Kinetic Signatures of RAS-BRAF Engagement Reveal Isoform Selectivity, Oncogenic Amplification, and Mutation-Dependent Inhibitor Resistance https://www.biorxiv.org/content/10.64898/2026.05.24.727535v1

Single-molecule nanophotonic resolution of binding dynamics from apo to fully liganded for a cyclic nucleotide-gated ion channel in cell-derived vesicles https://www.biorxiv.org/content/10.64898/2026.05.24.727213v1

A Sonification Framework for GPCR Molecular Dynamics: Auditory Signatures of β2-Adrenergic Receptor https://www.biorxiv.org/content/10.64898/2026.05.23.727422v1

Magnetic Levitation Derived Metabolomic Fingerprinting Enables Exploratory Discrimination of Breast Cancer Subtypes https://www.biorxiv.org/content/10.64898/2026.05.23.727414v1

Emergent Collective Bats Oscillation Dynamics on Tree Branches https://www.biorxiv.org/content/10.64898/2026.05.23.727420v1

OptiCell3D: Precise inference of mechanical cell properties from microscopy imaging https://www.biorxiv.org/content/10.64898/2026.05.23.727231v1

An autoinhibitory regulatory switch governs heterotypic phase separation and liquid-to-solid phase transition of TDP-43 and tau into cytotoxic amyloids https://www.biorxiv.org/content/10.64898/2026.05.23.727391v1

A DNA-binding protein senses DNA superhelicity to switch between bridging and nucleoprotein filament formation https://www.biorxiv.org/content/10.64898/2026.05.23.727375v1

Body Mass Index-Specific Nanoparticle Protein Corona Signatures in Late Pregnancy https://www.biorxiv.org/content/10.64898/2026.05.23.727413v1

High-Sensitivity Magnetic Levitation Reveals Intrinsic Protein Corona Heterogeneity on Identical Nanoparticles https://www.biorxiv.org/content/10.64898/2026.05.23.727410v1

Functional Differentiation of Type II and Type I Collagen Articular Models in Synovial Fluid Film Formation and Recombinant Lubricin Retention https://www.biorxiv.org/content/10.64898/2026.05.22.726594v1

Autocatalytic growth offset by constant degradation explains mass accumulation during B cell activation https://www.biorxiv.org/content/10.64898/2026.05.22.727310v1

The membrane imposes a conformational directivity switch on receptor tyrosine kinase dimers https://www.biorxiv.org/content/10.64898/2026.05.22.727318v1

An atomic interaction conserved for over 600 million years gates inhibitory neurotransmission https://www.biorxiv.org/content/10.64898/2026.05.22.727206v1

Modeling Reveals How Direct-Acting Antivirals Redirect HBV Capsid Assembly Pathways to Noninfectious Products https://www.biorxiv.org/content/10.64898/2026.05.25.727729v1

Stochastic spin selection in the mechanism of semiquinone formation at the ubiquinol oxidation Qo site of cytochrome bc1 https://www.biorxiv.org/content/10.64898/2026.05.22.727096v1

Cholesterol differentially regulates α-synuclein binding across membrane packing regimes https://www.biorxiv.org/content/10.64898/2026.05.21.726870v1

Motile and matrix-producing cells drive distinct modes of cell-scale motion in Bacillus subtilis colonies https://www.biorxiv.org/content/10.64898/2026.05.21.727008v1

Direct analytical estimation of thermodynamic parameters of thermo-TRP channels https://www.biorxiv.org/content/10.64898/2026.05.21.726968v1

Lipid Composition Modulates Secondary Structure at the Biocondensate-Membrane Interface https://www.biorxiv.org/content/10.64898/2026.05.21.726873v1

Assembly-pathway regulation dictates pH-responsive actuation in the R-body protein machinery https://www.biorxiv.org/content/10.64898/2026.05.21.725848v1

Anisotropic subdiffusion in the cytoplasm of living cells https://www.biorxiv.org/content/10.64898/2026.05.21.726834v1

Membrane Lipid Composition and Asymmetry Act as a Switch for Cell-Penetrating Peptide Translocation versus Leakage https://www.biorxiv.org/content/10.64898/2026.05.21.726760v1

Nanometer-scale RNA protein clusters (RPCs) Foster Helicase Activity of DEAD-box eIF4A https://www.biorxiv.org/content/10.64898/2026.05.23.727435v1

A Pipeline for Solving Edge-Matching Puzzles and Their Implications for Protein Folding https://www.biorxiv.org/content/10.64898/2026.05.23.727379v1

Cooperativity, dynamics, and the free-energy surfaces of charge-patterned IDPs https://www.biorxiv.org/content/10.64898/2026.05.21.726897v1

A unified ensemble-allosteric framework reconciles gain- and loss-of-function disease mutations in the IP3 receptor https://www.biorxiv.org/content/10.64898/2026.05.22.727127v1

Does the sequence of a disordered protein encode small molecule binding paths? https://www.biorxiv.org/content/10.64898/2026.05.20.726646v1

Growth bistability in small bacterial populations exposed to antibiotics https://www.biorxiv.org/content/10.64898/2026.05.21.726888v1

Tunable electrostatic interactions of lipid-coated quantum dots with biological membranes https://www.biorxiv.org/content/10.64898/2026.05.21.726631v1

AE-PocketMiner Uses Attention to Simultaneously Predict Cryptic Pockets and Their Allosteric Coupling https://www.biorxiv.org/content/10.64898/2026.05.21.726899v1

Pathway-resolved flux decomposition reveals hidden kinetic hierarchy in protein folding https://www.biorxiv.org/content/10.64898/2026.05.20.726702v1

The Rossmann2x2 Fold Attains its Native Structure Via a Defined Pathway of Sequential and Cooperative Folding Units https://www.biorxiv.org/content/10.64898/2026.05.21.726993v1

De novo design of RNA pseudoknots with deep learning https://www.biorxiv.org/content/10.64898/2026.05.21.726960v1

Force-regulated catch bonds and fusion peptide exposure drive coronavirus entry https://www.biorxiv.org/content/10.64898/2026.05.21.727024v1

How motile bacteria move water in soil https://www.biorxiv.org/content/10.64898/2026.05.20.725210v1

Domain Dissolution in Supported Lipid Bilayers Triggered by Unsaturated Phospholipid Addition https://www.biorxiv.org/content/10.64898/2026.05.20.726269v1

Structures of Cas9-Bound Double-Stranded DNA Mini-Circle Reveal Impacts of DNA Shape on Cas9 Target Interrogation https://www.biorxiv.org/content/10.64898/2026.05.20.726649v1

Energetically constrained turnover drives the emergence of aging https://www.biorxiv.org/content/10.64898/2026.05.19.726278v1

Beyond iron concentration: iron aggregation shapes quantitative MRI in the human brain https://www.biorxiv.org/content/10.64898/2026.05.19.726170v1

Development of a High-Throughput TR-FRET Assay for Identification of Small Molecule Inhibitors of the LILRB4 (ILT3)-SCG2 Immune Checkpoint Interaction https://www.biorxiv.org/content/10.64898/2026.05.19.726368v1

Two-Dimensional Phase Separation of DNA Nanomotifs Anchored to Lipid Bilayers https://www.biorxiv.org/content/10.64898/2026.05.19.724116v1

Spatiotemporal graph neural networks reveal conformational binding signature in protein dynamics https://www.biorxiv.org/content/10.64898/2026.05.19.726195v1

Durotactic Migration Driven by Anisotropic Matrix Stiffening and Mechanical Feedback https://www.biorxiv.org/content/10.64898/2026.05.19.726229v1

Ether linkages in phospholipids provide modular control of membrane mechanics https://www.biorxiv.org/content/10.64898/2026.05.20.723252v1

A quantitative imaging framework reveals density-dependent GPCR oligomerization and organization in living cells https://www.biorxiv.org/content/10.64898/2026.05.19.726161v1

Protein-DNA mesh assembly drives dsDNA-specific and duplex length-dependent activation of cGAS https://www.biorxiv.org/content/10.64898/2026.05.19.726263v1

Glycosaminoglycans Promote Amyloid-β Aggregation via Multivalent, pH-Dependent Interactions https://www.biorxiv.org/content/10.64898/2026.05.20.726382v1

Solution Phase Protein Adsorption to ss(GT)15-DNA Wrapped Single Walled Carbon Nanotubes https://www.biorxiv.org/content/10.64898/2026.05.18.725765v1

Cryo-EM Structure of a 95-Basepair Double-Stranded DNA Minicircle at 5.3 A Resolution https://www.biorxiv.org/content/10.64898/2026.05.19.726095v1