Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development! @ijmonod.bsky.social www.biorxiv.org/content/10.6...

So many tuft cells (yellow/orange) for #TuftTuesday. Immune cells are in green.

Beautiful images from @christlet.bsky.social labelling tubulin in neurons #journalclub www.biorxiv.org/content/10.6...

A protein called Uninflatable acts as a switch between glial cells growing and glial cells wrapping themselves around axons. 🔗 buff.ly/WRdybO3

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

Diffusion first, Binding second Organ-scale uniform immunostaining in 1 DAY🤠, via temporally controlling antibody reaction strength CuRVE + eFLASH 🐭👤Brain 62 Ab tested 👉deoxycholic acid + pH 👉compatible with transgenic fluorescent proteins #NatBiotech 2025 www.nature.com/articles/s41...

New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology

Hoping everyone's new year fluorescence is clear and bright. Happy #FluorescenceFriday.

New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵 rdcu.be/eVZ1A

I don't always get pretty, isolated, AND transfected primary neurons in culture, but when I do I take advantage.... Rat hippocampal neuron overexpressing ThymosinB4-mScarlet and imaged for 16hr on a @zeiss-microscopy.bsky.social LSM880 with Airyscan. #FluorescenceFriday #Microscopy

Felt a little festive at the microscope this morning for #FluorescenceFriday 🎄 Here’s the nervous system of a juvenile sea star ⭐️ Green = acetylated tubulin, red = nuclei Happy holidays!

✨ Blinking #nanobodies that work for single-molecule localization 🔬 Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!

Network of somatosensory axons and immune cells in the adult zebrafish skin. Credit to @errricpeterman.bsky.social. #ZebrafishZunday 🧪

I am presenting at the Science and Art Minisymposium at #CellBio2025 today! The line up is great this year. I am hands down the least qualified person presenting. It is a weird feeling but I am excited! Here is my title slide. Room 122 4pm

since you made it all the way to then end - we've already made transgenic lines with the mSG from Ando et al - it's amazing! here's a movie from our Cell Observatory project at the Advanced BioImaging Center 7/7

Our Science paper is out! Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group News: bit.ly/4avnkAr and bit.ly/3XBGVHS Great perspective by @vram142.bsky.social +K Zhang

For #FluorescenceFriday - RNAscope marking subfields of the hippocampus in a section of postmortem human 🧠 tissue. Image credit to the Imaging Development team @lieberinstitute.bsky.social 🔬🧪👩‍🔬

This distal gill tip is giving full branchial art vibes for #FluorescenceFriday 🦓🐟 — who knew oxygen exchange could be this pretty. 🔴 kdrl:mCherry highlights the vasculature ⚪ fgf10b:nEOS marks the pillar cells #Zebrafish #DevBio #SciArt

It's #FluorescenceFriday, and this is a reminder that I'm coordinating a collection on the Brain-Immune-Vascular interface in Dementia for @natureportfolio.nature.com, and we have several APC (Article Processing Charge) waivers available! Check out more here: www.nature.com/collections/...

New preprint! Do you like ocean waves? We found similar waves on bacterial colonies! We found that this collective behavior, known as rippling, is nothing but surface waves on an active nematic. @princeton.edu @mpipks.bsky.social @ub.edu @icreacommunity.bsky.social www.biorxiv.org/content/10.1...

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

New must-read review article for all lovers of #centrioles and #centrosomes 😍👇

One-day-old transgenic zebrafish embryo. Credit to Dr. Kazuhide Shaun Okuda. #ZebrafishZunday 🧪

Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins www.biorxiv.org/content/10.1...

I’m proud to present the main work from my postdoc, 3+ years in making from scratch, my ultimate #MimulusPropaganda up till now: The Moment That Symmetry Breaks. #plantscience #development #imaging #microscopy 🧪🌸🔬 w. Captain Yaowu & @biancatash.bsky.social www.biorxiv.org/content/10.1...

1/2 A special #FluorescenceFriday for me! 🌈 Live muscle precursors on a pupal fly testis (Lifeact-eGFP, 🔥-depth-coded). It's special because this is on the poster for the @sfb1348.bsky.social Meeting in May — my first time being featured as a speaker on a poster! 😀 Feeling very grateful & excited!

Gemini 3 created this figure in under 30 seconds from a couple reference images and a one sentence prompt So I’m at a loss for words, honestly #MicroscopyMonday

I like this movie, but a friend of mine likes to complain about the obvious stitching artifacts. I'll try harder next time, Michael. Vimentin (orange) and ER (blue) in an overnight acquisition.

Some cells are just in it for the drama! The bottom 5 microns of cells videoed through a microscope by @EmmaKoory. The middle cell rounds up (for fun?) and subsequently rounds up to divide. We missed so much of the action by just sampling the bottom. @CellBiology

Entire creation of new data that has no bearing upon any histological relevance. Remember LLM models are not open and we have no understanding of what NeuN, GFAP, or DAPI means in biological space within the LLM. This is nonsense. But it looks at first blush as "real" to the uninformed. Scary.

Gemini 3 created this figure in under 30 seconds from a couple reference images and a one sentence prompt So I’m at a loss for words, honestly #MicroscopyMonday

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Still posting cytoskeleton videos, it seems. Actin this time. Sample: Lifeact-eGFP in HeLa cells. Modality: Airyscan confocal Timestamp is mm:ss and the scale bar is 5 µm.

Happy #FluorescenceFriday! LSCM images of mixed species of Radiolaria, zooplankton. Huygens deconvolved to lure out elusive weak autofluorescence signal and noisy background. Thank you Outi Paloheimo (Imaging Facility of Tampere University)! Interested in participating? Join: svi.nl/ImageContest

vimeo.com/1139537563?s... I uploaded a version of that vimentin IF movie to my vimeo page. It's still compressed, but looks a lot better. Best results when you set the quality to 4k.

Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2) forum.image.sc/t/bigvolumeb...

The law of the jungle. Interactions of cells in a collective lead to global rotation. In 80% of the case HUVEC cells turn clockwise. How many cells does it take for this to happen?

Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.

Cool, the HAK-actin preprint was showcased by @prelights.bsky.social A good reason to read it if you haven't yet 😜

#ZebrafishZunday: Cytoplasmic (or ooplasmic) streaming leads to the segregation of embryo from yolk granules. Credit to @shamipourshayan.bsky.social & @heisenbergcplab.bsky.social. 🧪

Lung morphogenesis🦎 Squamate/Lizards Pressure-driven pushing of 🫁epithelium + Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae Smooth muscle mesh provides structural guide for epithelial protrusions #DevDyn 2025 anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...

Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish." lnkd.in/gN7z6th4

Meningeal vascular remodeling in 2~4 mo ovariectomized🐭 ⏬blood vessel length ⏫blood vessel tortuosity ⏫PDPL+ lymphatic vessel area fraction Ectopic vessel muscularization Perivascular scattered αSMA+ cells in dura mater #Cells_MDPI 2025 www.mdpi.com/2073-4409/14...

During my postdoc, I looked at hundreds of images like this 🤩 These are two apical caulonemal cells from moss Physcomitrium patens stained with MDY64 (shown in shades of orange). The natural autofluorescence of chlorophyll is in cyan. #microscopymonday #moss #plantcells #plantmicroscopy

Hydra (Hydra vulgaris) ✨Small but mighty! Hydra can regenerate its entire body, even its head 🧠 A classic model for regeneration, stem cell dynamics, and body axis patterning 📸 Image by Daniel Bressan de Andrade #ModelMonday #DevBio #Regeneration

Happy #MicroscopyMonday everyone! 🌟🔬 Here’s an image from Ivy of outer hair cells (OHCs) and inner hair cells (IHCs) from a P20 mouse.. 🐁✨#Microscopy #HearingResearch #Cochlea #Neuroscience #Neuroskyence

Check out this sneaky lamin A knockdown cell (pink dot) swimming against the tide (migration into gap) & slithering between its sisters. It also slides over another nucleus that deforms underneath it. MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.

my first #FluorescenceFriday post! Mouse hippocampus showing microglia, a lysosomal marker (CD68), and Aggrecan, a perineuronal net component. 😍 Image by Dr. Julia Dziabis!

Happy #FluorescenceFriday from these primary astrocytes grown on glass slides and robotically stained on the Biocare Oncore Pro X! 🧠🔬🧪 Cyan = GFAP Royal Purple = ALDH1L1 Salmon = Nuclear Counterstain