This is why we love #CalciumSignaling Look how mechanical damage triggers long range Ca2+ waves in this plant !! By @annalisabellandi.bsky.social, who is now around here ;) Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬

We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

Yinyin Zhuang, @xyshi.bsky.social et al. introduce land-ExM, a superresolution approach that simultaneously maps protein and #lipid ultrastructure to reveal 3D interactions of #membrane #organelles and condensates. rupress.org/jcb/article/... #ExM #Microscopy #StructuralBiology

This developing quail embryo looks like it's thinking fiery thoughts for #FluorescenceFriday 🐣🔥🧪. Imaged by the fantastic @vanderspuy.bsky.social

Force coordination distinguishes epithelial and mesenchymal modes of collective #chemotaxis. New study from Jorge Diaz and Roberto Mayor @mayorlab.bsky.social @ucl.ac.uk: rupress.org/jcb/article/... #Migration #motility #Development

We have two funded postdoctoral positions available. Topics encompass: -Next gen light-sheet fluorescence microscopy instrumentation -Structured illumination microscopy and other approaches to extend the resolution limit. -Nonlinear microscopy combined with adaptive optics / phase conjugation

Cells navigating microscale curved environments stretch their nuclei, triggering the membrane stretch-sensitive cPLA2 pathway, which in turn rewires cell signaling and morphodynamics to propel the cell forward and avoid steric hindrance pubs.acs.org/doi/10.1021/...

So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread: doi.org/10.64898/202...

How can structures at the vertex of 3 cells have effects at the tissue level? Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...

Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin. IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11. We also show a new role for vinculin as a mechano-chaperone

New paper out: AFM-tip fluctuations inside the actin cortex reveal that effective temperature can remain unchanged while time-irreversibility/entropy production drop (turnover inhibition). #CellMechanics #ActiveMatter #Nonequilibrium @poldresden.bsky.social @tudresden.bsky.social

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

Qian, W., Yamaguchi, N., Lis, P., Cammer, M., & Knaut, H. (2024). Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current Biology, 34(2), 245-259 #EpithelialMechanics doi.org/10.1016/j.cu...

Findings in Science demonstrate that successful mitosis may draw on more mechanisms than commonly assumed. Learn more in this #SciencePerspective: https://scim.ag/4axnAiA

To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime: rupress.org/jcb/article/...

New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders. Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS

Janssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....

20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.

#HappyNewYear ! Let's start 2026 with a @cellcommlab.bsky.social paper How many branches is OK during #CellMigration? It depends on the #cell: for ex. immune cells are just fine. In collab. w. #NirGov @hfspo.bsky.social Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬

How do migrating cell groups balance force and flexibility? Our new preprint shows that RhoGAP15B downregulates RhoA–Myosin activity to stabilise protrusions and enable efficient collective migration in vivo. Happy New Year! www.biorxiv.org/content/10.6...

CRC cells pulling on Collagen I show increased calcium fluctuations, visualized with the calcium reporter K-GECO1

Cell migration is a key cellular process that drives major developmental programs and diseases. Different assays have been developed, but they are often used interchangeably. In our new paper, we describe how to select the optimal assay. More details here: www.nature.com/articles/s41...

James, J., Winn, L. B., Mottram-Epson, P., & Köster, D. (2025). Paths to stability–actin regulation of adherens junction mechanics. Journal of Cell Science, #EpitheilalMechanicsReview doi.org/10.1242/jcs....

Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read! Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase. www.biorxiv.org/content/10.6... Happy holidays ✨🎄

From MBoC... Perihan Nalbant, et al., used optogenetics to boost the Rho activator GEF-H1 in mouse melanoma cells. The result: stronger contraction dynamics, expanding tumor spheroids, and single cells escaping—pointing to a role for Lbc GEFs in driving invasion. www.molbiolcell.org/doi/10.1091/...

Now that you have gathered you raw data from a cell migration assay, how do you analyze that data? In our review, we describe methods - including AI methods - to track migrating cells and extract as much information as possible. Read our paper here: www.nature.com/articles/s41...

How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work! www.nature.com/articles/s41... www.nature.com/articles/s41...

Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses? 🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!

This movie shows lysosomes (orange) and keratin (gray) in a cultured cell over 10 minutes.

From #amoeba to humans: new paper @natcomms.nature.com by the Grashoff group @sfb1348.bsky.social reveals evolutionary origin of animal cell adhesion and force transmission. Talin protein plays central role. See rdcu.be/eTFJR @uni-muenster.de

Ren, Fujita et al. reveal that MYO18B, an unconventional #myosin II, positively regulates lysosomal #exocytosis by promoting focal #adhesion maturation. rupress.org/jcb/article/... 📕 Part of The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...

New preprint! Do you like ocean waves? We found similar waves on bacterial colonies! We found that this collective behavior, known as rippling, is nothing but surface waves on an active nematic. @princeton.edu @mpipks.bsky.social @ub.edu @icreacommunity.bsky.social www.biorxiv.org/content/10.1...

Talin-tensin3 interactions regulate fibrillar #adhesion formation and tensin3 phase separation, say Xingchen Li, Igor Barsukov, Thomas Zacharchenko, Christoph Ballestrem, @mcrcellmatrix.bsky.social and colleagues: rupress.org/jcb/article/... #Cytoskeleton #Biochemistry #StructuralBiology

Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.

Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion, say Camilla Teng @xsciteng.bsky.social, Jeffrey Bush @jeffbush.bsky.social and colleagues @ctbatucsf.bsky.social: rupress.org/jcb/article/... #Development #Adhesion

Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.

Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...

- A postdoc to work on cancer extravasation (4-year project). - A postdoc help in completing Filopodia-related lab projects (2-year). - Multiple Marie Curie postdoc positions that will open in the fall. - We will open a 5-year position to cover my teaching (70% research and 30% teaching).

I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬 You can read the paper here: rdcu.be/eOKdU

Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose. buff.ly/r3BlzFj

Migration of cell populations is a fundamental process in morphogenesis and disease. Researchers have identified a novel form of collective mesenchymal cell migration during chick gastrulation, where cells self-organise into a dynamic meshwork structure. buff.ly/JDp0rUo

Dong R, et al. A tale of two distinct actin networks underlies the entire life cycle of focal adhesion. bioRxiv posted 13 November 2025 doi:10.1101/2025.11.12.688129. www.biorxiv.org/content/10.1...

Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost! PNAS www.pnas.org/doi/10.1073/...