Opportunity for scientists considering moving to Spain as tenured scientists! Happy to see openings in microbiology across the country (including at CNB which has incorporated fantastic micro eco/evo researchers lately) and functional & systems biology at IBFG www.ciencia.gob.es/en/Convocato...

Looking for a great first read for 2026? Look no further: Fantastic work spearheaded by my courageous colleague @changweiyu.bsky.social, with surprising findings not only for small RNA but also for exosome and gene expression aficionados

New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion

Highly recommended!!

A very interesting read on the major progress in llms this year. (Contrary to the popular opinion, llms very much haven't saturated their capabilities yet)

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...

All right it’s time for the annual “please tell us about one (or a few if you are ambitious) paper from 2025 that really impressed you and why we should all read it“! Go! If you tell us how it changed your view of the world and what makes it so powerful and consequential It would be excellent.

Congratulations to our Anna Obenauf, Senior Group Leader at the IMP, for receiving the EJI Ita Askonas Prize 2025 for her pioneering work uncovering how cancer evolution, therapy resistance, and immune evasion are intertwined. ➡️

I wrote a piece on LLMs, citation metrics, and the institution of science. It's been up for a couple of days, but it is officially "out" now.

Things are going great over at X, The Everything App

“A process which led from the amoeba to man appeared to the philosophers to be obviously a progress - though whether the amoeba would agree with this opinion is not known" - Bertrand Russell, 1976. Time-lapse video of Vampyrella lateritia eating Spirogyra algae from Science Source/Oliver Skibbe. 🦠

There used to be debates about—given the growth and self-organization of crystalline structures—whether they could be said to be alive. The current LLM "debate" is so debased and terrible that when reacting to deranged CEO claims, critics frequently do the equivalent of denying crystals grow at all.

I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...

Authorities are investigating possible ties between the shooting at Brown University and a professor who was killed at MIT, WPRI reports www.wpri.com/target-12/po...

I’m convinced that this map is reflecting reality perfectly.

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

It was a pleasure to write this News & Views article for the 4D Nucleome flagship article: www.nature.com/articles/d41... With great editorial support from @hollyasmith.bsky.social! Read the 4D Nucleome paper here: www.nature.com/articles/s41...

UBC is hiring elite senior faculty for the generously funded Canada Impact+ Research Chairs Program. Requires recruitment from outside Canada, but welcomes Canadians abroad to come home. Expressions of interest due 15 January. research.ubc.ca/federal-rese...

Clay letters from ancient Mesopotamia are alive with idiom, sayings, and everyday language that I love. Here are just a few random ones so you can enjoy them too.

Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17

1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? www.biorxiv.org/content/10.1... #TranscriptionFactors #IDPs #SingleMolecule #Biophysics

Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...

An MIT lab director was killed in a shooting at his home in Brookline, Massachusetts Monday night, the school confirmed. No one is in custody, Brookline police deputy superintendent said.

We’re launching the first Vienna BioCenter Mentoring Program, focused on “Career Transitions” and open exclusively to alumni of the Vienna BioCenter. The program connects early-career researchers with mentors from the VBC community, sign up here: https://alumni.training.vbc.ac.at/

Animals with misleading names. I'm seeing this go around as part of a viral tumblr thread so I thought I'd reshare it.

This vaccine shows strong signal for reducing or delaying dementia! And who wants to get shingles? Get this vaccine!

In the AI social sphere: - Developers like Claude Code + Claude Opus 4.5. - People appreciate that AI does not judge. Unlike coworkers, who may silently label you as incompetent if you ask one too many “stupid” questions, AI will answer every question - including the ones you are hesitate to ask.

🚨New paper out! In our @MolCellNews paper, we solve a piece of the puzzle of how our genome folds. We found the two specific molecular "brakes" in the CTCF protein that stop DNA loop extrusion. One of the final pieces of my PhD! tinyurl.com/29uuc5by

Can't believe it's that time of year - registration already open for next year's Transcription & Chromatin meeting. Almost half the talks are selected from the abstracts, so register soon before it fills up. This is a very lively meeting, with plenty of time to discuss over dinner & at the bar

The Center for Computational Biology at the Flatiron Institute is accepting applications for summer intern positions. CCB is a great place to work, and the intern program is excellent. Please check out the Computer Vision and Developmental Dynamics groups in particular. apply.interfolio.com/177779

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

The @erc.europa.eu i supporting some awesome epigenetics science!! Congrats @alexdemendoza.bsky.social @kellervalsecchi.bsky.social @leandroquadrana.bsky.social Nataliya Petryk, and others! There were also some GREAT ones who didn't make the cut this time. It sucks, but you rock!!

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So deserved! Congratulations, @plaschkalab.bsky.social

I’m a Professor. A.I. Has Changed My Classroom, but Not for the Worse. "My students’ easy access to chatbots forced me to make humanities instruction even more human." (gift link) www.nytimes.com/2025/11/25/m...

Jahreszeitlich veranlasste Information

The great slowdown: Germany at a standstill as ‘China shock’ hits As Europe’s biggest economy is pummelled by structural problems and external threats, rocky China ties are compounding the dreary picture My report from a rather depressing week in Berlin

Biggest commitment to a 3 second joke I've ever seen

what makes AI writing so distinct? it's the combination of a very smooth form with little information and person underneath. Or, as Bill Earnshaw calls it - "low calorie sentences". Having said that - I do find LLMs very helpful for writing, as long as one knows clearly what they want to say.

A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...

TT in Experimental Biophysics The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...

We’re hiring! The Department of Physics @sfuphysics.bsky.social at Simon Fraser U (in beautiful and vibrant Vancouver) seeks applications for an Assistant or Associate Professor in Experimental Biophysics, encompassing all scales of life from molecules to ecosystems. @sfuscience.bsky.social

Federico Teloni @fedeteloni.bsky.social is on the job market—someone smart should snap him up ASAP!!!

woo-hoo!! Congratulations to our neighbours @fedeteloni.bsky.social @gerlichlab.bsky.social and close collaborators! Don't miss the parallel paper by Ha & Scully labs @albertomarin.bsky.social

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

@science.org 🧬🔬 A vision of #chromosome organization | Science www.science.org/doi/10.1126/... @vram142.bsky.social et al.