DNA-Functionalized Nanoparticles for Multicolor Cathodoluminescence Imaging https://www.biorxiv.org/content/10.64898/2026.04.07.716901v1

Direct Membrane Penetration of Oligoarginines by Fluorescence and Cryo-electron Microscopy Combined with Molecular Simulations https://www.biorxiv.org/content/10.64898/2026.04.07.716952v1

Critical amino acid residues in the N-terminal domain of NADPH-dependent assimilatory sulfite reductase flavoprotein mediate octameric assembly https://www.biorxiv.org/content/10.64898/2026.04.08.717228v1

Molecular basis for ligand-gating of the human GluD1 receptor https://www.biorxiv.org/content/10.64898/2026.04.06.716743v1

Modeling disorder, secondary structure formation, and amyloid growth in FG-nucleoporins https://www.biorxiv.org/content/10.64898/2026.04.07.716937v1

Protein Language Models Encode Evolutionary Grammar but Conflate Topological and Thermodynamic Phases https://www.biorxiv.org/content/10.64898/2026.04.07.717117v1

Intrinsically disordered ligands for the control of receptor uptake by endocytosis https://www.biorxiv.org/content/10.64898/2026.04.06.716760v1

Theoretical estimate of the effective pKa of titratable lipids using continuum electrostatics https://www.biorxiv.org/content/10.64898/2026.04.06.716676v1

The low-field effect in radical pairs: a zero-field singlet-triplet basis picture https://www.biorxiv.org/content/10.64898/2026.04.05.716627v1

Energetic analysis of Na+/K+-ATPase using bond graphs https://www.biorxiv.org/content/10.64898/2026.04.05.716446v1

PI(4,5)P2-dependence of GABAA receptor channel function revealed by optogenetic manipulation of a binding site https://www.biorxiv.org/content/10.64898/2026.04.06.715776v1

Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs https://www.biorxiv.org/content/10.64898/2026.04.07.716332v1

Allosteric Mechanisms Underlying Long QT Syndrome Type 2 (LQT2) Associated Mutations in hERG Channels https://www.biorxiv.org/content/10.64898/2026.04.05.715988v1

A Spin-Glass Metabolic Hamiltonian optimized by Quantum Annealing Reveals Thermodynamic Phases of Cancer Metabolism https://www.biorxiv.org/content/10.64898/2026.04.05.715441v1

Disruption of Drosophila melanogaster Larval Locomotion Caused by Silver Ions https://www.biorxiv.org/content/10.64898/2026.04.03.716380v1

Reciprocal-space mapping of diffuse scattering by serial femtosecond crystallography reveals analog-specific disorder in insulin analogs https://www.biorxiv.org/content/10.64898/2026.04.03.716400v1

Structural principles of transcriptional collisions https://www.biorxiv.org/content/10.64898/2026.04.06.716678v1

Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels https://www.biorxiv.org/content/10.64898/2026.04.04.716525v1

Doubling the Field of View in Common-Path Digital Holographic Microscopy via Wavelength Scanning and Polarization Gratings https://www.biorxiv.org/content/10.64898/2026.04.03.716314v1

Structural Mechanism of TRPC3 Channel Activation by the Moonwalker Mutation https://www.biorxiv.org/content/10.64898/2026.04.03.716262v1

Unravelling the plausible metal-dependent catalytic mechanism of Inositol monophosphatase ortholog from Pseudomonas aeruginosa through the lenses of macromolecular crystallography and enzyme kinetics https://www.biorxiv.org/content/10.64898/2026.04.06.716684v1

High-speed 3D single-virus tracking reveals actin-aided viral trafficking of SARS-CoV-2 on the plasma membrane https://www.biorxiv.org/content/10.64898/2026.04.03.716319v1

Binding Structures, Mechanical Properties, and Effects on Cellular Behaviors of Extracellular Matrix Proteins on Biomembranes https://www.biorxiv.org/content/10.64898/2026.04.03.716427v1

PRISM: A High-Throughput Simulation Infrastructure for CADD Agents https://www.biorxiv.org/content/10.64898/2026.04.02.716083v1

Impact of intercalators on the properties of DNA analyzed by molecular dynamics simulations https://www.biorxiv.org/content/10.64898/2026.04.02.716032v1

A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design https://www.biorxiv.org/content/10.64898/2026.04.02.716066v1

Repeatable quantum-hardware execution of a fast local-topology surrogate for hyperthermal sarcomeric oscillations https://www.biorxiv.org/content/10.64898/2026.04.02.716025v1

Label-Free 4D Holotomography with Depth-Adaptive Segmentation for Quantitative Analysis of Lipid Droplet Dynamics in Hepatic Organoids https://www.biorxiv.org/content/10.64898/2026.04.01.707237v1

Osmotic pressure gradients in E. coli biofilms revealed by in-situ sensors https://www.biorxiv.org/content/10.64898/2026.04.02.716217v1

DM: a simple solution to suppress air-water interface interactions in cryo-EM https://www.biorxiv.org/content/10.64898/2026.04.02.716008v1

Quantitative comparison of fluorescent reporters by FCS excitation scan https://www.biorxiv.org/content/10.64898/2026.04.04.716477v1

Osmotically Induced Shape Changes in Membrane Vesicles https://www.biorxiv.org/content/10.64898/2026.04.03.716363v1

Nucleolar Condensation Orchestrates rRNA-dependent Mobility and Spatiotemporally Enriches rDNA-binding of Human Chromatin Remodeler BRG1 https://www.biorxiv.org/content/10.64898/2026.04.03.716269v1

Frustration Landscapes of Broadly Neutralizing SARS-CoV-2 Spike Antibodies Targeting Conserved Epitopes Reveal Energetic Logic of Escape-Proof and Escape-Prone Mechanisms https://www.biorxiv.org/content/10.64898/2026.04.02.716254v1

Several multiple sequence alignment perturbation methods enhance AlphaFold3 sampling of alternative protein states https://www.biorxiv.org/content/10.64898/2026.04.02.716037v1

The transmembrane domain regulates the kinetics of the SARS-CoV-2 spike conformational transition https://www.biorxiv.org/content/10.64898/2026.04.03.716256v1

On the feasibility of temporal interference stimulation of human brains using two arrays of electrodes https://www.biorxiv.org/content/10.64898/2026.03.31.715653v1

Rectifying AI-generated protein structure ensembles for equilibrium using physics-based computations https://www.biorxiv.org/content/10.64898/2026.03.24.714034v1

Structural Basis of M1 Muscarinic and H3 Histamine Receptor Inhibition in OPC Differentiation https://www.biorxiv.org/content/10.64898/2026.04.01.715893v1

Structural insights into interdomain interactions in Entamoeba histolytica APS kinase https://www.biorxiv.org/content/10.64898/2026.04.02.716029v1

Endocytosis shapes extracellular chemical gradients in autonomous cell-cell attraction https://www.biorxiv.org/content/10.64898/2026.03.31.715676v1

YY1-concentration-dependent formation of mechanically distinct DNA condensates through different interaction mechanisms https://www.biorxiv.org/content/10.64898/2026.03.31.715725v1

Transferability of ion force fields to OPC water: Maintaining single-ion and ion-pairing properties https://www.biorxiv.org/content/10.64898/2026.03.31.715553v1

Correcting Preprocessing Bias in Sparse Chromatin Contact Data Enables Physically Interpretable Reconstruction of Genome Architecture https://www.biorxiv.org/content/10.64898/2026.03.31.715622v1

Site-specific O-glycans influence lacritin structure and multimerization in tears https://www.biorxiv.org/content/10.64898/2026.03.30.715376v1

Shapes of condensate droplets containing filaments https://www.biorxiv.org/content/10.64898/2026.03.31.715246v1

A homogenization approach for spatial cytokine distributions in immune-cell communication https://www.biorxiv.org/content/10.64898/2026.03.31.715485v1

Coupling between sterol and sphingolipid structure in ordered membrane domains https://www.biorxiv.org/content/10.64898/2026.04.01.715929v1

Increased diffusion in livers with advanced fibrosis: pre-clinical and clinical observations with diffusion MRI https://www.biorxiv.org/content/10.64898/2026.03.30.715426v1

Protein-peptide binding pathways revealed by two-dimensional replica-exchange molecular dynamics https://www.biorxiv.org/content/10.64898/2026.03.30.715468v1