Cryo-EM reveals the structural basis of subtype-specific, noncompetitive inhibition of the human P2X3 receptor https://www.biorxiv.org/content/10.64898/2026.01.03.697462v1

LignAmb25: A Comprehensive AMBER Force Field Addressing Lignin's Structural and Chemical Diversity https://www.biorxiv.org/content/10.64898/2026.01.03.697499v1

Impact of competition between precursor and mature microRNAs on stochastic gene expression https://www.biorxiv.org/content/10.64898/2026.01.03.697472v1

Conformational changes upon pore blocker removal reveal conductive states of TMEM16A https://www.biorxiv.org/content/10.64898/2026.01.02.697443v1

A moments-based approach for inferring mechanisms of transcriptional regulation using nascent RNA data https://www.biorxiv.org/content/10.64898/2026.01.03.697452v1

Nanodisc-Mediated Visualization of Crowding-Induced Condensation and Membrane Reorganization in Two-Dimensional Membrane Environments https://www.biorxiv.org/content/10.64898/2026.01.02.697448v1

PUFA modulation of ASIC3 involves both specific and lipid solvent-like interactions https://www.biorxiv.org/content/10.64898/2026.01.02.697424v1

CholBindNet: Interpretable Neural Networks for Cholesterol Binding Site Prediction https://www.biorxiv.org/content/10.64898/2026.01.02.697429v1

A variational method for efficient estimation of diffusion and free-energy profiles along collective variables https://www.biorxiv.org/content/10.64898/2026.01.01.697292v1

Sequence-Only Prediction of Antibody Fab Thermostability Using Protein Language Model Embeddings https://www.biorxiv.org/content/10.64898/2025.12.30.697053v1

Memory from variability: Heritable short-term cellular memory emerges from stochastic biochemical reaction networks https://www.biorxiv.org/content/10.64898/2025.12.31.694479v1

Fluorescent peptides for membrane tension and domain structure reporting https://www.biorxiv.org/content/10.64898/2025.12.30.697119v1

Sloppiness and Action Confinement in Cell State Transitions: Are Single Cells Sloppy? https://www.biorxiv.org/content/10.64898/2025.12.31.697145v1

A systematic approach for the purification of fluorophore-labelled proteins via anion exchange chromatography https://www.biorxiv.org/content/10.64898/2025.12.30.697019v1

Template-based RNA structure prediction advanced through a blind code competition https://www.biorxiv.org/content/10.64898/2025.12.30.696949v1

Structural basis for hydrolytic splicing of a circularly permuted group II intron https://www.biorxiv.org/content/10.64898/2025.12.30.696962v1

Single-molecule behavior and cell-growth regulation in human RTKs https://www.biorxiv.org/content/10.64898/2025.12.29.696957v1

Viscoelasticity and interface properties of multi-component condensates govern protein sequestration and suppression of amyloid formation https://www.biorxiv.org/content/10.64898/2025.12.29.695806v1

A Generative Foundation Model for Cryo-EM Densities https://www.biorxiv.org/content/10.64898/2025.12.29.696802v1

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain https://www.biorxiv.org/content/10.64898/2025.12.25.696519v1

Structural basis for non-AUG translation regulation by 5MPs https://www.biorxiv.org/content/10.64898/2025.12.28.696766v1

A thermodynamic chromatin polymer model characterizes the epigenetic conditions for Hox collinearity. https://www.biorxiv.org/content/10.64898/2025.12.28.696739v1

Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens https://www.biorxiv.org/content/10.64898/2025.12.25.696505v1

Cell-in-Water: measurements using Optical Photothermal Infrared spectroscopy https://www.biorxiv.org/content/10.64898/2025.12.28.696748v1

Angle-resolved Measurements Reveal the Origin of Signal Anisotropy in Pump-probe Microscopy https://www.biorxiv.org/content/10.64898/2025.12.27.691690v1

Epigenetic state encodes locus-specific chromatin mechanics https://www.biorxiv.org/content/10.64898/2025.12.27.696709v1

To Predict is to Design: Unlocking Generative Capabilities in All-Atom Structure Predictors via Geometric Score Distillation https://www.biorxiv.org/content/10.64898/2025.12.23.696242v1

From Dimerization to Signaling: Molecular Dynamics Insights into EphA1 and EphA2 Isoform Specificity https://www.biorxiv.org/content/10.64898/2025.12.23.696317v1

Intrinsic conformational equilibria position arrestin-2 for activation https://www.biorxiv.org/content/10.64898/2025.12.24.696424v1

Sizing single trapped nanoparticles with interferometric scattering fluctuations https://www.biorxiv.org/content/10.64898/2025.12.23.696206v1

Conformational and Environmental Determinants of RNA Solvation Dynamics: Roles of Intrinsic Flexibility, Allostery, and Protein Binding https://www.biorxiv.org/content/10.64898/2025.12.24.696429v1

Screening and structural characterization of a nanobody targeting the thermostable green fluorescent protein https://www.biorxiv.org/content/10.64898/2025.12.23.696179v1

Sequence Complexity Dictates Polymer Mixing https://www.biorxiv.org/content/10.64898/2025.12.23.696237v1

How medically important antimicrobials bind to the 30S ribosomal subunit in a bacterial pathogen https://www.biorxiv.org/content/10.64898/2025.12.24.696192v1

Single-cell chiral symmetry breaking under confinement https://www.biorxiv.org/content/10.64898/2025.12.23.696323v1

Two-colour Imaging Fluorescence Correlation Spectroscopy (ImFCS) probes the influence of the juxta-membrane actin-cortex https://www.biorxiv.org/content/10.64898/2025.12.24.696335v1

Residue-Specific Modulation of Aggregation-Associated Interactions bySpermine in Tau, α-Synuclein, and Aβ40 https://www.biorxiv.org/content/10.64898/2025.12.23.696224v1

Metal-Triggered Rheological Switching in Engineered Lanmodulin Condensates https://www.biorxiv.org/content/10.64898/2025.12.22.696036v1

Integrating NMR restraints into coarse-grained simulations: toward accurate conformational ensembles of complex protein systems https://www.biorxiv.org/content/10.64898/2025.12.22.695971v1

Spatio-temporal resource landscapes govern the confinement and escape of therapy-resistant mutants in structured populations https://www.biorxiv.org/content/10.64898/2025.12.22.695823v1

Enhancing the imaging rate of high-speed atomic force microscopy using a combination of multiple techniques https://www.biorxiv.org/content/10.64898/2025.12.22.695957v1

Mechanistic Interpretability of Fine-Tuned Protein Language Models for Nanobody Thermostability Prediction https://www.biorxiv.org/content/10.64898/2025.12.22.695878v1

Evidence for the Progressive Improvement of All-Atom Force Fields in Reproducing Local Conformational Preferences of Flexible Peptides https://www.biorxiv.org/content/10.64898/2025.12.22.695171v1

A food chain of ribozymes built on an ancestral strand https://www.biorxiv.org/content/10.64898/2025.12.22.695801v1

The Structural Basis for RNA Binding and Recognition of the Disordered Prion-Like Domain of TDP-43 https://www.biorxiv.org/content/10.64898/2025.12.22.695782v1

Molecular interactions underlying selective partitioning of clients into MED1 and FUS condensates https://www.biorxiv.org/content/10.64898/2025.12.23.696191v1

Dynamic domain interactions encode possible CheA autophosphorylation mechanisms revealed by coarse-grained simulations https://www.biorxiv.org/content/10.64898/2025.12.21.695815v1

Quantum Computing Reveals Energetics of Tau Peptide Fragments https://www.biorxiv.org/content/10.64898/2025.12.21.695828v1

Backbone Hydrogen Bonding as a Determinant of Condensate Material States https://www.biorxiv.org/content/10.64898/2025.12.21.695814v1

Characterizing the Impact of Nucleoid-Associated Proteins on HU-DNA Interactions by Live-Cell Single-Molecule Tracking https://www.biorxiv.org/content/10.64898/2025.12.19.695591v1