month-May 2025' by the @sfbbm.bsky.social for their publication! The SFBBM highlight is available here: www.sfbbm.fr/index.php?op...