🚨🚨🚨🧪 H1B scientists who are traveling outside the USA. Please be aware that current advice is to return to the USA IMMEDIATELY

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

Trainees: Struggling to find the best figure arrangement for a manuscript draft? Do the 🧪 equivalent of an arts and crafts project: 1. Print draft figures and cut each panel into its own square. 2. Find a big table. 3. Move the panels around until you see the story. This is your paper. 🤓

Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.

1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

🚨 Happy to see this collaborative work out in @embojournal.org. How is spindle pole detachment at mitotic exit regulated and what happens to nuclear & chromosome organization when it goes wrong? Hint: chromosomes look like kidney beans! 🌮🌯 Tour-de-force by @spindlebehavior.bsky.social and team!

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

We are looking for a student to continue our work on chromatin evolution: www.nature.com/articles/s41... www.biorxiv.org/content/10.1... The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes. More info: recruitment.crg.eu/content/jobs...

The “problem” with vaccines? They so effective at preventing deaths that they create generations of people that question whether disease was a problem in the first place because they have never experienced the horrors of a world without vaccines.

🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️ academic.oup.com/nar/article/...

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB #Epigenetics #Chromatin #Lamin --- Gain deeper insights into gene regulation; epigenometech.com

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression www.biorxiv.org/content/10.1...

New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries www.sciencedirect.com/science/arti...

Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier @cnrs.fr @cnrsbiologie.bsky.social Congrats to all!

Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts https://www.biorxiv.org/content/10.1101/2025.08.08.669284v1

🚨🚨🚨 New collaborative results with Anne Dejean (@institutpasteur.bsky.social ) and very talented PhD student Amandine Goffeney. academic.oup.com/nar/article/... Trying to understand how SUMO represses innate immunity and IFNB1, we discovered an element with a unique function in 3D 🧬🧬🧬 organization

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Become our colleague! Tenure-track Assistant Professor position at The Center for Integrative Genomics, University of Lausanne, Switzerland. unil.ch/cig/en/home.... More details for how to apply are here: www.nature.com/naturecareer...

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Two major events today on our campus! 🚴‍♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social! 🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!

Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?

(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:

Looking forward to this exciting meeting!

Great job opportunity at The Center for Integrative Genomics, Lausanne University, Switzerland unil.ch/cig/en/home.... For a tenure-track Assistant Professor position. More details for how to apply are here nature.com/naturecareer...

Capture C identifies promoter interacting sequences. MPRA tests sequences for regulatory activity. Here, we combined them both to test sequences with their target promoter. Amazing work by @colinearnould.bsky.social, Pia Keukeleire, Martin Kircher and many others. www.biorxiv.org/content/10.1...

Very happy to participate in the 8th Brazilian Cytogenetics and Cytogenomics meeting in beautiful Brasília. A great opportunity to present our recent work and discussing with the Brazilian research community

📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

Our institute @iecb.bsky.social is looking for new group leaders. The call is also addressing plant scientists🌱! Join us in the beautiful city of Bordeaux! www.iecb.u-bordeaux.fr/en/news/grou...

Nature Genetics is looking to hire a new editor! Come join our team and help publish the most exciting research in genetics and genomics! Deadline is April 25th. springernature.wd3.myworkdayjobs.com/en-US/Spring...

Looking for a PhD in sunny Barcelona? ☀️🔬 Our team is hiring a PhD student for the @hologen.bsky.social project! 📅 Deadline: *Apr 20* ⚠️ READ THE MOBILITY RULE FOR THIS POSITION 🔁 Please, spread the word All the info here 👉 www.cnag.eu/jobs/phd-stu... #PhDlife #Genomics #HoloGen #Barcelona

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025

I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social qmul-jobs.tal.net/vx/mobile-0/.... Pls share.

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

Postdoc position #1 is live! Please apply / spread the word! lms.mrc.ac.uk/work/vacanci...

✨ PLUS QUE DEUX MOIS avant #pint25 ✨ 📍 +55 villes, du Parc naturel du Limousin à la Réunion et la Guyane 🔬 Des centaines de scientifiques passionné·e·s 🫂 500 organisateurs·trices à fond ! 📱 Programme : 31 mars 🎟 Tickets : 14 avril 👉 pintofscience.fr

Symposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘

🇫🇷 Pour les francophones 🇫🇷 : un résumé accessible de notre récente étude publiée dans @pnas.org (www.pnas.org/doi/10.1073/...) par @cnrsbiologie.bsky.social . Merci de mettre en avant notre travail 🙏

🥁Out on @pnas.org 👉Insulation between adjacent TADs is controlled by the width of their boundaries through distinct mechanisms 🔗https://www.pnas.org/doi/10.1073/pnas.2413112122 👏Congratulations to Andrea Papale, David Holcman at #IBENS and their collaborators @daannoordermeerlab.bsky.social!

Looking forward to talking about our recent Capture multi-omics work and how its helping us to understand the molecular mechanisms of genomic imprinting #GenomicImprinting25

Our study on how TAD boundaries actively influence the neighboring domains published today in @pnas.org: www.pnas.org/doi/10.1073/... Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.

Hint for those who can't get data from NCBI SRA archive: most (but not all) of this data is also mirrored at EBI www.ebi.ac.uk

Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development. Loss of a single CTCF motif is sufficient to cause embryonic lethality. www.sciencedirect.com/science/arti...

Stunning publication from @IbrahimCisse_ where they show a: “Direct observation of a condensate effect on super-enhancer controlled gene bursting” congratulations to @manyu_du @SimonStitzinger & all @Cisse_lab www.cell.com/cell/fulltex...