Here is my colleague Adam Riess, Nobel laureate, sharing his thoughts on advocating for science at a recent event at the US Capitol. aas.org/posts/news/2...

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

President Donald Trump today asked Congress to make massive and unprecedented cuts to the 2026 budgets of major federal science agencies. scim.ag/3Yszqnm

The president is recommending a 40% cut to next year’s NIH budget. This would be disastrous for our nation’s health and economy. Please contact your representatives, especially if they are Republicans, and tell them why this cannot happen. An easy option: 5calls.org

Effective immediately, the government says it will begin screening immigrant social media for activity that officials think indicates support for antisemitism.

Orderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors. www.cell.com/developmenta...

This a sign of the dark times in which we live & I'm not bragging about it. My team posted an open position for an industry research scientist and we got 20 times the response rate in the 1st week we normally would & the seniority of the applicants was way higher than the norm. All from academia.

High-throughput single cell -omics using semi-permeable capsules https://www.biorxiv.org/content/10.1101/2025.03.14.642805v1

How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪 Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻 🧵 @cp-immunity.bsky.social www.cell.com/immunity/ful...

Spatial transcriptomics holds great promise to understand biological tissue function, but the assignment of transcripts to cells has been a substantial bottleneck. For this reason, Elyas Heidari, a student in my lab and in @steglelab.bsky.social built segger. www.biorxiv.org/content/10.1...

“Nobody feels like their job is safe. Everyone is on edge,” said Kim Hasenkrug, an NIH scientist emeritus… “Even the top people can’t keep track because they’re hiring and firing so much. Direct supervisors of those who were terminated didn’t even know that it was happening.”

Wow this is a game changer. PhD scholarships and postdoctoral fellowships are now open to non-Canadians.

The Trump administration has terminated $800 million in grants to Johns Hopkins University, spurring the nation’s top spender on research and development to plan layoffs and cancel health projects

After last week publication from the lab on circuits of social isolation/satiety, today we publish a different line of research by @harriskaplan.bsky.social et al., on the development trajectories of hypothalamic POA cell types driving survival and social behavior. www.nature.com/articles/s41...

🧪 This study highlights why we should not focus so much on genetic factors or drug targets. The #exposome (environmental exposures) has greater impact on disease patterns and premature mortality than genetic factors. www.nature.com/articles/s41... #planetaryhealth #academicsky #medsky #idsky

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do. www.biorxiv.org/content/10.1...

It’s @katherinejwu.com with the receipts. The NIH memo undercutting the NIH came directly from Trump officials. www.theatlantic.com/health/archi...

One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...

🔈We've got the cover of the 2nd NG issue for 2025🙌 Read about the cover: In the comment👇 Also check out our research briefing🚨 (link below): nature.com/articles/s41... nature.com/articles/s41...

The no cost extension button is back and at least some are being granted. If this applies to you, go for it. PLEASE SHARE

Another crazed change from the Trump Administration: removing the NIH No-cost extension form

Do psychiatric GWASs find drug targets? Excited to see our work linking GWAS and pharmacological treatments in psychiatric disorders now published in JAMA Psychiatry jamanetwork.com/journals/jam... 🧬💊🎯 Big thanks to @bendfulcher.bsky.social @alexfornito.bsky.social Mark Bellgrove 🧵👇

Today is Retraction Day, when we observe the anniversary of the retraction (Feb. 2, 2010) of the fraudulent paper that purported to show a link between vaccines and autism. 🧪#medsky

Now on BioRxiv: we explored patient-derived GBM organoids & spheroids generated from the same resected tissue. Critically, both models maintain tumor cell composition & heterogeneity, with comparable tissue resemblance across data modalities (1/4) www.biorxiv.org/content/10.1...

Our new paper is out in BioRxiv. Using human fetal tissue and cortical organoids, we figured out how human bRG cells colonize the developing neocortex to expand the oSVZ stem cell niche. Turns out, it's a more complex process than we had anticipated! www.biorxiv.org/content/10.1...

Excellent work by @liwangneuro.bsky.social Arnold Kriegstein and colleagues, deepening our understanding of the molecular and cellular dynamics of the developing human neocortex. The identification of a tripotential intermediate progenitor subtype is a key finding 🧪🧠🧬 www.nature.com/articles/s41...

Brain cancer leverages the same tools as the developing brain 🧠! In our new study from the Kriegstein and Li labs, published today in @nature.com, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch www.nature.com/articles/s41...

Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2

We are recruiting a postdoc! Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼 📌 $73,588 💰 📌 access to postdoc housing 🏠 📌 Support for internationals 🌍 📌 Awesome view 😅 🙏 RT labs.icahn.mssm.edu/derubeislab/...

Wow, there's a lot of us here now. Reintroducing myself: I am Joel 👋🏿. My lab studies how the microbiome shapes the immune system in health & disease, using a mix of bench and computational approaches. I am also passionate about mentoring the next generation of scientists 🥼. #immunology #microbiome

@embl.org is searching for a "highly experienced, inspirational and dynamic leader" to serve as its new director general. Who do we wish to see at this position?

www.anthropic.com/research/sta... This is an excellent attempt (blog & paper) at bringing more statistical rigor to evaluation of ML models (this is specifically focused on LLM evals). I feel like we need to have similar clear standards for many types of predictive models in biology. 1/

Happy #FluorescenceFriday! Another favorite from 2024. Neurofilament #cytoskeleton and tau shown in a primary hippocampal neuron 🔬 #microscopy #neuroscience

UCSF hosted its first food pantry event for postdocs today, where a local food bank gives free food to UCSF employees. This picture represents about half the line that had formed 10 minutes before the market had opened. What the fuck are we doing here guys?

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1

The integrated transcriptomic cell atlas of human neural #organoids, Barbara Treutlein's lab, @fabiantheis.bsky.social @graycamplab.bsky.social @sergiuppasca.bsky.social @giorgiaquadrato.bsky.social and colleagues: www.nature.com/articles/s41...

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

And big-lab-group-think is a stifling influence. Last month I gave a talk at a local big pharma site and the director/host literally asked me “if [insert three big names of field] haven’t already thought of the idea you presented, how could it possibly be true/important?”

My goal is to understand the regulatory role of every nucleotide in the genome, and how this changes across every cell in the human body. If you are interested in doing a Ph.D. with me at UMass Chan Medical (Genomics and Comp Bio Department), see the links below. Deadline is Dec 1st.

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

More than ever, prospective PhD students are requesting meetings w/ me prior to submitting their application (due Dec 1). I traditionally do not meet because I think it creates inequities. (Not everyone knows to ask. I cannot meet w/ everyone who applies.) How do others handle this?

Happy Saturday from Canada! 🇨🇦

This worked for me!

We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.