Un poste de Maître de Conférence est ouvert pour rejoindre notre unité à Lyon ! Possibilité de rejoindre mon équipe pour travailler sur: - caractérisation des mécanismes de défense anti-phage - transfert horizontal et interactions entre éléments génétiques mobiles N'hésitez pas à me contacter

My team at @cbitoulouse.bsky.social is recruiting a postdoc #bioinformatics with solid experience in metagenomic analyses. Interest in evolution, ecology & MGEs is important. The offer stands until the perfect candidate is found, and it could be you 🫵 🔁 🙏 #microSky #phagesky #UTIsky @cnrs.fr

New bioRxiv preprint from our Lesterlin lab How early gene expression coupled to DNA processing boosts resistance plasmid spread. With @nfrk92.bsky.social in collab with Y. Yamaichi lab 👉 doi.org/10.64898/202...

🚨 New paper from our lab in Cell Reports @cp-cellreports.bsky.social, led by Clara Douadi! We show that bacteriophages can cross the intestinal barrier, with increased translocation in Crohn's disease. 🔗 www.cell.com/cell-reports... Many thanks to all the authors!

New publication from the Grangeasse's team at MMSB! Congratulations to all authors. In collaboration with Cecile Morlot (IBS, Grenoble) and David Rooper (Warwick university). To know more : rdcu.be/eVsin

#ResultatScientifique🔎| Comment la bactérie construit sa paroi : une chorégraphie moléculaire  ✍️ Christophe Grangeasse 🤝 @cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social 📕 @natmicrobiol.nature.com | buff.ly/AI5mJEe

@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs www.biorxiv.org/content/10.6...

Preprint alert📢! 
Ever wondered how much bacterial parasites influence evolutionary outcomes of their host? ➡️ We co-evolved two bacterial strains in conditions in which the costs and benefits of prophage carriage varied Here is what we found. 
www.biorxiv.org/content/10.6... 
#MicroSky #PhageSky 🧵

Our last 2025 joint lab meeting with the Guzzo lab is looking very Christmassy! @mguzzo.bsky.social @josie-e.bsky.social @mmsb-lyon.bsky.social

I am honoured to serve as Co-Chair of the LOC for @PhageCanada 2025 Virtual Symposium. With an amazing team, we’ve built a strong program featuring outstanding guest&keynote speakers, plus students and postdocs showcasing excellent phage research from across🇨🇦register now👇(1/2)

Two conferences two weeks apart, thank you to everyone who came and chatted to me at my poster (or in general) at the Phages.fr conference in Nancy and the @microbiologysociety.org #MicroEvo25 conference in Liverpool. It was great to show the first data from my postdoc and get advice and feedback

Two fully-funded PhD openings in my research group at the University of York. If you’re excited about viromes, phage biology, Nanopore sequencing, soils and the odd bit of alpine or agricultural field sampling, we’d love to hear from you! 🌱🦠🏔️ tiny.cc/c4pv001 tiny.cc/e4pv001

Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky journals.plos.org/plosbiology/...

🤯 Amazing work..! Looking forward to digging into the paper.

🚨#PhD studentship opportunity! Plasmids provide bacteria with antimicrobial resistance, but do they have more fundamental effects on behaviour? 🧫🦠💫🧟‍♂️ Apply for a 4y funded MRC DiMeN position with me and Jamie Wheeler @livuni-ives.bsky.social www.findaphd.com/phds/project...

PhD studentship opportunity! Join us at St Andrews to study the factors controlling plasmid transmission in the gut. Competition-funded as part of the EASTBIO DTP, co-supervised with Dr Jaclyn Pearson. Please share & pass on to anyone interested! 🦠🧫 Deadline 15th December👇

Interested in doing a PhD in phage biology? See below a super cool project on megaphage ecology and evolution available at the University of Jyväskylä (FIN) in Elina Laanto's lab (Project no. 4). Co-supervision provided by yours truly.

JOB OFFER #PhageSky We have a postdoc position opening in my group to investigate phage-MGE interactions ! We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social Contact me for more info ! >> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...

New pre-print www.biorxiv.org/content/10.1... Plasmid-dependent phage (PDPs) are ubiquitous, but the selective pressures that they impose on plasmids are not well understood. Project led by Daniel Cazares in collaboration with @brockhurstlab.bsky.social! #phagesky#microsky

#ResultatScientifique 🔎| Le complexe CST protège l’ADN en réparant les cassures même après dégradation partielle, limitant ainsi les mutations dangereuses 🧬 ✍️ @zhouxu.bsky.social 📕 @CellGenomics | buff.ly/84geAXj

DYK most P. aeruginosa carry filamentous phage(s) that don't need to kill the cell to reproduce? We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE. "Filamentous cheater phages drive bacterial and phage populations to lower fitness" 🔗 authors.elsevier.com/c/1lt5I3QW8S...

#Évènement🎟️| Lancement de la 3️⃣ème saison des #ÉchappéesInattendues du @cnrs.fr avec la conférence immersive de Jean-Michel Jault, biologiste au @mmsb-lyon.bsky.social sur l’antibiorésistance 🧫 des bactéries 🦠 pour la #FDS2025 📅 11 octobre 🕢 à 17h30 ✔️ sur inscription : bit.ly/confmmsb #FDSAURA

You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range. @rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social www.nature.com/articles/s41...

Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes. @nfrk92.bsky.social @narjournal.bsky.social academic.oup.com/nar/article/...

YprA family helicases provide the missing link between diverse prokaryotic immune systems https://www.biorxiv.org/content/10.1101/2025.09.15.676423v1

We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded. Link to the job emploi.pasteur.fr/offre-de-emp... Thx for sharing!

For anyone who has used pling for comparing plasmids using rearrangement distances ("how many structural events apart are these plasmids"), here's how to tweak parameters, and integrate it with typing info, and the host phylogeny www.biorxiv.org/content/10.1... github.com/iqbal-lab-or...

At last ! A tool specifically for phage-plasmid hunters. Check tyPPing by @karinailchenko.bsky.social and @eugenpfeifer.bsky.social

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Delighted to share our recently published work! Ever wondered how Klebsiella (and others) deals with capsule production’s costs ? The paper: journals.asm.org/doi/10.1128/... Thread👇

Happy to see our paper out! Functional assessment of anti-phage defence systems in their native clinical E. coli host royalsocietypublishing.org/doi/10.1098/... Thread in previous post 👇

How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky) doi.org/10.1098/rstb...

🎉🧪 The MEEP lab @mmsb.cnrs.fr celebrates its first anniversary! A year of experiments, caffeine-fueled late nights, and nerdy excitement. 🚀🔬 I'm very grateful to the team of amazing #WomenInScience who joined this incredible journey @josie-e.bsky.social Clarisse Plantady and Elodie Kenck.

Can CRISPR-Cas systems target any phage? Yes, no, it depends? What does it depend on? The second paper from my PhD came out today in a special issue of Phil Trans B on the ecology and evolution of bacterial immune systems doi.org/10.1098/rstb...

#ResultatScientifique🔎| Des scientifiques ont révélé comment le plasmide pOXA-48 rend les bactéries ultra-résistantes aux antibiotiques 🦠 🤝 @cnrs.fr @mmsb-lyon.bsky.social @cnrs-rhoneauvergne.bsky.social ✍️ @sbigot.bsky.social 📕 @natcomms.nature.com | buff.ly/u3Cy4Db

Plasmids can be lost from a bacterial community even under positive environmental selection: doi.org/10.1101/2025...

Cool preprint by Mathieu Berge @polardlab.bsky.social showing that the Spr1630 toxin (RipA) toxin targets the replication sliding-clamp (DnaN) and that this induces competence in Streptococcus pneumoniae. www.biorxiv.org/content/10.1...

#CNRSnews 📰 As antibiotic resistant bacteria are proliferating, causing millions of deaths worldwide, scientists are turning to a century-old, neglected solution: that of using bacteriophage viruses, which only attack bacteria

Check out the first preprint from our lab describing a direct molecular cross-talk between (p)ppGpp and c-di-GMP nucleotide messengers! Great work from first-author Corentin Jaboulay who was a postdoc in our lab, and great collaborations! @mmsb-lyon.bsky.social @cnrsbiologie.bsky.social

Cross-regulation of (p)ppGpp and c-di-GMP pathways controls a cell-cycle transition https://www.biorxiv.org/content/10.1101/2025.08.22.671821v1

www.nature.com/articles/s41... #phagesky #phage

Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨ 👉 www.nature.com/articles/s41... @cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social

This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

#phagesky I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ? Repost appreciated :)

Ever wondered why some bacteria have multiple CRISPR-Cas systems? Our new study led by Leah Smith shows how type I CRISPR systems can promote the acquisition and retention of new spacers into a co-occuring type III system. www.sciencedirect.com/science/arti...

As part of the ENW-XL UTIr project we have developed a novel fully defined synthetic artificial urine medium for urinary bacteria. www.biorxiv.org/content/10.1... #UTISky #AMR #MicroSky #MicrobiomeSky #InfectiousDiseases #ClinMicro

🧬💊Our new paper in @ismepublications.bsky.social🧬💊 "Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance" In collaboration with @umweltbundesamt.bsky.social Read the thread below: academic.oup.com/ismej/advanc... #AMR 1/9

New preprint out! 🧬🦠🌱 What shapes #phage–bacteria #networks in #plant environments? - Ecological origins of bacteria and phages? - Phage taxonomy? - Bacterial phylogeny? - #Prophages? #Defence-systems? 📖 here: www.biorxiv.org/content/10.1... Discover which of these actually shape the network 👇

#phage #phagesky #microsky

#phage #phagesky #microsky www.nature.com/articles/s41...