I finally used my birthday gift to paint a nerdy dish about cell fragmentation and extracellular vesicles 😍

#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.

And another Asgard paper. Cells in motion! Wow! www.biorxiv.org/content/10.1...

📢Internships on cellular nematics! 🔬Come for the pretty images, stay for the cool physics: each project combines in vitro experiments with advanced microscopy and image analysis. 📧Feel free to DM or email me with any questions.

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

🔬 Don’t hesitate to join this new lab ! Super cool science and inspiring young group leader !! ☺️👇

Why choose JCS? - FREE to publish (OA options available) - Fast-track option for papers with reports - Preprint friendly, format-free submission + scoop protection - Published by a not-for-profit publisher - A tree planted for every peer-reviewed article🌳 journals.biologists.com/jcs/pages/re...

The unique mechanosensitive probe Flipper-TR is at the core of an amazing article by @juanmagararc.bsky.social and @rouxlab.bsky.social team of membrane tension experts. Congratulations! There is a great 🧵 explaining the key findings how and why cells build membrane tension gradients ⬇️

Fantastic work, congratulations @juanmagararc.bsky.social !!

A new beautiful proof that Flipper-TR is an excellent reporter of membrane mechanics (and yes membrane are made of lipids ❤️‍🔥)

Incredible work, Juanma! It was an honor to be part of it. We already miss you in the lab, but we’ll be following your next discoveries very closely! 🤩🤩

Congrats Juanma! Thanks to all for your contributions in the long journey!

New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

- A postdoc to work on cancer extravasation (4-year project). - A postdoc help in completing Filopodia-related lab projects (2-year). - Multiple Marie Curie postdoc positions that will open in the fall. - We will open a 5-year position to cover my teaching (70% research and 30% teaching).

Felicidades querido JuanMa ! El Breaking lab, o el lab FLIPado (de FLIPR) será enorme...

Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

Actin dynamics sustains spatial gradients of membrane tension in adherent cells https://www.biorxiv.org/content/10.1101/2024.07.15.603517v1

Super moon. 8”x6” oil

Emerging trends of fluorescence lifetime imaging microscopy (FLIM): advances, challenges, and prospects www.biophysics-reports.org/article/doi/...

Check the new preprint of @juanmagararc.bsky.social ! All you wanted to know about FLIPER and all the things you need to take in account before doing a FLIPER-TR experiment :)

If you are planning to do Flipper-TR experiments or FLIM imaging in general, I strongly recommend reading this beautiful method paper first! Lots of information about optimal data acquisition for reliable data analysis! Nice work from Tithi, @rouxlab.bsky.social and @juanmagararc.bsky.social !

All you've ever wanted to know about FLIM analysis (and its application in Flipper-TR)!😱🤩🔬

An incredibly comprehensive and meticulous study of Flipper-TR lifetime analysis to make your membrane tension measurements using Flipper-TR more robust and reliable. Thanks to @juanmagararc.bsky.social and @rouxlab.bsky.social for this very valuable resource!

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM by Juan Manuel Garcia-Arcos and team: www.biorxiv.org/content/10.1...

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

🚨 New preprint out! “Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies. www.biorxiv.org/content/10.1...

📢New Actin Probe available at Spirochrome! Introducing SPY650-FastAct_X our latest actin probe with highly improved kinetics and no toxicity! spirochrome.com/product/spy6... The product is now available from our distributors Preprint from the @kjohnsson.bsky.social lab: doi.org/10.1101/2025...

How cells decide where to go? #CellMigration Last year we published our 1st paper @cellcommlab.bsky.social, showing how actin-based membrane oscillations define a new direction ( #cancer & non-cancer #cells ) Full www.nature.com/articles/s41... @naturephysics.bsky.social @focalplane.bsky.social 🧪🔬

#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules #Cancer cells switch strategies during metastasis to invade other tissues Naomi Wee (naomiwee.com) did this neat movie to explain it: www.youtube.com/watch?v=D9aD... #SciSky 🧪🔬 @cellcommlab.bsky.social

New preprint! When and how do active flows become turbulent? We found that, in unconfined active nematics, the transition to turbulence is discontinuous! With @the-chaotician.bsky.social @mpipks.bsky.social arxiv.org/abs/2501.060...

I mostly see the protein sculptures I build in the lighting of my workshop. It’s fairly static and dull lighting. When they are close to being finished, I bring them into the house and enjoy watching how they change under different natural lighting throughout the day. They are so much more dynamic!

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

i might be biased, but this place is amazing: great colleagues, vibrant campus, brilliant students/postdocs - and Vienna! perfect for starting an ambitious project. apply now for a GL position at the IMP … www.imp.ac.at/career/open-...

Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados! Feel free to share, add and distribute, so we can come together again! 😍 go.bsky.app/AEeXh86

I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added go.bsky.app/5Gzo7oZ

I have created a starter pack of scientists in der Schweiz so we can all hopefully find each other 🇨🇭🧪 go.bsky.app/8rF765Z

Sunday #NewPI thoughts

This is a movie of actin filaments in a cultured cell. I like watching it and I hope you do to.

Cell and developmental biologists--Join us at the 2025 Cell Contact and Adhesion Gordon Conference. We've assembled a strong and diverse program of speakers at the cutting-edge of science in our field 1/n Please repost www.grc.org/cell-contact...

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

Adoro Mastodon, pero no he podido contenerme: cc @irreductible.bsky.social

“I’ve noticed I’m not in your starter pack. Any particular reason for that?”

Ever wondered how eukaryotic cells got their nucleus? If so, check out Anja and my new hypothesis article - which builds on the ‘inside-out model of eukaryogenesis’: journals.asm.org/doi/10.1128/...

Now out in NSMB for those who missed our biorxiv back in 2023.. bacterial ESCRT-III-like #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😵‍💫 wonderful collaboration with Adai Colom’s lab and @rouxlab.bsky.social rdcu.be/dZSPQ

What are #theory and concepts in #biology? Come to our EMBL Heidelberg symposium (edition II) next May to find out more! Featuring such exciting topics as active matter, information processing, learning and computation, Physics of morphogenesis and much more! www.embl.org/about/info/c...

Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN

A couple of recent multi-author perspectives on the present and future of physical biology. www.sciencedirect.com/science/arti... www.cell.com/current-biol...

Popard Henri PhD defense. Group of Matthieu Piel “Cell size homeostasis under mechanical constraints” Thursday, November 14th, at 2:00 PM in Amphithéâtre Marie Curie, 1 rue Pierre et Marie Curie, 75005 Paris. u-paris.zoom.us/j/8390737615...