Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses? 🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!

If you or your trainees are just getting started with image analysis of cells & are #CellProfiler -curious, here is a fairly thorough walk-through demo I did recently. Loading files, extracting metadata (fun with Regex!), identifying objects, measuring, filtering, QC, exporting: youtu.be/fO5nJdhj_7I

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

New preprint! Do you like ocean waves? We found similar waves on bacterial colonies! We found that this collective behavior, known as rippling, is nothing but surface waves on an active nematic. @princeton.edu @mpipks.bsky.social @ub.edu @icreacommunity.bsky.social www.biorxiv.org/content/10.1...

Super excited to start as an ICREA Research Professor at the University of Barcelona! Really happy to join fantastic colleagues at @icreacommunity.bsky.social and @ub.edu. www.icrea.cat/community/ic...

📢Internships on cellular nematics! 🔬Come for the pretty images, stay for the cool physics: each project combines in vitro experiments with advanced microscopy and image analysis. 📧Feel free to DM or email me with any questions.

New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen

Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550 (publication coming soon!) Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

Vous faites des études de physique mais vous ne savez pas quel métier faire ? J'ai rédigé pour la Société française de physique @sfp-physique.bsky.social une description de nombreux métiers accessibles, à travers les témoignages de celles et ceux qui les exercent. www.metiersdelaphysique.fr

Hi, I’m David Brückner @davidbrueckner.bsky.social. I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information. buff.ly/RFxVeHh

Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps. @pnas.org @ub.edu www.pnas.org/doi/10.1073/... #ActiveMatter #Microfluidics #SoftMatter

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

Amazing story 😍 Just scan through it. Sophisticate, delicate and elegant 💥 Will read it in details again when time allows😋

Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ www.biorxiv.org/content/10.1...

Borges, A., Miranda-Rodriguez, J. R., Ceccarelli, A., Ventura, G., Sedzinski, J., Lopez-Schier, H., & Chara, O. (2025). ForSys: non-invasive stress inference from time-lapse microscopy. iScience, 28, 113685. #EpithelialMechanics buff.ly/jQ96TCK

If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back. I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains 1/ doi.org/10.1101/2025...

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM by Juan Manuel Garcia-Arcos and team: www.biorxiv.org/content/10.1...

An incredibly comprehensive and meticulous study of Flipper-TR lifetime analysis to make your membrane tension measurements using Flipper-TR more robust and reliable. Thanks to @juanmagararc.bsky.social and @rouxlab.bsky.social for this very valuable resource!

All you've ever wanted to know about FLIM analysis (and its application in Flipper-TR)!😱🤩🔬

Modifying mechanical constraint guides gastruloid patterning This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues: journals.biologists.com/dev/article/...

In this beautiful system, we could show uncoupling of gene expression profiles, morphology and patterning… #NotInTheGenes 😉 (also includes a method to do long term 🔬 of elongating gastruloids) Thank you to all involved @jeromewongng.bsky.social @thomasgregor.bsky.social @alexandremayran.bsky.social

#FluorescenceFriday: getting ready for #GEF25, playing with Ciarán's stunning ExM data

👩‍🔬J'ai commencé un kit de démarrage "chercheuses en France" go.bsky.app/TBEzKC #FemmesEnScience J'ai besoin de votre aide pour le remplir et donner de la visibilité aux chercheuses que vous connaissez et qui sont sur Bluesky ! ▶️Taguez celles que vous connaissez, je les ajoute !

Super clear thread for super cool science!

I love the pearling instability at the end ! 😍 What happens in the happy attached flagellum to stabilize its tubular shape?

Most striking, in some instances of spontaneous flagellar detachment, the flagellum can glide on its own - mercilessly leaving the cell body behind, stabbing it on the way if need be (don't do this at home).

#SmoothMuscleCell #Piezo1 Small intestinal motility SMC Piezo1 KO in 4~6 wk-old🐭 👉Muscularis thinning 👉⏬Food consumption 👉⏬SMC density w/o⏫apoptosis 👉⏬small intestinal motility 👉⏬Muscularis Orai1/3 Trpc4 IP3R ⏫Cav1.2 Ano1 👉⏬carbachol-induced tension #CommsBio 2025 www.nature.com/articles/s42...

In the New and Notable "Pulling Frank-Starling into another dimension," Megan L. McCain highlights the paper "Biaxial length-tension relationship in single cardiac myocytes ." buff.ly/XliGXNu

CellPose 4.0 is a beast. Segmented human microglia, in brightfield. Credit to Sydney Houser.

Super excited that our group will be supported by an ERC Starting Grant! In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions. We'll have PhD and Postdoc positions available, please get in touch if interested!

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...

Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium

Our study on endothelial mechanics made the news! 🤩 Super nice and clear article on our findings and their implications. www.snexplores.org/article/how-...

Nice discussions after the talk given online yesterday at cytophys.org, presenting the work of @pauguillamat.bsky.social @clairedessalles.bsky.social @yamini-ravichan.bsky.social @oriolmb.bsky.social and Tithi Mandal. Available on the lab youtube channel at: youtu.be/g-7HomnPdtk

I'm grateful for the Research Council of Finland for granting me the Academy Research fellowship! After getting over the shock I will soon move back to Finland to start as a group leader at the Institute of Biotechnology @helsinki.fi. Looking for a PhD student soon! www.aka.fi/en/about-us/...

Thank you @cp-newton.bsky.social for the very nice spotlight on our latest paper on endothelial mechanics! www.cell.com/newton/fullt...

Hi everyone! We are Newton, the flagship physics journal for Cell Press that launches in 2025. Starting our first post with an 🎇 EXCITING ANNOUNCEMENT 🎇 Our first article and Perspective are now online!!! Check them out @ www.cell.com/newton/newar... !

How can organs regenerate fast? Bioelectricity helps -- by coupling sub-second electrical injury signals to regenerative proliferation. First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social

Super proud of superstar postdocs @nerlielisa.bsky.social and @liujinghui.bsky.social for our lab's most recent preprint! We uncover how wound-induced electrical currents are generated and transmitted in tissues, triggering proliferation, essential for organ #regeneration #bioelectricity #QBio 👇

Re-growing adult organs: mothers do it best Tomotsune Ameku from the lab of @irenemiguel-aliaga.bsky.social @crick.ac.uk tells the behind the paper story of their work looking into maternal intestinal growth in mice during reproduction: thenode.biologists.com/re-growing-a...

Preprint alert: 🧠🌊🦓-🐟 Have you ever wondered how molecules move around the brain? Check out our latest preprint led by Halvor Herlyng from the team of Marie Rognes @utropstegn.bsky.social at @simularesearch.bsky.social and us at NTNU. www.biorxiv.org/content/10.1...

Nematics in action in vivo! Smooth muscle cells (mis-)orientation and their active stress matters to dorsal aorta function.

Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells. www.biorxiv.org/content/10.1...

Flocking and active solid behavior of epithelial cells in our new study in @pnas.org Great work of Y. Shen, J. O'Byrne and @andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez! | PNAS www.pnas.org/doi/10.1073/...

Just published!🎉 Excited to present Pickering lab's work on @pnas.org #IntussusceptiveAngiogenesis-On-A-Chip🤩 For 1st time in vitro, we rebuilt multicellular pillars composed of #EndothelialCells crossing a pressurized, flowing channel🤓 Kudos to our stellar Sabrina🌟 www.pnas.org/doi/10.1073/...

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi @ipparis.bsky.social @polytechniqueparis.bsky.social

Did you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...