Rapid and reliable quantification of cytosolic mRNA escape (RNASCAPE) https://www.biorxiv.org/content/10.64898/2026.04.07.716953v1

Extending the MARTINI 3 Coarse-Grained Forcefield to Polypeptoids https://www.biorxiv.org/content/10.64898/2026.04.10.717689v1

Integrating computational chemistry and machine learning to predict KRAS mutation-induced resistance https://www.biorxiv.org/content/10.64898/2026.04.10.717640v1

Structural features of E. coli Stx bacteriophage phi24B revealed with cryo-electron microscopy https://www.biorxiv.org/content/10.64898/2026.04.10.717836v1

The Central Coupler of the AAA+ ATPase ClpXP Controls Intersubunit Communication and Couples the Conversion of Chemical Energy into the Generation of Force https://www.biorxiv.org/content/10.64898/2026.04.10.717754v1

Proton tunneling at the ryanodine receptor Ca2+ activation site provides temperature-invariant noise for robust Ca2+-induced Ca2+ release https://www.biorxiv.org/content/10.64898/2026.04.08.717335v1

Recovering membrane interaction kinetics of single molecules from 3D tracking data https://www.biorxiv.org/content/10.64898/2026.04.08.717195v1

Molecular basis of protein-glycan cross-linking by CpCBM92A revealed by NMR spectroscopy https://www.biorxiv.org/content/10.64898/2026.04.08.717144v1

Deciphering Coccolith Formation: Advanced Microscopy Insights from the Biomineralisation of Gephyrocapsa huxleyi https://www.biorxiv.org/content/10.64898/2026.04.08.717164v1

Spatially patterned, spectral single-molecule microscopy https://www.biorxiv.org/content/10.64898/2026.04.08.715690v1

KinConfBench: A Curated Benchmark for Cofolding Models on Kinase Conformational States https://www.biorxiv.org/content/10.64898/2026.04.07.716788v1

Investigating a Relation between Amyloid Beta Plaque Burden and Accumulated Neurotoxicity Caused by Amyloid Beta Oligomers https://www.biorxiv.org/content/10.64898/2026.04.07.717091v1

Serial femtosecond crystallography reveals the pH-driven allosteric mechanism of hexamer glargine https://www.biorxiv.org/content/10.64898/2026.04.07.716775v1

Uncompromised, multimodal, multiscale structural analysis of the hierarchically organization in mineralized tissues https://www.biorxiv.org/content/10.64898/2026.04.07.717027v1

Generation-Establishment Tradeoffs Shape the Temporal Window of Recombinant Evolution https://www.biorxiv.org/content/10.64898/2026.04.07.717007v1

Membrane structural properties in Staphylococcus aureus are tuned by the carotenoid 4,4'-diaponeurosporenoic acid https://www.biorxiv.org/content/10.64898/2026.04.08.716698v1

Orthosteric and allosteric effects of anti-CRISPR II-C1 inhibition on GeoCas9 from integrated structural biophysics https://www.biorxiv.org/content/10.64898/2026.04.08.717222v1

Localized ribosome access and distal tuning via the Listeria prfA RNA thermometer https://www.biorxiv.org/content/10.64898/2026.04.08.717274v1

Dimerisation and twist reversal of the Lewy fold in α-synuclein mutants with Parkinson's disease and dementia https://www.biorxiv.org/content/10.64898/2026.04.07.716933v1

Simultaneous Denoising and Baseline Correction of Microplate Raman Spectra Using a Dual-Branch U-Net https://www.biorxiv.org/content/10.64898/2026.04.07.716998v1

Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins https://www.biorxiv.org/content/10.64898/2026.04.07.716910v1

Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations https://www.biorxiv.org/content/10.64898/2026.04.07.714519v1

Curvature-mediated prewetting organize mitochondrial nucleoid https://www.biorxiv.org/content/10.64898/2026.04.06.716811v1

DNA-Functionalized Nanoparticles for Multicolor Cathodoluminescence Imaging https://www.biorxiv.org/content/10.64898/2026.04.07.716901v1

Direct Membrane Penetration of Oligoarginines by Fluorescence and Cryo-electron Microscopy Combined with Molecular Simulations https://www.biorxiv.org/content/10.64898/2026.04.07.716952v1

Critical amino acid residues in the N-terminal domain of NADPH-dependent assimilatory sulfite reductase flavoprotein mediate octameric assembly https://www.biorxiv.org/content/10.64898/2026.04.08.717228v1

Molecular basis for ligand-gating of the human GluD1 receptor https://www.biorxiv.org/content/10.64898/2026.04.06.716743v1

Modeling disorder, secondary structure formation, and amyloid growth in FG-nucleoporins https://www.biorxiv.org/content/10.64898/2026.04.07.716937v1

Protein Language Models Encode Evolutionary Grammar but Conflate Topological and Thermodynamic Phases https://www.biorxiv.org/content/10.64898/2026.04.07.717117v1

Intrinsically disordered ligands for the control of receptor uptake by endocytosis https://www.biorxiv.org/content/10.64898/2026.04.06.716760v1

Theoretical estimate of the effective pKa of titratable lipids using continuum electrostatics https://www.biorxiv.org/content/10.64898/2026.04.06.716676v1

The low-field effect in radical pairs: a zero-field singlet-triplet basis picture https://www.biorxiv.org/content/10.64898/2026.04.05.716627v1

Energetic analysis of Na+/K+-ATPase using bond graphs https://www.biorxiv.org/content/10.64898/2026.04.05.716446v1

PI(4,5)P2-dependence of GABAA receptor channel function revealed by optogenetic manipulation of a binding site https://www.biorxiv.org/content/10.64898/2026.04.06.715776v1

Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs https://www.biorxiv.org/content/10.64898/2026.04.07.716332v1

Allosteric Mechanisms Underlying Long QT Syndrome Type 2 (LQT2) Associated Mutations in hERG Channels https://www.biorxiv.org/content/10.64898/2026.04.05.715988v1

A Spin-Glass Metabolic Hamiltonian optimized by Quantum Annealing Reveals Thermodynamic Phases of Cancer Metabolism https://www.biorxiv.org/content/10.64898/2026.04.05.715441v1

Disruption of Drosophila melanogaster Larval Locomotion Caused by Silver Ions https://www.biorxiv.org/content/10.64898/2026.04.03.716380v1

Reciprocal-space mapping of diffuse scattering by serial femtosecond crystallography reveals analog-specific disorder in insulin analogs https://www.biorxiv.org/content/10.64898/2026.04.03.716400v1

Structural principles of transcriptional collisions https://www.biorxiv.org/content/10.64898/2026.04.06.716678v1

Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels https://www.biorxiv.org/content/10.64898/2026.04.04.716525v1

Doubling the Field of View in Common-Path Digital Holographic Microscopy via Wavelength Scanning and Polarization Gratings https://www.biorxiv.org/content/10.64898/2026.04.03.716314v1

Structural Mechanism of TRPC3 Channel Activation by the Moonwalker Mutation https://www.biorxiv.org/content/10.64898/2026.04.03.716262v1

Unravelling the plausible metal-dependent catalytic mechanism of Inositol monophosphatase ortholog from Pseudomonas aeruginosa through the lenses of macromolecular crystallography and enzyme kinetics https://www.biorxiv.org/content/10.64898/2026.04.06.716684v1

High-speed 3D single-virus tracking reveals actin-aided viral trafficking of SARS-CoV-2 on the plasma membrane https://www.biorxiv.org/content/10.64898/2026.04.03.716319v1

Binding Structures, Mechanical Properties, and Effects on Cellular Behaviors of Extracellular Matrix Proteins on Biomembranes https://www.biorxiv.org/content/10.64898/2026.04.03.716427v1

PRISM: A High-Throughput Simulation Infrastructure for CADD Agents https://www.biorxiv.org/content/10.64898/2026.04.02.716083v1

Impact of intercalators on the properties of DNA analyzed by molecular dynamics simulations https://www.biorxiv.org/content/10.64898/2026.04.02.716032v1

A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design https://www.biorxiv.org/content/10.64898/2026.04.02.716066v1

Repeatable quantum-hardware execution of a fast local-topology surrogate for hyperthermal sarcomeric oscillations https://www.biorxiv.org/content/10.64898/2026.04.02.716025v1