New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

Thank you @impvienna.bsky.social for featuring our next career step! The support that Ulrich @hohmannulrich.bsky.social and I received from our postdoc labs (@pauligroup.bsky.social, @juliusbrennecke.bsky.social and @plaschkalab.bsky.social), and now from @imbmainz.bsky.social has been key!

Want to map protein-RNA interactions? Check out our new iCLIP3 protocol. Featuring steamlined library prep and visualisation of protein-RNA complexes without radioactivity! Bioinformatics workflow on top :) With the Müller-McNicoll and Zarnack labs! @zarnack-group.bsky.social @mixmue.bsky.social

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

@lorenzoorts.bsky.social previously worked as a postdoctoral fellow at @impvienna.bsky.social in Austria. She will establish a new lab at IMB to investigate how mRNA translation is activated in the early embryo. Welcome to IMB Laura! 💐 Read more here: www.imb.de/about-imb/ne...

Ulrich’s research will help advance our understanding of RNA biology & gene regulation, as well as how these mechanisms might be altered during viral infections & other diseases. @hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social www.imb.de/about-imb/ne...

New lab just dropped 👇

www.wur.nl/en/vacancy/f... Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!

Recruiting a postdoc for a fun project on insect immunity. An international consortium will study the role of the microbiome&phages in resilience to infection. Please repost! www.radboudumc.nl/en/vacancies/160441-postdoctoral-researcher-bioinformatics-of-microbiome-virus-host-interactions-in-insects

Early bird registration deadline of our joint meeting in Potsdam between March 10-13, 2026 - “Joint international meeting of the German @gfeev.bsky.social, Dutch (DSDB), and #SEBD for #DevBio “Development & Regeneration” is approaching fast. Please apply before the 15th of January!

🔍 #AskZebrafish: Does anyone in the US or Canada have any of the following mutant #zebrafish lines and would be willing to share? tert, klotho, cxcl12a, cxcl12b, cxcr4a and cxcr4b Any leads would be appreciated! (Yes, we know ZIRC has some frozen but trying to find live)

The Vienna BioCenter Summer School 2026 call is open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Diana Pinheiro from the IMP is recruiting! https://training.vbc.ac.at/summer-school/

Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner. #piRNA #histone #mRNA #maternal #RNAbiology #RNASky www.biorxiv.org/content/10.6...

What a way to start the new year with one more submission to BioRxiv. This one is on how GTSF-1 enable RdRP activity in nematodes (for Piwi aficionados: correct, it does not affect Piwi😊) www.biorxiv.org/content/10.6...

This nicely shows how the city of Mainz prioritizes bike-usage…one can get sued for not cleaning the walkway along your house, but the city leaves bike trails (but not car lanes of course) covered in ice…

Happy to share two BioRxiv manuscripts from our lab. One on genetic Argonaute interaction and unexpected non-correlation between small RNAs and their targets: doi.org/10.64898/202... The second on IDR processing and IDR-mediated Argonaute loading control: doi.org/10.64898/202... Merry Xmas😊

Very happy to be able to advertise our latest paper: A genetic framework for RNAi inheritance in Caenorhabditis elegans | EMBO reports www.embopress.org/doi/full/10....

If you are an enthusiastic, motivated and team-oriented life science researcher-in-spé, we are looking for you! We offer excellent science and working conditions. For more info on projects please see. Please help me spread this🙏 www.imb.de/students-pos...

If you are an enthusiastic, motivated and team-oriented life science researcher-in-spé, we are looking for you! We offer excellent science and working conditions. For more info on projects please see. Please help me spread this🙏 www.imb.de/students-pos...

💥Finally out! Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb). Now in @currentbiology.bsky.social : cell.com/current-biol... >

First #bluetorial. 🎉🎉 We’re very happy to share our latest biorxiv #preprint, just in time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. #TEsky #evosky #Celegans Short 🧵 with highlights.

Transposable elements drive regulatory and functional innovation of F-box genes https://www.biorxiv.org/content/10.1101/2024.12.17.628972v1

www.academics.com/jobs/univers... Please help us find a new colleague at Mainz University. Thanks! #evolbiol

We are looking for new group leaders. If RNA is your thing, and/or computational biology and you want to start your own group, check out these links. Feel free to contact me about these! And, please help me spread this. Thanks! www.imb.de/jobs/jobdeta... www.imb.de/jobs/jobdeta...

Universal Single Copy Knock-In System in Caenorhabditis elegans: One Plasmid to Target All Chromosomes https://www.biorxiv.org/content/10.1101/2024.12.06.627295v1

And since we're here... 🥼 Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬 More details via www.imb.de/jobs Application deadline is 5 January 2025 #sciencejobs #resilience #biostatistics

Join us in San Diego. A great meeting and also featuring the RNA Journal

Researchers in @labgrosshans.bsky.social & their collaborators developed a tool that maps how proteases—enzymes that process proteins—cut their targets. The work, published in Molecular Systems Biology, could revolutionize drug design for conditions like diabetes. www.fmi.ch/news-events/...

And don't forget: many nematode species have lost them altogether! A huge puzzle. doi.org/10.1002/wrna...

Interesting findings by the Zarnack and König labs: www.cell.com/molecular-ce... #RNAbiology

#RNASky #RNAbiology

Small RNA Biology starter pack, with a heavy bias towards our worm community! Just getting this started, and we'd like it to max out, so please message me if I've missed you (and apologies!)! go.bsky.app/HgPCPen

Excellent opportunity in Toronto.

Question to worm colleagues: do you know of a transgene that starts to be transcribed in Z2/3, and is not provided maternally?

Happy to share the publication of the IDRome paper:   Conformational ensembles of the human intrinsically disordered proteome   Work led by Giulio Tesei and Anna Ida Trolle    I'll post more later, but for now here is a link: www.nature.com/articles/s41...

New publication from our group: An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori www.embopress.org/doi/full/10.... We propose this may be how Piwi activity can be restricted environments suited for further piRNA production

Master's Thesis Opportunity! The Ameres lab is looking for a passionate master's student to delve into the mysteries of chemical RNA modifications ✨ ➡️ Apply here: tinyurl.com/39hhkd7t

🚨🚨🚨🤝🧬🔍 We are recruiting group leaders for the #GenomeBiologyDepartment at the I2BC (France). Open to all relevant topics, with particular interest in RNA biology, chromatin organization, genome stability and gene expression. i2bc.paris-saclay.fr/jobs/ DM me for info! Please RT🙏

The non-coding repetitive genome as a source of regulatory DNA elements in cancer: a highlight of the recent work from Biswajyoti Sahu: www.nature.com/articles/s41...

Are you an RNA biologist or developmental biologist studying cardiac development? Join us at our new lab at the Vascular Research Center @UK_Frankfurt . We are expanding our team: Currently hiring 1 Postdoc and 2 PhD students to study mRNA translation @ERC_Research Please share 🙏

Good start of the day: zebrafish grant from the DFG awarded🎉. Thanks anonymous reviewers for your support! Amazing how nerves still fire uncontrollably when such a mail arrives, and you do not yet know whether good or bad will follow…😄

Had a great time in Muenster, visiting the MaleGermCells Clinical Research Unit. Thanks to Erez Raz for the hospitality and Frank Tuttelmann BirgitStallmey LeahBiggs Ivan Bedzhov, Timo Strünker and Erez (again😊) for great discussions!

First step into small RNAs in ants together with the group of SusanneFoitzik. 🙏to former tweeter Ann Sophie Seistrup and Shamitha Govind from my group and all other colleagues on this work to realize this.

Yesterday evening I found out my friend got murdered in his house together with his wife and all his kids. He was a very good man who helped anybody as a principle, even if you weren't close with whatever you might need. A real Kibbutznik. I am broken. Everybody around me getting similar news.