Integrating NMR restraints into coarse-grained simulations: toward accurate conformational ensembles of complex protein systems https://www.biorxiv.org/content/10.64898/2025.12.22.695971v1

Spatio-temporal resource landscapes govern the confinement and escape of therapy-resistant mutants in structured populations https://www.biorxiv.org/content/10.64898/2025.12.22.695823v1

Enhancing the imaging rate of high-speed atomic force microscopy using a combination of multiple techniques https://www.biorxiv.org/content/10.64898/2025.12.22.695957v1

Mechanistic Interpretability of Fine-Tuned Protein Language Models for Nanobody Thermostability Prediction https://www.biorxiv.org/content/10.64898/2025.12.22.695878v1

Evidence for the Progressive Improvement of All-Atom Force Fields in Reproducing Local Conformational Preferences of Flexible Peptides https://www.biorxiv.org/content/10.64898/2025.12.22.695171v1

A food chain of ribozymes built on an ancestral strand https://www.biorxiv.org/content/10.64898/2025.12.22.695801v1

The Structural Basis for RNA Binding and Recognition of the Disordered Prion-Like Domain of TDP-43 https://www.biorxiv.org/content/10.64898/2025.12.22.695782v1

Molecular interactions underlying selective partitioning of clients into MED1 and FUS condensates https://www.biorxiv.org/content/10.64898/2025.12.23.696191v1

Dynamic domain interactions encode possible CheA autophosphorylation mechanisms revealed by coarse-grained simulations https://www.biorxiv.org/content/10.64898/2025.12.21.695815v1

Quantum Computing Reveals Energetics of Tau Peptide Fragments https://www.biorxiv.org/content/10.64898/2025.12.21.695828v1

Backbone Hydrogen Bonding as a Determinant of Condensate Material States https://www.biorxiv.org/content/10.64898/2025.12.21.695814v1

Characterizing the Impact of Nucleoid-Associated Proteins on HU-DNA Interactions by Live-Cell Single-Molecule Tracking https://www.biorxiv.org/content/10.64898/2025.12.19.695591v1

Drude SILCS-Nucleic: Harnessing Explicit Electronic Polarization in Targeting RNA and DNA for Drug Design https://www.biorxiv.org/content/10.64898/2025.12.20.695737v1

Fingerprints as Frozen Nematic Fields https://www.biorxiv.org/content/10.64898/2025.12.19.695577v1

The spatial and temporal spread of highly pathogenic avian influenza in North America: Newton's Cradle hypothesis https://www.biorxiv.org/content/10.64898/2025.12.19.695483v1

Fractionation-Free Protein Corona Quantification Through Synchrotron-Based Small-Angle X-ray Scattering https://www.biorxiv.org/content/10.64898/2025.12.19.695217v1

Contactless micro-elastography of single cells using oscillating microbubbles as shear wave sources https://www.biorxiv.org/content/10.64898/2025.12.19.695456v1

Myelin Basic Protein Binding Is Modulated by Leaflet Asymmetry and Lipid Composition https://www.biorxiv.org/content/10.64898/2025.12.19.695364v1

Multiscale modeling of blood circulation with cerebral autoregulation and network pathway analysis for hemodynamic redistribution in the vascular network with anatomical variations and stenosis conditions https://www.biorxiv.org/content/10.64898/2025.12.19.695348v1

Robust ciliary flows protect early Xenopus embryos from pathogens independent of multiciliated cell patterning https://www.biorxiv.org/content/10.64898/2025.12.19.694354v1

Structural basis of half-site reactivity in Class Ib ribonucleotide reductases https://www.biorxiv.org/content/10.64898/2025.12.21.695763v1

PIP2 Binding at Allosteric Site Blocks Activation in Human Rod CNG Channels https://www.biorxiv.org/content/10.64898/2025.12.19.695557v1

Kalman-filter Force Inference: an estimation framework for cellular forces from temporal evolution of epithelial morphogenesis https://www.biorxiv.org/content/10.64898/2025.12.19.695339v1

A geometric-surface PDE model for cell-nucleus translocation through confinement https://www.biorxiv.org/content/10.64898/2025.12.18.695144v1

Tuning the H2 Production Activity of ToHydA by Molecular Simulation-Informed Protein Engineering https://www.biorxiv.org/content/10.64898/2025.12.18.695218v1

Molecular basis for thermoresponsive protein condensation in plants https://www.biorxiv.org/content/10.64898/2025.12.18.695255v1

The structural disorder of Dsup and its interaction with the human nucleosome: A computational study https://www.biorxiv.org/content/10.64898/2025.12.17.694834v1

Drop on fixed target reaction initiation approach for serial and time resolved crystallography https://www.biorxiv.org/content/10.64898/2025.12.17.694847v1

Explainable Active Learning Framework for Ligand BindingAffinity Prediction https://www.biorxiv.org/content/10.64898/2025.12.17.694851v1

Self-blinking dye restores efficient use of nanobodies in single-molecule localization microscopy. https://www.biorxiv.org/content/10.64898/2025.12.17.694880v1

Learning Epithelial Elasticity via Local Tension Remodeling https://www.biorxiv.org/content/10.64898/2025.12.17.694921v1

Structural Basis of TACO1-Mediated Efficient Mitochondrial Translation https://www.biorxiv.org/content/10.64898/2025.12.18.695269v1

Wrinkles emerge from matrix complementarity in heterogenous biofilms https://www.biorxiv.org/content/10.64898/2025.12.18.695073v1

Single-Particle Tracking and Positional Phenotyping Reveals Variant-Specific Early Checkpoints in SARS-CoV-2 Cell Entry https://www.biorxiv.org/content/10.64898/2025.12.18.695048v1

In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association https://www.biorxiv.org/content/10.64898/2025.12.18.694444v1

Tunable multivalent Fe(II)-based glycoassemblies as mimetics for native high-mannose glycans. https://www.biorxiv.org/content/10.64898/2025.12.17.694979v1

Differential receptor activation defines the fundamental limit of chemotactic sensing https://www.biorxiv.org/content/10.64898/2025.12.17.694457v1

Boxcar Imaging FCS Reveals Membrane Raft Stabilization Kinetics in Antigen-Stimulated Mast Cells https://www.biorxiv.org/content/10.64898/2025.12.16.694662v1

Spatiotemporal mapping of microscale stiffness during collagen polymerization and crosslinking by optical multifrequency time-harmonic elastography https://www.biorxiv.org/content/10.64898/2025.12.16.694603v1

Capsid flexibility during Ty1 virus-like particle assembly https://www.biorxiv.org/content/10.64898/2025.12.17.694965v1

Enhanced sampling of protein conformations in AlphaFold3 with repulsive bias in the diffusion generative model https://www.biorxiv.org/content/10.64898/2025.12.17.693105v1

Single-molecule tracking of RNA-DNA hybrid removal enzymes important for lagging-strand replication https://www.biorxiv.org/content/10.64898/2025.12.17.694926v1

Single-molecule FRET with a minimalistic 3D-printed setup and dyes in the blue-green spectral region https://www.biorxiv.org/content/10.64898/2025.12.16.694555v1

Synaptic active zones are ordered nanostructures designed by supramolecular block copolymers https://www.biorxiv.org/content/10.64898/2025.12.15.691964v1

Substrates Coupling and Inhibition of the human Na+- dependent Cl-/HCO3-exchanger https://www.biorxiv.org/content/10.64898/2025.12.15.693380v1

Lipidomic Profile Reconstruction of TherapeuticMembrane Targets Using Physics-BasedOptimization with Limited Activity Data https://www.biorxiv.org/content/10.64898/2025.12.15.694365v1

Control of cellular cortical tension and shape by RhoGTPase signalling https://www.biorxiv.org/content/10.64898/2025.12.15.694413v1

Machine learning-based development of Gadolinium binding peptides https://www.biorxiv.org/content/10.64898/2025.12.14.694215v1

Excitable dynamics of ParA during bacterial cell division https://www.biorxiv.org/content/10.64898/2025.12.16.694648v1

Confinement prevents postmenopausal osteoporosis and obesity via nuclear mechanical remodeling https://www.biorxiv.org/content/10.64898/2025.12.15.693823v1