Local Confinement within Plasma Membrane Nanodomains Drives Constitutive Activity of GPCRs https://www.biorxiv.org/content/10.64898/2026.02.17.706370v1

Real-time mass-resolved label-free single-molecule immunoassay https://www.biorxiv.org/content/10.64898/2026.02.17.706360v1

Finite Element Modeling of the Scaphoid Shift Maneuver: Implications for Scapholunate Ligament injuries https://www.biorxiv.org/content/10.64898/2026.02.17.705556v1

Mechanism of Gating and Isoform-Specific Inhibition in Renal CLC Chloride Channels https://www.biorxiv.org/content/10.64898/2026.02.17.706469v1

High-Performance, Computer-Controlled Bipedal DNA Motor https://www.biorxiv.org/content/10.64898/2026.02.17.706383v1

Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational Design https://www.biorxiv.org/content/10.64898/2026.02.17.706319v1

Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers https://www.biorxiv.org/content/10.64898/2026.02.17.706271v1

Engineering nanocondensate formation through sequence composition and patterning https://www.biorxiv.org/content/10.64898/2026.02.17.706365v1

Estimation of Protein Melting Temperatures Using Small-Ladder Replica Exchange Simulations https://www.biorxiv.org/content/10.64898/2026.02.17.706302v1

Chemical interactions in polyethylene glycol-induced condensates lead to an anomalous FRET response from a flexible linker-fluorescent protein crowding sensor https://www.biorxiv.org/content/10.64898/2026.02.16.706251v1

Myosin Filaments of Vertebrate Skeletal and Cardiac Muscle are Highly Similar, but not Identical https://www.biorxiv.org/content/10.64898/2026.02.16.706210v1

A Goldilocks zone of DNA flexibility defines stable yet plastic nucleosomes, tuned by histone chemistry https://www.biorxiv.org/content/10.64898/2026.02.16.706184v1

Bringing calorimetry (back) to life https://www.biorxiv.org/content/10.64898/2026.02.16.706158v1

Cellular Chemical Dynamics Governing Signal Transduction and Adaptive Gene Expression: Beyond Classical Kinetics https://www.biorxiv.org/content/10.64898/2026.02.13.705865v1

Piezo2 tension sensitivity and its modulation by alternative splicing https://www.biorxiv.org/content/10.64898/2026.02.16.706133v1

Quantitative mapping of nanoscale EGFR-Grb2 assemblies by DNA-PAINT https://www.biorxiv.org/content/10.64898/2026.02.16.706070v1

Non-muscle actinopathy-associated loss-of-function actin variants modulate cytoskeletal reorganization https://www.biorxiv.org/content/10.64898/2026.02.13.705838v1

Ion Mobility Mass Spectrometry Guided Modeling with AlphaFold and Rosetta Improves Protein Complex Structure Prediction https://www.biorxiv.org/content/10.64898/2026.02.16.706193v1

Growth-dependent sensory bet-hedging enhances collective navigation https://www.biorxiv.org/content/10.64898/2026.02.13.705748v1

Large-scale exploration of protein space by automated NMR https://www.biorxiv.org/content/10.64898/2026.02.16.706194v1

Bacterial GTPases act as successive placeholders to mediate ribosome assembly and its coupling to translation initiation https://www.biorxiv.org/content/10.64898/2026.02.15.706057v1

Phasor analysis of RGB camera data enables fluorescence microscopy unmixing and brightfield segmentation in a commercial microscope https://www.biorxiv.org/content/10.64898/2026.02.13.705652v1

ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter https://www.biorxiv.org/content/10.64898/2026.02.12.705656v1

Why Life is Hot https://www.biorxiv.org/content/10.64898/2026.02.13.705721v1

Turning the Fluorescent Protein Barrel into a Programmable Electrostatic Device Reveals Differential Bleaching States of the Chromophore https://www.biorxiv.org/content/10.64898/2026.02.12.705679v1

Pathological stiffening by crosslinking glycation of titin https://www.biorxiv.org/content/10.64898/2026.02.13.705744v1

ATP-driven membrane binding and polymerization of bacterial actin MreB promotes local membrane fluidization https://www.biorxiv.org/content/10.64898/2026.02.13.705564v1

Substrate binding and activation mechanism of the essential bacterial septal cell wall synthase FtsW https://www.biorxiv.org/content/10.64898/2026.02.13.705525v1

Solvent Isotope Effect on the Stability of a Heterodimeric Protein https://www.biorxiv.org/content/10.64898/2026.02.12.705670v1

Multiscale Analysis of PNPLA2 and PNPLA3 Membrane Targeting https://www.biorxiv.org/content/10.64898/2026.02.12.705593v1

Energetic cross-talk of filter gate and lower helices drives polymodal regulation and disease in TREK K2P channels https://www.biorxiv.org/content/10.64898/2026.02.13.705734v1

A multistable slow-fast model of affective state switching under circadian drive https://www.biorxiv.org/content/10.64898/2026.02.11.705337v1

Human-engineered heart tissues recapitulate tissue-scale mechanisms underlying ventricular tachycardia https://www.biorxiv.org/content/10.64898/2026.02.11.705466v1

Membrane Curvature Generation by the Caveolin 8S Complex and the Role of Cholesterol https://www.biorxiv.org/content/10.64898/2026.02.11.705414v1

Exploring the effects of Golgi Reassembly and Stacking Proteins in lipid membranes https://www.biorxiv.org/content/10.64898/2026.02.11.705364v1

Artificial DNA-nano/microparticle motors: Factors governing speed, run-length, and unidirectionality revealed by geometry-based kinetic simulations https://www.biorxiv.org/content/10.64898/2026.02.11.705463v1

Recognition and Resolution of KRAS 5'UTR RNA G-Quadruplexes by hnRNPA1 https://www.biorxiv.org/content/10.64898/2026.02.13.705690v1

When lipids embrace RNA: pH-driven dynamics and mechanisms of LNP-mediated siRNA delivery https://www.biorxiv.org/content/10.64898/2026.02.11.705380v1

Conformational dynamics at the pre-miR-377 Dicer site governs selective small-molecule recognition https://www.biorxiv.org/content/10.64898/2026.02.11.705234v1

Muscle Diffraction at the Life Science X-ray Scattering Beamline https://www.biorxiv.org/content/10.64898/2026.02.11.705260v1

AlignPCA-2D: PCA-Reduced Euclidean Vector Alignment for 2D Classification in Cryo-EM https://www.biorxiv.org/content/10.64898/2026.02.11.705027v1

DNA binding drives phase separation of the Gcn4 bZIP domain and reveals its conformational ensemble in the diluted and condensate phases https://www.biorxiv.org/content/10.64898/2026.02.10.704833v1

Investigation of Regulation and Binding Patterns of the Human Cathelicidin Peptide LL-37 in Complexation with Nucleic Acids, and its Impact on Neutrophil Extracellular Traps https://www.biorxiv.org/content/10.64898/2026.02.09.704888v1

Sub-Millivolt Voltage Imaging Reveals Gap Junction-Mediated Bioelectric Contact Inhibition https://www.biorxiv.org/content/10.64898/2026.02.10.701308v1

Intracellular TDP-43 amyloid nucleates from arrested nascent condensates https://www.biorxiv.org/content/10.64898/2026.02.10.705006v1

Correlative scanning electron and super-resolution structured illumination microscopy https://www.biorxiv.org/content/10.64898/2026.02.09.704937v1

Neural Activity Related Sodium (NARS) fMRI Resolves Millisecond Neuronal Dynamics in the Rodent Cortex https://www.biorxiv.org/content/10.64898/2026.02.09.704765v1

Nonstop nanometric resolution of randomly moving point scatterers with focused light https://www.biorxiv.org/content/10.64898/2026.02.09.704780v1

Developing a fluorescent derivative of GagPol as a tool for live-cell imaging of HIV-1 assembly https://www.biorxiv.org/content/10.64898/2026.02.09.704847v1

A mechanism-aware stoichiometry platform resolves functional viral thresholds and induces antiviral hypersensitivity https://www.biorxiv.org/content/10.64898/2026.02.09.704886v1