Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Just out: BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function | PNAS www.pnas.org/doi/10.1073/... @mskcancercenter.bsky.social @kyriepappas.bsky.social #SawyersLabMSKCC

If you have not already, make sure to check out two fantastic recent preprints from the Patel and Wang labs on the same topic investigated using magnetic tweezers and angular optical trapping: doi.org/10.1101/2024... and doi.org/10.1101/2024...

🚨New preprint🚨We developed a transverse flow imaging approach to directly visualize bacterial replisomes challenged by topological barriers and discovered a fast rotational mode of replisome operation. Fantastic work by thomasmretzer.bsky.social and Hamdan Lab! tinyurl.com/replisomerot...

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Shout out to Sloan Kettering @mskcancercenter.bsky.social for supporting basic science / foundational biology... www.mskcc.org/news/cryo-el...

In our latest preprint, we uncover how CMG helicase overcomes covalent DNA-protein crosslinks. Check out our findings here: www.biorxiv.org/content/10.1...

Thrilled to share first part of my post-doc work, published today in @science.org www.science.org/doi/10.1126/... We use reconstituted replication system and cryo-EM to unravel an unexpected mechanism of DNA translocation employed by eukaryotic replicative helicase.

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

I am so proud to share a major part of my graduate school research, published today in Science, where we use cell-free replication assays and cryo-EM to describe a central mechanism of eukaryotic DNA replication: www.science.org/doi/10.1126/...

MSK has been recognized as one of the national's top workplaces for inclusion and diversity by @newsweek.com magazine. 🎉 MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...

In the midst of all the NIH & NSF chaos, I want to take a moment to focus on some good news and talk about science! 🧬✨ 🚨 New preprint alert! 🚨 doi.org/10.1101/2025... 🧵👇 (1/)

Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.

Please check out our preprint where we find that mitotic transcription helps ensure ecDNA inheritance through chromosomal tethering: www.biorxiv.org/content/10.1...

Setting up shop in advance of closing our profile on X.

Deadline to apply (Feb 10) is quickly approaching. If you are interested in learning about a postdoc opportunity at MSK, don't wait to apply.

Fascinating and thought-provoking new study by Tony Cesare's lab! It was a pleasure to write a News & Views about this work together with @villungerlab.bsky.social www.nature.com/articles/s41...

New year, new beginnings! 🎉 The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social! We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity. #NewPI #AcademicSky #WomenInSTEM (1/2)

Happy to share a new work from the lab on how DNA damage checkpoint can be down-regulated. rdcu.be/d5o3E. Congrats to all authors at @mskcancercenter.bsky.social and our Weill BCMB student @tzippora.bsky.social. gradschool.weill.cornell.edu/bcmb-allied-...

🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...

the Lai lab got a holiday gift ... so excited to share Seungjae Lee's work on surprising regulation of miRNA pathway at Science!! he did it all, from molecular genetics to biochemistry to genomics. and amazing collab with Makiko Yasuda lab brought it into mice. 1/3 www.science.org/doi/10.1126/...

🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...

It’s a wrap! The final version of our paper is out 🎉 where we characterize the multifaceted response of the transcript-activated type III CRISPR-Cas immunity. Here’s a skytorial (bluetorial?) by my awesome co-lead @akshilton.bsky.social #RNA #RNAsky #WomenInSTEM

Awesome paper, I think the authors are not on Bluesky yet

Another week, another great paper! Kudos to the amazing grad student, Chiara Masnovo who single-handedly initiated and led the project, and arranged a terrific collaboration with the Aharoni lab from Ben-Gurion University, and to the great members of the two labs. www.nature.com/articles/s41...?

Super excited for my first day as Assistant Prof at @cuanschutz.bsky.social in the Dept of Pharmacology! The lab is open, and now I can't wait to do exciting science! #FirstGen #newPI #STEM #AcademicLife #ExcitingScience #PhDLife #WomenInSTEM #MomInSTEM #GenomeStability #CellBiology #DNARepair

genesdev.cshlp.org/content/earl... It's now out! This work from Hexiao Wang is a real tour de force. The gist is that innate immune sensing in the nucleus may be a mechanism of replication for surveillance. Check it out!

Thrilled to join the amazing community here on Bluesky! 🌟 Kicking off our first post with exciting news: the advanced version of our preprint is now published in Nucleic Acids Research! 🙌 [Read here: academic.oup.com/nar/advance-... Here’s a quick recap of our findings previously shared on X: 👇

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

It's grad school/ job/ internship application season. Make sure your kids & friends know what we're looking for on the other side. I've seen too many applications for internships at Sloan Kettering (a cancer center) be focused on becoming a geologist or business consultant. hbr.org/2023/02/how-...

Calling all undergrads who are looking for a 10-week summer, #research opportunity at the interface of #biomedicine, #chemistry, #computational biology, & #engineering. Applications are now open! For more information visit us: bit.ly/Summer_MSK2025

#RNA enthusiasts in the NYC area? Come join us for the Tri-I RNA Club Winter Mini-Symposium! We’ll have great talks by trainees, followed by some food and drinks. Hope to see you there! #RNAsky #RNAbiology

The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...

A research team from MSK’s Sloan Kettering Institute and collaborators have identified a compound called gliocidin that may have the potential to improve the survival of patients with #glioblastoma – now in @natureportfolio.bsky.social #oncSKY #medSKY Read the study: www.nature.com/articles/s41...

A list of science journals (mostly biomed) to be updated as more join Bluesky go.bsky.app/5kmzyLp

Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab. www.pnas.org/doi/10.1073/pnas.2413298121

New synthetic biology / genomic recording lab opening in the New York city! Please reach out via choij10 _at_ mskcc.org if you are interested in joining / collaborating! Mskcc.org/research/ski/labs/junhong-choi

Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.

If you are interested in pursuing a PhD in biomedical sciences in New York City, it is still time to apply to the BCMB program run jointly by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center ! Deadline: Dec 1, 2024.

Reconstitution of SPO11-dependent double-strand break formation https://www.biorxiv.org/content/10.1101/2024.11.20.624382v1

Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11. SPO11 dimerization controls meiotic DNA double-strand break formation. www.biorxiv.org/content/10.1...

Interesting new method to map nucleosomes in 3D, "Proximity Copy Paste (PCP)". www.biorxiv.org/content/10.1... ▶️ mapped connectivity of nucleosomes in S. cerevisiae ▶️ chromatin is predominantly organized into regularly spaced nucleosome arrays ▶️ metaphase chromosomes packed by arrayed cohesin hubs

Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by Diana, Marta and Paula! www.cell.com/cell/fulltex...

Interested in chromatin architecture?
 Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution. www.biorxiv.org/content/10.1...

Game changer!