Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social 📩 Questions? Contact us ✉️ 🔗 Apply here: www.mpg.de/25243280/bio...

Similar huge trend at last round of @erc.europa.eu grant application. @ec.europa.eu must adapt to this trend!

Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

Looks like private funders, HHMI,CZI etc., are not going to “save” US research. Europe is setting up mechanisms to attract US researchers & it may work. But, common, target junior talent, don’t shower money on superstars who will be flying professors & return to US when the science winter passes.

Impressive work from @josesilvalab.bsky.social www.cell.com/cell/fulltex...

1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". www.cell.com/cell-stem-ce...

Online Now! Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs #stemcells

#jobAlert We are hiring! If you like #imaging ,gene regulation and a dynamic group please apply. We are looking for a research assistant with a master degree and prior experience in academia.

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

So excited to share my 1st paper !!🌞 Co-authored with @jules-vanaret.bsky.social @dunsingvalentin.bsky.social, we developped an integrated pipeline for imaging, segmenting and analysing cell-scale patterns in gene expression + tissue properties in complex 3D tissues elifesciences.org/reviewed-pre...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

A dream come true: my first first-author publication! 🧬 🎉 Working to unravel the mysteries of long-range gene regulation has been an incredible journey. Endless gratitude to Evgeny, the lab, and all of the amazing collaborators who helped make this happen 🙌

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Checkout the full story online now at Dev Cell, the product of a team effort with the help of our fantastic collaborators including @da-bar.bsky.social @borislenhard.bsky.social @mpercharde.bsky.social Article link: doi.org/10.1016/j.de...

🥇Sham Tlili has been awarded the CNRS 2025 Bronze Medal! She studies how physical forces shape living tissues by using mouse stem cell models known as gastruloids. A unique blend of physics & biology. 🔗 Read more: www.ibdm.univ-amu.fr/sham-tlili-w...

We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested. www.fmi.ch/education-ca...

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

We are excited to officially welcome a new group leader at the MPI-IE in #Freiburg. 🎉 Dr Juliane Glaser 🥳 – she studies epigenetic mechanisms of embryonic development, with a focus on transposable elements. 👉 Interview: www.ie-freiburg.mpg.de/6043545/2025... Welcome, @julianeg.bsky.social!

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

Save the date 📅! Our TriNational #devbio #stemcell Meeting 2025 will be held in Freiburg on Sept. 19th. As always, participation is free and talks will be selected from early career scientists. Joun us 😊 Info: devstemcell.org/home @biozentrum.unibas.ch @uni-freiburg.de @igbmc.bsky.social

Great work from Mochulska & Francois developing a generative framework for systematically building Dynamical Landscapes of cell fate decision making using modular dynamical components Important step to interpretable and predictive models of cellular differentiation www.biorxiv.org/content/10.1...

If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc. app.beetween.com/WeaselWeb/p/... Don't hesitate to apply or share the post !

Out today in @natmethods.nature.com : Spotiflow, our transcript localization method for imaging-based spatial transcriptomics. Led by amazing PhD student @albertdm.bsky.social, joint work w @gioelelamanno.bsky.social at EPFL / @scadsai.bsky.social www.nature.com/articles/s41... rdcu.be/epIB7

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

TF binding is usually anticorrelated with DNA methylation, but there are very few studies that actually investigate why. This is really nice work from Jacques Drouin's lab showing PAX7 physically interacts with UHFR1, blocking DNMT1 recruitment ‪@ircm.bsky.social‬ www.science.org/doi/10.1126/...

New preprint of @trono-lab.bsky.social and my PhD work! By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity. 🫀heartbeat on 🔁 repeat www.biorxiv.org/content/10.1... #TEsky

For an update on a set of recent preprints using gastruloids to investigate the interplay between morphogenesis, gene expression and physical parameters, on the robustness of patterning: journals.biologists.com/dev/article/...

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Our recent paper reports extremely long-range (up to 5.1 Mb 😲) regulation of certain genes in fly neurons and provides new insights into how they form (see short thread below 👇). genesdev.cshlp.org/gca?gca=gene...

📢 Fresh off the press and featuring new exciting experiments! 🧪 We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊 doi.org/10.1016/j.st... B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩

Symposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘

An EU wide effort to increase science funding, even if not solely targeting Americans, would be a huge long term win for them. US seems intent on coding leadership, just a matter of who takes it

PUBLIC RESEARCH!! ✊🧪 @standupforscifr.bsky.social @sufs-paris-rp.bsky.social @standupforscience.bsky.social

January has been a plentiful month for #gastruloid #preprints. Here @thomasgregor.bsky.social @denisduboule.bsky.social & colleagues introduce a new family of #hydrogels and probe the effect of mechanical constrains on morphogenesis www.biorxiv.org/content/10.1... #NotInTheGenes #InNumbersWeTrust

Check out this new paper from @thomasgregor.bsky.social 's lab on hydrogel embedding of mouse gastruloids to control gene expression and patterning.

🚨 Postdoc wanted 🚨 Ever wondered how mechanical forces shape the heart tube during embryogenesis?… I am looking for a postdoc with a background in developmental biology or biophysics to investigate this new topic as part of an ANR-JCJC 🚀🔬 Don’t hesitate to contact me 🤓🔗

With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron. tinyurl.com/5n6z9rt9

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!

🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders? Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing 🔗 www.biorxiv.org/content/10.1... Happy New Year, everyone! 🎉 🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇

This work was led by postdoc, Komal, and research scientist, Louise, @theCrick with the help of lots of others. The link to our biorxiv manuscript can be found here: biorxiv.org/cgi/content/... Feedback welcome, thanks for reading! 🙏 (7/7)

Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization www.biorxiv.org/content/10.1...

Our latest: how to generate the notochord "Timely TGFβ signalling inhibition induces notochord" A thread: www.nature.com/articles/s41...