Congrats to @annbaako.bsky.social for her successful thesis defense!! @justinperryphd.bsky.social and I are so proud of you! Look out for a new version of Ann's manuscript on modeling tissue-resident macrophage development from mouse PSCs coming soon. www.biorxiv.org/content/10.1...

I am excited to announce that I have received a Travel & Merit Award for the #ISSCR2026 Annual Meeting about my work modeling mouse cranial and cardiac neural crest development in vitro. Many thanks to my mentor @tvierbuchen.bsky.social for his guidance and support throughout this project @ISSCR.org

Mapping nerves in a whole embryos. We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry. More here: www.biorxiv.org/content/10.6...

We used @hcrimaging.bsky.social to reveal interesting new features of #neuralcrest development in #xenopus - Thanks to @dev-journal.bsky.social for featuring it on the cover! journals.biologists.com/dev/article/...

Tommy Vierbuchen @tvierbuchen.bsky.social shared his work with us today: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". see the recording at: www.youtube.com/playlist?lis... (more info at www.carlocolantuoni.org/seminar)

Nice preview of our paper by Hanwen Yu and Yan Liu. Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...

Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin

Hi bsky! How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion! (@bensteventon.bsky.social lab) tinyurl.com/2ncc8zap

Our next episode features Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠

📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms. doi.org/10.1016/j.cd...

I'm really happy to announce that my two main postdoctoral works have been published in the same issue of Developmental Cell! First, the final form of the mouse cortical organoid protocol (tinyurl.com/bddfmx8n), which I recently presented at Development presents (tinyurl.com/36udcpme) and…

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...

Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells www.cell.com/developmenta...

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

🐣✨ TUJ1 staining reveals the forming trigeminal ganglion in a chick embryo! Image taken by Rocio Márquez from @pstrobl.bsky.social lab, where they investigate how neural crest and placode cells communicate during the formation of this sensory structure 🔬🧪 #FluorescenceFriday

I gave in! After students asking for it, I now made a simple figure design checklist. To help all scientists w/o graphic skills create clear, accessible, and truthful charts! -> Out in @nature Cell Biology: rdcu.be/erwl4 #DataVisualization #PhD #SciComm Thx for review @bethcimini.bsky.social + 2

New paper from my group is out. We demonstrate that cranial neural crest (CNCC) induction requires the transcription factor SALL4 to physically recruit the BAF chromatin remodeller at CNCC-induction enhancers as early as at the neuroectodermal stage: www.biorxiv.org/content/10.1...

Super fun to se my photo on the cover of the latest issue of Developmental Dynamics. Sox10 expression in a common wall lizard embryo in somite stage 37 visualized with in situ hybridization. #EvoDevo #NeuralCrest #DevBio Read the paper here: doi.org/10.1002/dvdy...

A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB) https://www.biorxiv.org/content/10.1101/2025.05.15.654100v1

Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation. www.biorxiv.org/content/10.1...

Modeling tissue-resident macrophage development from mouse pluripotent stem cells https://www.biorxiv.org/content/10.1101/2025.05.01.651743v1

Big congratulations to my amazing lab mate Rachel on her successful thesis defense!!

New study shows genetic variation affects DNA #hypomethylation & imprint deregulation in naïve PSCs. Genetic variants may be potential biomarkers for epigenetically stable PSCs. ow.ly/aCVY50VilVY @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Our collaborative project with Matthias Stadtfeld and Jason Mezey labs has now been published. We examined how genetic variation impacts regulation of DNA methylation at the control regions of imprinted genes in naive pluripotent stem cells. www.cell.com/stem-cell-re...

You know how until recently drugs were mostly tested only in men? And they had to change regulations to include women (and btw they are trying to turn those back...) Turns out? Same is true for CATS and dogs! Most vet work is in DOGS. www.nytimes.com/2025/03/11/s... by @emilyanthes.bsky.social

In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. scim.ag/3FvpAKy #BrainAwarenessWeek

Agree and thank you for doing this important work, @labonnelab.bsky.social! Listen here: podcasts.apple.com/us/podcast/o...

NEW HUBBLE IMAGE SHOWING TWO GALAXIES INTERACTING 🤩

LIVE STREAM UP! m.twitch.tv/standupforsc...

When you've been in the cell culture hood all day and finally get to take off your gloves:

Very happy about this terrific special issue of Science Advances on women's health. Great work by the team! @science.org. www.science.org/toc/sciadv/c...

Researchers have developed a model to study why sensory neuron axons regenerate differently. buff.ly/4ijksHC

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years. Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.

Happy Valentine’s Day everyone!

Happy International Day of Women and Girls in Science! 🔬🧬 To the amazing women and girls in STEM, both in the MBL community and around the world—we support and celebrate you today, and all days. 📷: Dee Sullivan, Daniel Cojanu, Tom Vierus, Kelsey Chenoweth

Using national registry data from Denmark, 30 maternal diagnoses linked to offspring autism were identified with most associations attributable to family-level factors rather than direct causal effects of maternal diagnoses, according to a paper in Nature Medicine. 🧪

Dorsal view of a larval zebrafish brain. Credit to @clairewyart.bsky.social. #ZebrafishZunday 🧪

Few medical options are typically presented to people going through menopause, but t outlook for managing it is now starting to change. A feature in Nature outlines the emerging therapies, which includes a relook at hormone replacement therapy. #Medsky 🧪

This is the face of courage and compassion. Thank you Bishop Mariann Edgar Budde for speaking truth to power on behalf of the marginalized.

A challenge for basic scientists is to guarantee that the future generation of health-care professionals and policymakers understands the importance of addiction and mental health research. By Omar Abubaker, @karlakaun.bsky.social, @ericjnestler.bsky.social bit.ly/42oULRu #neuroskyence

www.jax.org/news-and-ins... Go Hilde!

Brain cancer leverages the same tools as the developing brain 🧠! In our new study from the Kriegstein and Li labs, published today in @nature.com, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch www.nature.com/articles/s41...

5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. The majority of them (3,088) are enriched at the protein but not RNA level. The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.

Now also here: NIDCR FaceBase, the one-stop-shop for genetic, genomic, functional genomic, morphology, phenotype, variation, and disease data for craniofacial research: www.facebase.org

I'm very happy to see my article "Genes, Culture and Scientific Racism", coauthored with Marc Feldman, published in Proc Natl Acad Sci USA (see rb.gy/x0e4lw). We explain why people wrongly believe race is a biological classification.

Happy to share our mouse cortical organoid system, which recapitulates in vivo tempos and cell types. We used it to identify gene expression changes across subspecies during development, which might underlie neuroanatomical differences and affect disease penetrance. www.biorxiv.org/content/10.1...

Interested in applying systems genetics approaches to study embryonic development? Tired of working with E14 mouse ESCs? Check out or recent pre-print developing experimental methods and stem cell resources for Diversity Outbred Mice! www.biorxiv.org/content/10.1...