Latest in #GENETICS: A gain-of-function genetic screen for the regulation of histone H1 function in #Drosophila identifies several factors that affect chromosome structure, histone H1 binding, and histone H1 exchange with greater impacts on genome organization and accessibility. 🔗 buff.ly/MujDw5H

📢 NEW GENOME ALERT in #G3journal The New World screwworm, Cochliomyia hominivorax, is an obligate parasite of warm-blooded animals and a major pest of livestock and wildlife. Its improved genome offers better resolution of the sex chromosomes and updated genome annotations. 🔗 buff.ly/nPZvItR

In #GENETICS, @marbeitman.bsky.social et al. used #Drosophila hybrids to uncover new molecular and neural mechanisms underlying the evolution of #courtship behavior, highlighting how genetic and sensory inputs shape species-specific behavioral outcomes. 🔗 buff.ly/kq9JL6n

A comparison between two commonly used mutant screening methods in #Daphnia identifies the strengths and limitations of each approach in detecting #CRISPR-induced changes in target genes. Read more in the May issue of #G3journal: buff.ly/MscngSC 📷️ credit: Bret Coggins

In #G3journal, @wbooker.bsky.social and Daniel Schrider used simulations to understand the evolution of small diploid and autotetraploid crop populations and to identify the conditions that support the evolution of pseudo-overdominance. 🔗 buff.ly/ziFWhXM

Dive deep into this new perspective piece in #GENETICS, emphasizing the limitations of classical genetics in deciphering genotype-phenotype relationships and the need for new experimental paradigms to understand context-dependent genetic effects. 🧬 🔗 buff.ly/VOi9xht

New results in #GENETICS support the most parsimonious model of background selection, where partially recessive deleterious mutations and adaptation to captivity can explain the genetic diversity in #Drosophila experimental data better than models of overdominance. 🪰 🔗 buff.ly/c4nXbJy

New findings in #GENETICS from @bendeskylab.com show that the conversion of dietary pro-vitamin A carotenoids to retinal by beta-carotene oxygenase 1 (bco1l) is essential for retinoic acid-dependent processes in larval and juvenile betta fish. 🐟️ 🧬 🔗 buff.ly/Dzx2NIH

Why do pix-1 #Celegans mutants show variability in phenotype severity in muscles? 🪱 A new genetic mapping in #GENETICS reveals that an enhancer to the ipmk-1 gene contributes to phenotype severity by influencing the proper assembly of Integrin adhesion complexes in muscles. 🔗 buff.ly/qtBrXHw

A mutant analysis in #GENETICS uncovers a new role for the #Celegans TWK26 potassium channel in lipid homeostasis—where it promotes intestinal oligopeptide absorption in concert with the FLR4 protein kinase—controlling intestinal physiology and metabolism. @sarahtorzone.bsky.social buff.ly/TPlUTuV

On the G3 cover: "A Bittersweet Symphony" Using a diverse cider germplasm from the USDA Malus collection, authors identified significant genetic markers for polyphenols, individual sugars, & malic acid. More⬇️🧵

At the Santeuil field C. elegans natural populations have been monitored for over a decade—there a stream meanders through the wood. Whole-genome sequencing data shows a tree-like haplotype network tracing the accumulation of mutations in selfing populations sampled along the stream across years. ⬇️🧵

What does ancient DNA reveal about biological kinships? Read this exciting study in #GENETICS that used Exponential Random Graph models for correlates of relatedness, identifying evidence for female exogamy and the existence of an elite class in ancient Avar. buff.ly/aSPLOTg @brohrlach.bsky.social

A longitudinal analysis published in #GENETICS highlights the central role of genetics in shaping dietary intervention outcomes, such as in intermittent fasting, in a mammalian model with physiological relevance to humans. #longevity #dietaryrestrcition 🔗https://buff.ly/lsvtZ6j

🪰 We asked what you’re looking forward to at #Dros27 — connection stood out! As organizer @seyeonchung.bsky.social shared, the fly community is welcoming & supportive. One of the best parts of this meeting is reconnecting with friends & meeting new faces. So, who are you excited to connect with? ⬇️

New in #GENETICS: @ornacf.bsky.social and the team discovered that Kar4—a putative transcription factor required for efficient mating in the budding #yeast Saccharomyces cerevisiae—increases the DNA-binding specificity of Ste12 globally. 🔗 buff.ly/q5ncnCV

This new study in #GENETICS establishes #Celegans as a model for #Hippo signaling, identifying Hippo-dependent and -independent signals that control WTS-1 in epithelia and intestine, respectively. 🪱 🔗 buff.ly/cdGmEPa

New research in #GENETICS shows how Rho GTPase signaling regulates synaptic transmission in the #Celegans egg-laying circuit, identifying Rho-1 signals downstream of Trio RhoGEF to promote egg laying. 🔗 buff.ly/YESIYAC

📢 NEW GENOME ALERT @laramiemckenna.bsky.social and the team present a highly contiguous, chromosome-scale, haplotype-resolved genome assembly for the southern live oak. Discover the American Campus Tree Genomes program in this #G3journal paper: 🔗 buff.ly/AVKatnX

Learn about a new simulation methodology in #G3journal that is designed to increase recombination rate in #breeding programs and to determine the effect of recombination on genetic gain using phenotypic and genomic selection. 🔗 buff.ly/vQrCTBr

What is the mutation rate in natural vs laboratory populations? What are the typical divergence times among and within species? In #GENETICS, Wei et al. analyzed the evolution of clonal #Celegans genotypes collected and sequenced in Santeuil wood, France.🪱 🔗 buff.ly/1rINY0W

The genetics community has lost a pioneering and often provocative force. J. Craig Venter, a key figure in sequencing the human genome and advancing synthetic biology, has died at age 79. 🔗: buff.ly/tbADU5l

A detailed characterization of polyadenylation profiles in 45 #yeast strains carrying mutations in proteins involved in chromatin, mRNA splicing, cleavage, mRNA stability, and RNA binding, reveals a wide variety of DNA and RNA processes that are affected. Learn more in #GENETICS: 🔗 buff.ly/8mfOM9P

A quantitative genetics model incorporates the influence of indirect maternal and paternal as well as parent-of-origin genetic effects on the additive genetic variance. Learn more in #GENETICS: 🔗 buff.ly/Y7GK1Ag

We’re already thinking about #Dros27—and we’d love to hear from you. What are you looking forward to at next year’s meeting? Who are you hoping to connect with? Tell us below. 🔽

Learn more about a new modeling approach in #GENETICS that maps one state space to another, enabling the computation of the inverse instantaneous coalescence rate (IICR) using Q-matrices of different dimensions. 🔗 buff.ly/kq9f3Ms

The April issue of #G3journal features the first-ever reference genome of a parasitic fly, Istocheta aldrichi—a crucial resource in conservation efforts, as it is used as a biological control agent for the invasive Japanese beetle in North America. 🪰🧬 buff.ly/WzBV2Bx

Please join us in congratulating 2026 GSA Early Career Medal recipient @mexpositoalonso.bsky.social of @ucberkeleyofficial.bsky.social!🎉 Recognized for pioneering research on plant adaptation, genetic diversity, & climate change, he is shaping the future of biodiversity science. 🔗: buff.ly/7MBsZ4l

Read the latest report in the April issue of #G3journal, which uses genetic mapping and CRISPR mutants to isolate Pid3 as a resistance gene for fungal Rice blast disease in rice cultivar Wanhui 66. 🌾 🧬 🔗 buff.ly/y88CrR3

Check out an important benchmarking study in the April issue of #G3journal 🛠️ Wang et al. compared computational tools used for cross-omics label transfer from scRNA-seq to scATAC-seq data and studied the impact of data and method properties on results. 🔗 buff.ly/P7aV4ei

🎂 Happy birthday to Charles Woodworth, born April 28! He first bred Drosophila in captivity and proposed fruit flies as a model organism in 1901.🪰 More than a century later, the global fly community is still building on that vision. 👀Got your eyes on #Dros27? Stay tuned for details coming soon!

A new report in the April issue of #G3journal reveals that #Drosophila males depend on visual cues to determine the anterior–posterior body axis of females, driving specific spatial patterns of distinct behavioral courtship elements. 🪰 💕 #flycourtship buff.ly/0zsLdLY

New in #GENETICS from @hainerlab.bsky.social: The nucleosome remodelers esBAF and INO80 selectively influence subcompartment identity and enhancer–promoter communication at key regulatory loci during higher-order chromatin organization in mice. 🔗 buff.ly/0eU5xg0

A genetic screen in #yeast reveals unusual, hypermorphic properties of Yta7—a chromatin remodeling factor and histone chaperone—variants and highlights the importance of nucleosome remodelers in establishing centromeric chromatin. Learn more in #GENETICS: buff.ly/58t1wOd

Happy #DNADay26! 🧬 On April 25, 1953, publication of DNA’s double helix structure changed science and opened new frontiers in genetics and genomics. Ready to share your field-changing research? #GENETICS and #G3Journal are ready for you: buff.ly/IuxIUCC

New data in #GENETICS show that at least 2 different populations of ligand-gated heteromeric acetylcholine receptors with different stoichiometries and properties coexist at the #Celegans neuromuscular junctions. 🔗 buff.ly/sdG0x1s

⚒️ New mutant lines help uncover a molecular mechanism of abnormal oocyte (ao)—a #Drosophila maternal-effect lethal gene—function that is distinct from histone gene repression. 🪰 Learn more in #GENETICS: 🔗 buff.ly/Fz2hy8p @harmitmalik.bsky.social @leilarieder.bsky.social @schmidtlablc.bsky.social

We are saddened to share the passing of Don Moerman, a valued member of the genetics community and a former editor at #G3Journal. Don, a longtime researcher at the University of British Columbia, was an integral part of the Worm community. He will be deeply missed. Read more: buff.ly/qXY007J

Cleavage and polyadenylation (CPA) factors mediate many post-transcriptional changes, such as splicing. Check out the latest study in the April issue of #GENETICS reporting a stress-dependent role of #Celegans CPA factor CFIM-1 in germline integrity. @wbderry.bsky.social 📑 🔗 buff.ly/RSoOAme

Genome Database for Vaccinium, a knowledge base for genetics, genomics, and breeding data of blueberry, cranberry, and other berries, continues to evolve based on community needs and emerging data types. 🫐 🍒 Find more about the latest features of the database in #GENETICS: 🔗 buff.ly/X1nvQlo

New research in #GENETICS from @msrivastava95.bsky.social, Ard Louis, and @n-martin.bsky.social focuses on fitness landscapes built from genotype–phenotype maps with a random phenotype-fitness map and makes analytic predictions about their topographical properties. 🔗 for the paper: buff.ly/VnQ796V

🔬Today is #WorldLaboratoryDay! Time to celebrate discoveries that begin at the bench. Whether you’ve just finished your first research paper, or you’re a seasoned pro, #G3Journal and #GENETICS are proud to publish your work. 🔗 Learn more: buff.ly/sQSKB2o

A #Drosophila genetic screen of miRNAs identifies miR-275 as a critical regulator of #circadian locomotor rhythmicity. 🪰 ⏰️ Learn more in #GENETICS: 🔗 buff.ly/WYWlWgz

The #Fungal26 photo gallery is live and ready for browsing. Relive your favorite moments, spot familiar faces, and revisit an incredible meeting with your fungal genetics community. 📷Take a look now: buff.ly/2rfTdr7

Javier Fernández-González, Seifelden M Metwally, and Julio Isidro y Sánchez introduce a new #rstats package, MateR, and provide equations and metrics for predicting family means and variances in breeding populations. Learn more in the April issue of #GENETICS: buff.ly/D1UD1g5

Where do potentially harmful mutations accumulate, and how does the interaction of evolutionary processes shape mutation load? New research in #GENETICS from @jochenwolflab.bsky.social and colleagues determines that in birds 🕊️ 🔗 buff.ly/tC2e3zN

🔍️ Explore the new ontology-based cross-species resource—CoMorbidity DataBase Mapper—that allows for joint analysis of genotype-phenotype associations in model organism databases. Learn more about this resource in the April issue of #GENETICS: 🔗 buff.ly/HhdzUIm

A new study published in the April issue of #GENETICS uses #yeast model to identify that the ribosomal protein ASC1 reduces TDP-43 toxicity via autophagy, revealing a new regulatory pathway in the neurodegenerative disease ALS. 🔗 buff.ly/bzGCa41

Latest study from @hainerlab.bsky.social probes the functions of nucleosome remodeling complexes in higher-order chromatin organization in mice. Learn more in the April issue of #GENETICS: 🔗 buff.ly/cDQzB28

The April issue of #G3journal highlights two new #bioinformatics tools 🛠️ 🧬 👉 PAQman for applications in long-read sequencing and 👉 WeavePop for short-read sequencing data 🧵