Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance. The regulation of most proteins is dominated by different regulatory mechanisms across cell types. Gratifyingly, this complex regulation defines simple rules ⬇️ www.biorxiv.org/content/10.1...

alert to all H1B holders, please share: Trump just banned H-1B employees from reentering US unless employer pays $100,000 "fee". Proclamation applies to both new H-1B entrants and current H-1B employees who are abroad. set to take effect tmrw sun sept 21. please return if you can. i am so sorry. 😢

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene www.science.org/doi/10.1126/...

Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social

Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra www.biorxiv.org/content/10.1...

Beautiful study, beautiful creatures.

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

We’re pleased to exclusively announce the longlist for the 2025 National Book Awards for Young People’s Literature. See it here.

Just read this paper by @tesarlab.bsky.social lab and collaborators on the role of SOX6 in oligodendrocytes and found it highly insightful and stimulating. www.cell.com/cell/fulltex... #development #transcription #enhancers

🚨🚨🚨 Please repost We are looking for postdocs to join our lab at NIH. Apply: www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply Learn more about training at NIH : www.training.nih.gov/research-tra...

🧵 An open letter to the US Open and USTA: Trump will attend the #USOpen as a guest of ROLEX. Yesterday, Trump declared 'WAR' on Chicago. The USTA has called for media censorship of dissent against Trump today. I played NCAA tennis many years ago and still play. Today I resign my #USTA membership.

Super proud of Njoud and her PhD thesis work. Here she demonstrates that mitochondrial dysfunction is one of the earliest defects in DRPLA-patient derived neurons. Furthermore, neurodegeneration and ROS accumulation can be rescued with phenylbutyrate treatment. www.biorxiv.org/content/10.1...

Scientists at Lund University form @cellreprolab.bsky.social have mapped the “genetic toolkits” to reprogram cells into dendritic immune cells, opening doors to more precise cancer immunotherapies. Read about the findings now in Immunity: 🔗 www.stemcellcenter.lu.se/article/scie... #Immunotherapy

“A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro” Nice work by @danielmedinacano.bsky.social @tvierbuchen.bsky.social @em6wong.bsky.social @stadtfeldlab.bsky.social 🧪🧫🧠 www.cell.com/developmenta...

… my work with the Stadtfeld lab @stadtfeldlab.bsky.social‬ on the role of OTX2 during definitive endoderm and anterior gut development is also out (tinyurl.com/3unwh3eb)! Thank you so much to all collaborators, and I’ll be more than happy to discuss these protocols with anyone interested!

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...

Excited to share our recent viewpoint with @storerlab.bsky.social led by Kirsten Sadler, on epigenetic mechanisms of regenerative resilience. Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...

Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells www.cell.com/developmenta...

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Online Now: Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation Online now:

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

To have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.

One week left until our next Development presents… webinar on #stemcells and #organoids, featuring talks from Toshi Yamada (UCSF), Chrysanthi-Maria (Anthie) Moysidou (@mdc-berlin.bsky.social‬) & Daniel Medina-Cano (MSKCC). 📅Wed 13 August 16:00 BST Register here: us02web.zoom.us/webinar/regi...

🚴 From @crg.eu to the roads of Europe, our PhD student Fabio and the #LongTREC team are combining cutting-edge science with sustainable travel. Now in London, and heading next to Cambridge! #LongCyclingForScience

Our latest work, just out now at JCI Insight on iPSC modeling of pulmonary fibrosis. The latest chapter in the Kotton-Beers collaboration! Congrats to co-first authors Drs. Rodriguez and Alysandratos for leading the way! insight.jci.org/articles/vie...

There's nothing quite like a cat sleeping.

Exciting new work by Miriam Gordillo and @toddevans24.bsky.social on signal-dependent lineage-promoting TF functions during mammalian gastrulation. www.biorxiv.org/content/10.1... #development #gastrulation #stemcells

Elegant new work from the Hochedlinger lab describing an essential balancing act of bivalent chromatin during blood cell formation. www.cell.com/cell/abstrac... #epigenetics #hematopoiesis

Please support and share.

Nice work from Du & Warmflash using micropatterned hESCs to dissect midbrain-hindbrain boundary formation Timing of WNT signalling, not strength or duration, specifies midbrain-hindbrain boundary Good example of recapitulating developmental signalling in vitro www.biorxiv.org/content/10.1...

New study published in Stem Cell Reports from @mskcancercenter.bsky.social identifies two enhancers essential for regulating #NANOG expression in human embryonic #stemcells ow.ly/JaI450W1bVa @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

#FragileNucleosome seminar happening tomorrow!

Intriguing new pre-print from the @stefanschoenfelder.bsky.social lab on unusual human enhancers. www.biorxiv.org/content/10.1... #pluripotency #epigenetics #transcription

Register now to attend our #DevPres webinar next week, featuring the winners of the @bsdb.bsky.social poster prize, @shifaant.bsky.social and @giuliapaci.bsky.social, and chaired by Abigail Tucker. 4 June at 15:00 BST us02web.zoom.us/webinar/regi...

*new interns, residents, and fellows start on July 1 *~11,000 house staff in US hospitals are on J-1 visas *these doctors are the backbone of rural & urban safety-net hospitals *most of these doctors go into primary care after training, often in the same community www.intealth.org/pdfs/J-1_US_...

Time to rub some noses. www.nytimes.com/2025/05/27/o...

Very interesting talks from @trompoukilab.bsky.social and @chribue.bsky.social in the next couple of weeks at the Cambridge Cancer Chromatin and Epigenetics Club www.haem.cam.ac.uk/events/ccec/...!

"Patriotism is supporting your country all of the time, and your government when it deserves it" - Mark Twain

title of assistant professor's talk: amino acid metabolism of effector T cells in LCMV infection title of senior full professor's talk: Why do cells eat?

For an update on a set of recent preprints using gastruloids to investigate the interplay between morphogenesis, gene expression and physical parameters, on the robustness of patterning: journals.biologists.com/dev/article/...

Beautiful and important work by the group of @yichenglong.bsky.social at Weill Cornell on the molecular determinants that direct epigenetic repression by Polycomb complexes. www.biorxiv.org/content/10.1... #epigenetics #stemcells #cardiogenesis #polycomb

Study by @kenzoivanovitch.bsky.social @jamesbriscoe.bsky.social @ucl.ac.uk published @embojournal.org featured in @theguardian.com 🎉👏!!! ➡️https://www.theguardian.com/science/2025/may/13/heart-cells-mouse-embryo-science-research #preprintpeerreview @reviewcommons.org ➡️ doi.org/10.1101/2023...

Modeling tissue-resident macrophage development from mouse pluripotent stem cells https://www.biorxiv.org/content/10.1101/2025.05.01.651743v1

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

This interview with @sarawickstrom.bsky.social is an excellent and inspiring read.

Very insightful summary of currently available approaches to model peri-implantation stages of human embryogenesis with stem cells. #development #embryogenesis #gastrulation.

Born Apr 22, 1909, Rita Levi-Montalcini defied war and prejudice to unlock a key to the brain: the nerve growth factor. Nobel Prize in 1986, her legacy empowers generations of scientists and lights the path in the fight against neurodegenerative disease. #RitaLevi #RitaLeviMontalcini 🧪

Perspective @natsmb.nature.com A transcription coupling model for how enhancers communicate with their target genes www.nature.com/articles/s41...

The 2025 European Summer School in Stem Cell Biology and Regenerative Medicine will take place 12-19 Sept 2025, on the beautiful Greek island of Spetses. Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀 Deadline for applications: 30th May 2025

Thank you for your inspiration and the many insights into the beautiful world of mammalian development, Alex Joyner!! bit.ly/4iSZoZ9 #science #devbio #genetics