New Dialogue and Debate from #G3Journal: Réka Howard and Alexander Lipka argue for simpler models in genomic selection and question whether complexity undermines scientific validity. Read more: buff.ly/CW7psYB

In the December issue of #GENETICS, @jeremyjberg.bsky.social et al. introduce an evolutionary model of complex disease susceptibility, identifying how diseases are shaped by selection acting on other pleiotropically related traits. buff.ly/QTZPpYQ

In #GENETICS, Wang et al. show that #yeast nuclear RNA-binding protein Hrp1 is an antitermination factor for RNA polymerase II, where its release from the elongation complex upon specific binding to the nascent transcript enhances termination. buff.ly/3SMJpyh

🚨 Apply for the James F. Crow Early Career Researcher Award! Honoring students and recent PhDs in population, evolutionary, and quantitative genetics. Finalists present at #PEQG26. Deadline: Jan 14, 2026. Learn more and apply now: buff.ly/AhJVE6Z

Dihydropyrimidine dehydrogenase (DPD) is a key enzyme in pyrimidine catabolism; severe toxicity led by its deficiency in patients is treated with 5-FU. Learn more in #GENETICS about the #Celegans model that assesses DPD deficiency and 5-FU sensitivity. buff.ly/t1MSWR6

In the December issue of #G3journal, Rockman et al. investigated the utility of obligately outcrossing #Caenorhabditis #nematodes as models for inbreeding depression, showing it is universal but highly variable among species and populations. buff.ly/BDIPbcZ

New in #GENETICS: @csagariya.bsky.social et al. used stochastic simulation to examine the impact of genotyping error and its interplay with marker density in single-nucleotide polymorphism (SNP) data. buff.ly/tZP70Ha

In #GENETICS, discover a single-cell RNAseq resource for adult females and males of Daphnia magna—a freshwater plankton crustacean, which is an emerging model for eco-physiology, toxicology, and evolutionary genomics. buff.ly/tDaKYUz

Takahiro Sakamoto and @samyeaman.bsky.social developed a new theoretical method to analyze complex multi-population models, allowing heterogeneity in selection, migration, and population density. Learn more about the model parameters in #GENETICS: buff.ly/6ymeQLe

📢 NEW GENOME ALERT The aquatic midge Chironomus riparius is an established indicator taxon for the water quality assessments in Europe. In #G3journal, Pettrich et al. present a novel long-read genome assembly of the organism. buff.ly/1Hf1bTb

New study in #GENETICS used mitochondrial transgenesis to show that S. cerevisiae mitotypes were sufficient for a partial boost to thermotolerance and respiration in the S. paradoxus background. buff.ly/QMPW4v4

Did you know abiotic stresses can severely impact crops? Explore the first paper in our new Omics Report section in #G3Journal, a peer-reviewed, rapid-review format for multi-sample omics datasets: buff.ly/mLggFmc P.S. We’re always open for submissions—share your research today!

Poster abstracts are open for #Dros26—don’t miss your chance to share your work. Posters offer one-on-one conversations, focused feedback, and connections that can shape your next steps. If you have results to share, submit today. We can’t wait to see your work! 🔗https://buff.ly/E3FQkvo

In #GENETICS: Arun et al. present a new method for estimating genetic variance for relative fitness that does not involve making measurements of fitness on individuals, but instead tracks changes in the genetic composition of the population. buff.ly/hJb8GcQ

Check out the latest review on human retrotransposon LINE/L1 activity in #GENETICS discussing the size distribution of 5′ truncations and how it varies depending on the age and subfamily of the element. buff.ly/5TnUrS9

There’s still time to submit to the #GENETICS special issue on Fitness landscapes: data, theory, and applications! Share your latest tools, models, or ideas reshaping how we understand fitness landscapes. 🔗https://buff.ly/PJBDOmV

Applications are open year-round for the Starter Culture Microgrant! GSA members at any career stage can apply for up to $2,000 to support projects that strengthen the genetics community. Have an idea with broad impact? Apply by December 31. Learn more: buff.ly/PCTlzzH

The latest study in #G3journal sheds light on the genetic architecture underlying domestication-related traits in cowpea, confirming that its domestication, similar to other crops, relies on selection in a few key genomic hotspots. buff.ly/Dup0TjN

A new mutant report in #G3journal characterizes null alleles of bag of marbles (bam) in different #Drosophila species to understand its evolutionary role in germline stem cell daughter differentiation in early gametogenesis. buff.ly/0q7Bz38

Sam Krabbenhoft, @peterwlewis.bsky.social & Melissa Harrison of UW–Madison use fruit flies to study pediatric diffuse midline glioma. A new #GENETICS study identifies genetic pathways that could guide future targeted treatments—showing the power of model organisms in cancer research: buff.ly/MjhnYuf

A theoretical model published in #G3journal links crown development with cell lineage sampling to show that branching architecture strongly influences the accumulation of unique somatic mutations in long-lived plants. buff.ly/SD78qfH

New in #G3journal: @doctorapples.bsky.social et al. used GWAS on hundreds of cider apple accessions from the USDA Malus collection and identified significant marker-trait associations for fruit quality. This resource will help in cider apple breeding efforts. buff.ly/j7oJ00i

📢 NEW GENOME ALERT A complete chromosome-level genome assembly of Diplodia sapinea, a fungal pathogen that primarily infects Pinus species, helped discover two accessory chromosomes for the first time in this pathogen.  Learn more in #G3journal: buff.ly/fzBbxvo

📢 NEW GENOME ALERT In #G3journal, Cucini et al. present the first genome assembly of Orchesella dallaii, an Italian endemic species of basal hexapods, generating a valuable resource for this often-overlooked taxonomic group. buff.ly/NOKPphf

The December episode of Genetics in Your World is now live!🎙️ ECS Multimedia Subcommittee member Debraj Manna interviewed Dr. Matthew Rockman (@wormsrock.bsky.social) of New York University about inbreeding depression in C. elegans. Listen now: buff.ly/7DVBt56

🚨Last chance to nominate an outstanding PhD researcher using Drosophila for the Larry Sandler Award! They'll present at #Dros26. Submit your nomination by tonight's deadline: buff.ly/KlxI3Bn

A new study in #G3journal showcases a heat shock-optimized CRISPR system integrated with the Gal4-UAS system that allows efficient phenotypic studies, clonal analysis, and mutant generation in Drosophila. buff.ly/i8fnur0

In #G3journal, Kim et al. present a clinically relevant murine model of triple negative breast cancer that captures robust genetic heterogeneity, enabling the identification of conserved modifiers and mediators of this deadliest subtype of breast cancer. buff.ly/1YVxXuZ

Benefit from presenting your research at #PEQG26—submit an abstract: buff.ly/QxCUbsW 🔑Showcase your research & advance your career 💡Get feedback & new perspectives from key leaders in the field ⭐Grow your presentation & communication skills 🤝Meet potential employers, mentors, collaborators

The latest #G3journal study provides the first genome-wide analysis of grizzly bears residing in British Columbia, which helped map genetic differences across the coastal-to-interior ecotone in the region. buff.ly/cONbhW9

📢 NEW GENOME ALERT in #G3journal The first full chromosome-level assembly of the olive fruit fly Bactrocera oleae will help develop new approaches to control this major pest of commercial olives. buff.ly/kZNj2hu

New research in #G3journal tested chemosensory behavioral responses in hundreds of #Celegans strains collected from around the world, identifying new quantitative trait loci associated with decreased response sensitivity to quinine. buff.ly/5hevs67

Join us in welcoming GSA’s newest Board members: VP David Greenstein, Treasurer @marymullins.bsky.social, & Directors Monica Colaiacovo (@colaiacovolab.bsky.social), Tania Reis, & @jrossibarra.bsky.social. We’re grateful for their leadership & excited for what’s ahead. Learn more: buff.ly/7LZjkoP

Thinking about submitting a poster abstract for #Dros26? 🪰 Posters offer one-on-one conversations, focused feedback, new connections, and visibility in a supportive community for all career stages. Learn more in the latest Genes to Genomes blog: buff.ly/UI0vukJ

Discover a new #CRISPR toolbox for #Drosophila in #G3journal CrisprBuildr, an #opensource, web-based application, helps design target gene modifications. This tool can serve as a template for other available genomes. buff.ly/BE75a9w

December #G3Journal cover: yeast starvation islands. While cultures of lab yeast knockout strains may grow relatively well in a synthetic defined medium, represented by the green island, not all knockout cultures grow as well in media with limited nitrogen (blue) or limited sulfur (yellow). 1/2🧵

The #GENETICS December cover shows a fluorescence confocal stack of a Drosophila melanogaster testis with DNA in Cyan Hot LUT & Mud, protein of interest in this study, in Orange Hot LUT (iyaf145). Read the full issue: buff.ly/VU6JV9n 📸: Tara M. Finegan, Andor Dragonfly 600 spinning disk confocal🔬

New in #G3journal: @wormsense.bsky.social and colleagues show the role of satiety in regulating the response strength and chemotaxis in attraction to isoamyl alcohol and 2-methyl-1-butanol, two products of bacterial fermentation, in #Celegans. buff.ly/r9Z91tu

Check out this new method in #GENETICS that allows population geneticists to jointly estimate time and population of origin for a mutation in a structured population and examine statistical performance using simulations. buff.ly/KK9ZVz0

In #GENETICS, @fbaumdicker.bsky.social and the team present a model that tests the effectiveness of CRISPR in sensitizing bacterial populations carrying resistance on nontransmissible plasmids, and helps assess the success probability of a treatment with antibiotics. buff.ly/H9S6Viv

🚨LAST CHANCE! Are you an undergraduate student attending a 2026 GSA Conference? Now is your last chance to apply for the GSA Undergraduate Travel Award. Apply by tomorrow & focus on your science, not your wallet: buff.ly/jUYE9Xd Use it to attend #Dros26, #Fungal26, #PEQG26, or #Yeast26 next year!

In #G3journal, Skovbjerg et al. investigate the circumstances under which the prediction accuracy of grain yield, plant height, and rust resistance in the 6-rowed winter barley breeding program. buff.ly/yaYSeZB

New research in #GENETICS presents a non-canonical checkpoint regulatory role of Elg1-RLC, which coordinates with the DDR pathway to safeguard the integrity of replication forks under replication stress. buff.ly/k3SMnvC

⏰ Don’t miss your chance to nominate for the 2026 Gruber Genetics Prize! Honoring up to 3 scientists for transformative genetics research—each receives a $500K unrestricted award. 🗓 Deadline: Dec 15, 2025 🔗 buff.ly/o2opMGT

Congratulations to the Fall 2025 Victoria Finnerty Undergraduate Travel Award recipients! 👏 We can’t wait to see your research at #Dros26. Learn more about their research: buff.ly/L4fQg9L

In #GENETICS, @kauralasoo.bsky.social and colleagues show how horizontal pleiotropy can mislead Mendelian randomization to infer implausible causal relationships between an exposure and an outcome. buff.ly/KSRgKeM

@fishfena.bsky.social et al. discovered two novel craniofacial genes responsible for extreme jaw development in pupfish using integrated comparative tissue-specific transcriptomics and speciation genomics. Learn more in #GENETICS: buff.ly/blKKbuZ

New research in #GENETICS from @azurita.bsky.social, Christopher Kyriazis, and @klohmueller.bsky.social demonstrates how unmodeled selection on synonymous mutations may affect downstream inferences of the distribution of fitness effects. buff.ly/IDY87W1

First or corresponding authors can get a $250 discount on APC/page charges at GENETICS and G3 when you attend a 2026 GSA Conference! Provide the code GSA2026 at the time of your paper submission. Questions? Don't hesitate to DM us! #Dros26, #Fungal26, #Yeast26, #PEQG26

New study in #GENETICS uses a sequence-only approach to infer regulatory networks. By performing gene orthology on hundreds of fungi genomes, the researchers predicted pathways for recombination in Candida and pathways for mating in Neurospora. buff.ly/H9bTEGo