☕Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signaling effectors to regulate intracellular signaling. 👉https://rdcu.be/frvPe www.nature.com/articles/s41...

Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

GOOD NEWS! A personalized mRNA vaccine, known as mRNA-4157, has shown promise in keeping melanoma, a deadly skin cancer, from returning. FIVE years later, NEARLY 70% of people in the vaccine group are CANCER-FREE. The vaccine also cut a person’s risk of the cancer metastasizing by NEARLY 60%.

I am thrilled to share my PhD work with @nicolettapetridou.bsky.social @embl.org: www.biorxiv.org/cgi/content/... A fun collaboration with Bernat Corominas-Murtra, Adrián Aguirre-Tamaral, @bart-smeets.bsky.social , Jef Vanghel and Tom Belpaire! Read the story in the comments below ⤵️

Tension-induced suppression of allosteric conformational changes coordinates #kinesin-1 stepping. From Tsukasa Makino, Michio Tomishige @utokyoofficial.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of our #Microtubules collection: rupress.org/jcb/collecti... #EESMicrotubules

Our newest review on septins as makers & breakers of membrane contacts in J Neurochem Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input. onlinelibrary.wiley.com/doi/10.1111/...

✍️ The @bladoux.bsky.social / @rmmege.bsky.social lab contributed to a new article 📖 @natmater.nature.com 📃 Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts 🔗 www.nature.com/articles/s41...

We are thrilled to announce our new preprint from the wonderful @sorayavillaseca.bsky.social Ever wondered how cells squeeze through tiny spaces in embryos? Neural crest cells use Dynein to transport their nucleus along microtubules. Check out the preprint!! www.biorxiv.org/content/10.6...

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

@julius-w.bsky.social @jclandoni.bsky.social @sulianamanley.bsky.social et al reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...

Pillai, E. K., Mukherjee, S., Gampl, N., McGinn, R. J., ... & Franze, K. (2026). Long-range chemical signalling in vivo is regulated by mechanical signals. Nature Materials, 1-11. doi.org/10.1038/s415... #EpithelialMechanics

Rodriguez, C., Jeong, H., Kim, J., ... & Guo, M. (2026). Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D. Biophysical Journal. #EpithelialMechanics doi.org/10.1016/j.bp...

How membranes shape up for lipid transfer

Higher education must rethink assessment practices in response to the growing integrity challenges posed by generative #AI, argue the authors of a new #SciencePolicyForum. https://scim.ag/4a6U9mj

We are excited to announce another new webinar series, this time on cell migration, hosted by @pjsaez.bsky.social & @valeriaventurini.bsky.social. In our 1st webinar, we’ll hear talks from @juanmagararc.bsky.social, @kyohalie.bsky.social & @djcohen.bsky.social. 🗓️11 June, 15:00 BST

Saishree S. Iyer and Anna Akhmanova @utrechtuniversity.bsky.social review the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/... #Centrioles #Cilia #Cytoskeleton

Optogenetic cross-linking of the actin cytoskeleton using DARPins www.biorxiv.org/content/10.6...

Spotlight: New work by Zheng et al. (rupress.org/jcb/article/...) elucidates how #adhesion proteins are rapidly moved along the cell edge to vertices in response to mechanical forces. Jiarui Jiang and @krothphd.bsky.social discuss the findings: rupress.org/jcb/article/... #Mechanobiology

Judith Zubia-Aranburu, Lingxiao Zhang, and Mingdong Dong @au.dk review multiscale forces governing #Tcell function, their disruption in disease, and how #mechanobiology can improve #immunotherapy design. rupress.org/jcb/article/... #Biophysics #Immunology

Microtubule dynamics control the direction of cardiomyocyte growth | Science www.science.org/doi/10.1126/...

The kind of paper that makes you love this job. Amazing and very complete study! Galvanin, a direct electric-field sensor during cell migration www.biorxiv.org/content/10.1...

1/ Our new preprint is out today.🎉 It started from a surprising control experiment while studying how talin binds vinculin. We were using the widely adopted A50I vinculin mutant to disrupt talin binding — but unexpectedly, it still bound talin. www.biorxiv.org/content/10.6...

happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...

📣 New preprint from our lab! How does the cell place septins to actin or microtubules (MTs) with septins being ~10-100 times less than actin/tubulin? We found a phosphorylation switch controlled by GSK3 that makes that call 🧫🔬🧵 biorxiv.org/content/10.64898/2026.05.06.723191v1 1/7

Regulation of the Cell Wall Integrity pathway at the contact site between mating partners in #yeast. New study by Erin Curtis, Aarshi Jain and Daniel Lew @mit.edu: rupress.org/jcb/article/... #CellSignaling #Microbiology

#FluorescenceFriday From the archives: The Actin Cortex. Plasma membrane (Lck-mScarlet-I 🔴) Cortical actin (GFP-Utrophin 🔵) 1205Lus

Kalukula, Y., Ciccone, G., Mohammed, D., Procès, A., Versaevel, M., Deridoux, A., ... & Luciano, M. (2025). Unlocking the therapeutic potential of cellular mechanobiology. Science advances, 11(44), eaea6817. #EpithelialMechanicsReview buff.ly/RUcvLfF

Happy #FluorescenceFriday, here is a macrophage engulfing a deformable particle imaged on our LLSM. This project from Mira Krendel's lab and the @aicjanelia.bsky.social just came out as a preprint today! www.biorxiv.org/content/10.6...

Our preprint on Antarctic fish cell cultures is out now! Loads of pretty nice super-resolution images. Read it here: www.biorxiv.org/content/10.6...

🧪 Following @wangjianxiong.bsky.social’s paper in Nature Comms published last night! I have written an article with @aunz.theconversation.com. Understand why on earth we would use quails to study the human spine and why the quails glow! theconversation.com/fluorescent-...

New perspective on caveolae www.nature.com/articles/s41...

Just out First Release in @science.org Microtubule dynamics control the direction of cardiomyocyte growth | Science www.science.org/doi/10.1126/...

Excited to share our paper on the NLRP3 inflammasome condensate at the Microtubule Organizing Center (MTOC) by "precise!" cryo-electron tomography (cryo-ET), in collaboration with Jue (phyllis) Wang in the labs of Grant Jensen (BYU) and Pete Dahlberg (Stanford)! www.science.org/doi/10.1126/...

Galectin-9 regulates #DendriticCell polarity and uropod contraction by modulating RhoA activity, say Guus Franken, Laia Querol Cano and colleagues: rupress.org/jcb/article/... 📕 JCB Immune Cell Biology collection 👉 rupress.org/jcb/collecti... #AAI2026

Tumor cells often metastasize in clusters with other cells, offering novel targets for treatments. Learn more: https://scim.ag/4vGFV50

How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.

Collective #migration requires balancing force and flexibility. @vitoryang.bsky.social, @polarityi3s.bsky.social et al. identify RhoGAP15B as a local brake on RhoA-#myosin contractility in border cells, stabilizing front protrusions and coordinating group movement rupress.org/jcb/article/...

Wolf, K., Wu, Y. I., Liu, Y., Geiger, J., Tam, E., Overall, C., Stack, M. S., & Friedl, P. (2007). Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature cell biology, 9(8), 893–904. #EpithelialMechanics buff.ly/cPNltZb

Experienced in nano-and micro-fabrication? MBI is recruiting a new Head of our Microfabrication Core Facility. More details in the flyer and at www.mbi.nus.edu.sg/jobs/seeking...

Can you guess why the microtubules are organized so differently at the bottom and top in this gigantic COS cell? (a game for you @manuelthery.bsky.social)

I'm so pleased to see this work on neural crest development out in Nature today! This was a truly fantastic collaboration with @gleesonlab.bsky.social, Keng loi (Harry) Vong and @xiaoxuyang.bsky.social. Huge thanks to everyone involved 👏 🧪🐣 #devbio www.nature.com/articles/s41...

New paper out 💥 3D cell-cell contact reconstitution with synthetic vesicles and (primary) immune cells to study how different proteins and carbohydrates influence the immune synapse dynamics. advanced.onlinelibrary.wiley.com/doi/10.1002/...

This is why we love #CalciumSignaling Look how mechanical damage triggers long range Ca2+ waves in this plant !! By @annalisabellandi.bsky.social, who is now around here ;) Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬

We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

Yinyin Zhuang, @xyshi.bsky.social et al. introduce land-ExM, a superresolution approach that simultaneously maps protein and #lipid ultrastructure to reveal 3D interactions of #membrane #organelles and condensates. rupress.org/jcb/article/... #ExM #Microscopy #StructuralBiology

This developing quail embryo looks like it's thinking fiery thoughts for #FluorescenceFriday 🐣🔥🧪. Imaged by the fantastic @vanderspuy.bsky.social

Force coordination distinguishes epithelial and mesenchymal modes of collective #chemotaxis. New study from Jorge Diaz and Roberto Mayor @mayorlab.bsky.social @ucl.ac.uk: rupress.org/jcb/article/... #Migration #motility #Development

We have two funded postdoctoral positions available. Topics encompass: -Next gen light-sheet fluorescence microscopy instrumentation -Structured illumination microscopy and other approaches to extend the resolution limit. -Nonlinear microscopy combined with adaptive optics / phase conjugation

Cells navigating microscale curved environments stretch their nuclei, triggering the membrane stretch-sensitive cPLA2 pathway, which in turn rewires cell signaling and morphodynamics to propel the cell forward and avoid steric hindrance pubs.acs.org/doi/10.1021/...

So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread: doi.org/10.64898/202...