How do you kill a MRSA superbug armed with 15 different anti-phage defense systems? You make a smarter phage. Check out our latest preprint on overcoming bacterial immunity using defense-guided engineering to build durable therapeutic phage cocktails! Led by Sarah Voss. doi.org/10.64898/202...

Jesus Christ this is bad

While the situation is grim at NIH, it's closer to catastrophic at NSF. They're just not able to move any money out the door. It appears OMB has them on lockdown. www.science.org/content/arti....

Our new experimental evolution study across 30+ locations using the plant Arabidopsis thaliana —— we direct "see" adaptation and extinction to different climates at the genetic as it happens! Read it in Science dx.doi.org/10.1126/scie... @ucberkeleyofficial.bsky.social @hhmi-science.bsky.social

Are the Mets…..good?

My in-terminal plasmid editor is ***actually*** coming together! Next big feature is a proper synbio module editor. Check back often; actively developing this! github.com/Binomica-Lab...

queens represent

"Anything found to be true of 𝘌. 𝘤𝘰𝘭𝘪 must also be true of elephants." (j. monod) "...but certainly not for 𝘉. 𝘴𝘶𝘣𝘵𝘪𝘭𝘪𝘴" (picked up by @emmseveri.bsky.social at a meeting), and also not for 𝘈𝘤𝘪𝘯𝘦𝘵𝘰𝘣𝘢𝘤𝘵𝘦𝘳, as @ckellison.bsky.social et al. found out now

Have you assumed/learned that DNA damage repair (DDR) via the SOS pathway (LexA, RecA, etc.) is universal (in bacteria)? turns out it's more a maze than a 'pathway'... #MicroSky

*This* problem definitely doesn't exist, but we're about to reinvent the problem of a WHOLE bunch of people getting made real uncomfortable in public about what they thought their chromosome were. So that'll be… "fun."

Runners at the corners adds to the kitty features 🐱

Very provocative new paper in @natmicrobiol.nature.com As global temps rise, drought is becoming more frequent and prolonged across many regions Paper shows climate-driven drying of soils can fuel antimicrobial resistance at its ecological source, independent of clinical antibiotic use 🧵 (1 of 6)

I think it's vitally important that everyone know that when baby bear cubs are orphaned and taken to our local wildlife center, they get fed and rehabbed by people masking their scent and wearing costumes like this so they don't get habituated to humans

LOBSTAH POUTINE The Red Sox will be serving "Lobstah Poutine" at Fenway Park this year! This ballpark food features crispy fries, lobster meat, clam chowder and crispy bacon all served in a custom lobster boat.

<laugh sobbing> We are so f@cked

Christ on a cracker

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com www.jobs.ac.uk/job/DQY475/r...

The only thing keeping me from trading on oil futures right now is the Saved by the Bell episode where Zach ended up trading potato futures and got stuck with a bunch of potatoes

There simply aren’t enough woodchippers for what I’d like to see done.

So, the thing is, this is completely ok IMO. The goal is not to evaluate authors (even if you know who they are), the goal is to avoid inherent biases and evaluate work as presented. Double blind is relatively easy step that moves in that direction. You don’t need to know authors to evaluate work.

Weirdest f*cking timeline ever

"Send the secret police to fix airport security delays" is a perfect summation of this administration's governing style. Nothing works and they don't know how to govern, but they do have a secret police force they can dispatch at will. Next the gestapo will be filling potholes in swing districts.

10/10 no notes

FYI: New online! Epistasis and co-adaptation in bacterial genome evolution

OK, I take it back - he isn't only a complete weirdo about trans women, just *mostly* trans women.

What…what does he think happens when people go thru customs upon arrival? Does he think Customs is just unable to stop someone with no documentation, but plucky ICE agents can lend a hand and arrest them?

Oh, this is cool

Here is it! Super new science from us on horizontal gene transfer & bact defense systems! Liyana OW YONG discovered the first-of-its-kind defense factor AbjA that triggers 'abortive conjugation' as a defense mechanism, by targeting the T4SS! How neat?! #MicroSky 1/7 www.biorxiv.org/content/10.6...

🚨 PhD opportunity in evolutionary microbiology! Join our lab to study how horizontal gene transfer drives host–microbe symbioses and ecological function Plus: a PDRA position in comparative genomics is available ✉️ [email protected] Apply below #PhD #Postdoc #Microbiology #Evolution #Genomics

Simply wondering if the tactical vests are necessary is all

At least say it with your chest

Every time I’m in Union Square I think about how Tammany Hall, the seat of power for New York for decades, is now a Petco

It’s all so stupid

Just want to draw college basketball fans’ attention to this matchup in NC State-Michigan

Science is amazing. A crippling horrid disease about to be eliminated .

I’ve done enough biology to know that, even though it’s probably harmless a majority of times, enough weird shit happens when you put random proteins into established systems that there’s no way this won’t turn out disastrously wrong

I want fully staffed public pools, and libraries that are cathedrals to public goods and a society where walling yourself off with money is viewed as sociopathic.

I don't normally subscribe to the "German has a word for it" thing because all languages can invent and borrow new words! That said, I can't stop thinking about "hobbyless" as an insult since I saw it a few days ago, so here you go It promotes a growth mindset!! www.tumblr.com/abbiistabbii...

"Bunch of guys obsessed with Ancient Sparta can't beat the Persians at sea" was probably one of the known-knowns, come to think of it.

If there is one thing I’ve learned is that if a project is struggling, adding a bunch of new trainees always helps, especially if they’re being paid and you’re not, and they’re the reason you’re not being paid

Proud dad moment: My son and his friend entered and won their first Lego building competition at the zoo yesterday. Two hours and the theme was “bird”.

Imagine you’re a new ICE agent that signed up to beat up and deport people and you’re put on luggage screening duty

Here’s the latest preprint from my work on evolved resistance to Type VI Secretion system (T6SS) weaponry, funded by a @wellcometrust.bsky.social Sir Henry Wellcome Fellowship. So happy to see this out! www.biorxiv.org/content/10.6...

Hi folks, there is a high likelihood I will be recruiting 1-2 PhD students to start in Spring 2027. Trying to get the word out early; please share broadly with your networks and encourage your students to reach out early. Info can be found on my webpage. fuesslab.wp.txstate.edu/opportunities/

Excited to announce our new journal from @isme-microbes.bsky.social ISME Host Microbe is live and now accepting submissions. Look forward to receiving your papers! #Microsky 🧫 🦠

Been getting a bunch of spam business loan calls…and I’m playing the Groundhog Day game with them. How far can I get on their script before they hang up on me. (Today I got as far as them asking whether my business made >200k in revenue, to which I responded “why would I need a loan if it did?”)

A piece of good news for basic scientists in training!

Chat, are we f*cked?