Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Happy to share our new review! Chromatin mechanics and regulatory protein function: insights from single-molecule force spectroscopy www.sciencedirect.com/science/arti...

Happy to share our new review! Chromatin mechanics and regulatory protein function: insights from single-molecule force spectroscopy www.sciencedirect.com/science/arti...

"Engineering a Mechanoresponsive DNA Origami Capsule for Drug Delivery to Narrowed Arteries" Happy we could contribute to this nice work from Yuval Garini's lab, who also prepared a beautiful cover. pubs.acs.org/doi/10.1021/...

Engineering a Mechanoresponsive DNA Origami Capsule for Drug Delivery to Narrowed Arteries pubs.acs.org/doi/10.1021/... Glad we could contribute to this interesting work from Yuval Garini's lab. Kudos to Hadas Omer and the team: Hadeel_Khamis, Zipora Lansky, Netanel Korin, Racheli Boeangiu

Engineering a Mechanoresponsive DNA Origami Capsule for Drug Delivery to Narrowed Arteries pubs.acs.org/doi/10.1021/... Glad we could contribute to this interesting work from Yuval Garini's lab. Kudos to Hadas Omer and the team: Hadeel_Khamis, Zipora Lansky, Netanel Korin, Racheli Boeangiu

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

Oldies but Goldies. from 2007. Light-powering Escherichia coli with proteorhodopsin www.pnas.org/doi/10.1073/...

@arielchazan.bsky.social @galitzlil.bsky.social

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.

Nice work by the Kurumizaka Lab in @natcomms.nature.com Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis www.nature.com/articles/s41...

1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? www.biorxiv.org/content/10.1... #TranscriptionFactors #IDPs #SingleMolecule #Biophysics

Super cool work on the function of intrinsically disordered regions in regulating transcription factor DNA binding.

The energy landscape of a single disordered protein (tau) and the impact of PTMs is resolved. An important step to understanding the function and dysfunction of disordered proteins from their conformational ensemble. Not yet peer reviewed. www.biorxiv.org/content/10.1...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? www.biorxiv.org/content/10.1... #TranscriptionFactors #IDPs #SingleMolecule #Biophysics

And, again, WHERE IS #BIGPHARMA in defending #basicscience? laying low? playing dead? Waiting it out? Do SOMETHING! SPEAK UP! Use your gigantic lobbying machine to defend us instead of peddling your wares and increasing your profits. Or do you think highly trained workforce grows on trees?

Wow - this is also the cofactor for the lyase activity of Cyp17A1 - required for production of androgens from pregnenolone/progesterone.

Congratulations to Prof. Nabieh Ayoub on receiving the Award for Outstanding Excellence in Teaching for the Spring Semester of 2024 biology.technion.ac.il/en/congratul...

Did you know that there is an enzyme called ATAC, which is not related to ATAC-seq? :) academic.oup.com/nar/advance-... This paper reports a very interesting finding that ATAC and SAGA increase TF binding to DNA target sites on nucleosome by an order of magnitude independent of histone acetylation

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Best practice mass photometry: A guide to optimal single molecule mass measurement https://www.biorxiv.org/content/10.1101/2024.12.03.624087v1

As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...

Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...

"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements. www.biorxiv.org/content/10.1...

Welcome Oded! @bejalab.bsky.social

Genome access is transcription factor-specific and defined by nucleosome position https://www.sciencedirect.com/science/article/pii/S1097276524006634

Regulation of transcription by condensates, great review by @bsabari.bsky.social and coll. www.nature.com/articles/s41...

So, here I am. The nucleosome police now flies under their official tag. Please follow me if you are interested in #chromatin, #nucleosome, #cryoEM, #scienceeducation, #hiking, #quilting, and #nature. Help me figure out this platform!