Asking BlueSky for help: For a review, I am trying to accurately credit the first paper that measured pairwise 3D distances between 2 pieces of DNA on the same chromosome (or cosmid). Is Trask 1989 the first? I know of earlier single-locus papers (1982). www.sciencedirect.com/science/arti...

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

Thrilled that our work is now finally out in Nature Comms! rdcu.be/eG3vP We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres. Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

Now hiring a computational postdoc (evolutionary genomics, molecular evolution) in my lab at Emory University. If you’re interested in population genetics, fitness landscapes, and viral evolution — get in touch. faculty-emory.icims.com/jobs/151181/...

Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...

#FWF Präsident Christof Gattringer befürchtet starke Budgeteinsparungen für #Grundlagenforschung in Österreich: 800 Arbeitsplätze könnten durch Kürzungen wegfallen. Die Unis würden dadurch weiter an Boden bei der Spitzenforschung verlieren. via @derstandard.at 👉 www.derstandard.at/story/300000...

Dream collaboration with the groups of Torben Heick Jensen (@heick.bsky.social; @au.dk) and Clemens Plaschka (@impvienna.bsky.social). Building in part on the incredible work from Ulrich Hohmann on human mRNA export. www.biorxiv.org/content/10.1...

thanks, Ewan. this would have been impossible without AlphaFold. We tried for years to express recombinant Drosophila Piwi for loading it with a defined piRNA. Only wizards like Ian MacRae, Phil Zamore, En-Zhi Shen & Jianping Wu succeeded with silkworm and mouse PIWI proteins.

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

When chanchitos fly, it happens 2,340 meters deep in the Ocean! This is a sea pig, or chanchito, if you’re a member of the #Uruguaysub200 science team. Scotoplanes sp. is a genus of deep-sea sea cucumbers of the family Elpidiidae. 🎥ROV SuBastian / Schmidt Ocean Institute

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

Based on feedback from applicants, reviewers and broader research community, the ERC Scientific Council decided to make changes in the 2026–27 calls for proposal for research funding. More details from the ERC President 👉 europa.eu/!hP3WWF What’s your take on this? Tell us! 👇

I guess this has probably already gone viral somewhere but I am simply dying at this picture of a bear that looks like it hired a photographer to do a glamour shoot

A very useful Hi-C theory by Polovnikov&Starkov - the contacts-vs-distance curve at short distances depends only on the contact radius and loop density (but not on the loop length!): www.biorxiv.org/content/10.1... This nicely corresponds to our experience in modelling mitotic chromosomes from Hi-C.

The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at

In this episode of the Epigenetics Podcast, we talked with @arnausebe.bsky.social from the @crg.eu in Barcelona about his work on chromatin evolution. #podcast #chromatin #epigenetics Listen here: www.activemotif.com/podcasts-arn...

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Fantastic opportunity. Vienna rocks!

Center for Living Systems -- seeking strong post docs at the interface of physics and biology. Consider applying by Oct. 13! docs.google.com/forms/d/e/1F...

Excited to share our preprint w/Gordana Wutz, Iain Davidson, Leonid Mirny, Jan-Michael Peters www.biorxiv.org/content/10.1... Evidence that PDS5A/B limits NIPBL-cohesin life w/effects on CTCF boundaries & chrm compartments, +mechanisms of compartment-extrusion interplay & cohesin regulation by PDS5

🚨 New paper out in Nature Comms! From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates. 👇 A short thread on how physical #genome organization emerges from molecular interactions: www.nature.com/articles/s41...

1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...

In the genomics community, we have focused pretty heavily on achieving state-of-the-art predictive performance. While undoubtedly important, how we *use* these models after training is potentially even more important. tangermeme v1.0.0 is out now. Hope you find it useful!

Do you want to push the boundaries of science together with world-class supervisors and colleagues? The ISTA-Fellowship Program offers fully funded two-year postdoctoral fellowships for highly qualified candidates. Apply now to take your next career step at ISTA: https://bit.ly/4kfKBZx

This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses. buff.ly/Ieh84gj

@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease. Details below careersearch.stanford.edu/jobs/computa... Plz RT

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

Insightful analysis of the complex role of NIPBL in loop extrusion in vivo!

Job Alert: A stealth startup focused on non-cancer diagnostics is keen to hire a deep learning for genomics/bio engineer. I am an advisor for the startup & closely involved. Please see the job description below and get in touch if interested. Plz forward.

Awesome job opportunity in Sweden!

WORK! I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects: - Nanopore protein sequencing - Archaeal CDV cell division - Microfluidics for synthetic cells - Nuclear Pore Complex - Origami mimics of peroxisomes Please apply! ceesdekkerlab.nl/come-join-us/ RT=👍

What an utter travesty

We're excited to share our new preprint, "Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development", led by Thomas Reimonn. www.biorxiv.org/content/10.1...

So love this explanation of the deification of AI and the singularity, sent to me by my son

Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier @cnrs.fr @cnrsbiologie.bsky.social Congrats to all!

🧬 Check out our latest paper in the PRL: doi.org/10.1103/7fh5... We use computer simulations and analytically solvable theory to study supercoiled DNA plasmids functionalized by pH-responsive groups. We show how charge annealing can reversibly switch the topological twist to writhe and vice versa.

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland

The Austrian Academy of Sciences (ÖAW)’s DOC Fellowship program supports outstanding PhD students by funding their innovative research projects. This year no less than 13 talented PhD Students at the Vienna BioCenter received this highly competitive fellowship www.viennabiocenter.org/about/news/d...

bottom line: the host is unable to launch a piRNA response unless the transposon inserts itself into an exon of a host gene expressed in gonads. The data is so black and white that it was a true pleasure to put the paper together. Baptiste’s experimental skills are showcased in the data/figures.

piRNAs are essential for transposon silencing in the animal germline. But how do hosts trap transposon sequences in genomic loci that help establish a piRNA response? Looking at a natural transposon invasion, Baptiste Rafanel and Kirsten Senti made some remarkable observations.

Just 2 weeks left! The Vienna BioCenter PostDoc Program is still accepting applications. We have 16 fully-funded fellowships available for researchers in biology, chemistry, physics, bioinformatics, and more. Apply now: training.vbc.ac.at/post-docs/vi... #VBCPostDoc

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

last call! submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Can’t wait to introduce bird-based storage into my backup system

Amazing stuff. I'd like to point you to the incredible graphical abstract for this recent Cell manuscript. doi.org/10.1016/j.ce...

Great opportunity! The Uni Vienna has launched a call (APART) for 4-funding for outstanding postdocs from a US institution. The host lab has to nominate by 1 August a candidate for further selection. Anyone interested in our work please contact me by email with CV/motivation letter. Hurry up!

So Tokamak Fusion reactors can be used to generate gold from mercury - preprint from Marathon Fusion scientists #QuantumAlchemy 🤯😳- arxiv.org/abs/2507.13461

🧬💻 We're hiring a #Bioinformatics #Developer @emblebi.bsky.social! Join the @ensembl.bsky.social Variation team building open-source tools to support global research & clinical genomics. Collaborative team; real impact. 👉 Apply: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... ⏰ Deadline: 10 August