This Review discusses the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes (£) go.nature.com/4qAwCQS #EndoSky #MedSky

Developmental transcription factors display a range of targeting H3K9me3 heterochromatin to open chromatin, for cell fate changes www.science.org/doi/10.1126/...

Our lab specialises on Stem Cells, Beta Cells and Diabetes. Naturally, we think a lot about glucose and what hyperglycaemia means. Have a read on our latest review in Nat Rev Endo to find out more! #atlab #stemcells #diabetes #research #imcb #astar #nus www.nature.com/articles/s41...

Congrats to Ariel, Yuval and all those involved. @chromatech.bsky.social

New online! Let the data speak — single-cell analysis with CellWhisperer

As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-... Know of a relevant event that’s missing? Please reply below

⭐NAR Breakthrough! ⭐ 🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/... #NARBreaktrhough #RNA #StructuralBiology

Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...

Are you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬 25 – 28 August 2026 Submit your abstract by 25 May: s.embl.org/trm26-01-bl #EMBLTranscript

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉 Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨ #PhD #3DGenome

What an amazing assay. DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform: www.biorxiv.org/content/10.1... This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site: network.febs.org/posts/febs-a...

FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate: Molecular Cell www.cell.com/molecular-ce...

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Latest from our lab - great work from Dor...for those interested in #Mkrn3, #puberty, #reproduction, #chromatin, #transcription, #bioinformatics.

Great to see this from a former student in my NUS lab - Adrian @drainteo.bsky.social - looks like a good read.

👇 rdcu.be/egkqK

Ever stuck choosing the right plot or trying to figure out how to make it look just right? My go-to resource is the R Graph Gallery (r-graph-gallery.com), which is full of examples and clear code for everything from scatterplots to Sankey diagrams! #dataviz #rstats #rladies

🧪 Scientists have created the first map of mitochondria throughout the entire brain https://go.nature.com/42j9YCV

We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in @naturecomms.bsky.social today: www.nature.com/articles/s41...

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

Two more weeks to send us your abstract! >20 abstract selected talks. Priority to junior scientists and cool biology on gene regulation (DNA/RNA/protein). Come to meet the world leaders in single molecule genomics and single molecule imaging! Help shaping the future of the field in the workshops!

Have a look at our newest commentary in @pnas.org : "G-quadruplexes and their unexpected ability to fold proteins" Full text: www.pnas.org/doi/10.1073/... #G4 #quadruplex #proteins #folding

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex

Congratulations to Laurine Decoster and collaborators from our lab on getting the The SNE Impact 2024 on their paper "A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice" 👏👏🎉🎊 www.nature.com/articles/s41...

This is cool rdcu.be/eeGyj

Women are twice as likely to develop Alzheimer’s disease as men. A feature in Nature Medicine reports how the changes to the female brain during menopause, along with social and cultural factors, might affect disease risk. #medsky #alzsky 🧪

New followers = time for a fresh intro! 👋 I’m Christopher, a reproductive biologist and group leader at @IBDMmarseille 🇫🇷 My lab uses #LiveImaging to explore how the dynamic #ovary produces healthy #eggs 🔬🥚 Please share & follow as we push the boundaries of #fertility research! 🔗 bit.ly/3zQPEh7

🚨 PhD Opportunity! 🚨 Passionate about ovarian biology? This cutting-edge PhD project combines live-cell microscopy & biophysical modelling to explore the dynamic ovary! 🧬🔬 I'm happy to chat more—DM or email me to set up a Zoom call 📩 And please share! 🙌🏼 [email protected]

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We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes. Check it out and apply: ceesdekkerlab.nl/come-join-us/ RT=nice!

Fantastic study and collaboration led by stellar postdoc @ioansarr.bsky.social, it was a pleasure to host you in the lab (& thanks to @embo.org for the visiting fellowship)

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

Sex related development of the hypothalamus 👇 www.nature.com/articles/s41...

This was an awesome meeting last time out- #enhancer folks should register now!

"Developmental Timing Across Species" @embo.org Workshop organised by @trayon.bsky.social @bassemh.bsky.social @mdiazcuadros.bsky.social @vanderhaeghenp2.bsky.social 📅6-9 May 2025 📍Paris Submit abstract and register by 1 April: thenode.biologists.com/developmenta... #EvoDevoTempo

PRC1 and PRC2 proximal interactome in mouse embryonic stem cells: Cell Reports www.cell.com/cell-reports...

A subcellular map of translational machinery composition and regulation at the single-molecule level | Science www.science.org/doi/10.1126/...

Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome. www.science.org/doi/10.1126/...

ChromoGen: Diffusion model predicts single-cell chromatin conformations | Science Advances www.science.org/doi/10.1126/...

Wow - this is also the cofactor for the lyase activity of Cyp17A1 - required for production of androgens from pregnenolone/progesterone.

Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹 Register now: ➡️ shorturl.at/AtAjz Exciting speaker lineup, many slots for talks selected from abstracts

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky

New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n

Does a cell’s gene expression always reflect its function? Evidence from zebrafish neurons suggests that transcriptionally similar cells can be functionally diverse @ishainer.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...

ICYMI: New content online: Tryptophan metabolism, exercise and depression

Open call! The EMBO Young Investigator Programme supports young group leaders in Europe and beyond. Apply by 1 April: www.embo.org/funding/fell... #ResearchFunding #LifeSciences 🧪