When Animals Turn Inside Out: The Eversion of Bloodworms https://www.biorxiv.org/content/10.1101/2025.11.05.686822v1

Massively parallel evolution reveals a biophysical scaling law between cell size and internal cell density https://www.biorxiv.org/content/10.1101/2025.11.05.686806v1

A hydrophobic cluster controls long-range allostery in the TRMT2A RNA recognition motif https://www.biorxiv.org/content/10.1101/2025.11.05.686750v1

Hepatitis B virus HBx protein masks epigenetic reader Spindlin1 via an inter-molecular zinc finger to subvert transcriptional control https://www.biorxiv.org/content/10.1101/2025.11.05.686744v1

Direct Optical Quantification of Chain Collapse, Reduced Dielectric, and Water Release Driving Protein Phase Separation https://www.biorxiv.org/content/10.1101/2025.11.04.686660v1

Identification of a First-In-Class Small Molecule CAPON Binder Using Affinity Selection-Mass Spectrometry Screening https://www.biorxiv.org/content/10.1101/2025.11.05.686689v1

Molecular Dynamics-Guided All-Atom Reconstruction of Cryo-ET Maps Reveals Mechanisms of Histone Tail-Mediated Chromatin Compaction https://www.biorxiv.org/content/10.1101/2025.11.05.686627v1

Temporal Dynamics of Antigen-Specific T Cell Expansion in Primary SARS-CoV-2 Infection https://www.biorxiv.org/content/10.1101/2025.11.04.686558v1

An agent-based model of Trypanosoma brucei social motility to explore determinants of colony pattern formation https://www.biorxiv.org/content/10.1101/2025.11.04.686461v1

Key determinants of VDAC-hexokinase I complex assembly revealed by a minimal vesicle-based interaction assay https://www.biorxiv.org/content/10.1101/2025.11.03.686449v1

Rule-based mitigation of charge asymmetry-triggered monoclonal antibody self-assembly https://www.biorxiv.org/content/10.1101/2025.11.03.686261v1

qcGEM: a graph-based molecular representation with quantum chemistry awareness https://www.biorxiv.org/content/10.1101/2025.11.02.686183v1

Geometry-Constrained Prediction of Catalytically Competent Kinase Domains Across the Human Kinome https://www.biorxiv.org/content/10.1101/2025.11.03.686188v1

Blind Prediction of Complex Water and Ion Ensembles Around RNA in CASP16 https://www.biorxiv.org/content/10.1101/2025.11.03.685595v1

Transforming a Fragile Protein Helix into an Ultrastable Scaffold via a Hierarchical AI and Chemistry Framework https://www.biorxiv.org/content/10.1101/2025.11.03.686355v1

Neutral Frustration Landscape Architecture of SARS-CoV-2 Spike -Antibody Interfaces Shapes Immune Evasion Mechanisms for Ultrapotent ... https://www.biorxiv.org/content/10.1101/2025.10.31.685956v1

Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril Core https://www.biorxiv.org/content/10.1101/2025.11.01.686027v1

Probing the energy landscape of α-Synuclein amyloid fibril formation by systematic K-to-Q mutagenesis https://www.biorxiv.org/content/10.1101/2025.11.01.685997v1

Dangling Ends of Third Strand and Duplex Drive Nucleic Acid Triplex Stabilization through Bimodal Association https://www.biorxiv.org/content/10.1101/2025.11.02.686076v1

SIMAIS: A swarm intelligence inspired biosensor for rapid protein detection https://www.biorxiv.org/content/10.1101/2025.10.31.685929v1

T cell costimulatory and inhibitory signals differentially modulate LAT condensate nucleation propensity after TCR ligation https://www.biorxiv.org/content/10.1101/2025.11.01.685673v1

A Python framework for magnetic tweezers real-time image processing and microscope control https://www.biorxiv.org/content/10.1101/2025.10.31.685671v1

Mapping Allosteric Rewiring in Viral RNA: Sequence-Encoded Control of Protein Binding Mechanisms https://www.biorxiv.org/content/10.1101/2025.11.01.685830v1

Structural basis for lipid binding by the blood protein vitronectin, a component of HDL https://www.biorxiv.org/content/10.1101/2025.11.01.685992v1

Studying macromolecular composition in cell-cell interfaces using 3D membrane reconstitution systems https://www.biorxiv.org/content/10.1101/2025.11.01.686034v1

Physical mechanisms of nanoparticle-membrane interactions: A coarse-grained study https://www.biorxiv.org/content/10.1101/2025.10.31.685850v1

CryoWriter: A Robotic Solution for Improved Cryo-EM Grid Preparation https://www.biorxiv.org/content/10.1101/2025.11.01.686008v1

Classification models distinguish functional and trafficking effects of KCNQ1 variants to enhance variant interpretation https://www.biorxiv.org/content/10.1101/2025.10.31.685955v1

Structural Mechanism of Prestin-Membrane Mechanotransduction https://www.biorxiv.org/content/10.1101/2025.10.31.685930v1

Mathematical modeling of light chain aggregation and cardiac damage in AL amyloidosis https://www.biorxiv.org/content/10.1101/2025.10.30.685705v1

A unifying model of LAT condensates in reconstitution experiments https://www.biorxiv.org/content/10.1101/2025.10.31.685772v1

The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA https://www.biorxiv.org/content/10.1101/2025.10.30.685619v1

Protein-protein interaction networks can be highly sensitive to the membrane phase transition https://www.biorxiv.org/content/10.1101/2025.10.30.685611v1

Viscoelasticity Analysis of Coarse-grained Cytoskeletal Simulations with Cytosim and Cytocalc https://www.biorxiv.org/content/10.1101/2025.10.30.685558v1

Glycation enhances protein association with lipid bilayer membranes https://www.biorxiv.org/content/10.1101/2025.10.30.685514v1

Two-dimensional NMR from a Single Pulse: Reconstructing Heteronuclear 2D spectra via off-resonance decoupling and Deep Neural Networks https://www.biorxiv.org/content/10.1101/2025.10.30.685498v1

Nuclear Packing Sets Fluidity Along the Epithelial to Mesenchymal Spectrum https://www.biorxiv.org/content/10.1101/2025.10.29.684532v1

Dual-Field Interference as a Common Biomechanical Origin of Cell Division, Differentiation, and Aging https://www.biorxiv.org/content/10.1101/2025.10.28.684574v1

Structural mechanisms of pump assembly and drug transport in the AcrAB-TolC efflux system https://www.biorxiv.org/content/10.1101/2025.10.29.685381v1

Structural and Functional Insights into Alkaline-pH Sensing by the Alka Channel https://www.biorxiv.org/content/10.1101/2025.10.29.685377v1

Cytokines control the physical state of immune tissue https://www.biorxiv.org/content/10.1101/2025.10.28.685215v1

Mechanical de-skewing enables high-resolution imaging of thin tissue slices with a mesoSPIM light-sheet microscope https://www.biorxiv.org/content/10.1101/2025.10.29.684106v1

Electric field intensity modulates keratocyte migration without altering turning dynamics https://www.biorxiv.org/content/10.1101/2025.10.29.684651v1

Two-Step Mechanism of Bruton's Tyrosine Kinase MembraneRecruitment and Activation https://www.biorxiv.org/content/10.1101/2025.10.28.685231v1

Uniform distribution of photosystems in dark-adapted Synechocystis cells https://www.biorxiv.org/content/10.1101/2025.10.29.685299v1

Quantitative comparison of methodologies for translation site imaging in living cells https://www.biorxiv.org/content/10.1101/2025.10.29.685314v1

Coupling Step-Wise Motility and Traction Force Patterns in chemotaxing cells https://www.biorxiv.org/content/10.1101/2025.10.28.685178v1

The dynamic response of the bacterial flagellar motor to its direct intracellular input signal https://www.biorxiv.org/content/10.1101/2025.10.28.684865v1

A conformationally heterogeneous bending pivot enables bent-to-straight transition in the central helix of mycobacterial FtsZ https://www.biorxiv.org/content/10.1101/2025.10.28.685025v1

Prioritizing Stability-enhancing Mutations using a Protein Language Model in conjunction with Physics-Based Predictions https://www.biorxiv.org/content/10.1101/2025.10.28.683791v1